Ho hlohlona ka phetolelo ke litšoaneleho le adjuvats tse sebelisitsoeng tlhahisong ea meriana le litaelo, 'me ke karolo ea bohlokoa ea mekoloto ea mekhahlelo. Joaloka phuna ea tlhaho ea polymer e nkiloeng, Ether e na le litšobotsi tsa bioderalli, methyl cebeloseENDE ENSEjoalo ka hydroxethyl celdroporese le selenyl cellulose ea boleng bo botle ba sebelisang litlhare tsa meriana. Hajoale, lihlahisoa tsa likhoele tsa lapeng e rekisoang haholo libakeng tse bohareng le tse tlase tsa indasteri, 'me boleng bo eketsehileng ha bo phahame. Indasteri e hloka ho feto-fetoha le ho ntlafatsa le ho ntlafatsa lits'ebetso tsa ho qetela tsa lihlahisoa tse phahameng.
Bareki ba pharmacetic ba bapala karolo ea bohlokoa ho nts'etsopele le tlhahiso ea liforomo. Ka mohlala, litokisetso tsa ho lokolla, lisebelisoa tsa polyter tse kang celtialose li sebelisoa e le li-pelletso tse khohletseng, li ile tsa lokolla lithethefatsi, lokollotse lithethefatsi tse tšehelitsoeng. Litokisetso le litokisetso tse bolokiloeng li sebelisitsoe haholo. Tsamaisong ena, li-polyments tse kang tsena tse nang le li-cellulo li sebelisoa e le thepa ea lithethefatsi ho laola sekhahla sa lithethefatsi ka nako e itseng ho fihlela sepheo se sebetsang.
Ho latela lipalo-palo tsa lefapha la boeletsi le lipatlisiso, ho na le mefuta e ka bang 500 ea mefuta-futa, mefuta e fetang 3000), ho na le phapang e kholo, 'me mefuta e ntse e nyane. Bareki ba phatlalatso ba lichankana ba li-rarithamine ba litaba ba ntlafatso ea 'maraka o moholo. Hoa utloahala hore li-ralibu tsa 'maraka oa naha tsa naha ke tsa litlaleho tsa marang-rang, Poprose, HydroxypropyproPypropy. Meroho ea limela, HPC, lactose.
"Kenyelletso ea Natulose e akaretsang bakeng sa letoto la litlolo tsa cellulose masimo, lihlahisoa tsa libusi tsa meriana le libakeng tse phahameng tsa indasteri le tsona li ka eketsoa ke boleng ba li-ratriulous tsa meriana. Etsa matlapa a matla a matrix a lokolloang
Sodium canboxeMethyl cellulolose (CMC-NA) ke sesebelisoa sa cellulose se nang le tlhahiso e kholo le tšebeliso ea lapeng le kantle ho naha. Ke selefounu ea ioni ea ionic Cmc-na e sebelisoa haholo ke meriana e tloaelehileng ea meriana. Hangata ho sebelisoa e le tšebeliso ea litokisetso tse tiileng le e le moemeli oa tokiso, o emisang le ho emisoa bakeng sa litokisetso tsa metsi. E ka sebelisoa e le thepa e qhibilihang ea metsi le thepa e etsang lifoto. Hangata e sebelisoa e le thepa ea lithethefatsi ea ho lokolloa ea ho lokolloa le ho lokolloa - ho lokolloa ka matla a ho lokolloa ka matla (e laoloang).
Ntle le sodium canboxemeethyl celbolose e le bakhethoa, ba Croscarmelose Sodium e ka sebelisoa e le litheolelo tsa meriana. Class-limboxl celbolese Sodium (CCMC-NA) ke ntho e sa hlakoloang ke metsi ka modumo e itseng ea con, e hloekisitsoeng. Moemeli oa lifapano oa sefapano e ka bua puo ea Glyne, AnhnDride Athhdride, Ashipikia Athhydride, a Profil ahhydride, le joalo ka. Sodium ea Croscarmelose e sebelisoa e le moferefere oa matlapa, li-capsules le granules litokisetsong tsa molomo. E itšetleha ka capillary le litlamorao tse ruruhang ho fihlela ho senyeha. E na le bothata bo botle le ho se sebetse hantle. Boithuto bo bontšitse hore tekanyo e tšelang ea Croscarmelose Sodium e kholo joalo ka Sodium canlllose
Methyl celllosese (MC) ke monothether ea se nang leeme o entsoeng ka k'hothone le lehong ka alkalide etheride chlolide. Methyl cellulose e na le qubu e ntle ea metsi mme e tsitsitse ho PH bophara ba 2.0 ho isa ho 13.0. E sebelisoa hohle ho bakhethoa ba meriana, 'me e sebelisoa matlapeng a marang-rang, litokisetso tsa apphlharm, li-capsuls tsa molomo, matlapa a molomo le litokisetso tsa holimo. Ntle le moo, litlhare tse lokollotsoeng, tsa mc li ka sebelisoa e le thepa ea kamente ea hydrophili, ho lokolloa thepa ea microcapule e ileng ea khomarela - e lokollotsoeng - jj.
