Hydroxypropypropypropinyl Methylcelllulose (HPMC) ke tšebeliso e mpe ea indasteri e fapaneng bakeng sa thepa ea eona e ikhethang. Ho tloha kahong ho meriana ea meriana, lijo ho litlolo, tsa HPMC li fumana ts'ebeliso ea lihlahisoa tse ngata haholo.
1. Likhatiso tsa lik'hemik'hale le sebopeho
HPMC ke synthetic e felisang semisetic, ho jella thepa le polymer e qhibilihileng ea metsi e tsoang cellulose. Mak'hliso, e entsoe ka thepa ea mokokotlo e nang le mekhoeng ka bobeli (-ch -ch3) le hydroxyproxyl (-Hech2ch (OH) CH3). Tekanyo ea libaka tsena e khetholla thepa le ts'ebetso ea HPMC. Ts'ebetso ea pele e ntlafatsa eallo ea metsi le litšobotsi tse ling tse lakatsehang, li etsa hore e be e loketseng lits'ebetso tse fapaneng.
2. Melemo ea Rheology
E 'ngoe ea mabaka a bohlokoa a ho sebelisa HPMC ke lipelong tsa eona tse ikhethang tsa Rheology. HPMC tharollo e bonts'a boitšoaro bo senang chelete, ho bontša litšobotsi tsa Pseudopro kapa tse tšesaane. Sena se bolela hore viscooty e fokotseha ka sekhahla se ntseng se eketseha, ho lumella ho sebetsa habonolo le ho sebetsa ka bonolo. Boitšoaro bo joalo ba lintho tsa ho litsi tsa bolumeli bo tšoana le ho haha, moo bo sebelisoang e le moemeli oa thipa le ho fokotsa mokhoa o ntlafalitsoeng le ho fokotsa mokhoa o ntlafalitsoeng le ho fokotsa mokhoa o ntlafalitsoeng le ho fokotsa mokhoa o ntlafalitsoeng le ho fokotsa mokhoa o ntlafalitsoeng le ho fokotsa ho akheha.
3. Ho boloka metsi
HPMC e na le bokhoni bo phahameng ba metsi ka lebaka la tlhaho ea hydrophilic. Thepa ena e bohlokoa likopo moo taolong ea mongobo e bohlokoa, joalo ka mefokolo ea thibelo ea thibelo. Ka ho kenya metsi kahare ho Matrix, HPMC e tiisa hore likaroloana tse nepahetseng tsa cement, li fella ka ntlafatso ea matla, ho fokotseha ha sehlahisoa sa ho qetela.
4. TLHOKOMELISO EA MOSEBETSI
Ntle le karolo ea eona e le moemeli oa ho holisa le ea metsi, HPMC e ka theha lifilimi tse pepenoang le tse feto-fetohang ha li omisoa. Thepa ena e fumana ts'ebeliso indasteri e kang li-Promaceceletucal Tsebo ea lifilimi ea HPMC e kenya letsoho boipiletsong bo botle, tšireletso, le ho laoloa ke ho lokolloa ha metsoako e mafolofolo lihlahisoa tse joalo.
5. Binder le Khomare
HPMC e sebelisoa haholo joalo ka mokhoa o hlabang le ho khomarela lits'ebetsong tse fapaneng. Li-Pharmaceuticals, e sebetsa e le mokhoa oa ho hlaka lifodikeng, ho sebetsana le tumello ea lipehelo tse ka matlapeng a kopaneng. Ho boloka thepa ea eona ea khang ea ho tsamaisa karolo ea ho tsamaisa, ho bolela bonnete ba botšepehi le litšobotsi tsa ho qhalana. Ka mokhoa o ts'oanang, ka indastering ea kaho, HPMC e sebetsa e le mokhoa o mongobo le mafutsana a seretse le gyps
6. Kholo e laoloang
Bokhoni ba HPMC ho laola tokollo ea metsoako e sebetsang ea meriti ea meriana le temo. Ka ho fetola boima ba polytrice, boima ba bilicalar, le degree, ba lokollotsoeng lithethefatsi kapa likotsi tsa khalemelo. Sechine sena se laoloang sechisitsoeng se tiisa ts'ebetso ea nako e telele, hangata e kolobisitsoe khafetsa, le katleho e ntlafalitsoeng ea metsoako e sebetsang.
7. Ho tsitsa le ho lumellana
HPMC e bonts'a botsitso ba botle le ho lumellana hantle le mefuta e mengata ea metsoako e meng e sebelisoang hangata ho liforomo. Ke ka lik'hemik'hale e kenang ka lik'hemik'hale, e seng ionic, 'me e lumellana le lintho tse manyolo le tse sa tsotelleng. Sena se etsa khetho eo e khethang bakeng sa lifobamo tse batlang tsa tsitsipano le tse tsielehileng meriana, lihlahisoa tsa lijo, lintho tsa tlhokomelo ea botho le likopo tsa tlhokomelo ea indasteri le lits'ebetso tsa tlhokomelo.
8. Ts'ireletso le tumello ea taolo
Ho tsamaisa ntlha e 'ngoe ea bohlokoa ts'ebeliso e pharalletseng ea Hpmc ke profil ea eona ea polokeho ea eona le tumello ea taolo ea lits'ebetso tse fapaneng. HPMC hangata e nkuoa e le Sireletsehileng (GRAS) ea tsamaiso e kang ea lijo le tsamaiso ea lithethefatsi (FDA) le Balaoli ba polokeho ea Europe (Efsa). Ha se chefo, e seng khopisang le e sa khopineng, e etsang hore e be e loketseng tšebeliso ea molomo, ho hahlaula ka liphallelo, hammoho le lijong le lihlahisoa tsa litlolo.
9. Ho fapanyetsana
Mohlomong e 'ngoe ea mabaka a kholisang haholo mabapi le ho tsebahala ha HpMC ke ho feto-fetoha ha eona. Boholo ba thepa ea eona e sebelisa tšireletso ea eona ho indastering e mengata le lits'ebetsong. Ho tloha ho fetola rheology ea likoluoa tsa indasteri ho ntlafatsa ts'ebetso ea litlolo tsa letlalo, HPMC e fana ka tharollo ho ba nang le limiriadudulad. Ho ikamahanya le maemo maemong a fapaneng a ts'ebetso le ho ikamahanya le metsoako e fapaneng ho etsa hore e rate litsebi tse batlang litsebi tse tsoang ka molao-motheo.
HydroxypropypropypropinyL methylcelllulolose (HPMC) ke polymer ea nang le malinyane e nang le tšebeliso ea eona ea thepa ea thepa e ikhethang le likopo tse fapa-fapaneng. Ho tsoa meputsong ea eona ea ho Ruta Mehala ea Bolumeli ba Bolumeli ho bokhoni ba eona ba lifilimi, HPMC e sebetsa e le molaoli ea fapaneng. Ts'isinyeho ea eona, botsitso le ho ikemela le ho iketsahalla ho matlafatsa boemo ba eona joalo ka khetho e khethollang bakeng sa liforomo lefatšeng ka bophara. E le liphallelo tsa theknoloji le likopo tse ncha, bohlokoa ba HPMC bo lebelletsoe ho tsoela pele ho hola, ho eketseha ha moqoqo oa sehlahisoa likarolong tse fapaneng.
Nako ea poso: Mar-26-2024