HydropxpropyL methylcell phapang ea mohlala oa mohlala

HydroxypropypropyLese (HPMC)Ke tšebeliso e mpe ea indastering ea indastering e fapaneng, ho kopanyelletsa le megation, lijo, litlolo le kaho. Thepa ea eona le lits'ebetso li fapana ho latela sebopeho sa eona sa liseleccular, tse ka fetoloang ho lumellana le litlhoko tse ikhethang.

Sebopeho sa lik'hemik'hale:

HPMC ke mofetoheli oa cellulose, polymer ea tlhaho e fumanoang limela.
Ke hydropypropyl le methyl tsa methyl li khomaretsoe lihlopha tsa hydroyl of the sydrone khutlela morao.
Karolelano ea libaka tsena e khetha thepa ea HPMC, e kang snoubility, genation, genation le bokhoni ba ho etsa lifilimi.

SUPTITITITITITITITITITITIONS (DS):

DS e bua ka palo e tloaelehileng ea lihlopha tse bonoang ka sehlopha sa glucose se ka morao ho silecone.
Boleng ba DSS bo phahameng bo fella ka hydrophphilicity e kholo, skoubili le bophahamo ba bo bong.
Low DS HPMC e tsitsitse haholoanyane ebile e na le e hanyetsanang e hanyetsanang, e etsa hore e be loketse likopo tsa thepa ea kaho.

Boima ba limocular (mw):

Boima ba molengcular bo ama liketsahalo, bokhoni ba ho etsa lifilimi le thepa ea tšebetso.
Boholo ba limolek'hule tsa lipalesa tsa molek'hule li na le pono e phahameng le thepa e ntle ea lifilimi, e etsang hore e tšoaneloe ke tšebeliso ea li-pharmatical tse bolokiloeng.
Li-variants tse ka tlase tsa 'mele li khethoa bakeng sa lits'ebetso tseo ho lakatsehang tse ka tlase le ho hlakoloa ka sekhahla.

Boholo ba tsona:

Boholo ba karolo e susumetsa thepa ea phallo ea phofo, sekhahla sa dissure, le ntho e ts'oanang ho liforomo.
Lits'ebetso tse ntle tsa "
Likarolo tsa coarser li ka fana ka thepa e ntle ea phalle e ka motsoako o omileng empa e ka hloka linako tse telele tsa Heldration.

Mocheso oa borena:

Mocheso oa bokhachane o bolela mocheso oo hpmc o le mong oa HPMMC o le maemong a tsoang tharollong ea gel.
Mehato e phahameng ea sebaka le boima ba limok'hule ka kakaretso e lebisa ho mocheso o tlase oa grolation.
Maro a Mahala a ho utloisisa a atoloha a bohlokoa ka mekhoa ea ho tsamaisa lithethefatsi le tlhahiso ea li-gels bakeng sa lits'ebetso tsa holimo.

Melemo ea futhumatsang:

Ho tsilatsila hoa turrmal ho bohlokoa ho lits'ebeliso moo HPMC e hlaseloa ka lebaka la ho sebetsa kapa ho boloka.
PESM HPMC e ka bonts'a botsitso ba futhumatsang botumo ka lebaka la boteng ba tse ling tsa labile.
Mekhoa ea Tlhahlobo ea Tlhahlobo e joalo ka calositsity e fapaneng le ea ho hlahlojoa kapa ho hlahlojoa ha thermogravimetrice (TGGAGE e sebelisoa ho lekola thepa ea motlakase.

Boitšoaro le Boitšoaro ba StlaDing:

Boitšoaro le Boitšoaro ba ho ruruha bo latela boima ba DS, bomolao bo botle le mocheso.
Li-vas tse phahameng tsa DS le li-moleleana tsa limolek'hule hangata li bonts'a litsi tse kholo le ho ruruha ka metsing.
Ho utloisisa litlolo le ho ruruha ho bohlokoa ho etsa mekhoa ea ho tsamaisa lithethefatsi e laoloang e laoloang

Li-rheolojipolo tsa Rheology:

Lipehelo tsa rheoloji ea Rheology e kang Litšoantšiso, Shear Karaoke o Mofutsana le Lipapatso li bohlokoa lits'ebetsong tse fapaneng.
HpmcLitharollo li bontša boits'oaro ba pseudopro, moo Vecosity e fokotsehang ka sekhahla se ntseng se eketseha.
Matloana a liphiri tsa HPMC a susumetsa ts'ebetso ea hau ea indasteri e kang ea lijo, litlolo le meriana le meriana.

Phapang lipakeng tsa mehlala e fapaneng ea HPMC e tsoang ho fapana ka sebopeho sa lik'hemik'hale, mocheso oa lifofane, mocheso oa lifofane, mocheso oa lifofane le lipehelo tsa litlolo le thepa ea litšila. Ho utloisisa liphapang tsena ke tsa bohlokoa bakeng sa ho khetha pheko e nepahetseng bakeng sa lits'ebetso tse itseng, ho tloha litlhahisong tsa pharmaceuta ho ea lisebelisoa tsa kaho.