Na HPMC e qhibiliha ka metsing a chesang?

Hydroxypropyl methylcellulose (HPMC)ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng tse kang tsa meriana, litlolo, kaho le lijo. E 'ngoe ea litšobotsi tsa eona tse hlokomelehang ke ho qhibiliha ha eona metsing, haholo-holo metsing a chesang.

1. HPMC ke eng?

HPMC ke semi-synthetic, inert, viscoelastic polymer e nkiloeng ho selulose. E fumanoa ka ho phekola cellulose ka alkali le propylene oxide, e lateloa ke methylation. Ts'ebetso ena e fella ka polima e qhibilihang ka metsing e nang le thepa e ntlafalitsoeng ho feta cellulose ea tlhaho.

2. Ho qhibiliha ha HPMC ka Metsing

HPMC e bonts'a ho qhibiliha ho hoholo ha metsi, haholo ha metsi a futhumala. Sollubility ena e bakoa ke boteng ba lihlopha tsa hydrophilic ka har'a molek'hule ea HPMC, e leng lihlopha tsa hydroxyl (-OH) le li-link tsa ether. Lihlopha tsena li sebelisana le limolek'hule tsa metsi ka hydrogen bonding, ho thusa ho qhibiliha ha HPMC ka tharollo ea metsi.

3. Phello ea Mocheso ho Solubility

The solubility eaHPMCe eketseha ka mocheso. Lithempereichara tse phahameng, limolek'hule tsa metsi li na le matla a maholo a kinetic, a lebisang ho matlafatseng ho tsamaea ha limolek'hule le ho kenella hantle ha metsi ka har'a matrix a polymer. Sena se fella ka kinetics ea ho qhibiliha ka potlako le ho qhibiliha ho holimo ha HPMC metsing a chesang ha ho bapisoa le metsi a batang.

4. Kopo ho Meetso ea Meriana

Meetsong ea meriana, HPMC e sebelisoa hangata joalo ka ntho e tiisang matla, stabilizer, le filimi eo pele e neng e le mefuteng ea litekanyetso tse tiileng tsa molomo joalo ka matlapa le li-capsules. Ho qhibiliha ha eona metsing a chesang ho etsa hore e be e loketseng ho lokisetsa litharollo tsa metsi kapa ho emisoa ha metsoako ea lithethefatsi. Mohlala, HPMC e ka qhibiliha ka metsing a chesang ho etsa gel ea viscous, eo ka nako eo e ka sebelisoang e le setlamo sa ho kopanya likaroloana tsa lithethefatsi ha ho etsoa matlapa.

5. Sebelisa Linthong Tsa Kaho

Indastering ea kaho, HPMC e sebelisoa lihlahisoa tse thehiloeng ho samente joalo ka likhomaretsi tsa lithaele, seretse le li-renders. Ho qhibiliha ha eona ha metsi ho lumella ho hasana habonolo le kabo e tšoanang ka har'a matrix a samente. Ka ho etsa filimi e sireletsang ho potoloha likaroloana tsa samente, HPMC e ntlafatsa ts'ebetso, ho boloka metsi, le ho khomarela lisebelisoa tsena tsa kaho.

6. Bohlokoa Lefapheng la Lijo

HPMC e boetse e bapala karolo ea bohlokoa indastering ea lijo, moo e sebelisoang e le setei, emulsifier le stabilizer lihlahisoa tse fapaneng tsa lijo. Ho qhibiliha ha eona metsing a chesang ho etsa hore ho be le litharollo tse hlakileng, tse nang le li-viscous tse kenyang letsoho mofuteng o lakatsehang le ho tsitsisa ha lihlahisoa tsa lijo. Mohlala, HPMC e ka qhibiliha ka metsing a chesang ho etsa gel, ebe e eketsoa ho lisoso, sopho, kapa lijo tse theolelang ho ntlafatsa melomo ea bona le botsitso.

7. Qetello

HPMCe qhibiliha ka metsing a chesang, ka lebaka la tlhaho ea eona ea hydrophilic le sebopeho se ikhethang sa lik'hemik'hale. Thepa ena e etsa hore e be motsoako oa bohlokoa lits'ebetsong tse fapaneng ho pholletsa le liindasteri tse fapaneng, ho kenyeletsoa meriana, kaho le lijo. Ho utloisisa boits'oaro ba ho qhibiliha ha HPMC ho bohlokoa bakeng sa baetsi ba lihlahisoa le bahlahisi ho ntlafatsa ts'ebeliso ea eona lihlahisoa le litlhahlobo tse fapaneng.