IIMPAWU ZOKUFUNDA EKHAYA KUNYE NOBUCHULE NGOKULUNGISELELWEYO I-DYDROXPOPLL METHyLCELXELCELCELY (HPMC) kwiCandelo lezoLiso, iZilungiso eziGqibeleleyo, kwi-getilin Izicelo kwicandelo lemidlalo entsha efana nokumiswa okunamathela kunye nebhadile. Ngenxa yomehluko kwisilingo semolekyuli kunye nokubonisa i-HPMC, inemifanekiso kunye nokusetyenziswa kwe-insubsation, ukunamathela, ukumiswa, ukumiswa, ukumiswa kunye nokuqulunqa ifilimu. Isetyenziswe ngokubanzi kumalungiselelo ngamayeza kwaye iya kudlala indima enkulu kwicandelo lamalungiselelo. Ngofundo olunzulu lwepropathi yalo kunye nokuphuculwa kwetekhnoloji yokwenziwa, i-HPMC iya kusetyenziswa ngokubanzi kuphando lweefom zedosi ezintsha kunye neenkqubo ezintsha zokuhambisa iziyobisi, ngaloo ndlela zikhuthaza ukuphuculwa okuqhubekayo kwefom.
hydroxypropyl methylcelceluplose; amalungiselelo ngamayeza; I-chinemeruticals.
I-PARMMACOOCATION ayisiyonto yokwenyama yokuqulunqa amalungiselelo e-Raw, kodwa inxulumene nobunzima, umgangatho weziyobisi, ukusetyenziswa kwezisombululo, ukusebenza kweziyobisi, kunye nophuhliso lwelitsha Iifom ze-dosis kunye neendlela ezintsha zolawulo. ihambelana kakhulu. Ukuvela kwamachiza amatsha amayeza kuhlala kuphakamisa ukuphuculwa komgangatho wokulungiselela kunye nophuhliso lweefom zedosi ezintsha. I-HydroxyPOpyl Methylcelceltulose yenye yezona zinto zithandwayo zamayeza ekhaya nakwamanye amazwe. Ngenxa yobunzima bayo be-molecular kunye novimba, inemisebenzi yokuxhasa, ukubopha, ukutya, ukuqaqamba, ukumiswa, kunye nokulinganisa. Iimpawu kunye nokusetyenziswa njengokucofa kunye nokwenza ifilimu kusetyenziswa ngokubanzi kwitekhnoloji yamayeza. Eli nqaku ikakhulu lihlaziya ukusetyenziswa kwe-hydroxypropyl methylcelcelculose (i-HPMC) ekwenziwayo kwiminyaka yakutshanje.
1.Iipropati ezisisiseko ze-HPMC
I-HydroxyPOpyl Methyl Selelose (HPMC), ifomula yemolekyuli yi-C8H15O8- (CO18O8 ye-sellyulose. Ingaveliswa ngeendlela ezimbini: Inye ye-methyl yebanga elifanelekileyo inyangwa ngoNah kwaye emva koko yaphendulwa nge-proplene oxide iphantsi kobushushu obuphezulu kunye noxinzelelo oluphezulu. Ixesha lokuphendula kufuneka lihlale ixesha elide ngokwaneleyo ukuba livumele i-methyl kunye ne-hydroxypropy ye-elektrong iqhagamshelwe kwi-anhydroglucose kwi-selupose ye-sellyulse, kwaye inokufikelela kwinqanaba leseli; Enye yeyokunyanga i-cotton icocekile okanye i-fiber ye-fiber ene-caustic soda, kwaye emva koko iphendule nge-cethane edit kunye ne-propleynene oxide kwaye emva koko iphucule. , ityhuwe kumgubo ocolekileyo kunye ne-Granules.
Umbala wale mveliso mhlophe ukuya eMildy White, ngaphandle kwe-odol kwaye engenakuthelekiswa nanto, kwaye ifom ingumgubo wegranur okanye umgubo ohamba kakuhle. Le mveliso inokutshitshiswa emanzini ukwenza icace gca kwisisombululo esimhlophe se-CLUIDAL kunye nohlobo oluthile. I-Sol-Gel-GelConversan inokwenzeka yenzeka ngenxa yokutshintsha kobushushu besisombululo kunye noxinzelelo oluthile.