HydroxypropypropypropinyL methylcelllulose (HPMC) ke sesebelisoa se seng sa Ioni sa ionic le lehong le ka bongata ba chlolide ea methylene le methyl chloride. Ha e na ho hloka moriri. Hydroxypropyproping Methylcelulose ke mefuta e mengata ea mcelloulo e fetisitsoeng ka potlako ho tlhahiso, tšebeliso le boleng lilemong tse 15 tse fetileng. Hape ke e 'ngoe ea baahlolinisi ba seholosehi ba seholo ka ho fetisisa ba sebelisoang lapeng le kantle ho naha. E sebelisitsoe e le botumo ba meriana nako e ka bang 50. Lilemo tsa nalane. Hajoale, ts'ebeliso ea HPMC e bonahala haholo likarolo tse ling tse latelang:
E 'ngoe e tšoana le ho hlaba le ho senyeha. HPMC ha e le morui e ka etsa hore ho be bonolo ho koloba, 'me ho ka hola makhetlo a makholo kamora ho ntlafatsa ho felisoa kapa ho lokolloa letlapa. HPMC e na le pono e matla, 'me e ka ntlafatsa sebopeho sa sebopeho le ho ntlafatsa tumello ea lisebelisoa tse tala ka crisp kapa mokhoa o boima. HPMC e nang le Visicossity e tlase e ka sebelisoa e le mokhoa o mongata ebile o sentse, mme HPMC e nang le pono e phahameng e ka sebelisoa e le chelete e ngata feela.
Taba ea bobeli, e sebelisoa e le ntho e tobileng le e laoloang e hlophisehileng le e laoloang bakeng sa litokisetso tsa molomo. HPMC ke ntho e tloaelehileng ea Mydrogel Mattrix litokisetsong tse tšehelitsoeng. HPMC ea sehlopha se tlase sa Viscosity (5 ~ 50FA ■ Ho ka sebelisoa matlapa a ho atoloha le a ho emisoa le HPMF. HPMC e qhibiliha mokelikeli oa gastrointestinastel, e na le melemo ea khatello e ntle, ho theoha hantle, ho lahleheloa ke lithethefatsi tse matla tse sa anngoeng ke PH. Ke thepa e boima haholo ea hydrophilic e ileng ea tsamaisana hantle ea litokisetso tsa tokiso 'me hangata e sebelisoa e le lisebelisoa tsa tokiso tse tšehelitsoeng le tse thibetsoeng - li lokolloe lisebelisoa tse thusang.
Ea boraro e joalo ka moemeli ea etsang lifilimi tse etsang lifilimi.Hpmce na le thepa e ntle ea lifilimi. Filimi e thehileng ke eona ke yunifomo, pepeneneng, le ho thata, ebile ho thata ho khomarela tlhahiso. Haholo-holo bakeng sa lithethefatsi tse bonolo ho amohela mongobo ebile ha ho na letho, e e sebelisa haholo e le karolo ea ho itšehla thajana ebile ho thibela filimi ho fetola 'mala. HPMC e na le litlhaloso tse fapaneng tsa lipono tsa pono. If selected properly, the quality and appearance of the coated tablets are better than other materials, and its common concentration is 2% to 10%.
