Theknoloji ea mocheso ea hydroxypropyl methylcellulose (HPMC)

Hydroxypropyl Methyl Cellulose (HPMC) ke ether e seng ionic cellulose e sebelisoang haholo kahong, meriana, lijo, liphahlo le liindasteri tse ling. Lintho tsa eona tse ikhethang tsa 'mele le lik'hemik'hale li e fa botsitso bo babatsehang le ts'ebetso e sebetsang libakeng tse phahameng tsa mocheso. Ka tlhokahalo e ntseng e hola ea lits'ebetso tsa mocheso o phahameng, ho hanyetsa mocheso o phahameng le theknoloji ea phetoho ea HPMC butle-butle e fetohile sebaka sa lipatlisiso.

1. Lintho tsa motheo tsa HPMC

HPMC e na le ho qhibiliha ha metsi hantle, ho tenya, ho etsa filimi, ho etsa emulsifying, botsitso le ho lumellana ha lintho. Tlas'a maemo a phahameng a mocheso, ho qhibiliha, boitšoaro ba gelation le thepa ea rheological ea HPMC e tla ameha, kahoo ho ntlafatsa theknoloji e phahameng ea mocheso ho bohlokoa ka ho khetheha bakeng sa tšebeliso ea eona.

2. Litšobotsi tse ka sehloohong tsa HPMC tlas'a tikoloho e phahameng ea mocheso

Thermal gelation

HPMC e bonts'a ts'ebetso e ikhethang ea gelation ea mocheso maemong a mocheso o phahameng. Ha mocheso o nyolohela ho mefuta e itseng, viscosity ea tharollo ea HPMC e tla fokotseha 'me gelation e tla etsahala ka mocheso o itseng. Tšobotsi ena e bohlokoa ka ho khetheha thepa ea kaho (e kang seretse sa samente, seretse sa ho itšebetsa) le indastering ea lijo. Ka mohlala, libakeng tse phahameng tsa mocheso, HPMC e ka fana ka ho boloka metsi hantle le ho tsosolosa metsi ka mor'a ho pholile.

Botsitso bo phahameng ba mocheso

HPMC e na le botsitso bo botle ba mocheso 'me ha ho bonolo ho bola kapa ho etsa denature ka mocheso o phahameng. Ka kakaretso, botsitso ba eona ba mocheso bo amana le boemo ba ho fetola le tekanyo ea polymerization. Ka phetoho e khethehileng ea lik'hemik'hale kapa ntlafatso ea tlhahiso, ho hanyetsa mocheso oa eona ho ka ntlafatsoa e le hore o ntse o ka boloka thepa e ntle ea rheological le ts'ebetso libakeng tse phahameng tsa mocheso.

Ho hanyetsa letsoai le ho hanyetsa alkali

Libakeng tse phahameng tsa mocheso, HPMC e na le mamello e ntle ho li-acids, alkalis le electrolyte, haholo-holo ho hanyetsa alkali e matla, e leng se nolofalletsang ho ntlafatsa ka katleho ts'ebetso ea kaho ka thepa e thehiloeng ho samente le ho lula e tsitsitse nakong ea tšebeliso ea nako e telele.

Ho boloka metsi

Ho boloka metsi a mocheso o phahameng oa HPMC ke tšobotsi ea bohlokoa bakeng sa ts'ebeliso ea eona e pharaletseng indastering ea kaho. Libakeng tse phahameng tsa mocheso kapa tse omeletseng, HPMC e ka fokotsa mouoane oa metsi ka katleho, ea liehisa samente hydration reaction, le ho ntlafatsa ts'ebetso ea kaho, kahoo e fokotsa ho hlahisa mapetsong le ho ntlafatsa boleng ba sehlahisoa sa ho qetela.

Ts'ebetso ea bokaholimo le ho qhalana

Tlas'a tikoloho e phahameng ea mocheso, HPMC e ntse e ka boloka emulsification e ntle le ho qhalana, ho tsitsisa tsamaiso, 'me e sebelisoa haholo ka liphahlo, lipente, thepa ea mohaho, lijo le masimo a mang.

