HydroxypropypropyLese (HPMC) ke motsoako o sa qhomelang metsi ka metsing a fumanehang ka ho fetoloa ha lik'hemik'hale tsa celluulolese ea tlhaho. E sebelisoa haholo lijong, meriana le indasteri ea kaho, haholo-holo e le khokahano, emuckener le ho emisoa ke meputso ea meriana. Ts'ebetso ea kopo, litšobotsi tsa li-viscosion tsa tharollo ea hpmc li sa bohlokoa ts'ebetsong ea eona masimong a fapaneng.
1. Tsamaiso le thepa ea hydroxypropyl methylcell
Sebopeho sa limolek'hule sa hpmc se na le lihlopha tse peli tse bonoang, hydroxypropypropyl (-ch₂Chohch₃) le methyl (-ch₃), e etsang hore e be le alloubility ea metsi le ho feto-fetoha. Chain ea HPMC molecular e na le sebopeho se sa tsitsitseng, empa e ka etsa sebopeho sa marang-rang se fapaneng sa mefuta e telele, e bakang keketseho ea Viscosity. Boima ba eona ba limolek'hule, mofuta oa mofuta oa sebaka se ntjhanye le degree ea hydroxypropit.
2. Litšobotsi tsa ViscoSity tsa tharollo e sa sebetseng
Litšobotsi tsa liketsahalo tsa tlhahlobo ea phetetso ea HPMC li amana le lintlha tse kang tsa ho tsepamisa mohopolo. Ka kakaretso, Viscosity ea tharollo ea HPMC e eketsa keketseho ea mahloriso a eona. Lifu tsa eona li bonts'a boitšoaro bo senang bocha, joalo ka ha the Shear, pono ea tharollo e fokotseha, pono ea tharollo e fokotseha, e bonts'a molumo o mong le o mong oa phenomen.
(1) Phello ea ho tsepamisa maikutlo
Ho na le kamano e itseng lipakeng tsa liketsahalo tsa HPMC tse telele le mahloriso a eona. Ha ho tsepamisa mohopolo oa HPMC hoa eketseha, 'me tšebelisano ea limolek'hule e ntlafatsoang, le kamano e hokahanyang, e bakang keketseho ea pono ea tharollo. Ka meaho e tlase, pono ea phetetso ea HPMC e eketsa ka mokhoa o hlakileng le keketseho e phahameng ea tharollo e tloaetse ho ba boleng bo tsitsitseng 'me bo fihlela boleng bo tsitsitseng.
(2) Phello ea boima ba limolek'hule
Boima ba limok'hule tsa HPMC ka kotloloho li ama pono ea tharollo ea eona ea ho holofala. HPMC e nang le boima ba molek'hule e bolelele ba balek'hule ebile e ka theha sebopeho sa marang-rang se rarahaneng haholoanyane tharollo, e fella ka pono e phahameng. Ho fapana le moo, HPMC e nang le boima ba molek'hule e na le sebopeho sa marang-rang le pono e tlase ka lebaka la liketane tsa eona tse khutšoane. Ka hona, ha re etsa kopo, ho bohlokoa haholo ho khetha HPMC ka boima ba molek'hule ho fihlela sephetho se loketseng.
(3) Phello ea mocheso
Mocheso ke karolo ea bohlokoa e amang pono ea tharollo ea HPMC. Ha mocheso oa eketseha, ho sisinyeha ha limoleke tsa metsi ho matlafatsa 'me pono ea tharollo e fokotseha. Sena ke hobane ha mocheso o tsoha, tokoloho ea Chain ea HPMC ea eketseha le tšebelisano lipakeng tsa limok'hule tse fokolisang, ka ho etsa joalo fokotsa pono ea tharollo. Leha ho le joalo, karabelo ea HPMC e tsoang li-batches kapa li-brands tse fapaneng le tsona li ka boela li fapana, kahoo maemo a mocheso a hlokahala ho latela litlhoko tse tobileng tsa kopo.
(4) Phello ea boleng ba PH
HPMC ka boyona ke motsoako o seng oa ionic, 'me pono ea tharollo ea eona e halefileng e tsotella liphetoho ho PH. Le ha HPMC e bontša litšobotsi tse tsitsitseng tsa liforomo kapa tse sa nke lehlakore, li-stcubility tsa HPMC li tla ameha maemong a acidic kapa alkaline. Ka mohlala, tlas'a maemo a mangata a mafili a matla kapa a matla a alkaline, limolek'hule tsa HPMC li kanna tsa nyenyefatsa pono ea tharollo ea eona ea ho holofala.
3. Tlhahlobo ea Rheology ea litšobotsi tsa liketsahalo tsa hpmc tse sa feleng
Boitšoaro ba Rheology ba Tharollo ea HPMC hangata bo bonts'a litšobotsi tseo e seng Ny -Ian Smetoid hangata li sa anye tse kang tšobotsi ea ho tsepamisa maikutlo le boima ba mohale. Ka kakaretso, ka litekanyetso tse tlase tsa Shear, tharollo ea hpmc e bonts'a pono e phahameng, ha sekhahla sa shear se ntse se eketseha, viscosity ea fokotseha. Boitšoaro bona bo bitsoa "Shear thess" kapa "Shear e thetsang" 'me e bohlokoa haholo likopo tse ngata tse sebetsang. Ka mohlala, masimong a bokooa, litokisetso tsa meriana, ho sebetsa lijo, ho sebetsana le litšila tse thata tsa HPMC.
4. Ke lintlha tse ling tse amang pono ea pherekano ea HPMC e nang le
(1) phello ea letsoai
Ho eketsoa liroboto tsa letsoai (joalo ka sodium chloride) a ka eketsa pono ea tharollo ea HPMC. Lebaka ke hobane letsoai le ka ntlafatsa tšebelisano lipakeng tsa limolek'hule ka ho fetola matla a Ioni a tharollo ea tharollo, ka tsela eo a neng a eketsa liketsahalo tsa marang-rang, ka tsela eo li eketsa maikutlo. Leha ho le joalo, phello ea mofuta oa mofuta oa letsoai le pono e hlokang ho fetoloa ho latela maemo a itseng.
(2) Phello ea litlatsetso tse ling
Ho eketsa litlatsetso tse ling (joalo ka maqhubu, li-polymer, joalo-joalo, tharollo ea hpmc le tsona li tla ama lifate. Mohlala, liphoofolo tsa limela li ka fokotsa liketsahalo tsa HPMC, haholo ha ho tsepamisa maikutlo ho phahama. Ntle le moo, polymers e itseng kapa likaroloana li ka sebelisana le HPMC le ho fetola thepa ea liphiri tsa tharollo ea eona.
Litšobotsi tsa li-viscosity tsahydroxypropypropinyl methylcell Tharollo e anngoeng ke lintlha tse ngata, ho kenyeletsoa boima ba 'mele hangata ho bonts'a thepa ea Rheolo ea Newtonian le sher. Kutloisiso le ho tseba litšobotsi tsena tsa li-viscosity tsena li tla thusa ho ntlafatsa tšebeliso ea HPMC ka likopo tse fapaneng. Likolong tse sebetsang, mofuta o loketseng oa HPMC o loketseng le maemo a ts'ebetso a lokela ho khethoa ho latela litlhoko tse ikhethang tsa ho sheba lintho tse loketseng tsa pono le thepa ea li-parries.
Nako ea poso: Mar-01-2025