HPMC (hydroxypropyl methylcellulose) ke motsoako oa polymer o sebetsang haholo o sebelisoang haholo ho thepa ea mohaho, haholo-holo ka thepa e thehiloeng ho samente. Kenyelletso ea HPMC e ka ntlafatsa haholo ts'ebetso ea lisebelisoa tse thehiloeng ho samente, ho kenyelletsa le ho matlafatsa ho hanyetsa mapheo, ho ntlafatsa ts'ebetso ea ts'ebetso le ho laola ts'ebetso ea hydration, ka hona ho fokotsa ka katleho ketsahalo ea ho phatloha.
Lik'hemik'hale le thepa ea 'mele ea HPMC
HPMC ke semi-synthetic polymer e fetotsoeng ka lik'hemik'hale ho tloha selulose. Sebopeho sa eona sa limolek'hule se kenyelletsa li-substituents tsa methyl le hydroxypropyl, tse fanang ka ho qhibiliha ho ikhethang, ho teteaneng, ho boloka metsi le thepa ea ho etsa lifilimi. Likarolo tsa eona tsa mantlha li kenyelletsa:
Ho boloka metsi a phahameng: HPMC e na le bokhoni bo botle ba ho boloka metsi 'me e ka etsa filimi ea ho boloka metsi ka har'a thepa ho fokotsa ho tsoa ha metsi mouoane.
Thickening phello: HPMC ka haholo eketsa viscosity ea slurry, ka tsela eo ntlafatsa tshebetso lona.
Lintho tsa ho etsa lifilimi: Bokhoni ba eona bo botle ba ho etsa filimi bo ka etsa filimi e tenyetsehang holim'a thepa, e fana ka tšireletso e eketsehileng ea 'mele.
Mokhoa oa tšusumetso ea HPMC ho petsoha ha thepa e thehiloeng ho samente
1. Ho boloka metsi le ho fokotsa mapetsong a omileng a shrinkage
Lisebelisoa tsa samente li na le shrinkage e kholo ea volumetric nakong ea ho thatafala, haholo-holo ka lebaka la tahlehelo ea metsi le ho omisa ho fokotseha ka lebaka la karabelo ea metsi. Ho omisa mapetsong a shrinkage hangata ho bakoa ke mouoane o potlakileng oa metsi ka har'a slurry ea samente nakong ea ts'ebetso e thata, e bakang ho fokotseha ho sa lekaneng ha molumo, ka hona ho baka mapetsong. Thepa ea ho boloka metsi ea HPMC e na le karolo ea bohlokoa ho sena:
E fokotsa moea oa mouoane oa metsi: HPMC e boloka mongobo ka har'a seretse sa samente, kahoo e fokotsa sekhahla sa mouoane oa metsi. Phello ena ea ho boloka metsi ha e thuse feela ho lelefatsa nako ea karabelo ea hydration, empa hape e fokotsa ho omisa ho fokotseha ho bakoang ke mouoane oa metsi.
Uniform hydration reaction: Kaha HPMC e fana ka tikoloho e tsitsitseng ea metsi, likaroloana tsa samente li ka ba le mokhoa o ts'oanang le o lekaneng oa hydration, ho fokotsa ho se tšoane ha khatello ea kelello ka hare le ho fokotsa kotsi ea ho phunyeha ho bakoang ke ho fokotseha ho omileng.
2. Ntlafatsa viscosity le ho fana ka ho tšoana ha thepa
HPMC e na le phello e matla, e bapalang karolo ea bohlokoa ho ntlafatsa ts'ebetso le ho tšoana ha thepa e thehiloeng ho samente:
E Eketsehile Viscosity: HPMC e eketsa viscosity ea slurry, e ntlafatsa ts'ebetso nakong ea kopo, e lumella slurry ho phalla hantle le ho tlatsa hlobo kapa mapetsong, ho fokotsa likheo le libaka tse sa tšoaneng.
Kabo e ts'oanang: Ka ho eketsa viscosity ea slurry, HPMC e etsa hore ho ajoa ha li-fillers le likhoele ka har'a slurry ho be le sebopeho se ts'oanang sa kahare nakong ea ts'ebetso e thata le ho fokotsa ho phatloha ka lebaka la khatello ea maikutlo ea sebakeng seo.
3. Ntlafatsa thepa ea ho etsa filimi le tšireletso ea holim'a metsi
Thepa ea ho etsa filimi ea HPMC e thusa ho theha lesela le sireletsang holim'a thepa, le nang le phello e ntle ho fokotsa mapetsong a holim'a metsi:
Tšireletso ea sefahleho: Lera le feto-fetohang la filimi le entsoeng ke HPMC holim'a thepa e ka sireletsa holim'a khoholeho ea mobu ke tikoloho ea ka ntle le tahlehelo e potlakileng ea mongobo, kahoo e fokotsa ho etsahala ha mapetsong a holim'a metsi.
