Hydroxypropyl methylcellulose e na le mefuta e mengata ea lisebelisoa

Hydroxypropyl methylcellulose (HPMC)ke polymer e feto-fetohang e fumanang tšebeliso e pharaletseng liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang. E tsoa ho selulose, HPMC e hapile tlhokomelo e kholo bakeng sa lits'ebetso tsa eona tse fapaneng ho pholletsa le meriana, kaho, lijo, litlolo, le tse ling.

Sebopeho sa Lik'hemik'hale le Thepa:

HPMC ke semi-synthetic, polymer e qhibilihang ka metsing e nkiloeng ho selulose.
Sebopeho sa eona sa lik'hemik'hale se na le mokokotlo oa cellulose o nang le methyl le hydroxypropyl substituents.
Tekanyo ea ho kenya sebaka (DS) ea lihlopha tsa methyl le hydroxypropyl e etsa qeto ea thepa ea eona le ts'ebeliso ea eona.
HPMC e bonts'a thepa e ntle haholo ea ho etsa lifilimi, e teteaneng, e tlamang le e tsitsitseng.
Ha e chefo, ha e na chefo, ha e na chefo, ebile ha e na tikoloho, e etsa hore e lokele lits'ebetso tse fapaneng.

Lisebelisoa tsa Meriana:

HPMC e sebelisoa haholo mekhoeng ea litlama e le mothusi.
E sebetsa e le tlamahano ea liforomo tsa letlapa, e fana ka momahano le botšepehi ba letlapa.
Mehaho ea eona ea tokollo e laoloang e etsa hore e be e loketseng bakeng sa litlatsetso tsa nako e telele le tokollo e atolositsoeng.
HPMC e boetse e sebelisoa ka tharollo ea ophthalmic, suspensions, le metsoako ea lihlooho ka lebaka la thepa ea eona ea mucoadhesive.
E ntlafatsa viscosity le botsitso ba mefuta ea litekanyetso tsa mokelikeli joalo ka syrups le suspensions.

Indasteri ea Kaho:

Lefapheng la kaho, HPMC ke motsoako o ka sehloohong oa thepa e thehiloeng ho samente.
E sebetsa e le setei, se bolokang metsi, le mofetoleli oa rheology ka seretse, li-grouts le likhomaretsi tsa lithaele.
HPMC e ntlafatsa ts'ebetso, e fokotsa karohano ea metsi, 'me e matlafatsa matla a ho khomarela lihlahisoa tsa kaho.
Ho lumellana ha eona le lisebelisoa tse ling tse kang metsoako ea samente ho kenya letsoho mosebetsing o akaretsang oa thepa ea kaho.

Indasteri ea Lijo le Lino:

HPMC e amohetsoe hore e sebelisoe joalo ka tlatsetso ea lijo ke mekhatlo e laolang lefats'e ka bophara.
E sebelisoa e le setepi, se tsitsisa, le emulsifier lihlahisoa tse fapaneng tsa lijo.
HPMC e ntlafatsa sebopeho, viscosity, le molomo oa lisoso, sopho, lijo tse theolelang, le lihlahisoa tsa lebese.
Ho lino tse tahang, e thibela sedimentation, e ntlafatsa ho fanyeha, 'me e fana ka ho hlaka ntle le ho ama tatso.
Lifilimi tse jeoang tse thehiloeng ho HPMC le lirafshoa li lelefatsa bophelo ba lishelefo ea lijo tse senyehang le ho ntlafatsa boipiletso ba tsona ba pono.

Litlolo le Lihlahisoa tsa Tlhokomelo ea Motho:

HPMC ke motsoako o tloaelehileng ho litlolo, tlhokomelo ea letlalo, le litlolo tsa tlhokomelo ea moriri.
E sebetsa joalo ka motenya, emulsifier, le moemeli ea emisang ka har'a litlolo, litlolo le li-gel.
HPMC e fana ka sebopeho se boreleli, se monate le ho ntlafatsa botsitso ba li-emulsion ho litlolo tsa litlolo.
Ka lihlahisoa tsa tlhokomelo ea moriri, e ntlafatsa viscosity, e fana ka melemo ea boemo bo botle, 'me e laola rheology.
Lifilimi le li-gel tse thehiloeng ho HPMC li sebelisoa ho limaske tse hlokomelang letlalo, litlolo tse sireletsang letsatsi, le maqeba a maqeba bakeng sa thepa ea tsona ea mongobo le lithibelo.

Lisebelisoa tse ling:

HPMC e fumana lits'ebetso liindastering tse fapaneng tse kang masela, lipente, likoahelo le lirafshoa.
Ka masela, e sebelisoa e le mokhoa oa ho etsa boholo, botenya, le pente ea khatiso mekhoeng ea ho daea le ea khatiso.
Lipente le lipente tse thehiloeng ho HPMC li bonts'a mamaretso a ntlafalitsoeng, thepa ea phallo le ho emisoa ha pigment.
Ka li-ceramics, e sebetsa e le setlamo sa 'mele ea ceramic, ho matlafatsa matla a matala le ho fokotsa ho phunyeha nakong ea ho omisa.

Hydroxypropyl methylcellulose (HPMC)e hlahella e le polymer e sebetsang ka bongata e nang le mefuta e mengata ea lits'ebetso ho liindasteri tse fapaneng. Motsoako oa eona o ikhethang oa thepa e kenyelletsang ho qhibiliha ha metsi, bokhoni ba ho etsa lifilimi, le taolo ea rheological e etsa hore e be ea bohlokoa haholo ho tsa meriana, kaho, lijo, litlolo le ho feta. Ha lipatlisiso le boqapi li ntse li tsoela pele ho hola, HPMC e kanna ea fumana lits'ebetso tse fapaneng le tse ncha, e tiisang boemo ba eona ba ho ba polymer ea bohlokoa le e fapaneng lefatšeng la sejoale-joale.