Hydroxypropyl Methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering ho tloha ho tsa meriana ho isa ho tsa kaho ka lebaka la thepa ea eona e ikhethang. Ke motsoako oa selulose, 'me lihlopha tsa hydroxyl li nkeloa sebaka ke lihlopha tsa methoxy le hydroxypropyl, tse matlafatsang ho qhibiliha ha eona metsing le lihlapolli tse ling tsa tlhaho.
Solubility Litšobotsi tsa HPMC
1. Ho qhibiliha ha Metsi
HPMC haholo-holo e qhibiliha ka metsing. Ho qhibiliha ha eona metsing ho susumetsoa ke lintlha tse 'maloa:
Mocheso: HPMC e qhibiliha ka metsing a batang kapa a mocheso oa kamore. Ha e futhumatsa, HPMC e ka etsa gel; ha ho pholile, gel e qhibiliha hape, e etsa hore e khutlisetsoe morao. Thermal gelation ena e na le thuso lits'ebetsong tse kang ho lokolloa ha lithethefatsi tse laoloang litlhare.
Maikutlo: Maemo a tlase (0.5-2%) hangata a qhibiliha habonolo. Likhakanyo tse phahameng (ho fihla ho 10%) li ka hloka ho tsosoa le nako e eketsehileng.
pH: Litharollo tsa HPMC li tsitsitse ho pholletsa le mefuta e mengata ea pH (3-11), li etsa hore li feto-fetohe mekhoeng e fapaneng.
2. Litlhapi tsa Organic
Leha haholo-holo e qhibiliha ka metsing, HPMC e ka boela ea qhibiliha ka har'a metsoako e meng ea tlhaho, haholo-holo e nang le maemo a itseng a polar. Tsena li kenyelletsa:
Joala: HPMC e bonts'a ho qhibiliha ha lino tse tahang tse tlase joalo ka methanol, ethanol le isopropanol. Joala bo phahameng ha bo sebetse hantle ka lebaka la liketane tsa bona tse telele tsa hydrophobic.
Li-Glycols: Propylene glycol le polyethylene glycol (PEG) li ka qhala HPMC. Hangata li-solvents tsena li sebelisoa hammoho le metsi kapa lino tse tahang ho ntlafatsa ho qhibiliha le botsitso ba tharollo.
Ketones: Li-ketone tse ling tse kang acetone le methyl ethyl ketone li ka qhala HPMC, haholo ha li kopantsoe le metsi.
3. Metsoako
HPMC e ka boela ea qhibiliha ka metsoako ea solvent. Ka mohlala, ho kopanya metsi le lino tse tahang kapa li-glycol ho ka ntlafatsa ho qhibiliha. Tšebelisano lipakeng tsa lihlapolli li ka fokotsa bongata bo hlokahalang ba sehlapi se le seng, 'me ea ntlafatsa ho qhibiliha.
Mokhoa oa ho Qhala
Ho qhibiliha ha HPMC ka lihlapolli ho kenyelletsa ho senya matla a li-intermolecular pakeng tsa liketane tsa HPMC le ho theha likamano tse ncha le limolek'hule tsa solvent. Lintlha tse susumetsang ts'ebetso ena li kenyelletsa:
Hydrogen Bonding: HPMC e theha maqhama a haedrojene ka metsi le metsoako e meng ea polar, e thusang ho qhibiliha.
Tšebelisano ea Polymer-Solvent: Bokhoni ba limolek'hule tsa solvent ho kenella le ho sebelisana le liketane tsa HPMC li ama ts'ebetso ea ho qhibiliha.
Mechanical Agitation: Ho hlohlelletsa ho thusa ho arola lihlopha le ho khothalletsa ho qhibiliha ha junifomo.
Mehopolo e sebetsang bakeng sa ho qhala HPMC
1. Mokhoa oa ho qhala
Bakeng sa ho qhibiliha ka katleho, latela mehato ena:
Keketso Butle-butle: Butle-butle eketsa HPMC ho solvent ka ho sisinyeha kamehla ho qoba ho hohola.
Taolo ea Mocheso: Qhala HPMC ka metsing a batang ho qoba ho ruruha pele ho nako. Bakeng sa li-solvents tse ling, ho futhumala hanyenyane ho ka thusa.