Ho koaheloa ka mokhoa o bonolo: Lera lena la filimi le na le tekanyo e itseng ea ho feto-fetoha ha maemo 'me le ka monya karolo ea khatello ea kelello nakong ea ho senyeha hanyenyane, ka hona ho thibela kapa ho fokotsa ho atolosoa ha mapetsong.
4. Laola mokhoa oa hydration
HPMC e ka laola tšebetso ea hydration ea samente, e bapalang karolo ea bohlokoa ho fokotsa khatello ea maikutlo e bakoang ke ho se leka-lekane ha hydration:
Butle-butle hydration: HPMC e ka fokotsa karabelo e potlakileng ea hydration, e lumella hore metsi a slurry ea samente a lokolloe butle-butle, kahoo a fana ka tikoloho e ts'oanang le e tsitsitseng ea hydration. Phello ena ea butle-butle e fokotsa khatello ea maikutlo e bakoang ke ho se leka-lekane ha hydration, kahoo e fokotsa kotsi ea ho phatloha.
Mehlala ea ts'ebeliso ea HPMC ka thepa e fapaneng e thehiloeng ho samente
HPMC e sebelisoa haholo ka thepa e thehiloeng ho samente, ho kenyelletsa empa e sa felle feela ho mekato ea ho ikemela, masela a kantle a lebota, lirekere le lisebelisoa tsa ho lokisa konkreite. E latelang ke mehlala e meng e khethehileng ea ts'ebeliso:
1. Lisebelisoa tsa fatše tse ikemetseng
Lisebelisoa tsa fatše tse ikemetseng li hloka thepa e ntle ea metsi le ho tlamahane ha li ntse li qoba mapetsong a holim'a metsi. HPMC e ntlafatsa phallo le bokaholimo ba thepa ka litlamorao tsa eona tse teteaneng le ho boloka metsi ha e ntse e fokotsa ho hlaha ha mapetsong a holim'a metsi.
2. Pente ea ka ntle ea lerako
Pente e ka ntle e hloka ho khomarela hantle le ho hanyetsa mapetso. Thepa ea ho etsa filimi le ho boloka metsi ea HPMC e ntlafatsa ho khomarela le ho feto-fetoha ha koae, ka tsela eo e matlafatsa ho hanyetsa ha lekhalo le boemo ba leholimo.
3. Lisebelisoa tsa ho lokisa
Lisebelisoa tsa ho lokisa konkreite li hloka matla a phahameng le ho thatafala ka potlako ha li ntse li boloka shrinkage e tlaase ea ho omisa. HPMC e fana ka bokhoni bo botle ba ho boloka metsi le matla a ho laola metsi, ho lumella thepa ea ho lokisa hore e boloke ho fokotseha ho tlaase nakong ea ts'ebetso e thata le ho fokotsa kotsi ea ho senya ka mor'a ho lokisoa.
Litlhokomelo tsa ho sebelisa HPMC
Leha HPMC e na le phello e kholo ho fokotseng ho putlama ha thepa e thehiloeng ho samente, lintlha tse latelang li ntse li hloka ho hlokomeloa nakong ea ts'ebeliso:
Taolo ea litekanyetso: Tekanyo ea HPMC e lokela ho lumellana ka thata le litlhoko tsa foromo. E ngata haholo kapa e nyane haholo e tla ama ts'ebetso ea thepa. Ka kakaretso, litekanyetso li pakeng tsa 0.1% - 0.5%.
Ho Kopanya Uniformity: HPMC e hloka ho tsoakoa ka botlalo le lisebelisoa tse ling ho netefatsa hore e sebetsa ho pholletsa le slurry.
Maemo a kaho: Tikoloho ea kaho (joalo ka mocheso, mongobo) le eona e na le tšusumetso ho phello ea HPMC, 'me e lokela ho lokisoa ka nepo ho latela maemo a itseng.
E le kenyelletso e sebetsang e thehiloeng ho samente, HPMC e phetha karolo ea bohlokoa ho fokotsa ho phunyeha ha thepa e entsoeng ka samente ka thepa ea eona e ikhethang ea ho boloka metsi, ho teteaneng, ho etsa lifilimi le ho laola metsi. E liehisa mouoane oa metsi, e ntlafatsa ho tšoana ha lintho, e sireletsa holim'a lintho tse bonahalang, 'me e laola ts'ebetso ea hydration, kahoo e fokotsa haholo kotsi ea ho phatloha. Ka hona, ha ho sebelisoa lisebelisoa tse thehiloeng ho samente, tšebeliso e utloahalang ea HPMC e ke ke ea ntlafatsa feela ts'ebetso ea thepa, empa hape e eketsa bophelo ba eona ba tšebeletso le ho fokotsa litšenyehelo tsa tlhokomelo.
Nako ea poso: Jun-26-2024