Na HPMC e qhibiliha ka metsing a chesang?

HydroxypropypropyLese (HPMC)Ke polymer e feto-fetohang indastering e mengata ea indasteri e fapaneng e kang merimacecEicals, litlolo, kaho le lijo. E 'ngoe ea lintho tsa eona tse ke keng tsa qala ke tsatsijoe ka metsing, haholo-holo ka metsing a chesang.

1. HpMC ke eng?

HPMC ke semi-synthetic, inert, Viscoelastostic polymer e tsoa ho Cellloulose. E fumanoa ka seleng ea ho tapa le Cellulose le Alkali le Exprene Oxide, e lateloang ke methylation. Ts'ebetso ena e fella ka polymer ea quadmer ea metsi ka thepa e ntlafalitsoeng ka holim'a selefounu ea tlhaho.

2. Fulbility of Hpmc ka metsing

HPMC e bonts'a tse ntle haholo tsa kutu, haholo ha metsi a futhumetse. Sello sena se bakoa ke boteng ba li-hydrophphilic ka molek'hule ea HPMC, ka lebitso la hydroxyl (--oh) le lihlopha tsa ether le ether Lihlopha tsena li sebelisana le limolek'hule tsa metsi ka hydrogen ho tlala, e tsamaisang pherekano ea HPM ka lithapollo tsa metsi.

3. Kameho ea mocheso ho sokoudity

Sello saHpmce eketseha ka mocheso. Lihlopheng tse phahameng, limolek'hule tsa metsi li na le matla a maholo a 'mala, a etsang hore moqolo o ntlafatse limolek'hule le ho kenella hantle ha metsi ka har'a polymer matrix. Sena se fella ka li-kinotic tsa dissulict tse potlakileng le li-solubility tse phahameng tsa HPMC ka metsing a chesang a bapisoa le metsi a batang.

4. Sepopo ho likhama tsa meriana

Ho meriana ea meriana, HPMC e sebelisoa e le moemeli oa ho holisa, ea hlollang, 'me filimi e nakong e nakong e hlakileng ea liqhomane le li-capsules. Stubility ea eona ka metsing a chesang e etsa hore e be e loketseng tharollo ea ho pheha khang kapa ho sitisoa ha liforomo tsa lithethefatsi. Mohlala, HPMC e ka qhibiliha ka metsing a chesang ho etsa gel ea li-viscous e ka sebelisoang e le mokhoa oa ho fana ka tšebeliso ea lithethefatsi ho fana ka dikaroung tsa litheko.

5. Sebelisa lihlopheng tsa kaho

Indasteri ea kaho, HPMC e sebelisoa lihlahisoa tsa thibelo e kang ea samente, HPMC e sebelisoa ka lidolara tsa thibelo, tse kang likhakano tsa Tile, litlōnta. Alicaubility ea eona ea metsi e lumella ho hasana habonolo le ho tsamaisoa ka mokhoa o tšoanang ka har'a samente Matrix. Ka ho theha filimi e sirelletsang ho pota-potisisa ha li sireletseha, HPMC e ntlafatsa bokhoni, ho boloka metsing le ho tšoarela thepa ena ea kaho.

6. Bohlokoa ba indastering ea lijo

HPMC e boetse e bapala karolo ea bohlokoa indastering ea lijo, moo e sebetsang e le bolo ea thipa, emmolifier le lihlahisoa tse fapaneng tsa lijo. Stubility ea eona ka metsing a chesang e thusa ho hlophisoa ha tharollo e hlakileng le e hlakileng e kenyang likotlo tse lakatsehang le ho tiisetsa ha liforomo tse lakatsang. Mohlala, HPMC e ka qhibiliha metsing a chesang ho etsa gel, e kenngoeng ho Sauce, sopho ea ho ntlafatsa melomo le bosepa.

7. Qeto

Hpmce qhibiliha metsing a chesang, ka lebaka la sebopeho sa 'mele sa hydrophphilic le sebopeho sa lik'hemik'hale. Thepa ena e etsa hore e be motsoako oa bohlokoa likolong tse fapaneng tsa likopakeng tsa indastering e fapaneng, ho kenyelletsa merafo, moaho le lijo. Ho utloisisa boitšoaro ba balekane ba HPMC ho bohlokoa bakeng sa litlhare le bahlahisi ho ntlafatsa ts'ebeliso ea bona lihlahisoa le liforomo tsa bona.