Hydroxypropyl methylcelculose (hpmc)Ngaba i-sellyu ye-unicose i-ersulose i-ete ithole ngefestile elungileyo, i-adhesion, ipropati yokukhupha kunye nokulawulwa kwempahla, kwaye isetyenziswa ngokubanzi kumzi-mveliso wamayeza. Njengombono wamayeza, i-chancelcel®hpmc ingasetyenziswa kwiitafile, iicapsules, ezigcinelweyo, ukukhululwa, amalungiselelo e-Ophthalmic kunye neenkqubo eziphezulu zokuhambisa iziyobisi.
I-1. I-Percicochemical Progras ye-HPMC
I-HPMC yinto ye-polymer ye-polymer efunyenwe yi-methylating kunye ne-hydroxyy ifolday yendalo, kunye nokungaziphathi kakuhle kwamanzi kunye nokucacisa i-biomative. I-solubaility yayo ichatshazelwanga lixabiso lobushushu kunye nexabiso le-pH, kwaye linokungcungcutheka emanzini ukwenza isisombululo se-viscous, esinceda ukukhululwa kwamachiza. Ngokwe-viscofity, i-HPMC inokwahlulwa yangamacandelo amathathu: UVIKILE OLUFANELEKILEYO (5-100 MPASIT), i-vikosity ephakathi (i-100000 ye-MPAF) kunye ne-pavmosity ephezulu (elungele iimfuno ezahlukeneyo zokulungiselela.
2. Ukusetyenziswa kwe-HPMC kumalungiselelo amachiza
2.1 Isicelo kwiitafile
I-HPMC inokusetyenziswa njenge-binder, i-intergranti, izixhobo zokuhamba kunye nokulawulwa kweSteleton Sypings kwitafile.
I-Binder:I-HPMC inokusetyenziswa njenge-binder kwigransotion emanzi okanye i-gransetion yokuphucula amandla, ubunzima betafile kunye nokuzinza kweziyobisi.
Intsholongwane:I-HPMCITY ye-HPMC ingenziwa njenge-intercran ekukhuthazeni i-tacturnition yetafile kwaye inyuse ireyithi yokutshabalalisa iziyobisi emva kokudumba ngenxa yokungafuneki kwamanzi.
Izinto zokuhamba:I-HPMC yenye yezona zinto ziphambili zethebhulethi, ezinokuphucula ukubonakala kweziyobisi, zikhulise incasa embi yeziyobisi, kwaye zinokusetyenziswa kwi-Oneic Coating okanye ifilimu ekhathazayo kunye neeplastiki.
Izixhobo ezilawulwa-zilawula: I-HECMCIty ye-HPMC inokusetyenziswa njengemibandela ye-skeleton ukulibazisa ukukhutshwa ngamachiza kwaye ifezekise ukukhutshwa okanye ukukhululwa. Umzekelo, i-HPMC K4m, i-HPMC K15m kunye ne-HPMC K100m zihlala zilungiselela iitafile-zigunyazisiwe.
2.2 Isicelo kwiNkqubo yeCapsule
I-HPMC inokusetyenziselwa ukuvelisa i-capsules ye-tipsus ethatyathwayo ukuze ithathe indawo ye-gelatin capsules, ezilungele izixhobo ze-generian kunye nabantu abangathathi phelelo kwiicaphus ezihlaselweyo. Ukongeza, i-HPMC inokusetyenziselwa ukuzalisa i-Liquise okanye i-semisid capsules ukuphucula uzinzo nokukhupha iimpawu zeziyobisi.
2.3 Isicelo se-Ophthalmic
I-HPMC, njengeyona nto iphambili kwiinyembezi ze-artificificial, inyusa ixesha lokuhlala lihla, lisongeza ixesha lokuhlala leziyobisi kumgangatho we-Ocular, kunye nokuphucula ubutyebi. Ukongeza, i-HPMC inokusetyenziselwa ukulungisa ii-geses zamehlo, iifilimu zamehlo, njl njl.
2.4 Isicelo kumalungiselelo okuhambisa iziyobisi
I-Nuinccel®HPMC ineepropathi ezintle zefilimu kunye ne-biomatising, kwaye inokusetyenziselwa ukulungiselela i-parchermal patches, iiglasi kunye neekhrim. Umzekelo, kwiinkqubo zokuhambisa iziyobisi, i-HPMC inokusetyenziswa njengezixhobo ze-matrix ukwandisa izinga lokungena kwiziyobisi kwaye zisandisa ixesha lesenzo.
2.5 Isicelo kulwelo lomlomo kunye nokumiswa
I-HPMC inokusetyenziswa njenge-tickener kunye ne-stabilize iphucule iipropathi ze-shiculic zolwelo lwe-olwel nonqunyanyisiweyo, zithintele amasuntswana aqinileyo ekuhlalweni, kwaye uphucule iziyobisi kunye nokuzinza kweziyobisi.
I-2.6 iSicelo sokuzibandakanya
I-HPMC inokusetyenziswa njengomphathi we-Inlers owomileyo (i-DPIS) yokuphucula ulwelo kunye nokusasazeka kweziyobisi, yandisa umxholo weziyobisi, kwaye ngaloo ndlela kuphucule umphumo wonyango.
I-3. Izibonelelo ze-HPMC kwiNkqubo yokuKhulula
I-HPMC inezi mpawu zilandelayo njengokukhutshwa okuzinzileyo:
Umoya olungileyo wamanzi:Inokuvela ngokukhawuleza emanzini ukwenza isithintelo se-gel kwaye silawule inqanaba lokukhutshwa ngamachiza.
I-biomatining elungileyo:Ayikhathazeki kwaye ingakhathali, ayicaphukisi ngumntu omntu, kwaye inendlela ecacileyo yeMetabolic.
Iinguqu ezinamandla:Ilungele iintlobo ezahlukeneyo zeziyobisi, kubandakanya iziyobisi ezinyibilikayo kunye ne-hydrophobic.
Inkqubo elula:Ilungele iinkqubo ezahlukeneyo zokulungiselela ezifana nokutshata ngqo kunye nokudityaniswa okumanzi.
Njengowona uthandabuze kakhulu amayeza,I-HPMCisetyenziswa ngokubanzi kumacandelo amaninzi anjengeetafile, i-capsules, i-ophthalimis, amalungiselelo aphezulu, njl., ngakumbi kumalungiselelo okukhululwa azinzileyo. Kwixa elizayo, ngokuphuhliswa okuqhubekayo kwetekhnoloji yokulungiselela yamayeza, indawo yesicelo ye-IninCel®HPMC iya kwandiswa, ibonelela ngeshishini lamayeza ngendlela efanelekileyo kwaye ekhuselekileyo.
IXESHA LOKUQALA: FEB-08-2025