Ngenxa yomehluko kumxholo wale mixholo mbini ngokwamazantsi kunye ne-hydroxylpyl, iintlobo ezahlukeneyo zeemveliso zivele. Kwingcinezelo ethile, iintlobo ezahlukeneyo zeemveliso zineempawu ezithile. I-Viscosity kunye neqondo lokuhlaselwa kwe-thermal, ke ngoko lunezinto ezahlukeneyo kwaye unokusetyenziselwa iinjongo ezahlukeneyo. I-Pharmacoviea yamazwe awahlukeneyo inemigaqo kunye nezimvo ezahlukileyo kwimodeli: i-European PharmacooOpoeias ezahlukileyo kunye namanqanaba ahlukeneyo okufakwa kwimarike, kwaye iyunithi yi "MPA S ". Kwi-pharmacopoeia, iinombolo ezi-4 zongezwa emva kwegama eliqhelekileyo ukubonisa umxholo kunye nohlobo ngalunye oluphatheliseko Ipesenti, amanani amabini okugqibela amele ipesenti ye-hydroxypropy.
I-Calocan's Hydroxypropyl Methylcelcelcelose inothotho lwe-3, eyokuthi e Serinta, F Grice kunye uthotho, uthotho uthotho, uthotho ngalunye luneemodeli ezahlukeneyo ukuba zikhethe kuzo. I-Eesties isetyenziswa kakhulu njengengubo yefilimu, esetyenziselwa ukuthuthuka kwetafile, indawo evaliweyo yecwecwe; E, F F Usetyenziswa njenge-viscofisifies kwaye ukhulule iiarhente zokubuyela kwi-Ophthalimis, ukumiswa kweearhente, ii-arhente zamacebo olwelo, iitafile kunye neebhanti zegramules; I-K engcengechungquthetho isetyenziswa kakhulu njengemithi yokukhupha kunye ne-hydrophilic gel matrix yelungiselelo elicothayo nelilawulwa.
Abavelisi basekhaya ikakhulu babandakanya iFuzhou. I-2 Mfayili yeKhemikhali, i-Huzhou yokutya kunye ne-Comple Jinxian Luzhou Phaya i-Ahuocheng Ahua Promachical CO ., Ltd., Xi'an humic emichiza, njl.
2.Izibonelelo ze-HPMC
I-HPMC iye yenye yezona zinto zisetyenziswa ngamayeza zisetyenzisiweyo ekhaya nakwaphesheya, kuba i-HPMC inezibonelelo zokuba ezinye izinto zingenazo.
2.1 Ukuzenzela amanzi okubandayo
Inyibilikisi emanzini abandayo apha ngezantsi engama-40 ℃ okanye i-70 i-ethanol, ngokusisiseko i-enzonzoword emanzini ashushu ngaphezulu kwe-60 ℃, kodwa ingaba nejel.
2.2 Inert ye-chemic
I-HPMC luhlobo lwe-ionic seluplose i-ether, isisombululo sayo ayikho i-ionic kwaye ayisebenzi ngeetyuwa zensimbi okanye i-ionic computers, ke ezinye izinto azisabelanga ngayo ngexesha lenkqubo yokuvelisa.
2.3 Uzinzo
Ihlala kuzo zombini i-acid kunye ne-alkali, kwaye inokugcinwa ixesha elide phakathi kwe-PH 3 nele-11 ngaphandle kokutshintsha okukhulu kwi-viscosity. Isisombululo se-ACPMC sinefuthe ye-Anti-Maildew kwaye igcina uzinzo lolwazi oluhle ngexesha lokugcina ixesha elide. I-chigmc i-HPMC inezinzo ezisemgangathweni ezingcono kunezo zisebenzisa umdla wesintu (njenge-dextrin, isitatshi, njl njl.).
2.4 Utshintsho lwe-viscosity
I-Viscovitity eyahlukileyo ye-HPMC inokuxubelwa kwinani ezahlukeneyo, kwaye uVecofity unokutshintshwa ngokomthetho othile, kwaye unolwalamano oluhle oluhle, ngoko ke umlinganiso unokukhethwa ngokweemfuno.
2.5 I-Metabolic
I-HPMC ayifunxanga okanye ibekwe emzimbeni, kwaye ayiboneleli ngobushushu, ngoko yindawo yokulungiselela amayeza akhuselekileyo. 2.6 Ukhuseleko lujongwa ngokubanzi ukuba i-HPMC yinto engenabungozi kwaye engacaphukisi, idosi ye-Deathal idosi yempuku yidosi ye-5. 2 GGG - 1. Idosi yemihla ngemihla ayinabungozi emzimbeni womntu.
