Zombini i-hydroxypropyl methylcelceluplose ne hydroxyythl seluplose yisellulose

Hydroxypropyl methylcelculose (hpmc)kunye ne-hydroxyyl seluplose (hec) zizibini ezibalulekileyo zeselselose zisetyenziswa kakhulu kumashishini ahlukeneyo ngenxa yepropathi yabo eyahlukileyo. Ngelixa zombini zithathwe kwi-seluplose, zinemimandla eyahlukileyo yemichiza kwaye bonisa iimpawu ezahlukeneyo kunye nokusetyenziswa.

1. Intshayelelo kwi-Selesese Derivatives:
I-seluplose yi-Polysackacchaacchaackar yeNdalo efumaneka kwiindonga zeseli ezityalo, eziquka imixokelelwane ye-glucose idityaniswe ngu-β (1 → 4) Glycosidic. I-selsulose Derivetives ifunyanwa ngokutshintsha imichiza ukuphucula iipropathi ezithile okanye zazise imisebenzi entsha. I-HPMC kunye ne-HEC zizinto ezimbini ezisetyenziswa kakhulu kumashishini asusela kwimizi evela kumachiza aseKwakha.

2. Synthesis:
I-HPMC idityanisiwe ngokuphendula ngokuphendula nge-proplone oxide ukuba ingenise amaqela e-hydroxypropy kwaye emva koko i-methyl chloride yokwazisa amaqela e-methyl. Oku kuphumela ekufakweni kwamaqela e-hydroxyl kwikhonkco leselselose Calulose, ukuvelisa imveliso ngokuphucula ukubenzela amandla kunye nezinto ezenza ifilimu.

I-hec, kwelinye icala, iveliswa ngokuphendula ngokuphendula nge-senglone oxide ukubandakanya amaqela e-hydroxyyl. Inqanaba lokufakwa endaweni (DS) kwi-HPMC kunye ne-HEC lingalawulwa ngokuhlengahlengisa iimeko zokuphendula, ezichaphazela iipropathi zabo ezinjenge-viscofity, ukuzonwabisa, kunye nokuziphatha kwengqolowa.

I-3. UKHENKILE:
I-HPMC kunye ne-hec yahlukile kwiindidi zamaqela athabathayo aqhotyoshelwe kwi-selsebone. I-HPMC iqulethe zombini i-hydroxypropy kunye namaqela e-methyl, ngelixa i-HCC iqulethe amaqela e-hydroxyyl. Ezi zixhobo zibeka izinto zidlulisela iimpawu ezizodwa kwicandelo ngalinye, liphembelela indlela abaziphethe ngayo kwizicelo ezahlukeneyo.

4. Iipropathi zomzimba:
Zombini i-HPMC kunye ne-HEC zii-polymers ezinyibilikayo zamanzi ezineepropathi ezigqwesileyo. Nangona kunjalo, babonisa umahluko kwi-viscofity, amandla omzimba, kunye nobuchule bokwenza ifilimu. I-HPMC idla ngokuba ne-viscofity ephezulu xa kuthelekiswa ne-HEC kwiindawo ezilinganayo, zenza ilungele izicelo ezifuna ukuthambisa okukhulu.

Ukongeza, iifom ze-HPMC zicoceke kwaye zibhengezo ngakumbi zefilimu ngenxa yokuthathwa kwezinto zayo ze-methyl, ngelixa i-hec ithambile kwaye iqhube iifilimu eziguquguqukayo. La mahluko kwiipropati zefilimu zenza umntu ngamnye akwazi ukufunyanwa kwezicelo ezithile kwiimveliso zamachiza, iimveliso zononophelo lobuqu, kunye namashishini okutya.

5. Izicelo:
5.1 Ishishini lamayeza:
Zombini i-HPMC kunye ne-HEC zisetyenziswa ngokubanzi kwiifomu zamayeza njengababizi, ii-thickers, kunye neearhente zokuzithobela kwefilimu. Baphucula ingqibelelo yetafile, ukulawula iziyobisi, kunye nokuphucula i-spotifel kwifomu engamanzi. I-HPMC ikhetha ukwenziwa kweenkqubo zokukhutshwa okuzinzileyo ngenxa yenqanaba le-hydration ecothayo, ngelixa i-HCC isetyenziswa ngokusetyenziswa kwezisombululo ze-Ophthalmic kunye neekhrives eziphezulu ngenxa yokucaca kwayo kunye nokuhambelana nolwelo lwebhayoloji.

5.2 Ishishini:
Kwishishini lokwakha,I-HPMCkwayeHecbaqeshiwe njengezongezelelo kwizinto ezisekwe kwisamente, ezinjengokufa, i-griuts, kwaye zinikeze. Baphucula ukusebenza, ukugcinwa kwamanzi, kunye nokunamathela, kukhokelela kwintsebenzo ephuculweyo kunye nokuqina kwemveliso yokugqibela. I-HPMC ihlala ikhethwa ngomthamo wayo ophezulu wokugcina amanzi, enciphisa ukuqhekeka kwaye kuphuculwe ixesha.

5.3 Iimveliso zononophelo lobuqu:
Zombini ezi zinto zikhutshwayo zifumana izicelo kwiimveliso zononophelo zobuqu ezifana ne-shampoos, i-lotions, kunye neekhrizs njengearhente zokubambisa, ii-eullisiers, kunye nokuzinzisa. I-HEC inika inguqulelo egudileyo kunye ne-glossy yokwenziwa, iyenza ilungele iimveliso zokhathalelo lweenwele kunye neekhrim zekhusi. I-HPMC, kunye nepropathi yayo yefilimu ebalaseleyo, isetyenziswa kwi-sunscreens kunye neendlela zokwenza izinto ezifuna ukumelana kwamanzi kunye nokunxiba ixesha elide.

5.4 Ishishini lokutya:
Kwishishini lokutya, i-HPMC kunye ne-HCS isebenza njengamalungu okuzinza, ukuzinzisa, kunye nabathengisi kwiimveliso ezahlukeneyo kubandakanya iisosi, ukunxiba, kunye needessert. Baphucula imilomo, thintela i-synereressis, kwaye bophucule iimpawu zemvakalelo zokwenziwa kokutya. I-HPMC ihlala ikhethwa inkcazo yayo yokucaca kunye nokuzinza kobushushu, kuyenza ilungele ukusetyenziswa kwe-gels efuna i-gels ebonakalayo kunye ne-emulsions ezizinzileyo.

6. ISIQINISEKISO:
I-HydroxyPOpyl Methylcelceltulose Ngelixa zombini zibonelela ngeepropathi ezihle kakhulu kwaye zenza ifilimu, zibonisa ukungafani ku-viscofity, ukucaciswa kwefilimu, kunye nokuziphatha hydration. Ukuqonda lo mahluko kubalulekile ekukhetheni ukukhutshwa okufanelekileyo kwezicelo ezithile kumashishini anjengamayeza, ukwakhiwa, ukhathalelo lobuqu, nokutya. Njengoko uphando luyaqhubeka ukuqhubela phambili, ukuqhubeka nokulungiswa ngakumbi kunye nokusetyenziswa kwezicelo zeselselose zilindelwe, zinegalelo ekwenzeni ukubaluleka kwazo kumacandelo ahlukeneyo eeshishini.