I-HydroxyPOpyl Methylcelceltulose (HPMC), ekwabizwa ngokuba yi-hypromellose, yipolymer eguquguqukayo esetyenziswa ngokubanzi kumzi-mveliso wamayeza. Yinto engu-semi-sybhletic, i-intert, i-polymer polymer ethathwe kwi-sellyulose, i-polysacchaacchacchaackacki yendalo. I-HPMC ixabisekile ngenxa yomoya wayo emanzini, ongenatyhefu, kunye nokukwazi kwayo ukwenza iifilimu kunye ne-gels.
I-1. Binder kwifomu yecwecwe
Enye yezicelo eziphambili ze-HPMC kwi-Hermaceuticals injenge-binder kwifomu yecwecwe. I-HPMC iqashwe ukuqinisekisa ukuba izithako kwithebhulethi zinamathela kunye kwaye zihlala zizinzile de uzimisele. Iipropathi zayo ezibophelelayo ziphucula amandla eetafile, zibethelela ukuba zingabinakuphazamisa okanye ukophula ngexesha lokupakisha, ukuthutha kunye nokuphatha. Ukongeza, indalo yase-HPMC iqinisekisa ukuba ayisabelanga kwezinye izithako, ukugcina uzinzo kunye nokusebenza kakuhle kwezithako ezisebenzayo (APIS).
2. I-Matrix elawulwa i-matrix
I-HPMC ibalulekile ekuphuhlisweni kokukhutshwa okulawulwayo (CR) kunye nokukhutshwa okuzinzileyo (SR). Ezi fomu zenzelwe ukukhupha ichiza kwinqanaba elimiselweyo, ukugcina amanqanaba echiza angaguqukiyo kwigazi ngaphezulu kwexesha elongeziweyo. I-HPMC ye-HPMC ye-HELMC ye-gel-ye-gel -c yokwakhiwa kwe-gestrointenal fluids iyenza ilungele le njongo. Yenza i-viscous gel gell ijikeleze ithebhulethi, ukulawula ukungafani kwechiza. Olu phawu luyingenelo ikakhulu ngamachiza ngesalathiso sonyango olunqabileyo, njengoko sinceda ekugcineni ugxininiso lwePlasma olufunwayo, ngaloo ndlela kunceda ukusebenza kakuhle kunye nokunciphisa iziphumo ebezingalindelekanga.
3. Umboniso bhanyabhanya
Enye into ebalulekileyo ye-HPMC ikwifilimu ekhupha iitafile kunye neecapsules. Amatyala asekwe-HPMC akhusela ithebhulethi kwizinto zokusingqongileyo ezifana nokufuma, ukukhanya, kunye nomoya, ezinokuthi zinciphise izithako ezisebenzayo. Ifilimu ekhuphayo ikwandisa isibongozo setafile, iphucula imaski yokungcamla, kwaye inokusetyenziselwa ukubonelela ngokhuseleko lwe-ARDIC, ukuqinisekisa ukuba ichiza likhutshwa kwiindawo ezithile ze-gestrointenal phecanal phecanal phecanal phecanal. Ngaphaya koko, iingubo ze-HPMC zinokuyilwa ukuguqula iprofayili yokukhupha ichiza, inzala kwiinkqubo zokuhambisa ekujoliswe kuzo.
4. Iarhente yokuthambisa
I-HPMC isebenza njengearhente esebenzayo yokutsalwa kwezinto ezingamanzi ezifana nesiraphu kunye nokunqunyanyiswa. Ukukwazi kwayo ukwandisa i-viscosity ngaphandle kokutshintsha ezinye iipropathi zokwenza oko kuyingenelo ekuqinisekiseni ukusasazwa kwechiza kwichiza, kunye nokuthintela i-sedation yamasuntswana, kunye nokubonelela ngomlomo onqwenelekayo. Le ndawo ibaluleke ngokukodwa kwi-Peediatric kunye ne-Geriatric Pleurations, apho kubaluleke khona.
