1. Intshayelelo:
Kumsebenzi wamayeza, ii-binders zidlala indima ebalulekileyo ekuqinisekiseni ingqibelelo kunye nokusebenza kweefom zedosi. Phakathi kweenkqubo ezahlukeneyo ze-boinder ezikhoyo, i-HydroxyPopyl MethylcelcelcelUlose (i-HPMC) ibonakale njengokhetho oluqhelekileyo kunye nolusebenzise kakhulu.
2.Imisebenzi yeenkqubo ze-HPMC Binder:
I-HPMC, i-sessoyth polymer ethathwe kwi-sellyulose, ibonelela nge-procrum yeepropathi ezifanelekileyo zendlela yamayeza. Oku kubandakanya:
Ukusetyenziswa kwezinto zokusebenza: I-HPMC ibonisa uluhlu olubanzi lwamabakala ee-viscosity, ivumela iifomula ukuba zilungelelanise ukusebenza kwawo kwiifom zethamo ezithile kunye neemfuno zokulungisa. Ukuqhelana kuyandisa ukusetyenziswa kwayo kuko nje ukwenziwa kwayo kwezinto ezahlukeneyo zokwenza amayeza, kubandakanya iitafile, iicapbules, iifilimu, kunye namalungiselelo aphezulu.
I-Binder kwaye i-Hinterggran: I-HPMC isebenza zombini njenge-Binder, iququzelela amandla anokuthengiswa kwiitafile, kwaye njengokukhutshwa kwenkani, ukukhuthaza ukukhululwa ngokukhawuleza kweziyobisi. Oku kulungelelanisa iinkqubo zokusebenza kwaye kuphucule ukusebenza kweefom zomnxeba zomlomo, ngakumbi amacwecwe akhutshiweyo.
Ukuhambelana: I-HPMC ibonisa ukungangqinelani noluhlu lwezinto ezahlukeneyo ezisebenzayo (APIS) kunye neziko, zisenza ilungele ukwenziwa kweemveliso ezibanzi zeziyobisi. Imo yayo ye-ITERT kunye nokungabikho kokudibana kunye neentsontelo ezibuthathaka ekuqinisekiseni ukuzinza kwenkqubo kunye nokusebenza kakuhle.
Iipropathi ezenziweyo zefilimu: I-HPMC inokwenza iifilimu eziguqukayo kunye ne-fildired xa ihlulekile kwi-Fight Remmus ezinqamlezileyo, iipilisi ezihamba ngefilimu, kunye nezinye iinkqubo zokuhambisa ifilimu. Ezi filimu zinika izibonelelo ezifana nokuthotyelwa koguli, idosing prosing, kunye nokuqatshelwa ngokukhawuleza kwesenzo.
Ukukhutshwa okuthengisiweyo: ngokuguqula iBanga le-viscosity kunye ne-HPMC kwifomu, ukukhutshwa ngamachiza i-kinetics kunokubakho kakuhle ukufezekisa i-Counterducted, igcinwe, okanye i-Reffeed, okanye iProfayili ye-Refled. Obunikako luyingenelo ikakhulu ekuqulunqa iifom zokukhutshwa komlomo, apho ukugcina amanqanaba onyango kwixesha elidlulileyo kubalulekile.
3. Iimpapasho kunye neziBonelelo kwiindawo zokwakha:
Ifomu yetafile:
I-HPMC Binders idlulisela ukukhetha okuhle kunye nokuhamba kweepropathi kwiigranus, ngokuququzelela iinkqubo ezifanelekileyo.
Ukudumba okulawulwayo kunye nokuziphatha hydimer ze-HPMC kwiitafile zegalelo kwi-iyunifoni yeziyobisi kunye nokukhutshwa kwe-kinetics enokuqikelelwa, kuqinisekisa iziphumo ezingaguqukiyo.
Iifomulators zingakwazi ukuvumelana nokuhambelana kwe-HPMC kunye nezinye izicelo zokuphuhlisa ukumiswa kwethebhulethi yethebhulethi, kubandakanya imisebenzi eyongezelelweyo enjengokungcamla - imaski yokhuselo, ukukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama, kunye nokukhululwa komswakama.
Ifomu ye-Capsule:
I-HPMC isebenza njenge-binder eguquguqukayo ekuqulunqweni kwecaphule egcwalisiweyo yeplanga, enika i-engection ye-hydrophilic kunye ne-hydrophobic apis.
Ukukwazi kwayo ukwenza iifilimu ezinamandla ziququzelela ukuphuculwa kwenkqubo ye-capsue ene-capsule edibeneyo kunye nokukhutshwa kozinzo ze-API kunye nokuzinza kwe-API kunye ne-bioaaiffFent.
Ifomu esekwe kwifilimu:
Iifilimu ze-HPMC ze-HPMC zibonelela ngeenzuzo ezininzi kwiifom ze-dosage zemveli, kubandakanya ukwahlula-bhambano, ukufunyanwa kwebhayoloji ephuculweyo, kunye nokuphuculwa kwesigulana, ngakumbi kwimicimbi yabantwana kunye ne-Geriaatric.
Iipakethi ze-Paridermal zenziwe ngeifilimu ze-HPMC zibonelela ngokuhanjiswa kweziyobisi ngolusu, ukuhambisa i-plasma yokuxakeka ngokuzinzileyo kunye nokunciphisa iziphumo ebezingalindelekanga zenkqubo.
Ifomu ePhezulu:
Kwimigangatho yentloko efana ne-gells, iikhrim, kunye ne-oyile, i-HPMC isebenza njenge-Rheoology Modifier, ibonelela ngokutshata okufunekayo kunye nokusasazeka.
Ipropathi yayo yokwenza ifilimu yandisa ukunamathela kwi-obehlaseli yokwenziwa kwezikhumba, ukwandisa ixesha lokuhlala kunye nokwenza lula ukuhanjiswa kweziyobisi.
I-HydroxyPOpyl Methylcelcelsulose (HPMC) ibonelela ngesigulo sezibonelelo kwiindawo zokuqulunqwa kwamachiza, ngenxa yeepropathi zawo ezihambelanayo kunye nokwenza isicelo ezizezona zonke iifom ze-dosage. Ukusuka kwiicwecwe kunye neecaphus ukuya kwiifilimu kunye neefomu eziphezulu, i-HPMC yenza ukuba iifomula zifezekise ulawulo oluchanekileyo malunga nokukhululwa kweziyobisi, ukuphucula ukubambelela ngomonde. Njengoko ishishini lamayeza liyaqhubeka ukuvela, i-HPMC ihlala ililitye lokuqulunqwa, ukuqhuba ubuchule kunye nokuphucula iziphumo zonyango.
IXESHA LOKUQALA: I-MAD-07-2024