3.Ukusetyenziswa kwe-HPMC kwifomu
3.1 Njengokuba ifilimu yokuhamba kwefilimu kunye nempahla yokwenza ifilimu
Sebenzisa i-HPMC njengendawo enemiboniso bhanyabhanya yefilimu, ithebhulethi edityanisiweyo ayinazo izibonelelo ezibonakalayo ekuthetheni iitafile kunye neetafile ezihlanganisiweyo zeSodukayo, kodwa ubunzima bayo, isidanga sokufuma, isidanga sokufuma, isidanga sokufuma. , ukuthuka ubunzima kunye nezinye izikhombisi ezisemgangathweni zingcono. Inqanaba le-viscosity eliphantsi le mveliso isetyenziswa njengezinto ezibonisa ifilimu zamanzi kwiitafile kunye nenqanaba le-viscosity elisetyenziswa njengezixhobo zokuhlola ifilimu, zihlala zixinezelekile kwi-2% ukuya kwi-20% ukuya kwi-20% %.
I-Zhang jix et al. isebenzise indlela yefuku lokwenza indawo yokuqulunqa ukwenziwa kwe-PRET nge-HPMC njengefilimu. Ukuthatha i-HPMC yefilimu ye-HPMC, isixa se-polyvinyl utywala kunye ne-Polythyene Glyolings njengezisombululo zokuhlola ifilimu yisalathiso esinemiboniso bhanyabhanya, kunye nolwalamano phakathi kovavanyo Isalathiso kunye nezinto zokuhlola zichazwa yimodeli yemathematics, kwaye inkqubo yokuqulunqa inyani iyafumaneka. Ukusetyenziswa kwayo kukusebenza ngokulandelelana kwe-fieldroxypropyl methylcelcelce (hpmce5) 11.00 G, i-Polyvingl Polythylene Glythylene Glythylene Glythylene Glythylene Glythylene ifikelela kwifuthe eligqibeleleyo . I-Zhang Yuan iphucule inkqubo yokulungiselela, isetyenziswe i-HPMC njenge-Binder yokutshintsha isitayile, kwaye itshintshe itafile ye-jinuasicicicicicicicicicicicicicicicicicicicicicicicicicicicicicle, iphucule i-ficturescoficicicicicicicicicicicicicicicicicicicicicicicicicicicicion, ndiphucule amacwecwe, ukuphucula uzinzo lwethebhulethi. Inkqubo efanelekileyo yokuqulunqa igqitywe ngovavanyo lwe-orthogonal, oko kukuthi, ukugxininiswa kwe-slorry yayiyi-2% ye-HPMC ngo-70% ye-ethanol ngexesha lokuthobela, kwaye ixesha elitshatileyo ngexesha le-parumples yayiyi-15 imiz. Iziphumo ze-jinuets zefiliki zefilimu ezilungiselelwe yifilimu ezilungiselelwe yinkqubo entsha kunye nonyango ziphuculwe kakhulu ngembonakalo, ixesha lokungasebenzi kakuhle kunye nenqanaba eliphambili kunelo eliveliswa yinkqubo yokuphela kwefilimu yaphuculwa kakhulu. ifikelele ngaphezulu kwe-95%. I-Liiiie, Lu Xiahui, njl njl. Ichaphazela ukukhululwa kwamayeza. I-Huang Yunning Rodon's Dolon Coloon Playts Plainting Playts, kwaye isetyenzisiwe i-HPMC kwisisombululo esikrakra somaleko wokudumba, kwaye iqhezu layo elininzi laliyi-5%. Ingabonwa ukuba i-HPMC inokusetyenziswa ngokubanzi kwinkqubo yokuhanjiswa kweziyobisi ekoloni.
I-Hydroxypropyl Methylcelcelgalose ayisiyiyo kuphela ifilimu ebalaseleyo yefilimu, kodwa inokusetyenziswa njengento yokwenza ifilimu kwifom yefilimu. I-Wang Toshin njl njlnjun. I-propylene Glycol ihlangabezana neemfuno zokukhutshwa kancinci nokhuseleko, kwaye zinokusetyenziswa njengoxwebhu lokulungiselela ifilimu.
I-3.2 njenge-binder kwaye i-suintebgraph
Inqanaba le-Viscosity elisezantsi le mveliso linokusetyenziswa njenge-binder kwaye ihluma iitafile, iipilisi kunye nenqanaba le-viscosity, kunye nenqanaba le-Vicofity eliphezulu linokusetyenziswa kuphela njenge-binder. Umthamo uyahluka ngeemodeli ezahlukeneyo kunye neemfuno. Ngokubanzi, umthamo we-binder yeetafile zegranungs ezomileyo yi-5%, kunye nethamo ye-binder yeetafile zegrama ezimanzi yi-2%.
