HydroxypropypropyLese (HPMC)Ke polymer ea khelohileng hangata likopanong tse fapaneng tsa lits'ebeliso, ho kenyelletsa meralo, lihlahisoa tsa lijo, litlolo tsa lijo. Boleng ba HPMC bo ka fapana ho latela lintho tse kang boima ba bo bong bo hlakileng, vis), e leng bohloeki, e susumetsang ts'ebetso ea eona likolong tse itseng.
Lintlha tsa Bohlokoa Tse amang boleng ba Hydro XypropyL methylcelll
Boima ba Molecular
Boikutlo ba limok'hale (MW) bo bua ka mosobok'hule ea tšoenyeho ea tšoantšetso®hpmc ebe o phetha karolo ea bohlokoa ho lekola pono ea eona le tuubility. HPMC e phahameng ea limolek'hule hpmc e tloaetse ho ba le pono e phahameng, e thusang lits'ebetsong tse kang ho lokolloa ha lithethefatsi kapa e le moemeli oa ho holisa lifoleteng tse fapaneng.
Boima bo tlase ba molek'hule (lmw): Ho felisoa ka potlako, liketsahalo tse tlase, ho loketse haholoanyane lits'ebetso tse kang ho bokolla le ho etsa lifilimi.
Boima ba molek'hule e phahameng (hmw): Ho felisoa ha meno a fokolang, pono e phahameng, e loketseng ho feta ea ho toela le ho ts'oaroa le ho laoloa ke lithethefatsi.
Degree of Singlution (DS)
Tekanyo ea sebaka se buuoang ho fihlela moo lihlopha tsa hydroyy li leng ka morao ho celdrone mokokotlo oa celdrone li nkeloa ka lihlopha tsa methyl le tsa hydroxyl. Taba ena e ama thepa ea qubu ea tharollo le e litšila ea polymer.
Tlase ds: E fokotse sello sa metsi, matla a kariki a phahameng.
PLALI DS PUP DS: Tefo ea metsi a eketsoeng, e fokotsa matla a manyane, 'me thepa e laoloang hamolemo ho li-pharmacleicals.
Viscosity
Litaba ke karolo ea bohlokoa ea ho khetha hore na HPMC e ka etsa joang hantle, hpmc e ka e etsa hantle, e tsikitlanya le likopo tse ngata. HPMC e theko e phahameng ea HPMC e sebelisoa lits'ebetsong joalo ka emulsions, li-sypensente le li-hydroge
Lipaleng tse tlaseHangata, e sebelisoa lijong, tlhokomelo ea motho, le litlhahiso tsa meriana bakeng sa ho theha filimi le ho tlama.
Litaba tse phahameng: E sebelisoa ho likhama tse laoloang ke meriana, li-gels tse matla tse phahameng le lithibelo tsa lishganare.
Bohloeki
Boemo ba litšila, bo kang solvent, letsoai le sa tloaelehang, le letsoai le le leng le lenyenyane, le ka ama ntho e tšoeroe haholo predonbc. Hangata limaraka tse phahameng tsa boitšoaro bo phahameng hangata li hlokahala ho lits'ebetso tsa meriana le lijo.
Mokhabiso oa Pharmaceutical: Tlhoekiso e phahameng, hangata e tsamaeang le taolo e thata ka li-solvent tse saletseng le lithipa-tsatsi.
Sehlopha sa Liindasteri: Bohloeki bo tlase, e amoheleha bakeng sa lits'ebetso tse sa sebetseng kapa tse sa phethoang.
Fulubility
Khoele ea HPMC ka metsing e itšetlehile ka boima ba eona ba limok'hule le tekanyo ea sebaka. Ka tloaelo, hpmc e qhibiliha ka metsing a batang, e e etsa khetho e ntle bakeng sa likopo tse fapaneng tse hlokang mekhoa e thehiloeng metsing.
Low Fullity: E sa qhibiliha hanyane, e sebelisetsoang lits'ebetso tse sireletsehileng tse sireletsehileng.
E phahameng ea solubity: E qhibiliha haholoanyane, e loketseng likopo tse hlokang ho felisoa kapele.
Ho tsitsa ho hoama ha futhumatsang
Bokhoni ba futhumatsang ba HPMC ke ntho ea bohlokoa, haholo-holo indastering e kenyelletsang ho etsoa lithemparelong tse phahameng. Bokhoni bo phahameng ba mollo bo ka ba bohlokoa ho likopo tse kang makhapetla a matlapi le khoebong ea lijo.
Matla a Gel
Matla a gel a bua ka bokhoni ba HPMC ho theha gel ha e tsoakoa ke metsi. Matla a phahameng a gel a lakatsa ho lits'ebetso tse kang lits'ebetso tse laoloang tsa lithethefatsi tse laoloang, 'me ka tloaelo matla a ho lokolloa a hanyetsoang ka tloaelo a khethoa ka likopo tse kang ho emisoa le emumul.
