I-Hydroxypropyl Methylcelcelsulose (i-HPMC) isetyenziswe ngokubanzi kwimizi-mveliso eyahlukeneyo ngenxa yokwakhiwa kweekhemikhali ezahlukeneyo kunye neepropathi.
1. Ubume bemichiza:
a. I-seluplose yase-Wallbone:
I-HPMC yi-selsulose ikhutshiwe, oko kuthetha ukuba isuselwa kwisellulose, i-polysacchacchacchaackacchaackacki yendalo efumaneka kwiindonga zeseli ezityalo. I-selsulose iquka iiyunithi eziphindaphindayo ze-β-dlucose edityaniswe ngu-(1 → 4) Glycosidic.
b. Faka:
Kwi-HPMC, i-hydroxyl (---) I-Hydroxyl (---) I-Hydroxyl (-------) I-Hydroxyl (-----) I-Hodlose ye-Selelose i-Selenene ithathe indawo ye-methyl kunye namaqela e-hydroxypropy. Oku kwenzeka endaweni yenzekile ngendlela yokuphendula. Inqanaba lokufakwa endaweni (DS) libhekisa kwinani eliphakathi lamaqela e-hydroxyl I-DS ye-methyl kunye namaqela e-hydroxypropy ahlukile, echaphazela intsebenzo ye-HPMC.
2. Synthesis:
a. I-ether:
I-HPMC ihambelane nendlela yokuphendula ye-e-Itelulose nge-propylene oxide ne methyl chloride. Inkqubo ibandakanya ukuphendula i-seluplose nge-proplone oxide ukuba ingenise amaqela e-hydroxypropy kwaye nge-methyl chloride ukwazisa amaqela e-methyl.
b. Inqanaba lolawulo lolawulo:
I-DS ye-HPMC inokulawulwa ngokuhlengahlengisa iimeko zokuphendula njengeqondo lobushushu, ixesha lokuphendula, kunye nokuphinda uhambelane.
I-3. Ukusebenza:
a. Umoya wobuchule:
I-HPMC inyibilikiswa emanzini kunye nezinye izinyibilikisi zezinto eziphilayo, ezinje nge-methanol kunye ne-ethanol. Nangona kunjalo, isomeleza yayo inciphisa ukonyusa ubunzima bemolekyuli kunye nenqanaba lokufaka endaweni.
b. Imo yefilimu:
I-HPMC yenza ifilimu ebonakalayo, eguqukayo xa inyibilikisiwe emanzini. Ezi filimu zinamandla amahle kunye neepropathi zomqobo.
C. Viskosity:
IZisombululo ze-HPMC ezibonisa indlela yokuziphatha ye-HPMC, ethetha ukuba i-viscofity yabo ihla ngenqanaba lokwanda kwe-Shear. Uhlobo lwe-viscosity yezisombululo ze-HPMC luxhomekeke kwizinto ezinje ngoxinzelelo, ubunzima bemolekyuli, kunye nesidanga sokufaka endaweni yoko.
d. Ukugcinwa kwamanzi:
Enye yepropathi ephambili ye-HPMC kukukwazi ukuthenga amanzi. Le ndawo ibaluleke kakhulu kwizicelo ezahlukeneyo ezinjengezinto zokwakha, apho i-HPMC isetyenziswa njengearhente ye-gickener kunye ne-reling-remen.
e. Ubembelele:
I-HPMC ihlala isetyenziswa njengokunamathela kumashishini ahlukeneyo ngenxa yokukwazi kwayo ukwenza iibhondi ezinamandla kumanye amaphetha.
4. Isicelo:
a. Ishishini lamachiza:
Kwii-pharmaceuticals, i-HPMC isetyenziswa njenge-binder, iarhente yokuhlambela ifilimu, iarhente yokukhutshwa kwefilimu, kunye ne-viscosity modifier kwifom yetafile.
b. Ishishini lokwakha:
I-HPMC yongezwa kwizifakethe esekwe kwisamente, iiplastam ezisekwe kwi-gypsim kunye ne-tile ye-tiles yokuphucula ukusebenza, ukugcinwa kwamanzi kunye nokunamathela.
C. Ishishini lokutya:
Kumzi-mveliso wokutya, i-HPMC isetyenziswa njenge-thickener, i-stabilizer kunye ne-emulsifier kwiimveliso ezinjengesosi, ukunxiba kunye ne-ice cream.
d. Iimveliso zoKhathalelo lobuqu:
I-HPMC isetyenziswa njenge-gicker, i-enulsifier kunye ne-arhente yokwakha ifilimu kwiimveliso zononophelo lomntu njengeziqhwithi, i-lotions kunye neekhrim.
e. Iipeyinti kunye neengubo:
Kwimifanekiso kunye nengubo, i-HPMC isetyenziselwa ukuphucula ukusasazwa kwe-pigment, ulawulo lwe-viscosity kunye nokugcinwa kwamanzi.
I-HydroxypropyTelmethylcelcelcelcelcebalose (i-HPMC) yindawo eguquguqukayo ngoluhlu olubanzi lwezicelo kuwo onke amashishini. Ukuqulunqwa kwekhemikhali eyahlukileyo, i-synthesis kunye neepropathi zenza isithako esibalulekileyo kwiindawo zamachiza, izinto zokwakha, ukutya, iimveliso zononophelo lomntu kunye neepeyinti. Ukuqonda iipropathi ze-HPMC kuvumela ukusetyenziswa ngokwesiko kwimimandla eyahlukeneyo, igalelo kukhetho lwalo olubanzi kunye nokubaluleke kakhulu kwiinkqubo zemveliso zanamhlanje.
IXESHA LOKUQALA: NgoFebwe-22 ukuya ku-2224