Hydroxypropyl methylcelculose (hpmc)yindawo esetyenziswayo ye-polymer ye-polymer esetyenziswayo, esetyenziswa ngokubanzi kwiindawo zamayeza, ukutya, izinto zokwakha, izixhobo zokuthambisa kunye nezinye iinkalo. I-HPMC inomoya ofanelekileyo kunye neempawu ze-viscosity kwaye zinokwenza isisombululo esizinzileyo, ke sinendima ebalulekileyo kwizicelo ezininzi. Ukwenzela ukunika umdlalo ngokupheleleyo kwintsebenzo ye-HPMC, indlela echanekileyo yokuchithwa ibaluleke kakhulu.
1. Iqondo lobushushu eliqhelekileyo lokuchitha amanzi
I-HPMC inokuchithwa kumanzi abandayo, kodwa ihlala izakhono ziyafuneka ukuphepha ukwahluka. Ukwenzela ukuphucula isiphumo sokuphelisa, la manyathelo alandelayo anokusetyenziswa:
Inyathelo 1: Yongeza i-HPMC ukuya emanzini
Kumaqondo obushushu egumbi, ukutshiza kuqala i-HPMC ngokulinganayo kumphezulu wamanzi ukuthintela ukugalela inani elikhulu le-HPMC emanzini ngexesha elinye. Kuba i-HPMC yindawo ye-polymer ye-polymer, yongeza ngokuthe ngqo isixa esikhulu se-HPMC siya kubangela ukuba ifumane amanzi kwaye idumbe ngokukhawuleza emanzini ukwenza into efana nejeli.
Inyathelo 2: Ukuvuselela
Emva kokongeza i-HPMC, qhubeka nokuvuselela ngokulinganayo. Kuba i-HPMC inamasuntswana amahle, iya kudumba emva kokufumana amanzi ukwenza into efana nejeli. Ukuvuselela kunceda ukukhusela i-HPMC ukusuka kwi-ageglomeras kwi-clumps.
Inyathelo lesi-3: Yima kwaye UQHELEKILE
Ukuba i-HPMC ayichithwanga ngokupheleleyo, isisombululo sinokushiyeka sime okwethutyana size siqhubeke sivuselela. Iya kuhlala ichithwe ngokupheleleyo ngaphakathi kwiiyure ezimbalwa.
Le ndlela ilungele izihlandlo apho ukuthandaza akunyanzelekanga, kodwa kuthatha ixesha elide ukuqinisekisa ukuba i-HPMC ichithwe ngokupheleleyo.
2. Indlela eshushu yokuchithwa kwamanzi
I-HPMC inyibilikisa ngokukhawuleza kumanzi afudumeleyo, ukufudumeza ubushushu bamanzi kunokukhawulezisa inkqubo yokuphelisa. Iqondo eliqhelekileyo lokufudumeza lisetyenziswa ngama-50-70 ℃, kodwa iqondo eliphezulu kakhulu (njengama-80 ℃) linokubangela i-HPMC ukuba ilawulwe, ke iqondo lobushushu kufuneka lilawulwe.
Inyathelo loku-1: Ukufudumeza Amanzi
Fudumeza amanzi ukuya malunga ne-50 ℃ kwaye uyigcine rhoqo.
Inyathelo 2: Yongeza i-HPMC
Fefele hpmc kancinci emanzini ashushu. Ngenxa yobushushu bamanzi aphezulu, i-HPMC iya kunyibilikisa ngokulula, ukunciphisa ukwahluka.
Inyathelo 3: Ukuvuselela
Emva kokongeza i-HPMC, qhubeka uvuselela isisombululo se-ACTEAR. Indibaniselwano yokufudumeza nokuvuselela inokukhuthaza ukuchithwa ngokukhawuleza kwe-HPMC.
Inyathelo 4: Gcina iqondo lobushushu kwaye uqhubeke nokuvuselela
Ungagcina ubushushu obuthile kwaye uqhubeke nokuxhokonxa de i-HPMC ichithwe ngokupheleleyo.
I-3. Indlela yokutshabalala
I-HPMC inokuchithwa kungekuphela nje emanzini, kodwa nakwimitha yotywala (njenge-ethanol). Eyona ndlela iphambili yendlela yokuphelisa utywala kukuba inokuphucula ukunyibilisela kunye nokusasazeka kwe-HPMC, ngakumbi kwiinkqubo ezinemixholo ephezulu yamanzi.
