I-seluplose ethu elungiselelwe ukukhululwa kwamachiza kwiinkqubo ze-hydrophilic matrix

I-Selease Telupe, ngakumbiHydroxypropyl methylcelculose (hpmc), baqeshwe ngokubanzi kwifom yamayeza yokukhutshwa kweziyobisi kwiinkqubo ze-hydrophilic matrix. Ukukhutshwa kweziyobisi ezilawulwayo kubalulekile ukuze kuqhube iziphumo zonyango, ukunciphisa iziphumo ebezingalindelekanga, kunye nokuphucula ukuthotyelwa koguli. Nantsi indlela indlela oocaphuli baselunxwemeni.

I-1. Inkqubo ye-Hydrophilic ye-Matrix:

• Ingcaciso: Inkqubo ye-Matrix ye-hydrophilic yinkqubo yokuhambisa iziyobisi apho isithako semidlalo esisebenzayo (API) sisasazeke okanye singene kwi-tydrophilic matrix.
• INJONGO: I-matrix ilawula ukukhululwa kwechiza ngokukhutshelwa kwe-polymer yayo nge-polymer.

2. Indima yeSeluplose

• I-Viscosity kunye nePropathi ye-Gel-
  • I-HPMC yaziwa ngokuba kukwazi kwayo ukwenza i-geses kwaye yonyusa i-viscofity yezisombululo ze-accous.
  • Kwiinkqubo zeMatrix, i-HPMC inegalelo ekumiselweni kweMatrix ye-getitinous eyenza ichiza.
• Imeko ye-hydrophilic:
  • I-HPMC i-hydrophilic ye-hydrophilic, iququzelela intsebenzo yayo ngamanzi kwi-gestrointenal phecanal.
• Ukudumba okulawulwayo:
  • Ekunxibelelaneni ne-Gastric Flaid, iMatrix ye-Hydrophilic ishukumile, iyenza i-gel fall ijikeleze amasuntswana enzala.
• I-EChempascation yeziyobisi:
  • Ichiza lisasazeke ngendlela efanayo

3. Indlela yokukhululwa elawulwayo:

• Ukwahluka kunye nokhukuliseko:
  • Ukukhutshwa okuthengisiweyo kwenzeka ngokudityaniswa kwendlela yokuhlutha kunye neendlela zokukhukuliseka.
  • Amanzi angena kwi-matrix, ekhokelela kwi-gel ukudumba, kwaye amachiza ayahluka ngokusebenzisa ungqimba lwegel.
• Ukukhutshwa komyalelo we-zero:
  • Iprofayile yokukhutshwa elawulwayo ihlala ilandela i-zero-oda ye-zero-odola, ibonelela ngereyithi yokukhupha iziyobisi ngokuhamba kwexesha.

I-4. Izinto ezibangela ukukhululwa kweziyobisi:

• I-Polymer Distination:
  • Uxinzelelo lwe-HPMC kwi-matrix ichaphazela inqanaba lokukhululwa kweziyobisi.
• Ubunzima bemolekyuli ye-HPMC:
  • Amabakala ahlukeneyo e-HPMC enemilinganiselo yemolekyuli eyahlukeneyo inokukhethwa ukuba ilayise iprofayili yokukhupha.
• Ukuluka kweziyobisi:
  • Ukunyibilika kweziyobisi kwiMatrix kuchaphazela iimpawu zayo zokukhutshwa.
• I-matrix ye-matrix:
  • Inqanaba le-gel ukudumba kunye ne-matrix yefrasity yempembelelo yeziyobisi.

5. IINGXAKI ZE-SWELTULONE KAKUHLE kwiiNkqubo zeMatrix:

• I-Biomitication: I-Selessese ebhaka ngokubanzi yi-biompact kwaye inyamezeleke kakuhle kwiphecana le-gestrointeltenal.
• Ukusebenza
• Uzinzo: I-Selese Sethen ibonelela ngokuzinza kwinkqubo ye-matrix, ekuqinisekiseni ukukhutshwa ngamachiza ngokuhamba kwexesha.

6. Izicelo:

• Ukuhanjiswa kweziyobisi ngomlomo: Iinkqubo ze-hydrophilic ze-hydrophilic zisetyenziselwa ukwenziwa kwamachiza ngomlomo, ukubonelela ukukhutshwa okuzinzileyo nolawulwa.
• Iimeko ezingapheliyo: Ilungele iziyobisi ezisetyenziswa kwiimeko ezingapheliyo apho kuqinisekiswa khona ukukhululwa kwamachiza aqhubekayo.

7. Ukuqwalaselwa:

• Ulungelelwaniso lwendlela yokwenziwa: Ukuqulunqwa kuya kwenziwa ngokufanelekileyo ukufezekisa iprofayili yokukhutshwa kweziyobisi enqwenelekayo ngokusekwe kwiimfuno zonyango lweziyobisi.
• Ukuthotyelwa komthetho: I-Seleulose e Bute ePrimoceuticals kufuneka ihambelane nemigangatho yolawulo.

Ukusetyenziswa kwee-Selessese e-Tydrophilic ze-hydrophilic ze-hydrophilic Syscocilic zibonisa ukubaluleka kwabo kwizimo zenziwa ngamayeza, ukuhambisa indlela yokufezekisa ukukhutshwa ngamachiza.