3. Theknoloji ea ho fetola mocheso o phahameng oa HPMC

E le ho arabela litlhoko tsa kopo ea mocheso o phahameng, bafuputsi le likhoebo ba thehile mekhoa e fapaneng ea ho fetola HPMC ho ntlafatsa ho hanyetsa mocheso le botsitso ba ts'ebetso. Haholo-holo e kenyelletsa:

Ho eketsa tekanyo ea ho fetola

The degree of substitution (DS) le molar substitution (MS) ea HPMC li na le phello e kholo ho hanyetsa mocheso oa eona. Ka ho eketsa tekanyo ea ho kenya sebaka sa hydroxypropyl kapa methoxy, mocheso oa eona oa mocheso oa mocheso o ka fokotsoa ka katleho 'me botsitso ba eona bo phahameng ba mocheso bo ka ntlafatsoa.

Phetoho ea Copolymerization

Copolymerization le li-polymers tse ling, tse kang ho kopanya kapa ho kopanya le polyvinyl alcohol (PVA), polyacrylic acid (PAA), joalo-joalo, e ka ntlafatsa ho hanyetsa mocheso oa HPMC le ho boloka thepa e ntle ea ts'ebetso tlas'a mocheso o phahameng oa mocheso.

Phetoho ea ho kopanya

Botsitso ba mocheso oa HPMC bo ka ntlafatsoa ka ho kopanya lik'hemik'hale kapa ho kopanya 'mele, ho etsa hore ts'ebetso ea eona e be e tsitsitseng tlas'a maemo a phahameng a mocheso. Ka mohlala, tšebeliso ea silicone kapa polyurethane phetoho e ka ntlafatsa ho hanyetsa mocheso le matla a mochine oa HPMC.

Nanocomposite phetoho

Lilemong tsa morao tjena, kenyelletso ea li-nanomaterials, tse kang nano-silicon dioxide (SiO₂) le nano-cellulose, e ka ntlafatsa ka katleho ho hanyetsa mocheso le thepa ea mechine ea HPMC, e le hore e ntse e ka boloka thepa e ntle ea rheological tlas'a tikoloho e phahameng ea mocheso.

4. Tšimo ea kopo ea mocheso o phahameng oa HPMC

Lisebelisoa tsa ho haha

Lisebelisoa tsa kaho tse kang seretse se omeletseng, sekhomaretsi sa lithaele, phofo ea putty, le sistimi ea kantle ea ho kenya lerako, HPMC e ka ntlafatsa ka nepo ts'ebetso ea kaho tlasa tikoloho ea mocheso o phahameng, ho fokotsa ho phatloha, le ho ntlafatsa ho boloka metsi.

Indasteri ea lijo

Joalo ka tlatsetso ea lijo, HPMC e ka sebelisoa lijong tse halikiloeng tse halikiloeng ka mocheso o phahameng ho ntlafatsa ho boloka metsi le ho tsitsa ha lijo, ho fokotsa tahlehelo ea metsi le ho ntlafatsa tatso.

Lekala la bongaka

Indastering ea meriana, HPMC e sebelisoa e le ho roala letlapa le lisebelisoa tse tsoelang pele ho ntlafatsa botsitso ba mocheso oa lithethefatsi, ho lieha ho lokolloa ha lithethefatsi, le ho ntlafatsa bioavailability.

Ho Cheka Oli

HPMC e ka sebelisoa e le tlatsetso bakeng sa mokelikeli oa ho cheka oli ho ntlafatsa botsitso ba mocheso o phahameng oa mokelikeli oa ho cheka, ho thibela ho putlama ha lerako, le ho ntlafatsa ts'ebetso ea ho cheka.

HPMC e na le gelation e ikhethang ea mocheso, botsitso ba mocheso o phahameng, ho hanyetsa alkali le ho boloka metsi tlas'a tikoloho e phahameng ea mocheso. Ho hanyetsa mocheso oa eona ho ka ntlafatsoa ka ho eketsehileng ka phetoho ea lik'hemik'hale, phetoho ea copolymerization, phetoho ea li-cross-link le phetoho ea nano-composite. E sebelisoa haholo liindastering tse ngata tse kang kaho, lijo, meriana le petroleum, e bonts'a menyetla e meholo ea 'maraka le menyetla ea ts'ebeliso. Nakong e tlang, ka lipatlisiso le nts'etsopele ea lihlahisoa tsa HPMC tse sebetsang hantle, likopo tse ngata libakeng tsa mocheso o phahameng li tla atolosoa.