I-LI HOTHAO et scred i-binder yeetafile zeTinidalisole. I-8% PolyvinyLylpylpylone (PVP-K30), i-40% i-Sydrry Scourry, i-2.0% i-Hydroxylcel. Ukulungiswa kweetafile ze-tinalisole. Ukubonakala kwenkangeleko yamacwecwe ecace kwaye emva kokuba ukhathalelo kuthelekiswa, kwaye ubunzulu, ubunzima bexesha lokusasaza, kunye nenqanaba lokuchitha amacwecwe ogqirha awahlukeneyo. Results The tablets prepared by 2.0% hydroxypropyl methylcellulose were glossy, and the friability measurement found no edge chipping and cornering phenomenon, and after coating, the tablet shape was complete and the appearance was good. Ke ngoko, iitafile zeTinidalisole zilungiselelwe nge-2.0% ye-HPMC-k4 kunye ne-50% ye-ethanol njengoko isetyenzisiwe ii-bibors. IGuan Shihai ifunde inkqubo yokuqulunqwa kweetafile, kwaye ihlole iipesenti ezingama-50 ze-ethanol, i-10% ye-ethanol inamathisi, i-10% ye-ATHP kunye ne-50% ye-ethanol enezalathiso zovavanyo. , 5% cmc-na kunye ne-15% isisombululo se-HPMC (5 MPA s). Iziphumo zamashiti alungiselelwe nge-50% ethanol paste, i-10% ye-10% ye-50% ye-ethanol kunye ne-5% cmc-na ayenobuqili obuthathaka, kodwa obungafezekanga kunye neemfuno zokudibana; I-15% yesisombululo se-HPMC (5 i-5 Mpando), umphezulu wethebhulethi ugudileyo, ubunzulu bufanelekile, kwaye ukucuthwa kulungile, okunokuhlangabezana neemfuno zokudibana. Ke ngoko, i-HPMC (i-5 MPA S) yakhiwe njengembeko.
3.3 Njengomntu omiselweyo
Inqanaba le-viscosity lemveliso yale mveliso isetyenziswa njengearhente yokumiswa ukuba ilungiselele ukulungiswa kwe-cust-uhlobo. Inesiphumo sokumiswa kakuhle, kulula ukuhlengahlengisa, ayinamathele eludongeni, kwaye inamasuntswana amnandi. Idosi eqhelekileyo yi-0.5% ukuya kwi-1.5%. Ingoma yengoma et al. Isetyenziswe rhoqo i-Polymer ye-Polymer ye-Polymer ye-Polymer Methylcelcelsulose, Sodium Carboxymethylcelose, Podimen, Xotan Gum, Gantan Gum, iMethylcelcelceltulose. ukunqunyanyiswa komileyo. Ngomyinge we-sediment ye-sediment yokumiswa kwezimiso ezahlukeneyo, isalathiso sohlengahlengiso, kunye ne-geology, i-viscofity ye-morcopic kunye ne-morphology ye-morsopic yaqwalaselwa, kunye nokuzinza kwamasuntswana amachiza aphantsi kwakuphandwa. Iziphumo zokumiswa komileyo ezilungiselelwe nge-2% ye-HPMC njengoko iarhente yokumisa inesifo esilula kunye nokuzinza okuhle.
Xa kuthelekiswa ne-methyl seluplose, hydroxypropyl methyl sellielse ineempawu zokwenza isisombululo esicacileyo, kwaye incinci kakhulu ye-fibrous engasasazwanga, i-HPMC isetyenziswa njengearhente yokumisa i-ophthalimic. Liu hie et al. Isetyenziswe i-HPMC, hydroxypropyl seluplose (HPC), iCarbomer 940, Polythylene Glycocone zikhethiwe njengezimpawu zokuhlola kwi-arhente yokumisa elona nqanaba liphambili. Iziphumo zibonisa ukuba i-acyclovir gonsered ilungiselelwe yi-0.05% ha kunye ne-HPMC ye-W.99% ye-HPMC njenge-Arhente yokuNikeza, kwaye ukulungiselela ukunyuka kwesondo kuyanda.
3.4 Njengomntu ovuthuzayo, iarhente ecothayo nengalawulekiyo kunye ne-Poemer
Inqanaba le-viscosity lemveliso elisetyenziselwa ukulungiswa kwe-hydrophilic getix ye-hydrophilic ye-hydrophilic ye-hydrophilic ye-hydrophilic, iibhloko kunye neearhente zokukhupha ezilawulayo ze-matrix, kwaye inefuthe lokulibazisa ukukhutshwa ngamachiza. Uxinzelelo lwayo yi-10% ukuya kwi-80%. Amabakala o-viscosity asetyenziswa njenge-porogens yokukhutshwa okuzinzileyo okanye amalungiselelo okukhutshwa kwemali. Idosi yokuqala efunekayo kwifuthe lonyango lweetafile zinokufunyanwa ngokukhawuleza, emva koko ukukhululwa okuzinzileyo okanye isiphumo sokulawulwa kwegazi kugcinwe emzimbeni. . I-Hydroxypropyl Methylcelcelcelose i-hydady yenze i-gel fall xa idibana namanzi. Indlela yokukhululwa kweziyobisi kwithebhulethi yeMatrix ikakhulu ibandakanya ukwahluka kwe-gel kunye nokukhukuliseka kwegel. I-Jung Bo shim et al elungiselelwe iitafile ze-carvevilol ezigcinakileyo ze-HEPGMC nge-HPMC njengezixhobo zokukhululwa ezizinzileyo.
