Hydroxypropyl seluplose, i-famermaceOutical iqaqamba, yahlulwe yangenisa i-hydroxypropy ye-hydulose ethathiweyo (L-HPC) kunye ne-Hydcropyl ephezulu ye-hydulose yeseluplose (H-HPC) ngokomxholo we-hydroxypropy. I-L-HPC ifungwe kwisisombululo se-colloidal emanzini, inepropathi ye-adherion, ukuqulunqwa kwefilimu, ukwenziwa kwearhente, kwaye isetyenziswa ikakhulu njengendawo yokuqhekeza kunye ne-binder; Ngelixa i-H-HPC inyibilikisa emanzini kunye neenyibilikisi ezahlukeneyo zobushushu begumbi, kwaye zine-thermoplasticisticasticity elungileyo. , cohesiveness and film-forming properties, the formed film is hard, glossy, and fully elastic, and is mainly used as a film-forming material and coating material. Ukusetyenziswa okuthile kwe-hydropufyl seluplose kumalungiselelo aqinileyo ngoku aziswa.
1. Njenge-proborject yamalungiselelo aqinileyo anjengeetafile
Umphezulu we-hydroxypropyl ye-clestase ye-clestalline ye-Crystalline ayilingani, kunye nendlela ebonakalayo yelitye elifana nelitye. Olu candelo lomphezulu olungaphezulu lungenzi kuphela ukuba lube yindawo enkulu, kodwa xa inyanzelwa kwithebhulethi kunye neziyobisi, iipores zepirethi zisenziwa kwithebhulethi, ukuze i-capilt ixhamle umswakama Inqanaba lokufumana kunye nokuthathwa kwamanzi kunyuswa ukudumba. UkusebenzisaL-hpcNjengoko umculo unokwenza ithebhulethi iphazamiseke ngokukhawuleza kumgubo ofanayo, kwaye iphucule kakhulu i-diorvice, itsiselwe kunye nokuchithwa kwebhayiliji yecwecwe. Umzekelo, ukusetyenziswa kwe-L-HPC kunokukhawulezisa ukuchithwa kweetafile zeparacetamol, iitafile ze-aspirin, kunye neetafile ze-Chloriramine, kunye nokuphucula umgangatho wokuchithwa. Ukwahlula-hlulo kunye nokuchithwa kwamachiza anyibilikiswe kakuhle njengeetafile ze-arloxacin nge-l-hpc njengoko kungcono kakhulu kunabo banxibe i-pvpp enxibelelene ne-vcpp enxibelelene. Sebenzisa i-L-HPC njengendawo yangaphakathi ye-subnteles kwi-capsules iluncedo ekuchitheni iigranus, ukunyusa indawo yokuguqulela indawo phakathi kwechiza kunye nokuchithwa kwechiza, kwaye kuphucula ukusetyenziswa kwebhayili. Ukulungiselela kwangoko amalungiselelo aqinileyo amelwe kukuzibandakanya ngokukhawulezayo kunye nokuzibandakanya kwangoko, ukunyibilikisa ngokukhawuleza, ukuncitshiswa okukhulu, ukunciphisa i-biophastinal ye-esophagus kunye ne-gestrointenal kwaye nithobele kakuhle. Kwaye ezinye izibonelelo, zihlala isikhundla esibalulekileyo kwicandelo lekhemisi. I-L-HPC yenye yezona zinxibelelanisi zezona zibalulekileyo zokukhulula ngokukhawuleza ngenxa ye-hydrophicicity enamandla, i-hygroscoficity, ixesha elifutshane le-hysteris yokwakhiwa kwamanzi, kunye nokuseta okukhawulezayo kwe-afting. Yinto efanelekileyo ye-suinterbrant yetafile yokuphazamiseka ngomlomo. I-paracetamol yomlomo ye-paracetamoll yalungiswa nge-L-HPC njenge-chinterbrant, kwaye amacwecwe ahlazisa ngokukhawuleza ngaphakathi kwi-20s. I-L-HPC isetyenziswa njenge-suinterpent yetafile, kwaye idosi ngokubanzi i-2% ukuya kwi-10%, ubukhulu becala i-5%.