Tse 'ne e sebelisoa e le thepa ea cappule. Lilemong tsa morao tjena, ka ho phatloha hangata ea mafu a liphoofolo tsa lefats'e, ha a bapisoa le li-capsules tsa Gletin, li-capsules tse ncha tsa pharma le lijo. PFIZER e entse ka katleho ho tsoa ho HPMC ho limela tsa tlhaho le li-capsules tsa meroho ea VCAPTM. Ha ho bapisoa le li-capsules tsa Getatin Hollow, li-capsules tsa meroho li na le melemo e mengata, ha ho na kotsi e phahameng ea karabelo, le botsitso bo phahameng. Sekhahla sa ho lokolloa ha sethethefatsi se tsitsitse, 'me liphapang tsa motho ka bo' ngoe li nyane. Kamora ho khelosoa 'meleng ea motho, ha e abeloe mme e ka pepesetsoa. Ho tsoa 'meleng. Mabapi le maemo a polokelo, kamora liteko tse ngata, hoo e batlang e le brinttle e se nang mongobo, le li-indexes tse fapaneng tsa li-capsule tse feteletseng ha li amehe. Ka kutloisiso ea batho ba li-capsules tsa batho le phetoho ea likhopolo tsa bongaka malapeng le linaheng tse ling, tlhokeho ea marapo oa li-capsules e tla hola ka potlako.
Ea bohlano ke moemeli ea emisang. Mokhoa oa ho emisoa ka sefofane ke mokhoa o tloaelehileng oa dialiniki o tloaelehileng, e leng tsamaiso e tiileng eo lithethefatsi tse qhalanang ka metsi. Ho tsitsa ha sistimi ho khethoa boleng ba litokisetso tsa metsi a emisang. Tharollo ea Coloidal ea HPMC e ka fokotsa khatello e matla ea metsi, fokotsa matla a mahala a likaroloana, 'me a tsitsisa tsamaiso e sa qhaleheloang ke lerata. Ke moemeli ea sa khaotseng haholo. HPMC e sebelisoa e le thipa bakeng sa marotholi a mahlo, e nang le litaba tsa 0.45% ho 1.0%.
HydroxypropypropyL ke conluulose (HPC) ke monothether ea se nang leeme o entsoeng ka k'hothone le lehong ka alkalization le propride ea oxide. HPC hangata e qhibiliha ka metsing ka tlase ho 40 ° C le solt tse ngata tse amanang le litaba tsa hydroxypropyl le tekanyo ea polymerizypropity. HPC e ka lumellana le lithethefatsi tse fapaneng 'me e na le botle bo botle.
Hydroxypropyl cellulose ea tlase(L-hpc)e sebelisoa haholo joalo ka ha ho na le tafole ea letlapa le binder. Litšobotsi tsa eona ke: ho bonolo ho tobetsa le ho ntlafatsa le ho ntlafatsa matla a polasetiki le ho ntlafatsa boleng ba letlapa, le ho ntlafatsa phello e sithabetsang.
HydroxypropypropyLel cellulose e ka sebelisoang e le moemeli ea tlamang bakeng sa matlapa, granules le granules e ntle tšimong ea meriana. H-HPC e na le thepa e ntle haholo ea lifilimi, 'me filimi e hlahisang lifilimi le e thata, e ka bapisoang le lipalesa. Ka ho kopanya le baemeli ba bang ba anti-metsi a enngoeng, ts'ebetso ea filimi e ka ntlafala, 'me hangata e sebelisoa e le thepa ea lifilimi e tsamaeang le lifilimi. H-HPC e ka sebelisoa e le litaba tsa matlatoe ho lokisa matlapa a tobileng a tokiso, le liqhetsa tse peli tse tšehelitsoeng habeli.
Hydroxethyl Cellulose Hec o sebelisoa haholo e le bolotsana, moemeli ea sireletsang, a khothehang, ea hlolloang, ea hlolloang, ea ho emisoa ke moemeli ea etsang lifilimi. E ka sebelisoa ho basius ea emulsions, lisebelisoa le marotholi a mahlo bakeng sa meriana ea lihlooho tsa lihlooho. Mokelikeli oa molomo, matlapa a tiileng, li-capsules le liforomo tse ling tsa litekanyetso. Hydroxethyl Cemloulose e kenyellelitsoe ho The Larmakopoes and Year of Naha ea US le Apaticopoeia.