I-HydroxyPOpyl Methylcelcelcelose ikwasetyenziswa ngokubanzi kwiitafile ze-matrix ezikhutshelweyo ze-China ze-China, kwaye uninzi lwezithako ezisebenzayo, iinxalenye ezisebenzayo kunye namalungiselelo angaqhelekanga asetyenziswayo. Liu wen et al. Isetyenziswe i-15% ye-hydroxypropyl methylcelcelcelose njenge-Matrix yeMatrix, i-1% ye-1% ye-microcrystalline njengeefilimu ze-jaohe ye-jingfang taches kwitafile yomlomo. Imodeli yi-hidiuchi equation. Inkqubo ye-formula yokwenziwa ilula, ukulungiselela kulula, kwaye idatha yokukhupha izinzile, ehlangabezana neemfuno ze-chineccopoopoeia yaseTshayina. I-Tang Guanguang et al. Isetyenziswe i-sandins iyonke ye-Astragalus njengechiza lemodeli, i-HPMC Matritts, kwaye yakhangela izinto ezichaphazela ukukhutshwa kweziyobisi kumacwecwe e-China kwi-HPMC Matrix. Iziphumo njengemithi ye-HPMC eyandayo, ukukhutshwa kwe-Astragaloline yehle, kwaye ipesenti yexabiso leziyobisi inobudlelwane obuhlanganisiweyo kunye nenqanaba lokuchitha i-matrix. Kwi-hypromellose hpmc matrix yetafile, kukho ubudlelwane obuthile phakathi kokukhululwa kwenxalenye ye-Chinese Chinese kunye ne-HPMC ye-HPMMC ye-Hydrophilic iyafana nayo. I-Hydroxypropyl Methylcelcelgalose ayihambelani ne-hydrophilic comples, kodwa nakwizinto ezingezizo ze-hydrophilic. I-Liu Guihua isebenzise i-17% ye-hydroxypropyl methylcelcelcelculose (HPMck15m) njengeetafile ze-matrix ezigcinakileyo, kunye ne-tiann xube xumia ze-cubiptions ngokukhutshwa kwe-granux kunye nendlela yetafile. Iziphumo ezizinzileyo zibonakale, kwaye inkqubo yokulungiselela yayizinzile kwaye inokwenzeka.
I-HydroxyPOpyl Methylcelcelcelose ayisebenzi nje kwiitafile ze-matrix ezigciniweyo zezinto ezisebenzayo kunye neenxalenye ezisebenzayo zamayeza e-China, kodwa zisetyenziswe ngakumbi kumalungiselelo e-China eTshayina. I-Wu Huichao et al. Isetyenziswe i-20% ye-hydroxyl i-methyl selsulose (i-HPMck4M) njengeyona ndlela ye-matrix, kwaye isebenzise i-powner yoxinzelelo lwe-pille hydrophilic gest enokukhupha ichiza eliqhubekayo kwaye liziiyure ezili-12. I-sapin rg1, i-ginseorded rb1 kunye nePanax Saphong Sapin R1 yayisetyenziswa njengezikhombisi zovavanyo lokuphanda ukukhululwa kwe-vitro, kwaye i-equation iquation ifanelekile ukuba ifunde indlela yokukhutshwa ngamachiza. Iziphumo zokukhutshwa kweziyobisi ezihambelana ne-lero-odolo ye-zero-odola kunye ne-ritger-pitger-peppopos, apho i-geppas-peppoposiide ikhutshwe ngu-En-Fick Loulion, kunye nezinto ezintathu ePanax
I-3.5 yokukhusela iglue njenge-thickener kunye ne-colloid
Xa le mveliso isetyenziswa njenge-gickener, ipesenti yesiqhelo yokugxila yi-0.45% ukuya kwi-1,0%. Inokonyusa ukuzinza kwe-hlue ye-hydrophobic, yenza i-colloid ekhuselweyo, thintela amasuntswana ukusuka ekuhleni nasekuhleni, ngokuthintela ukwenziwa kweendawo ze-sediments. Ipesenti yayo eqhelekileyo yi-0.5% ukuya kwi-1.5%.
