Thelekisa i-CMC kunye ne-HPMC kwizicelo zamachiza

Kwintsimi yamayeza, i-Sodium Carboxymethylcelcelcelcelcelcelcelose (CMC) kunye ne-HMCRXYPLLL MethylcelcelElceLcelose (i-HPMC) zisetyenziselwa amayeza amabini amayeza kunye nemisebenzi.

Isakhiwo sekhemikhali kunye neePropathi
I-CMC yi-selsulose yamanzi efunyaniswa efunyenwe ngokuguqula inxenye yamaqela e-hydroxyl kwi-sellybose kwiqela le-carboxymethyl. Ukubenzela amanzi kunye nokubonisa i-CMC kuxhomekeke kwinqanaba layo lokufaka endaweni kunye nobunzima bemolekyuli, kwaye ihlala isebenza njenge-gickener elungileyo kunye nearhente yokumisa.

I-HPMC ifunyenwe ngokutshintsha indawo yamaqela e-hydroxyl ye-seluplose ne methyl kunye namaqela e-hydroxypropyl. Xa kuthelekiswa ne-CMC, i-HPMC inesingqala esibanzi, inokuchithwa kumanzi abandayo kwaye ashushu, ibonise i-viscofity elizinzileyo kwiinqobo ezahlukeneyo ze-PH. I-HPMC ihlala isetyenziswa njengefilimu yangaphambili, ukubambelela, i-tickener kunye ne-arhente yokukhutshwa kwe-tickener kunye ne-chickener kunye ne-rickener kunye ne-Guard elawulwa kwi-Pmemaceuticals.

Ifildi yesicelo

Iitafile
Kwimveliso yeetafile, i-CMC isetyenziswa ikakhulu njenge-suintergran kwaye inamathelele. Njenge-suinterggranti, i-CMC inokufumana amanzi kwaye idumbe, ngaloo ndlela ikhuthaza ukwahlula-hlulwa kweetafile kunye nokwandisa inqanaba lokukhupha amachiza. Njengomthi webhanti, i-CMC inokuphucula amandla eetafile.

I-HPMC isetyenziswa ikakhulu njengemiboniso bhanyabhanya yangaphambili nelawulwa iarhente yokukhupha kwiitafile. Ifilimu eyenziwe yi-HPMC inamandla amakhulu okulinganisa kwaye inxibe ukunganyangeki, okunokukhusela ichiza kwimpembelelo yendawo yangaphandle. Kwangelo xesha, iipropathi zokwenza ifilimu ze-HPMC zinokusetyenziselwa ukulawula inqanaba lokukhutshwa kwechiza. Ngokuhlengahlengisa uhlobo kunye nedosi ye-HPMC, ukukhutshwa okuzinzileyo okanye isiphumo esilawulwayo sinokufezekiswa.

Iicapbules
Kwilungiselelo le-capsule, i-CMC alisetyenziswanga, ngelixa i-HPMC isetyenziswe ngokubanzi, ngakumbi ekuvelisweni kweecapsules ezinemifuno. Iigobolondo zemveli zenziwe ikakhulu nge-gelatin, kodwa ngenxa yengxaki yemithombo yezilwanyana, i-HPMC iye yaba yinto efanelekileyo. Iqokobhe le-Capsule elenziwe nge-HPMC alinalo kuphela i-biomatini elungileyo, kodwa ihlangabezana neemfuno zezityalo.

Amalungiselelo olwenzi
Ngenxa yepropathi yayo ebalaseleyo kunye nemilinganiselo yokumiswa, i-CMC isetyenziswa ngokubanzi amalungiselelo olwelo ezinje ngezisombululo zomlomo, amachaphaza amehlo kunye namalungiselelo aphezulu. I-CMC inokunyusa u-viscosity weZilungiso ezingama-5, ngaloo ndlela kuphuculwe ukumiswa kunye nokuzinza kweziyobisi nokuthintela i-sedation yeziyobisi.

Ukusetyenziswa kwe-HPMC kumalungisa amanzi kugxilwe ikakhulu kwi-thi chuiners kunye ne-emulsiber. I-HPMC inokuhlala sizinzile kuluhlu lwe-pH kwaye inokuhambelana neziyobisi ezahlukeneyo ngaphandle kokuchaphazela ukusebenza kakuhle kwamachiza. Ukongeza, iipropathi zokwenza ifilimu ze-HPMC zikwasetyenziswa kumalungiselelo aphezulu, anjengesiphumo sokukhusela ifilimu kumanzi amdaka.

Ukulungiswa kwemvume
Kumphakamo olawulwayo, ukusetyenziswa kwe-HPMC kuyinto ebalaseleyo. I-HPMC iyakwazi ukwenza uthungelwano lwe-gel, kwaye inqanaba lokukhutshwa kwechiza linokulawulwa ngokuhlengahlengisa uxinzelelo kunye nesakhiwo se-HPMC. Le propati isetyenziswe ngokubanzi kwiitafile ze-orals ezikhulelweyo kunye nokufakwa. Ngokwahlukileyo, i-CMC ayisetyenziswanga kumalungiselelo okukhutshwa okulawulwayo, ikakhulu ngenxa yokuba ijeli ye-Injini ye-IT ayizinzanga njenge-HPMC.

Uzinzo kunye nokuhambelana
I-CMC inozinzo olugwenxa kwiinqobo ezahlukeneyo ze-PH kwaye ichaphazeleke ngokulula ziimeko ze-Acid-. Ukongeza, i-CMC ayihambelani nokuhambelana kwezithako ezithile zeziyobisi, ezinokubangela ukunqunyulwa kweziyobisi okanye ukusilela.

I-HPMC ibonisa uzinzo oluhle ngaphezulu kwe-PH ye-PH, ayichaphazelekanga ngokulula kwisiseko se-acid, kwaye ihambelana nokuhambelana ngokupheleleyo. I-HPMC inokuthi ihambelane nezithako ezininzi ngaphandle kokuchaphazela uzinzo kunye nokusebenza kwechiza.

Ukhuseleko nemigaqo
Zombini i-CMC kunye ne-HPMC zithathwa njengezi-manani ezikhuselekileyo zamayeza kwaye zivunyiwe ukuba zisetyenziswe kumalungiselelo e-phammacopoopoeias kunye neearhente zolawulo kumazwe ahlukeneyo. Nangona kunjalo, ngexesha lokusetyenziswa, i-CMC inokubangela ukungasebenzi kakuhle okanye ukungalunganga kwe-gestrointenal, ngelixa i-HPMC ingafane ibangelwe kwangaphambili ukuphendula.

I-CMC kunye ne-HPMC inezibonelelo zabo kwizicelo zamayeza. I-CMC isebenza isikhundla esibalulekileyo kumalungiselelo olwenzi ngenxa yepropathi ebalaseleyo kunye nemilinganiselo yokumiswa, ngelixa i-HPMC isetyenziswe ngokubanzi kwiitafile, iicapbules kunye nezigqeba ezilawulwayo zevidiyo. Ukukhethwa kwamalungiselelo amayeza ngamayeza kufuneka kusekwe kwipropathi yezatifikethi ezithile kunye neemfuno ezithile zokulungiselela, kuthathelwa ingqalelo ngokupheleleyo izibonelelo kunye nokungalunganga zombini, kunye nokukhetha ezona zinto zilungileyo.