Kwintsimi yamachiza, i-sodium carboxymethylcellulose (CMC) kunye ne-hydroxypropyl methylcellulose (HPMC) zimbini ezisetyenziswa ngokuqhelekileyo i-excipients zamachiza ezineempawu ezahlukeneyo zeekhemikhali kunye nemisebenzi.
Ubume bemichiza kunye neempawu
I-CMC yimveliso ye-cellulose enyibilikayo emanzini efunyenwe ngokuguqula inxalenye yamaqela e-hydroxyl ye-cellulose ibe ngamaqela e-carboxymethyl. Ukunyibilika kwamanzi kunye ne-viscosity ye-CMC ixhomekeke kwiqondo layo lokuthatha indawo kunye nobunzima be-molecular, kwaye ngokuqhelekileyo iziphatha njenge-thickener elungileyo kunye ne-arhente yokuxhoma.
I-HPMC ifunyenwe ngokutshintsha inxalenye yamaqela e-hydroxyl ye-cellulose kunye namaqela e-methyl kunye ne-hydroxypropyl. Xa kuthelekiswa ne-CMC, i-HPMC ine-solubility ebanzi, inokunyibilika emanzini abandayo kunye nashushu, kwaye ibonisa i-viscosity ezinzileyo kumaxabiso ahlukeneyo e-pH. I-HPMC isoloko isetyenziswa njengefilimu yangaphambili, incamathelisa, ityebe kunye nearhente yokukhululwa elawulwayo kumayeza.
Indawo yosetyenziso
Amacwecwe
Kwimveliso yamacwecwe, i-CMC isetyenziswa kakhulu njenge-disintegrant kunye ne-adhesive. Njenge-disintegrant, i-CMC inokufunxa amanzi kwaye idumbe, ngaloo ndlela ikhuthaza ukuchithwa kweepilisi kunye nokunyusa izinga lokukhululwa kwamachiza. Njengesibophelelo, i-CMC inokuphucula amandla oomatshini beetafile.
I-HPMC isetyenziswa kakhulu njengefilimu yangaphambili kunye ne-arhente yokukhululwa elawulwayo kwiipilisi. Ifilimu eyenziwe yi-HPMC inamandla omatshini abalaseleyo kunye nokumelana nokunxiba, okunokukhusela ichiza kwimpembelelo yendawo yangaphandle. Kwangaxeshanye, iipropathi ezenza ifilim ze-HPMC zisenokusetyenziswa ukulawula izinga lokukhutshwa kwechiza. Ngokulungelelanisa uhlobo kunye nomthamo we-HPMC, ukukhululwa okuzinzileyo okanye umphumo wokukhululwa olawulwayo unokufumaneka.
Iipilisi
Ekulungiseleleni i-capsule, i-CMC isetyenziswa kancinci, ngelixa i-HPMC isetyenziswa ngokubanzi, ngakumbi ekuveliseni i-capsules yemifuno. Iigobolondo ze-capsule eziqhelekileyo zenziwe nge-gelatin, kodwa ngenxa yengxaki yemithombo yezilwanyana, i-HPMC iye yaba yinto efanelekileyo. Igobolondo le-capsule elenziwe nge-HPMC alinayo nje i-biocompatibility efanelekileyo, kodwa ihlangabezana neemfuno zemifuno.
Amalungiselelo olwelo
Ngenxa yokuqina kwayo okugqwesileyo kunye neempawu zokunqunyanyiswa, i-CMC isetyenziswa ngokubanzi kumalungiselelo olwelo anjengezisombululo zomlomo, amathontsi eliso kunye namalungiselelo ezihloko. I-CMC inokunyusa i-viscosity yamalungiselelo olwelo, ngaloo ndlela iphucula ukunqunyanyiswa kunye nokuzinza kwamachiza kunye nokuthintela ukuchithwa kweziyobisi.
Ukusetyenziswa kwe-HPMC kumalungiselelo olwelo kugxininiswe kakhulu kwii-thickeners kunye ne-emulsifiers. I-HPMC ingahlala izinzile kuluhlu olubanzi lwe-pH kwaye inokuhambelana neentlobo ezahlukeneyo zamachiza ngaphandle kokuchaphazela ukusebenza kwamachiza. Ukongezelela, iipropati zokwenza ifilimu ye-HPMC nazo zisetyenziselwa ukulungiswa kweengqungquthela, ezifana nefuthe lokukhusela ifilimu kumaconsi amehlo.
Amalungiselelo okukhululwa alawulwayo
Kumalungiselelo okukhululwa okulawulwayo, ukusetyenziswa kwe-HPMC kuvelele ngokukodwa. I-HPMC iyakwazi ukwenza ijeli yothungelwano, kwaye izinga lokukhululwa kweyeza liyakwazi ukulawulwa ngokulungelelanisa uxinaniso kunye nesakhiwo se-HPMC. Le propati isetyenziswe ngokubanzi kwiipilisi ezikhutshwa ngomlomo eziqhubekayo kunye nokufakelwa. Ngokwahlukileyo, i-CMC isetyenziswa kancinci kumalungiselelo okukhutshwa okulawulwayo, ikakhulu ngenxa yokuba ulwakhiwo lwejeli elwenzayo aluzinzile njenge-HPMC.
Ukuzinza kunye nokuhambelana
I-CMC inozinzo olulambathayo kumaxabiso ahlukeneyo e-pH kwaye ichatshazelwa lula ziimeko-bume ze-asidi. Ukongeza, i-CMC ayihambelani kakuhle kunye nezithako zamachiza athile, ezinokubangela ukuba iziyobisi zibe nemvula okanye ukusilela.
I-HPMC ibonisa uzinzo oluhle kuluhlu olubanzi lwe-pH, aluchatshazelwa lula yi-acid-base, kwaye lunokuhambelana okuhle kakhulu. I-HPMC inokuhambelana nezithako ezininzi zamachiza ngaphandle kokuchaphazela uzinzo kunye nokusebenza kakuhle kwechiza.
Ukhuseleko kunye nemimiselo
Zombini i-CMC kunye ne-HPMC zithathwa njengezixhobo ezikhuselekileyo zamachiza kwaye zivunyiwe ukuba zisetyenziswe kumalungiselelo amayeza ngama-pharmacopoeias kunye nee-arhente zokulawula kumazwe ahlukeneyo. Nangona kunjalo, ngexesha lokusetyenziswa, i-CMC inokubangela ukuphazamiseka okuthile okanye ukungakhululeki kwesisu, ngelixa i-HPMC ingafane ibangele iziphumo ezibi.
I-CMC kunye ne-HPMC zinezibonelelo zazo kwizicelo zamayeza. I-CMC ikwindawo ebalulekileyo kumalungiselelo olwelo ngenxa yokuqina kwayo okugqwesileyo kunye neempawu zokunqunyanyiswa, ngelixa i-HPMC isetyenziswe ngokubanzi kwiipilisi, ii-capsules kunye namalungiselelo okukhutshwa okulawulwayo ngenxa yeempawu zayo ezibalaseleyo zokwenziwa kwefilimu kunye nokulawulwa kokukhutshwa. Ukukhethwa kwamalungiselelo amayeza kufuneka kusekelwe kwiimpawu ezithile zamachiza kunye neemfuno zokulungiselela, ngokuqwalasela ngokubanzi iingenelo kunye nokungalunganga kwazo zombini, kunye nokukhetha oyena mntu ufanelekileyo.
Ixesha lokuposa: Jul-19-2024