I-Hydroxyloploploploplopy (i-HPMC) yi-polymer esetyenziswe ngokubanzi kwishishini lamayeza kwaye yifomula ebalulekileyo. Isetyenziswa ikakhulu njengokunamathela kwimithamo eqinileyo (enjengeetafile, iicaphule, kunye namasuntswana), i-viscofity yaphucula iarhente kunye nokuhombisa.
Kwilungiselelo leziyobisi, ukutshitshiswa kwezithako ezisebenzayo kubalulekile ukuba ifumane kwaye ivelise iziphumo zonyango. Nangona kunjalo, ukupheliswa kwezithako ezisebenzayo kuvantelwa yifomula. Ke ngoko, kubalulekile ukuba uqonde indlela yokuziphatha yokuchitha i-HPMC kwifomula yechiza kuba ichaphazela ukusebenza kohlobo lwedosi.
Indlela yokuphelisa i-HPMC
Ikhemesti yase-US (i-USP) inomgangatho osemgangathweni we-HPMC. Le ndlela idla ngokubandakanya ukusetyenziswa kwezixhobo zokuncancisa, ezihambelana kwaye zilinganisa ukususwa kwe-dosimus yohlobo lwe-dosage kwindawo ephakathi yesisombululo. Uvavanyo lubandakanya ukubeka umthamo kwibhasikithi okanye i-paddle, kwaye ibhasikithi okanye i-paddle ijikeleza kwisitya esinendawo enesidima.
I-Solkity iphakathi kufuneka ikhethwe ngokwendlela elindelweyo yedosi (njengokuqina komzimba okanye ukunyibilikisa). Indawo yokuhlala eqhelekileyo ye-HPMC ibandakanya amanzi, i-phostphate buffer ijusi yejusi (SGF) okanye i-stid ye-analog).
Ukuqinisekisa ukuphindaphinda kunye nokuchaneka, iiparamitha zovavanyo kufuneka zibekwe emgangathweni, njengezantya ezijikelezayo, ubushushu, kunye nokuchitha ivolumu kunye nexesha lesampulu. Emva koko sebenzisa indlela efanelekileyo yohlalutyo lokuhlalutya isisombululo sesampulu ifunyenwe ngamaxesha ahlukeneyo ukumisela inani le-HPMC yokutya kwe-HPMC.
Amanyathelo okuthintela xa esenza iimvavanyo zokuchithwa kwe-HPMC
1. Ukukhetha indawo yokulahla inkunkuma: Ukukhethwa kwendawo yokwahlula-hlula kusekwe ekusebenziseni ifom yedosi. Ukukhetha ukuchithwa okufanelekileyo kokuchithwa kubaluleke kakhulu kuba kuya kuchaphazela indlela yokulahla inkululeko ye-HPMC.
2. Ukuqinisekisa ngokuchanekileyo indlela yomhlaba: Ukuqinisekisa indlela yesono ukuqinisekisa ukuba kufanelekile kwaye kubalulekile ukufezekisa iimfuno zearhente yomthetho. Ukuqinisekiswa kufuneka kubandakanya ukuphinda umlinganiso kunye nokuphinda komlinganiselo.
3. Ukulungelelaniswa komgangatho weeparamitha zovavanyo: Ukuvavanywa kwakhona, njengokujikeleza kwesantya, ubushushu, kunye nokuchithwa kwenqanaba eliphakathi kuchaphazela iziphumo zokuchithwa. Ke ngoko, ezi parameter kufuneka zibekwe emgangathweni ukuqinisekisa ukufezekiswa kunye nohlalutyo oluchanekileyo.
4. Isampulu: Isampulu yesampulu ibalulekile ekufumaneni iisampulu ezimele zivela kwi-PIOPIUM. Nika ingqalelo ixesha kunye nesampulu yokuqinisekisa ukuba isampulu iqokelelwa kwithuba elingacacanga.
5. Indlela yokuhlaziya: Khetha indlela yohlalutyo lohlalutyo ziya kuqinisekiswa, kwaye kufanele ukuba ube neemvakalelo ezifanelekileyo, ukukhetha kunye nokuchaneka.
Ngamafutshane, uvavanyo lwe-HPMC sisixhobo esibalulekileyo ekuphuhlisweni kweziyobisi kunye nefomula yeziyobisi. I-laboratri yoLawulo lweLebhu iqhutywa rhoqo ukuqinisekisa ukukhululwa ngokuchanekileyo kwezithako ezisebenzayo, kwaye ichiza likhuselekile kwaye liyasebenza. Impazamo kwimeko efanelekileyo yovavanyo inokukhokelela ekungaqondini kunye neengxelo zobuxoki ngokusebenza kweziyobisi. Ke ngoko, kubalulekile ukulandela imigangatho kunye namanyathelo okhuseleko ngexesha lovavanyo lokuchitha.
Ixesha lokuphumla: Jun-29-2023