I-5. I-Stabitizer ngokunyanzeliswa
Kwimigaqo yesihloko njengekhrim, iigels, kunye nee-ointments, i-HPMC isebenza njengesiqhelo kunye ne-enulsifier. Inceda ukugcina ukungqinelana kunye nokuzinza kokubekwa, ukuqinisekisa ukuba izithako ezisebenzayo zisasazwe ngokulinganayo. I-HPMC ikwabonelela ngolungelelwaniso olugudileyo, ekhuthaza isicelo kunye nokuthathwa kwemveliso kulusu. Indalo yayo engacaphukiyo yenza ukuba ilungele ukusetyenziswa kwifomu yolusu olunobuthathaka.
I-6. I-Ophthalmic ilungiselela
I-HPMC isetyenziswa ngokufanelekileyo kwi-Opthalimic amalungiselelo, njengamanye iinyembezi ze-accicial kunye nonxibelelwano lwezisombululo zelensi. Iipropathi zayo ze-viscoelastic ziyalingisa ifilimu yendawo yendalo, ibonelela ngoxinzelelo kunye nomswakama emehlweni. I-HPMC ye-HPMC ye-HPMC iluncedo ngokukodwa kubantu abanesifo esomileyo seliso, sinika ukukhululeka ngokucaphuka kunye nokungalunganga. Ukongeza, i-HPMC isetyenziswa kwiinkqubo zokuhambisa iziyobisi, apho i-AIDS ekusebenzeni ngexesha lokunxibelelana lechiza kunye nomgangatho we-ocular, ekwandiseni ukusebenza ngonyango.
7. Ukuqulunqwa kweCapsule
I-HPMC ikwasetyenziswa ekwenzeni i-cepsules ezinzima nethambileyo. Isebenza njengenye indlela eya eGelatin, ibonelela ngekhephu le-generian yeegobolondo zecapsule. I-HPMC CAPULES ithanda umxholo wazo osezantsi, onokuba yingenelo kumachiza abuthathaka. Bakwabonelela ngokuzinza ezingcono kwiimeko ezahlukeneyo zokusingqongileyo kwaye zincinci ekudibaniseni unxibelelwano, umbandela oqhelekileyo kunye neekhaphethi ze-gelatini ezinokuchaphazela iiprofayili zokukhulula iziyobisi.
I-8. I-Bioaaaint yokuphucula
Kweminye imisebenzi, i-HPMC inokuphucula ukungafumaneki kweziyobisi ezinyibilikayo. Ngokwenza i-gel matrix, i-HPMC inokunyusa umgangatho wokuchitheka kwechiza kwi-gestrointenal phecanal, ukuqhubela phambili. Oku kubaluleke kakhulu ngamachiza anomoya ophantsi wamanzi, njengoko ukuphunyezwa okuphuculweyo kunokuba nefuthe elikhulu ekusebenzeni ngonyango lweziyobisi.
I-9. Izicelo ze-MucoAdive
I-HPMC ibonisa iipropathi ze-MUCOMSHIP, zenza ukuba zilungele iinkqubo zokuhambisa iziyobisi kunye neziyobisi. Ezi nkqubo zifuna ichiza ukuba lilandele i-membrane ye-mucous, zibonelela ngokukhululwa ixesha elide kunye nokuthathwa ngokuthe ngqo kwigazi legazi, ukudlulisela imetabolism yokuqala. Le ndlela iluncedo kumachiza ashiyekileyo kwindalo yesisu okanye onesifo sebhayili yomlomo.
Ukusebenza kwe-hydroxypropyl methylcelculose (i-HPMC) kwifom yamachiza akunakuba ngaphezulu. Izicelo zayo zokuhlala ukusuka kwithebhulethi yokubopha kunye nefilimu ekwakhethayo yokuthambisa kunye nokuzinzisa iiarhente kwiifom ezahlukeneyo. Ukwazi kukaHPMC ukuguqula iiprofayili zokukhutshwa kweziyobisi, ukuphucula i-biaaaaadhes, kwaye ukubonelela nge-mucoadhesterion kugxininisa ukubaluleka kwayo kuphuhliso lweenkqubo eziphambili zokuhambisa iziyobisi. Njengoko ishishini lamayeza liyaqhubeka ukuvela, indima ye-HPMC iya kwandula ukwenziwa, iqhutywa ngophando oluqhubekayo kunye nenkqubo ejolise ekupheliseni ukuhanjiswa kwamachiza kunye nezigulana.
IXESHA LOKUQALA: IJuni-05-2024