Sesebelisoa sa Ethyl (EC) ke e 'ngoe ea libui tse sebelisoang haholo tsa metsi. EC ha se chefo, e tsitsitseng, e sa tloaelehang ka metsing, tharollo ea asiti, acid kapa alkana li qhibilihe ka li-solvent tse kang Ethano le methanol. Solvent e tloaelehileng e sebelisoa ke solvent e tsoakiloeng ea Toluene / ethanol 4/1 (boima). C e na le lits'ebeletso tse ngata tsa lithethefatsi tse tsamaisang moriana, 'me e sebelisoa haholo e le phepelo e fapaneng ea lifilimi ho lokisa lisebelisoa tse khokhothetsoeng le li-pellets tse khokhothetsoeng, joalo ka encaes Quaps lingoliloeng tse thusang ho lokisa microcapsus tse tšehelitsoeng; E ka boela ea sebelisoa haholo e le sehlahisoa se tsamaisang sekhachane ho lokisa ho se ha hahelloa. Ho ka sebelisoa haholo theknoloji ea pharmacceutical e le ntho e etsang ntho e etsang filimi le koae e sirelletsang, 'me e ka sebelisoa e le moqapi oa motlakase ebile e se u filoe. Joaloka mokhathala o sirelletsang litafole, ho ka fokotsa kutloisiso ea matlabo le mongobo o mongobo le ho thibela lithethefatsi hore li se ke tsa nyahama le ho fokotsoa ke mongobo; E ka theha lera le toro ea khokahano e liehang butle mme e na le likokoana-hloko tsa polymer ho lokolla phello ea lithethefatsi ka mehla.
Ka kakaretso, metsi a qhibilihileng Sodium celboxese, Methyl cellulose, Hydroxypropylase, Hydroxypropy Le thepa e laoloang bakeng sa litokisetso tsa molomo, li-fimance tse sebelisang lifilimi, lisebelisoa tsa capsule le ho emisoa. Ha ba le bateng ba kantle ho naha ba tsoang kantle ho naha (Shin-etsu Japan, Jack Wolff le Ashlane) ba eketsehile ho ba teng ha bona naheng ena. Matsete ka har'a kopo. Dow Wolff o phatlalalitse hore e tla eketsa tlhokomelo ea eona 'marakeng, mekhoere le litlhoko tsa' mele tsa teng tsa Machaena ho tla loanela ho ba haufi le 'maraka. Karolo ea Wolf e arotsoe ea ponts'o ea li-confalos le crailcon ea United States e thehile le ho laoloa ke toro ea lefats'e. E na le basebetsi ba fetang 1 200 ba litoropong tse 9, ba 15 ba thepa le lik'hamphani tse 6 tsa GMP. Litsebi tsa lipatlisiso tse sebelisitsoeng li fana ka lits'ebeletso ho bareki ka linaha tse ka bang tse 160. As A. Kunjing, Changzhou, Kunjing, Kunjing, Kunjen le Riiang
Ho latela lipalo-palo webosaeteng ea Sengoli sa China, Ether ea lapeng e ne e le bophahamo ba cellulose Ether le Buka ea Lichelete e ne e le lithane tse likete tse 360. Ka 2017, buka ea sebele ea ho rekisa IonicCmce ne e le lithane tse 234 000, keketseho ea selemo sa 181% ka selemo sa selemo sa 181, ka selemo sa batho bao e seng ionic Cmc, keketseho ea selemo sa 8,2% ea selemo. Ntle le HPMC (Ho aha Lihlahisoa tsa Lintho tse Nyane,Hpmc(Pharmaceutical Kere), HPMC (sehlopha sa Lijo), MC, Hemc, joalo-joalo. Ethe e se e ntse e hola ka potlako bakeng sa lilemo tse fetang leshome, 'me tlhahiso e fetohile ea pele. Leha ho le joalo, boholo ba litaba tsa lik'hamphani tsa cellulose Ether li sebelisoa haholo bohareng le qetellong ea indasteri, mme boleng bo eketsehileng ha bo phahame.
Hajoale, boholo ba bongata ba celpeloses call ea lapeng ether ba ka nako ea bohlokoa ea phetoho le ntlafatso. Ba lokela ho tsoela pele ho eketsa boiteko ba lipatlisiso le ntlafatso, 'maraka oa sehlahisoa, ba sebelisoe ka botlalo China,' me ba eketsa litlamo tsa ho hola kapele kamoo likhoebo li tla khona ho hola kapele kamoo ho ka khonehang. Tlatsa phetoho le ntlafatso, kenya pheletso ea indasteri ea indasteri, 'me u fihle ho sign le nts'etsopele e tala.
Nako ea ho romella: April 25-2024