Wang Zhen et al. Sebenzisa i-L9 ye-L9 Orthogonal yovavanyo lokwenza uphando ngenkqubo yokulungiselela ye-carbon evulekileyo ye-carbon esebenzayo. Imeko efanelekileyo yenkqubo yokuzimisela okuphezulu kwe-carbon esebenzayo ye-Carbon esebenzayo yokusebenzisa i-0.5% ye-Sodium Carxymethyl I-14.0% ye-Hydroxyl I-14.6% ye-Sydroxyl ye-Ficylcelox, iimeko zenkqubo zinceda ukuphucula Uzinzo lwe-carbon esebenzayo. Zhang Zhiqiquiang et al. Iphuhlise i-ph-the the phvofloxacin hydrochloride ye-on-gethalmic-ukuya e-Gel enefuthe elinemisebenzi, esebenzisa i-carbopol ye-gespylcelose njengearhente yokuthambisa. I-GOGOLDOPERORK i-ERGEALS, ekugqibeleni ifumana uMyalelo oLungileyo yi-Levofloxacin i-shdrochloride 0.1 G, iCarbopol (i-Desboorium i-3 g, i-phosphoric acid i-slodium chydrople , 0.03 g ye-ethym paraben, kwaye amanzi esongezwa ukwenza i-100 ml. Kuvavanyo, umbhali wakhangela i-hydroxypropyl methylcelcelcelse yedatha yenkampani yebala lemibala eneenkcukacha ezahlukeneyo (i-K4m, e50 i-E5M ekhethiweyo ye-HPMC E50 lv njenge-tickener. I-tickener ye-PH-ejongene levokraxacin hydrochloride igesi.
3.6 Njengesixhobo se-capsule
Ngokwesiqhelo, i-capsule ye-capsule ye-capsules i-getini. Inkqubo yemveliso yeqokobhe le-capsule ilula, kodwa zikho iingxaki kunye ne-phenomena njengokhuseleko olungathathi ntweni kunye neziyobisi ezinobungozi, kunye nokuncitshiswa kwe-typermotion ye-capsule ye-capsule ngexesha lokugcina ityhefu ngexesha lokugcina. Ke ngoko, i-HydroxyPyl Methylcelcelcelose isetyenziswa njengezixhobo ze-gelatin ye-gelatin ye-capsules, ephucula ukwenziwa kweecapsules, kwaye ikhuthazwe kakhulu ekhaya nakwelinye ilizwe.
Sebenzisa i-Theophylline njengechiza elilawulayo, i-podczeckck et al. ifumanise ukuba inqanaba lokutshabalalisa ichiza le-capsules ene-hydroxypropyl methylcelcel yerobhothi yayinkulu kune-gelitin capsules. Isizathu sohlalutyo kukuba ukwahlulwa kwe-HPMC kukuqhekeka kwecapbule yonke ngexesha elinye, ngelixa i-gelitin capsule yeyokhiwo yenethiwekhi kuqala, emva koko i I-HPMC CAPULE ilungele ngakumbi i-capsule gores yefomu yokukhutshwa kwangoko. Chiwele et al. Kukwafikelele kwisigqibo esifanayo kwaye sathelekisa ukutshitshiswa kwe-gelatin, igelatini / i-polythylene glycol kunye ne-HPMC. Iziphumo zibonise ukuba iigobolondo ze-HPMC zazichithwa ngokukhawuleza phantsi kweemeko ze-ps ezahlukeneyo, ngelixa i-gelatini capsules zichaphazeleka kakhulu ziimeko ezahlukeneyo ze-ps. Tang yue et al. I-stict yohlobo olutsha lwe-capsule yeqokobhe le-Dose-Dose ye-Dose ye-Poser I-Inrier Pierier Commer. Xa kuthelekiswa neqokobhe le-HydroxyPOpyl Methylcelceluplose kunye neqokobhe le-gelatin, uzinzo lweqokobhe le-gepin kunye neepropathi zeqokobhe kwigobolondo eziphantsi kweemeko ezahlukeneyo, kwaye kuvavanyo lwe-FRAREAL lwenziwa. Iziphumo zibonisa ukuba kuthelekiswa ne-gelatin capsules, i-HPMC ye-HPMC ye-Hople ilunge ngakumbi kukhuselo lwe-gelatin ye-gelatin capsule, i-HPMC Capsule ilungele kakhulu i-capsules yomigude.
