Hydroxypropypropyproping Methylcellll) ke polymer e sa fetoheng haholo Ke mosireletsi oa selefoulese, ka lihlopha tsa hydroxyl li nkiloe ka lihlopha tsa mekhoa le hydropyL
Litšobotsi tsa sollubility tsa hpmc
1. Mollo oa metsi
HPMC e qholotsa ka metsi. Studility ea eona ka metsing e susumetsoa ke lintlha tse 'maloa:
Mocheso: hpmc e qhibiliha ka metsing a batang kapa a mocheso. Ha HPMC e ka baka gel; Ho pholile, gel ea qhibiliha hape, e etsa hore e fetohe. Bohahlauli bona bo futhumatsang bo na le thuso ho lits'ebeliso joalo ka ha li laoloe ke lingaka tsa lithethefatsi mamating.
TLHOKOMELISO: Litholoana tse tlase (0.5-2) ka kakaretso li qhibiliha habonolo. Meabo e phahameng (ho fihla ho 10%) e ka hloka ho hlohlelletsa le nako.
PH: Litharollo tsa HPMC li tsitsitse ho phallo e pharaletseng (3-11), e etsang hore li khahlano le liforomo tse fapaneng.
2. LITLHAKISO TSA BOPHELO
Ha a ntse a qhibiliha ka likhoka, hpmc e ka boela ea khelosa li-solvents tse ling, haholo-holo tse nang le maemo a fapaneng a polar. Tsena li kenyeletsa:
Alkmobc e bonts'a li-solubility tse ntle joalo ka methanol, Etathal le Isiop, le Isgopanol. Ho na le makhasi a phahameng ha a sebetse ka lebaka la liketane tsa bona tse telele tsa hydrophobic.
Glycols: proplylene Glycol le Polyethylene Glycol (Peg) e ka qhibiliha HPMC. Hangata li-solvents hangata li sebelisoa hammoho le metsi kapa li-alraba ho ntlafatsa botsitso le bo bong bo tsitsitseng ba tharollo.
Ketones: Kettones tse ling tse kang Acestone le Methyl Ethyl Ketoto a ne a ka qhala hpmc, haholoholo ha a tsoakoa ka metsi.
3. Metsoako
HPMC e ka boela ea qhibiliha ka har'a motsoako oa soltvent. Mohlala, ho kopanya metsi ka li-alhala kapa glycol ho ka ntlafatsa linyeeletsing. Khaso pakeng tsa li-solvet li ka theola khatello e hlokahalang ea ho lebala le leng, ho etsa qhobosheane.
Mochini oa ho qhalana
Khethollo ea HPMC ka li-pherekano e kenyelletsa ho roba matla a ho inkela pakeng tsa HPMC le ho theha likamano tse ncha le limolek'hule tsa solvent. Lintlha Tse Tšosang ts'ebetso ena li kenyeletsa:
Hydrogen e le 'ngoe ea Fydrojene: HPMC e hlakisa mekhoa ea haedrogen ka metsi le li-solvent tse ling tsa polar.
Tšebeliso ea polymer-solvent
Moresi oa Mecha: Ho hlohlelletsa ho thusa ho khaohana le ho khothalletsa ho felisoa junifomo.
Mehopolo e Molemo ea ho qhala HpMC
1. Mokhoa oa ho qhala
Bakeng sa khefulo e sebetsang, latela mehato ena:
Ho kenyelletsa ka grad: butle-butle eketsa HPMC ho ea solvent ka ho hlohlelletsa kamehla ho qoba ho khopatsa.
Taolo ea mocheso: li qhibiliha HPMC ka metsing a batang ho qoba khonyo ea pele ho nako. Bakeng sa li-solvents tse ling tsa manyolo, ho futhumala hanyane ho ka thusa.
Mekhoa ea ho kopanya: Sebelisa baitlami ba mechini kapa homozenizers ba ho kopanya, haholo-holo meahong e phahameng.
