Izibonelelo ze-HPMC kwifomu elawulwayo

Izibonelelo zeI-HPMCKwifomu yokukhutshwa elawulwayo

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-polymer esetyenziswe ngokubanzi kwifom yamayeza, ngakumbi kwifomu elawulwayo. Ukuthandwa kwayo kusuka kwipropathi yayo eyahlukileyo eyenza ilungele kakuhle kwizicelo ezinjalo. Nazi ezinye zeengenelo zokusebenzisa i-HPMC kwifomu elawulwayo:

Ukusetyenziswa kwezinto: I-HPMC inokusetyenziswa kwiifom ze-dosage ezahlukeneyo kubandakanya iitafile, iicaphule, kunye neefilimu, zenza ukuba zibe ziinkqubo ezahlukeneyo zokuhambisa iziyobisi. Ukutshintsha kwendlela yokusebenza ikuvumela ukuba ubeguquguqukele ngoyilo lokuqulunqwa kwemfuno yokukhutshwa kweziyonsi ezithile.

Ukukhutshwa okuthengisiweyo: Enye yeembono eziphambili ze-HPMC kukukwazi ukulawula ukukhutshwa kweziyobisi ngexesha elongezelelweyo. I-HPMC yenza i-gel fall xa ihhwanqe, esebenza njengomqobo, ilawula ukungafani kwamachiza kwifom yedosi. Le ndawo ibalulekile ekufezekiseni iiprofayili ezizinzileyo zeziyobisi, ukuphucula ukuthotyelwa koguli, kunye nokunciphisa i-frequency yedosi.

I-hydration Inqanaba le-hydmc ye-hydmc inokuguqulwa ngokutshintsha ubunzima bayo bemolekyuli, inqanaba lokufaka kunye nebakala lokubonisa. Oku kuvumela ulawulo oluchanekileyo malunga nenqanaba lokukhululwa kweziyobisi, ukuvumela ukwenziwa kwenzululwazi ukuba ifomula ye-pharmacokineticlic yelichiza.

Ukuhambelana:I-HPMCIhambelana noluhlu olubanzi lweethafa ezisebenzayo zeyeza (i-APIS), izihlobo, kunye neendlela zokulungisa. Ingasetyenziswa kuzo zombini iziyobisi ze-hydrophobic kunye ne-hydrophobic, zenza ilungele ukwenziwa kwemveliso ebanzi yeemveliso zamachiza amachiza.

Ayisiyo inetyhefu kwaye i-biompatat: I-HPMC isuselwa kwisellulose, i-polymer yemvelo eyenzekayo, isenza ityhefu kwaye ingenabungozi kwaye i-biompatid. Yamkelwe ngokubanzi ukuba isetyenziswe kwiindawo zamachiza kwaye ihlangabezana neemfuno zolawulo lokhuseleko kunye nokusebenza kakuhle.

Ukuphuculwa kokuzinza: I-HPMC inokuphucula uzinzo lwamachiza ngokuzikhusela ekunciphiseni kwezinto ezibangelwe yimiba yendalo esingqongileyo njengokufuma, okukhanyayo. Le ndawo iyingenelo ikakhulu kumachiza anomdla wokuphelisa ukonakaliswa okanye abonise uzinzo.

Ukufaniswa komthamo: I-HPMC ye-HPMOC ekufezekiseni ukusasazwa kwe-iyunifogram kwi-dosage kwifom ye-dosage, kukhokelela kwi-Kinetics ekhupha i-kinetics kwiyunithi. Oku kuqinisekisa ukufana komthamo kwaye kunciphisa ukwahluka kumanqanaba ePlasma, kukhokelela kwiziphumo zonyango.

Ukungcamla: I-HPMC inokusetyenziselwa ukwenza i-mask cast incasant okanye ivumba lamachiza athile, ukuphucula ukwamkelwa kwesigulana, ngakumbi kuluntu kunye ne-Geriatoric apho inkxalabo ixhalabile.
Izibonelelo zoqoqosho: i-HPMC isebenza ngexabiso lendleko nakwezinye ii-polymers ezisetyenziswa kwifomu elawulwayo. Ukufumaneka kwayo kunye nokukhululeka kwayo kwemveliso yokufaka igalelo kwizibonelelo zalo zoqoqosho, zenza ukhetho olukhawulezileyo lweenkampani zamayeza.

Ukwamkelwa kolawulo:I-HPMCidweliswe kwi-pharmacopeas eyahlukeneyo kwaye inembali ende yokusetyenziswa kwimigaqo yamayeza. Ukwamkelwa kwayo kulawulo kuyinze lula inkqubo yokuvunywa yeemveliso zeziyobisi eziqukethe i-HPMC, ukubonelela ngendlela ekhawulezayo ukuya kwintengiso yabavelisi bamachiza.

I-HPMC ibonelela ngeenzuzo ezininzi kwifomu elawulwayo, kubandakanya ukukhutshwa kwamachiza okulawulwa kweziyobisi, ukungasebenzi kakuhle, ukuphuculwa, ukuphuculwa kwezinto kunye nokwamkelwa kolawulo. Iipropathi zayo ezizodwa zenza ukuba ibe yi-polymer engathandekiyo kuphuhliso lweefom ze-dosage ezizinzileyo, igalelo kwiziphumo zezigulana kunye nemveliso yemveliso yamayeza.