Mekhoa ea ho Kopanya: Sebelisa li-stirrers tsa mochini kapa li-homogenizer bakeng sa ho kopanya hantle, haholo maemong a holimo.
2. Ho tsepamisa maikutlo le Viscosity
Khatiso ea HPMC e ama viscosity ea tharollo:
Boikoetliso bo tlase: E hlahisa tharollo ea viscosity e tlase, e loketseng lits'ebetso tse kang liphahlo kapa li-binders.
High Concentration: E etsa tharollo kapa gel e nang le viscosity e phahameng, e sebetsang mefuteng ea meriana bakeng sa tokollo e laoloang.
3. Ho lumellana
Ha o sebelisa HPMC ha o etsoa, etsa bonnete ba hore e lumellana le metsoako e meng:
pH Stability: Netefatsa hore likarolo tse ling ha li fetole pH ho feta mofuta o tsitsitseng oa HPMC.
Temperature Sensitivity: Nahana ka thepa ea gelation ea mocheso ha u rala mekhoa e amanang le ho fetoha ha mocheso.
Lisebelisoa tsa HPMC Solutions
Litharollo tsa HPMC li sebelisoa liindastering tse fapaneng ka lebaka la thepa ea tsona e ikhethang:
1. Meriana ea meriana
HPMC e sebetsa joalo ka setlamo, sa pele sa lifilimi, le moemeli ea laoloang oa tokollo:
Matlapa le Li-Capsules: Litharollo tsa HPMC li thusa ho tlama metsoako le ho etsa lifilimi bakeng sa tokollo ea lithethefatsi e laoloang.
Li-gels: E sebelisoa ka mokhoa oa lihlooho bakeng sa ho teteka le ho tsitsisa ha eona.
2. Indasteri ea Lijo
Joalo ka tlatsetso ea lijo, HPMC e sebelisoa bakeng sa ho tsitsisa le ho emulsifying thepa:
Li-thickeners: E ntlafatsa sebopeho le botsitso ka li-sauces le liaparo.
Tlhahiso ea Lifilimi: E etsa lifilimi tse jeoang bakeng sa ho roala le ho kenya li-encapsulations.
3. Kaho
Litharollo tsa HPMC li ntlafatsa thepa ea thepa ea kaho:
Samente le Seretse: E sebelisoa e le ntho e thibelang metsi le ho boloka metsi lihlahisoa tse entsoeng ka samente.
Lipente le Liaparo: E fana ka taolo ea rheological le botsitso lipente.
Mekhoa e tsoetseng pele ea ho qhala
1. Ultrasonication
Ho sebelisa maqhubu a ultrasonic ho qhala HPMC ho ka ntlafatsa sekhahla sa ho qhibiliha le katleho ka ho pshatla likaroloana le ho khothalletsa ho hasana ha junifomo.
2. Ho Kopana ha High-Shear
Li-mixer tse phahameng li fana ka ho kopanya ho matla, ho fokotsa nako ea ho qhibiliha le ho ntlafatsa homogeneity, haholo-holo ka lihlahisoa tse phahameng tsa viscosity.
Mehopolo ea Tikoloho le Polokeho
1. Biodegradability
HPMC e khona ho senyeha, ho e etsa hore e se ke ea senya tikoloho. E fokotseha ka likarolo tsa tlhaho, e fokotsa tšusumetso ea tikoloho.
2. Polokeho
HPMC ha e chefo ebile e bolokehile hore e ka sebelisoa lijong, meriana le litlolo. Leha ho le joalo, maqephe a data a polokeho (SDS) a lokela ho hlahlojoa bakeng sa ho sebetsana le litataiso tsa polokelo.
Ho qhala HPMC ka nepo ho hloka ho utloisisa litšobotsi tsa eona tsa ho qhibiliha le ho hokahana le lihlapolli tse fapaneng. Metsi e ntse e le eona ntho e ka sehloohong e qhibilihisang, ha li-alcohol, li-glycol le metsoako ea solvent li fana ka tharollo e 'ngoe bakeng sa lisebelisoa tse itseng. Mekhoa e nepahetseng le menahano e netefatsa ho felisoa ka nepo, ho ntlafatsa ts'ebeliso e fapaneng ea HPMC ho pholletsa le indasteri.
Nako ea poso: Jun-14-2024