3.7 Njengebhayilopha
Itekhnoloji ye-bioadion isebenzisa umdla kwii-biomers. Ngokulandela i-MUCOSA ye-biolos, iphucula ukuqhubeka kunye nokuqina komfowunelwa phakathi kokulungiselela kunye ne-MUCOSA, ukuze ichiza likhululwe kancinci kwaye lithathe i-MUCOSA ukuze ifezekise injongo yonyango. Isetyenziswe ngokubanzi okwangoku. Unyango lwezifo ze-Gastrointenal Tract, i-Vagina, uMculo Mucosa kunye namanye amalungu.
Itekhnoloji ye-gustrointentinion ye-biadisestion yinkqubo entsha yokuhanjiswa kweziyobisi ephuhliswe kule minyaka idlulileyo. Ayisondisi kuphela ixesha lokuhlala leGestrointenal Tect, kodwa iphucula intsebenzo yoqhakamshelwano phakathi kwechiza kunye neseli yeseli kwiseli yeseli, kwaye yenza ukubanjiswa kweziyobisi Iiseli ezincinci ze-Epithelial ze-Epitineal ziyaphuculwa, ngaloo ndlela ziphucule i-biaaaais yechiza. I-Weia et al al. I-skring thectt yecwecwe kunye nethamo ye-HPMPT4m kunye neCarbomer 940 njengeyona nto ibalulekileyo ye-biedilm ukulinganisa i-biesing birting phakathi komgangatho wamanzi kwingxowa yeplastiki. , kwaye ekugqibeleni bakhethe umxholo we-HPMDD40 kunye neCarbomer 940 ukuya kwi-15 ne-27,5 MG kwindawo ye-biebt ye-Nicaebt, ebonisa ukuba i-Hydroxyl ye-HETYLCHLELE) inokunciphisa kakhulu ukuphuculwa ukunamathela kumalungiselelo kwizicubu.
Amalungiselelo omlomo anohlobo olutsha lwenkqubo yokuhanjiswa kweziyobisi efundwe ngakumbi kwiminyaka yakutshanje. Amalungiselelo omlomo anokubambelela kwichiza kwinxalenye echaphazelekileyo yotywala yomlomo, engasayi kusandisa ixesha lokuhlala lechiza kwi-MUCOSA yomlomo, kodwa ikhusela i-MUCOSA yomlomo. Isiphumo esingcono sonyango kunye nokuphuculwa kwebhayili yebhayili yengca. Xue xiaoyan et al. Ukuphucula ukwenziwa kweetafile zomlomo ze-Insulin, usebenzisa i-Apple PecTIN, i-chitosan, i-carbomer 934P, i-HPMCEATPOPLL Iphepha lokubulala elinamachaphaza amabini. Ithebhulethi elungiselelwe i-insulin yomlomo inesakhiwo esinamafutha anesiphene, esithandwayo ngenxa yokukhutshwa kwe-indrophobic, kwaye sinokukhuthaza ukukhululwa kwe-hydrophobic, nto leyo enokuqinisekisa ukukhutshwa kwechiza kunye nokuphepha ukuphulukana kwechiza. Hao Jifu et al. Kwakulungiselele ubuhlalu obuluhlaza okwesibhakabhaka olwela i-oralshesheives usebenzisa i-baiji iglue, i-HPMC kunye neCarbomes njengezixhobo zebhayiloji.
Iinkqubo zokuhambisa iziyobisi, itekhnoloji yebhayiloji isetyenziswe ngokubanzi. Zhu ying et al. used carbomer (CP) and HPMC as adhesive materials and sustained-release matrix to prepare clotrimazole bioadhesive vaginal tablets with different formulations and ratios, and measured their adhesion, adhesion time and swelling percentage in the environment of artificial vaginal fluid. , Ugqirha ofanelekileyo wakhutshwa njenge-CP-HPMC1: 1, iphepha elinamathela elilungiselelweyo lalinendlela yokudlala elungileyo, kwaye inkqubo yayilula kwaye inokwenzeka.
I-3.8 njenge-gel
Njengokulungiselela okumbethelele, ijeli inoluhlu lweenzuzo ezifana nokhuseleko, ubuhle, ukucoca ngokulula, iindleko eziphantsi, kunye nokuhambelana neziyobisi. Umkhombandlela wophuhliso. Umzekelo, ijeli ye-Paridermal yifom yedosi entsha efundwe ngakumbi kwiminyaka yakutshanje. Ayinakuphephe ukutshatyalaliswa kwamachiza kwiphecana le-gestrointenal kwaye linciphise ukwalelwa kwe-rak-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-to-quire quire quist zegazi, kodwa ube yenye yeenkqubo zokuthumela iziyobisi ezifanelekileyo. .
