Hydroxypropyl methylcellulose, commonly known as HPMC, is a widely used pharmaceutical excipient and food additive. Ngenxa yomoya obalaseleyo obalaseleyo, ubuchule bokubopha kunye neempawu zokwenza ifilimu, isetyenziswe ngokubanzi kumzi-mveliso wamayeza. I-HPMC ikwasetyenziswa kwishishini lokutya njenge-thi chuker, i-emulsifier kunye nokuzinza. Ukucoceka kwe-HPMC kubaluleke kakhulu kumashishini okutya kunye nokutya njengoko kuchaphazela ukusebenza nokhuseleko lwemveliso. Eli nqaku liza kuthetha ngokumisela ukucoceka kwe-HPMMC kunye neendlela zayo.
Zithini ii-HPMCcs?
I-Hydroxypropylmethylcelcelcelcelcelcelcel Ubunzima bayo bemolekyuli buyi-10,000 ukuya kwi-1 000 000 i-daltons, kwaye ngumgubo omhlophe okanye ongekho mhlophe okanye ongenakumlibala. I-HPMC inyibilikiswe ngokulula emanzini, kwaye inyibilize ezinye izinto eziphilayo ezinjenge-ethanol, i-butanol, kunye ne-chloroform. Inepropathi eyahlukileyo efana nokugcinwa kwamanzi, amandla okubopha kunye nokubopha, okwenza ilungele amashishini amayeza kunye nokutya.
Ukuzimisela kwe-HPMMC Puity
Ukucoceka kwe-HPMC kuxhomekeke kwizinto ezininzi ezinje ngenqanaba lokufakwa endaweni (DS), umxholo womswakama kunye nomxholo we-ash. I-DS imele inani lamaqela e-hydroxyl athathwe ngamaqela e-hydroxypropy kwimolekyuli. Inqanaba eliphezulu lokufaka endaweni yonyusa ukubethwa kwe-HPMC kwaye iphucula amandla okwenza ifilimu. Kwelinye icala, inqanaba eliphantsi lokufaka endaweni yoko likhokelela ekunciphiseni ukuncipha kunye neempawu ezimbi zefilimu.
Indlela yokuzimisela i-HPMC
Kukho iindlela ezininzi zokumisela ubunyulu be-HPMC, kubandakanya isikhundla se-Acid-isiseko, uhlalutyo lwezinto eziphezulu, i-chromatography ye-chromatography (i-HPPC), i-ir). Nazi iinkcukacha zendlela nganye:
Isiseko se-acid-isiseko
Indlela isekwe kwimpembelelo yokungathathi cala phakathi kwamaqela akwa-Acidic kunye osisiseko kwi-HPMC. Okokuqala, i-HPMC ichithwe kwisinyibilikisi kunye negama elaziwayo le-acid okanye isisombululo esisisiseko songezwa. Isishumi saqhutywa kude kufike i-PH ifikile. Ukusuka kwinani le-acid okanye isiseko esisetyenzisiweyo, inqanaba lokufaka endaweni libaliwe.
Uhlalutyo lwesiseko
Amanyathelo ohlalutyo lwesiseko Ipesenti yezinto nganye ekhoyo kwisampulu, kubandakanya ikharbon, i-hydrogen, neoksijini. Inqanaba lokufakwa endaweni lingabalwa ukusuka kwinani lezinto nganye kwi-HPMC.
Intsebenzo ephezulu ye-chromatography (i-HPPC)
I-HPLC yindlela yokuhlalutya ngokubanzi eyahlulahlulahlulahlula umxube ngokusekwe kwindlela abasebenzisa ngayo kunye nezigaba zesikhululo kunye neselula. Kwi-HPMC, inqanaba lokufakwa endaweni linokubalwa ngokulinganisa umyinge we-hydroxyl ukuya kumaqela e-methyl kwisampula.
I-infrared spectroscopy (ir)
I-infrared spectroscopypypy iluncedo lohlalutyo olulinganisa ukufunxa okanye ukuhanjiswa kwemitha ye-infrared yisampulu. I-HPMC ineencopho ze-herces ezahlukeneyo ze-hydroxyl, methyl kunye ne-hydroxylple, enokusetyenziselwa ukumisela inqanaba lokufaka endaweni.
Ukucoceka kwe-HPMC kubalulekile kwimizi-mveliso yamayeza kunye nokutya, kwaye ukuzimisela kwayo kubalulekile ukuqinisekisa ukhuseleko kunye nokusebenza kakuhle kwemveliso yokugqibela. Iindlela ezininzi ziyafumaneka ukumisela ubunyulu be-HPMC, kubandakanya isikhundla se-Acid-isiseko, uhlalutyo lwezinto eziphezulu, i-HPPC, ne-IR. Indlela nganye inezibonelelo zayo kunye nezinto ezingalunganga kwaye inokukhethwa ngokweemfuno ezithile zesicelo. Ukugcina ubunyulu be-HPMC, kufuneka igcinwe kwindawo eyomileyo, epholileyo kude nelanga kunye nezinye izinto ezingcolileyo.
IXESHA LOKUQALA: AUG-25 ukuya ku-2023