Tafole e bapisang: likarolo tsa boleng ba hydroxypropyprol methylcell
| Setsi sa | Hpmc e tlase | Hpmc ea boleng bo holimo | Tšusumetso ho ts'ebetso |
| Boima ba Molecular | Boima ba molek'hule (LMW) | Boima bo phahameng ba molek'hule (HMW) | LMW e qhibiliha ka potlako, HMW e fana ka litšoantšo tse phahameng le li-gels tse phahameng. |
| Degree of Singlution (DS) | E tlase ds (sebaka se tlase) | Phahamisang DS (sebaka se eketsehileng) | Low DS e fana ka matla a motlakase a motlakase, DS e phahameng e ntlafatsa eallo. |
| Viscosity | Viscosity e tlase, e qhibiliha kapele | Litaba tse phahameng tsa liketsahalo tse phahameng, ho holisa, ho theha gel | Lipaleng tse tlase li loketse ho hana habonolo, liketsahalo tse phahameng tsa boemo bo matla le ho tšoarella. |
| Bohloeki | Mekhahlelo e Phahameng ea Litšisinyeho (letsoai la li-inthganic, solvents) | Ho hloeka ho phahameng, litšila tse fokolang tse tlase | Bohloeki bo phahameng bo netefatsa polokeho le katleho, haholo-holo liphatlalatso le lijo. |
| Fulubility | A se nang thuso ka metsing a batang | Scobility e ntle ka metsing a batang | Khoebo e phahameng e na le thuso bakeng sa likotoana le likopo tse potlakileng tsa ho lokolla. |
| Ho tsitsa ho hoama ha futhumatsang | Bokhoni bo tlase ba futhumatsang | Ho tsitsa e phahameng haholo | Botsitso ba mollo o phahameng ba ne ba khetha libakeng tse phahameng. |
| Matla a Gel | Matla a tlase a Gel | Matla a phahameng a gel | Matla a phahameng a gel a hlonepha a hlokahala bakeng sa ho lokolloa le ho lokolloa ha sistimi e laoloang le ho rama. |
| Ponahalo | Yellow Alating kapa e sa tsoa putsoa, e sa lumellane | E tšoeu ho tloha-mosoeu, e boreleli, e boreleli | HPMC ea boleng bo holimo e tla ba le ponahalo e tšoanang, e bonts'ang maemo a ho feto-fetoha le maemo. |
Lipolelo tsa boleng ba kopo
Liiporitiwa tsa pharmaceutical: Ho pharmatical, bohloeki, bohloeki, bohloeki, boima ba limoke, boima ba limole, ho na le matla a bohlokoa ho sebetsa hpmc. Ho lokolloa ha metsoako e sebetsang ea meriana (apis) e itšetlehile haholo ka thepa ea HPMC, moo boima ba limolek'hule le maemo a nepahetseng a li-amity
Indasteri ea lijo: Bakeng sa lihlahisoa tsa lijo, haholo-holo likopo joaloka likokoletso tsa lijo, li-agrigi tse ngotsoeng le li-hubilipity tse tlase hangata li ratoa. HPMC ea boleng bo holimo ea ho beha lijo tsa boleng bo holimo e tiisa polokeho ea bareki 'me e kopana le litekanyetso tsa tšebeliso.
Boleko le tlhokomelo ea botho: Ka litlolo, li-tshethetheho Mona, ipono le tharollo ke tsa bohlokoa ho theha lipalo tse tsitsitseng tse kang li-loutions, lisele le lihlahisoa tsa moriri.
Ts'ebeliso ea Liindasteri: Likopanong tsa indasteri, tse kang lipelong, litšeho le bokotla, limaraka tse phahameng tsa nalane li entsoe hangata bakeng sa sebopeho sa ho holisa le ho theha filimi. Shebana le botsitso ba ho futhumatsa, bohloeki, bohloeki le pono ke hola ho netefatsa ts'ebetso ea sehlahisoa se matla maemong a thata.
Boleng baHydroxypropypropinyl methylcelle ka susumetsa haholo pele ho indasteri e fapaneng. Ka ho utloisisa lintlha tse tlatsetsang tšobotsi ea eona - tse kang boima ba li-molek'huoana, tekanyo ea lipelaelo, pono, bohloeki, u ka khetha sehlopha se futhumatsang bakeng sa kopo e 'ngoe le e' ngoe. Ebang ke oa tšebeliso ea pharmacticacal, tlhahiso ea lijo kapa ea indasteri, kapa e netefatsa hore sehlopha se nepahetseng sa HPMC se khetholloa ho tla ntlafatsa katleho le katleho ea sehlahisoa sa ho qetela.
Nako ea ho romella: Jan-27-2025