Zhu jingjie et al. ifundwe isiphumo sama-itriki eyahlukeneyo ekukhutshweni kwe-Scutelin Platroty Geel, kwaye ihlolwe i-carbomer (i-980nf) kunye ne-HELDROXPOPLL (HPMDT15m) njenge-gel matrictin efanelekileyo kwi-Skutelin. I-gel matrix yePlastids yotywala. Iziphumo zovavanyo zibonisa ukuba 1. I-0% yeCarbomer, 1. . Ngexesha lokuvavanywa, kwafunyaniswa ukuba i-HPMC ingayitshintsha indlela yokukhupha iziyobisi ye-carbomer ye-carbomer ngokufaneleka kwe-kinetic equation, kunye ne-1.0% ye-HPMMC ingaphucula i-1.0% ye-carbomer matrix. Isizathu sokuba i-HPMC yandiswa ngokukhawuleza, kwaye ukwanda ngokukhawuleza kwinqanaba lokuqala lovavanyo kwenza umsantsa wemolekyuli ye-carbomer ye-carbomer ye-carbomer ye-carbomer ekhulu, ngaloo ndlela ukukhulula izinga lokukhupha iziyobisi. UZhao Wenue et al. I-carbomer esetyenzisiweyo-934 kunye ne-HydroxyPOpyl Methylcelcelgalose Inkqubo yokulungiselela ilula kwaye inokwenzeka, kwaye umgangatho ohambelana nejeli ye-Ophthalmic ye "Chinese Pharmacopoeia" (yoshicilelo ngo-2010) iimfuno zomgangatho.
I-3.9 Infippy i-inhibitor yenkqubo yokuzimela
Inkqubo yokuhambisa iziyobisi (i-SMEDDS) luhlobo olutsha lwenkqubo yokuhambisa iziyobisi, engumbambisi, ozinzileyo kunye nokungabonakali kwechiza, isigaba seoyile, i-eUlsifier. Ukuqulunqwa kommiselo kulula, kwaye ukhuseleko kunye nokuzinza kulungile. Ichiza elinyibilikayo le, i-fiber ye-fiber ye-fiber ye-polymer, efana ne-HPMC, i-Polyvinylpylpylpylidone (PVP), njl njl. Yandisa ukungasebenzi kweziyobisi kwaye kuphuculwe i-bioaaaaiff.
Peng Xuan et al. Ilungisiwe i-Silibin i-Sulistrated Standature yokuzimela ngenkqubo yokuhambisa iziyobisi (i-S-Seddds). I-Oxyyeyyyene Hydrogeled Ioli (i-cremopir rh40), i-12% Capric Cacliri Plythyle i-Glythylene Glyculane i-e-mlysifier, kwaye i-50 ye-MGG-1 hpmc. Ukongeza i-HPMC ukuya kwi-SEEDDS ingayikhulula i-selitin yasimahla yokunyibilika kwi-S-Sedds kwaye ikhusele i-Silibin ekuthini. Xa kuthelekiswa nefomu ye-Micro-milmsion yemveli, isixa esikhulu se-surfacnt esongezwa ukuthintela ukungenisa iziyobisi ezingaphelelanga. Ukongezwa kwe-HPMC kungagcina ukubethwa kwe-silifin kwi-distom ephakathi, ukunciphisa ukwenziwa kwe-inshurensi kwiziko lokuziqhelanisa. idosi yearhente.
I-4.ConConConcied
Ingabonwa ukuba i-HPMC isetyenziswe ngokubanzi kumalungiselelo ngenxa yepropathi yayo yomzimba, yekhemikhali kunye ne-bimic, kodwa i-HPMC ikwaneentsilelo ezininzi kumalungiselelo, njengento yokukhutshwa kwe-pre- kwaye emva koko. methyl metacrylate) ukuphucula. Kwangelo xesha, abanye abaphengululi baphanda ngethiyori ye-osmotic kwi-HPMC ngokulungiselela iitafile ze-carbamazepine ezinzileyo kunye ne-verapamil hydrochloride yokuqhubela phambili. Kwigama, ngakumbi abaphandi benza umsebenzi omninzi wokusetyenziswa okungcono kwe-HPMC kumalungiselelo, kunye nophando olunzulu lwezakhiwo, i-HPMC iya kusetyenziswa ngokubanzi kwiifom zedosi entsha kunye neefom zedosi ezintsha. Kuphando lwenkqubo yamayeza, kwaye emva koko kukhuthaze uphuhliso oluqhubekayo lwekhemesti.
IXESHA LOKUQALA: I-Oct-08-2022