2. TLHOKOMELISO LE PERCOSCOMity
TLHOKOMELISO EA HPMC e fana ka pono ea tharollo:
TLHOKOMELISO: Liphetho ka Tharollo e tlase ea Libaka tse tlase, e loketseng likopo joaloka makhapetla kapa makala.
TLHOKOMELISO E PHETHANG: e etsa tharollo e phahameng kapa gel, e na le thuso mererong ea meriana bakeng sa ho lokolloa ho laoloang.
3. Kamohelo
Ha u sebelisa HPMC ho liforomo, netefatsa hore ho lumellana le lisebelisoa tse ling:
PH botsitso bah: netefatsa hore likarolo tse ling ha li fetole ph ho feta hpmc.
Boikutlo ba mocheso: Nahana ka thepa ea monyali ea ho futhumala ha e rala mekhoa e amanang le liphetoho tsa mocheso.
Likopo tsa Tharollo ea HPMC
HPMC tharollo ea indasteri e fapaneng ka lebaka la thepa ea bona e ikhethang:
1. Meriana
HPMC e sebetsa e le mojalebe, filimi e ne e sebetsa le moemeli ea laoloang:
Matlapa le li-capsules: Tharollo ea HPMC e thusa ho tlama metsoako le ho etsa lifilimi bakeng sa ho lokolloa ha lithethefatsi tse laoloang.
Li-gelsi: sebelisoa ka litlhahiso tsa tota bakeng sa thepa ea eona e tobatsang le e tsikitlanya thepa.
2. Indasteri ea lijo
Ha e kenyelletsa lijo, hpmc e sebelisoa bakeng sa thepa ea eona e tsitsitseng le e nyenyefatsang:
Bosholu ba thipa: bo ntlafatsa botsitso le botsitso ho tloha ka lebaka la liaparo le liaparo.
Sebopeho sa Filimi: e baka lifilimi tse fetotsoeng bakeng sa bosholu le maqakabetsing.
3. Kaho
Tharollo ea HPMC e ntlafatsa thepa ea thepa ea kaho:
Samente le seretse: E sebelisoa e le moemeli oa bolokolohi le moea oa ho boloka metsi lihlahisoa tse thehiloeng ho and-canment.
Paints le Likotsi: Ho fana ka taolo ea Rheological le botsitso ba lipere.
Mekhoa ea Distoration e tsoetseng pele
1. Ultranetion
U sebelisa maqhubu a ultrasonic ho qhibiliha HPMC ho ka ntlafatsa sekhahla sa disfonot le katleho ka ho nyenyefatsa likarolo le ho hasaha ha likarolo tse sa tsoakoang.
2. Ho kopanya ka ho hlaka
Bakhanni ba phahameng ba menyafo, ba fana ka mokhoa o matla, ba fokotsa nako ea Dellitotion le ho ntlafatsa Posterneity, haholo-holo likōmo tse phahameng.
Mehopolo ea tikoloho le ea polokeho
1. BIODDRADADADY
HPMC e biodegraday, e etsang hore e be le botsoalle le tikoloho. E baka likarolo tsa tlhaho, ho fokotsa ts'itiso ea tikoloho.
2. Ts'ireletso
HPMC ha e chefo ebile e bolokehile hore e sebelisoe lijong, meriana le libuso. Leha ho le joalo, likhetla tsa polokeho ea polokeho (SDS) li lokela ho hlahlojoa bakeng sa ho sebetsana le litataiso tsa polokelo.
Ho qhibiliha HPMC ka nepo ho hloka hore u utloisise litšobotsi tsa eona tsa solobability le tona ea li-solvelt. Metsi a lula a lahlōla ea mantlha, a ntse a le-Alkhole, Glycol, Glycols le motsoako oa solvent o fana ka tharollo e fapaneng ea likopo tse tobileng. Mekhoa e nepahetseng le mekhabiso e netefatsa ho felisoa ka ho feta, ho ntlafatsa indasteri e fapaneng ea HPMC
Nako ea poso: Jun-14-2024