I-2. Njengombophelelo kumalungiselelo anje ngeetafile kunye negranules
Ubume obuqhelekileyo be-L-HPC kukwenza ukuba ibe nefuthe elikhulu kakhulu ngeziyobisi kunye namasuntswana, owonyusa umgangatho wobumbano, kwaye unentsebenzo elungileyo yokubumba. Emva kokucinezelwa kwiitafile, ibonisa ubunzima kunye nobunzima, ngaloo ndlela kuphucula umgangatho wenkangeleko yetafile. Ingakumbi kwiitafile ekungekho lula ukwenza, ukukhululeka okanye kulula ukuyityhila, ukongeza i-L-HPC kunokuphucula isiphumo. Ithebhulethi ye-ciprofloxacin hydrochloride ineempawu ezigwenxa, kulula ukuyiqhekeza kwaye inamathele, kwaye kulula ukwenza i-L-HPC, inkangeleko efanelekileyo, kunye nexabiso elifanelekileyo, kunye nexabiso elifanelekileyo lihlangabezana neemfuno ezisemgangathweni. Emva kokongeza i-L-HPC kwithebhulethi yokusasaza, imbonakalo, ubunzulu, ukuphazamiseka okungapheliyo kunye nezinye izinto kuphuculwe kakhulu kwaye kuphuculwe. Emva kwesitatshi kumayeza okuqala sathatyathwa yi-L-HPC, ubunzima betafile ye-Azithromycin bonyuswe, ubunzulu baphuculwa, kwaye iingxaki zecwecwe ezilahlekileyo zisonjululwe. I-L-HPC isetyenziswa njenge-binder yamacwecwe, kwaye idosi ngokubanzi yi-5% ukuya kwi-20%; Ngelixa i-H-HPC isetyenziswa njenge-binder yeetafile, iigram, njl njl, kwaye idosi ngokubanzi yi-1% ukuya kwi-5% yamalungiselelo.
3. Isicelo kwi-filim cailing kunye nokuzinza okuzinzileyo kunye nokulawulwa kokulawulwa
Okwangoku, izinto ezinyibilikayo zamanzi zihlala zisetyenziswa kwi-filimu yefilimu ibandakanya i-hydroxypropythylcelose (i-HPMC), i-HPMCYPOPYLCPY I-HydroxyPOpyl seluplose idla ngokusetyenziswa njengearhente yefilimu kwifilimu ephathekayo kwimveliso yezixhobo ezinzima, ngenxa yefilimu yayo, ifilimu ye-elastic. Ukuba i-hydroxypropyl seluplose ixutywe nenye yeearhente zokunyangwa kobushushu, ukwenziwa kokudibana kwayo kunokuphucula ngakumbi.
Sebenzisa izihlobo ezifanelekileyo kunye neendlela zokwenza ichiza kwiitafile ze-matrix, iitafile ze-gistric ezisasaza, amacwecwe adityanisiweyo, i-osmotic, i-osmotic ye-pumps, i-osmotic ye-osmotic, intsingiselo ye-osmotic, iyonyusa i ichiza egazini. Uxinzelelo, ukunciphisa imeko engathethekiyo, ukunciphisa inani lamayeza, kwaye kulwelwe ukwandisa isiphumo esine-carative kunye ne-DOSE encinci, kwaye unciphise impendulo engalunganga. I-Hydroxypropyl seluplose yenye yezona zinto zibalulekileyo zamalungiselelo aphambili. Ukuchithwa nokukhutshwa kweetafile ze-diclofneenac sodium zilawulwa ngokusebenzisa i-hydroxlypropyl yeseluplose yeseluplose kunye ne-Ethyl Selelose njengezixhobo ezidibeneyo ne-skeleton. Emva kolawulo lomlomo kunye nokunxibelelana nejusi ye-gastric, umphezulu weetafile zeDiclofenac Sodium ziya kunyibilika kwijeli. Ngokupheliswa kwejeli kunye nokuphazamiseka kweemolekyuli zamachiza kwisithuba seGal, injongo yokukhutshwa ngokuthe ngcembe kweemolekyuli zamachiza. I-Hydroxyproplopy isetyenziswa njenge-Matrix elawulwa yicwecwe lecwecwe, xa umxholo we-blocker seyyl selsel selsel selset, kunye nechiza elivela ngqo kwitafile enomxholo ophezulu ye-hydroxyproplopl yokukhutshwa iselula. I-pellets edityanisiweyo ilungiselelwe ngokusebenzisaL-hpckunye nenxalenye ethile ye-HPMC njengesona sisombululo sokuthoba sokukhathalela njengokudumba, kwaye njengokukhutshwa kwecala elilawulayo lokudibana ne-Ethyl Selelose kusasaza. Xa i-tion stursing rees kunye nedosi ilungisiwe, ngokulawula ubukhulu becala lolawulo olulawulwayo, iipellethi ezihlanganisiweyo zinokukhululwa ngexesha elilindelekileyo. Iindidi zeendidi zeepellet ezinamaphiko anengxaki eyahlukileyo yolawulo lwe-subled ixutywe ukwenza iicapsules zokukhutshwa kweShuxiong. Kwisithuba sokuchitha, iipellets ezahlukeneyo ezihlanganisiweyo zingazikhulula ngokulandelelana ngamaxesha ahlukeneyo, ukuze iindawo ezahlukileyo zezinto ezenziwe ngomzimba kunye neekhemikhali zayo zifezekiswa ngaxeshanye njengokukhululwa okuzinzileyo
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