Ukuphendula kwekhemikhali kwi-Hydroxypropyl Methylcelcelcelgalose

Hydroxypropyl methylcelculose (hpmc)yi-polymer ye-pullymer yamanzi aqhele ukusetyenziswa kwicandelo lemizi-mveliso kunye nezonyango, kwaye uneenqobo ezibanzi zamaxabiso ezicelo, ezifana nokukhutshwa kweziyobisi, ukwenziwa kokutya kunye nezinto zokwakha. Ukuphendula kwekhemikhali kwinkqubo yekhemikhali kwi-Scerment ikakhulu kuhambelana ngokucokisekileyo kunye nokuguqulwa kwesellulose kunye nemisebenzi yemetabolic ye-microorganisms. Ukwenzela ukuba uqonde ngcono ukuphendula kwehemikhali ye-HPMC kwinkqubo yobuqhetseba, kufuneka kuqala siqonde indlela yayo esisiseko kunye nenkqubo yokuphelisa i-seluplose.

1. Isakhiwo esisisiseko kunye neePropathi ze-Hydroxypropyl Methylcelcelce

I-HPMC yindawo efunyaniswayo efunyenwe ngokutshintsha kweekhemikhali yesellulose yendalo (SelelUlose). I-backbone ye-molecular ye-molecose yimolekyuli ye-glucose (c6h12O6) iqhagamshelwe ngu-β-1,4 Glycosidic Bonds. I-seluplose genent inzima ukunyibilikisa emanzini, kodwa ngokusazisa i-methyl (-och3) kunye ne-hydroxypropyl (-c3h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h7h. Inkqubo yokuguqulwa kwe-HPMC ngokubanzi ibandakanya impendulo yesellulose ne-methyl chloride (Ch3cl) kunye notywala botywala (i-C3H6O) phantsi kweemeko ze-Alkaline, kwaye imveliso yesiphumo inobuqhetseba.

I-2. Ukuphendula kwamachiza ngexesha lokubila

Inkqubo ye-HPMMC ihlala ixhomekeke kwisenzo se-microorganisms, esebenzisa i-HPMC njengomthombo wekhabhoni kunye nomthombo wezondlo. Inkqubo ye-HPMMC ibandakanya la manqanaba aphambili:

2.1. Ukonakaliswa kwe-HPMC

I-seluplose uqoqosho iqulunqwe kwi-GLucose United, kwaye i-HPMC iya kuncitshiswa ziintsholongwane ngexesha lenkqubo ye-fermentage, iwayenzelwe iswekile encinci (njengeglucose, xylose). Le nkqubo idla ngokubandakanya isenzo sezinto ezininzi zeselfowuni. Eyona nto iphambili ekuphenduleni

I-Selsulose hydrolysis rees: i-β-1,4 Glycosidic kwiimolekyuli zesellulose ziya kwaphulwa yi-hylulose hydrolase (i-endocelling), i-Endocelliase), i-Eligoskides, njl. Njl.). Ezi sweshe ziya kuba ziphinda zibuyele kwimetaboltad kwaye zisetyenziswa zii-microorganisms.

I-Hydrolysis kunye ne-Degradisation ye-HPMC: i-methyl kunye ne-hydroxyproplonts yokuthathela ingqalelo kwi-HPMC Mulekcule iya kususwa ngokuyinxenye yi-hydrolysis. Indlela ethile yokuphendula ye-hydrolysis ayikayiqondi ngokupheleleyo, kodwa inokucinga ukuba kwindawo ebunjiweyo, i-hydrolysic reaction ikhathazwe yi-enzymes (njenge-hydroxyl esterase). Le nkqubo ikhokelela ekutyeni kwamakhonkco e-HPMC molecular kunye nokususwa kwamaqela asebenzayo, ekugqibeleni ukwenza iimolekyuli ezincinci zeswekile.

2.2. I-microbial metabolic

Nje ukuba i-HPMC ichithwe kwiimolekyuli ezincinci zeswekile, i-microorganisms ziyakwazi ukuguqula ezi slears zibe ngamandla ngokusebenzisa izinto ezingekhoyo. Ngokukodwa, i-microorganisms iphosa i-glucose kwi-ethanol, i-lactic acid okanye ezinye iimetaboli ngendlela yokubonisa. Ii-microorganisms ezahlukeneyo zinokufudukela kwimveliso ye-HPMC ye-HPMC kwiindlela ezahlukeneyo. Indlela ye-metabolic eqhelekileyo ibandakanya:

I-GlyColysis yendlela: Iglucose ikhutshiwe kwi-enzymes kwaye iguqulwe ibe ngamandla (i-ATP) kunye neMetabolites (njenge-lactic acid, ethanol, njl. Njl.).

Ukuveliswa kwemveliso yokuxhwithela: Ngaphantsi kweemeko ze-anaerobic okanye ze-hypovis, i-microorganisms iguqula i-glucose okanye iimveliso zayo ze-acids, i-acetic acid, esetyenziswa ngokubanzi kwiinkqubo ezahlukeneyo zemizi mveliso.

2.3. I-Resox Reaction

Ngexesha lenkqubo yobuso ye-HPMC, ezinye ii-microorganisms zinokuguqula iimveliso eziphakathi ngokuphendula kwakhona. Umzekelo, inkqubo yemveliso ye-ethanol ihamba kunye ne-Renox Reaction, iGlucose inyanzelwa ukuba ivelise i-pyruvate, kwaye emva koko iPyruviate iguqulwe ibe yi-ethanol ngokucutha. Oku kuphendula kubalulekile ekugcineni i-metabolic yokulingana kweeseli.

I-3. Izinto zolawulo kwinkqubo ye-Fermeation

Ngexesha lenkqubo yobuso ye-HPMC, izinto zokusingqongileyo zinempembelelo ebalulekileyo ekuphenduleni kwamachiza. Umzekelo, i-DH, ubushushu, ichithwe isiqulatho seoksijini, ubuchule boMbane, njl njl. Ngokukodwa iqondo lobushushu kunye nomsebenzi wee-enzymes ezincinci zinokwahluka kakhulu phantsi kweemeko zobushushu kunye neemeko ze-ps, ke ziyimfuneko ukulawula ukonakaliswa kwe-HPMC kunye nenkqubela phambili egudileyo ye-metabolis ye-microorganisms.

Inkqubo ye-Fermeation yeI-HPMCKubandakanya ukuphendula okuntsonkothileyo kwekhemikhali, kubandakanya i-hydrolysis ye-sellyulise, ukonakaliswa kwe-HPMC, i-metabolism yeswekile, kunye nesizukulwana seemveliso ezenziweyo. Ukuqonda oku kungancedisi kuphela inkqubo ye-HPMC, kodwa ikwabonelela ngenkxaso ye-theoretical yemveliso enxulumene nemveliso. Ngokwenza nzulu kophando, iindlela ezifanelekileyo nezisebenzayo zoqoqosho zinokuphuhliswa kwixesha elizayo ukuphucula ukonakaliswa kwe-HPMC kunye nesivuno semveliso, ukukhusela ukusingqongileyo kunye namanye amasimi.