Inyathelo loku-1: Khetha isimo esifanelekileyo sotywala
Izinyibilikisi zotywala ezinjenge-ethanol kunye ne-Iyopropanol zihlala zisetyenziselwa ukunyibilikisa i-HPMC. Ngokubanzi, i-70-90% yesisombululo se-ethanol inefuthe elingcono ekupheliseni i-HPMC.
Inyathelo 2: Ukupheliswa
Ngokukhanya ngokuthe ngcembe i-HPMC kwi-Souten yotywala, ivuselela ngelixa yongeza ukuqinisekisa ukuba i-HPMC ichithwe ngokupheleleyo.
Inyathelo 3: Ukuma kunye nokuvuselela
Inkqubo ye-SOLTY SOLLTST yokuphelisa i-HPMC ithe ngokukhawuleza, kwaye ihlala ithatha imizuzu embalwa ukufezekisa ukuchithwa okugqibeleleyo.
Indlela yokuphelisa intetho yotywala ihlala isetyenziswa kwimo yesicelo efuna ukutshitshiswa okukhulu kunye nomxholo wamanzi asezantsi.
I-4. Indlela yokuNikeza yamanzi axubeneyo
Ngamanye amaxesha i-HPMC ichithwe kumxube wenxalenye ethile yamanzi kunye nesinyibilikisi. Le ndlela ifaneleke ngakumbi kwiimeko apho i-viscosity yesisombululo okanye umyinge wokuchithwa kufuneka uhlengahlengiswe. Izinto eziqhelekileyo eziqhelekileyo zibandakanya i-acetone, ethanol, njl.
Inyathelo 1: Lungisa isisombululo
Khetha umyinge ofanelekileyo wesinyibilikisi kunye namanzi (umzekelo, ama-50% amanzi, i-50% yeSholvent) kunye nobushushu kwiqondo lobushushu elifanelekileyo.
Inyathelo 2: Yongeza i-HPMC
Ngelixa ishukumisa, ngokuthe ngcembe yongeza i-HPMC yokuqinisekisa ukutshitshiswa kwe-piram.
Inyathelo 3: Uhlengahlengiso ngakumbi
Njengoko kufuneka, umyinge wamanzi okanye isinyithi kunokongezwa ukuze uhlengahlengise ukulinganisa kunye nokubonisa i-HPMC.
Le ndlela ilungele izihlandlo apho izinyibilikisi zezinto eziphilayo zongezwa kwizisombululo zezemozulu zokuphucula umgangatho wokuchitha okanye uhlengahlengiso lwepropathi yesisombululo.
I-5. Indlela yokuchitha i-Ultrasonic
Usebenzisa isiphumo se-oscopy of RATRAUTON ye-Ultrasound, indlela yokuchitha i-Ultrasonic inokukhawulezisa inkqubo yokupheliswa kwe-HPMC. Le ndlela ilungele kakhulu i-HPMC eyomeleleyo ekufuneka ichithwe ngokukhawuleza, kwaye inokunciphisa ingxaki ye-ageglomerance enokwenzeka ngexesha elishukumisayo.
Inyathelo 1: Lungisa isisombululo
Yongeza i-HPMC kwinani elifanelekileyo lamanzi okanye isisombululo esisezantsi samanzi.
Inyathelo 2: Unyango lwe-Ultrasonic
Sebenzisa isicoci se-ultrasonic okanye okanye i-ultrasonic sitsiba kwaye siyiphathe ngokobume kunye nexesha elimiselweyo. Iziphumo ze-Oscodition ze-Utultrasound zinokukhawulezisa inkqubo yokupheliswa kwe-HPMC.
Inyathelo 3: Jonga isiphumo sokuphelisa
Emva konyango lwe-ultrasonic, jonga ukuba isisombululo sichithwe ngokupheleleyo. Ukuba kukho ilungu eliyinxalenye engasebenziyo, unyango lwe-ultrasonic lunokuphinda lwenziwe kwakhona.
Le ndlela ilungele ukusetyenziswa kwezicelo ezifuna ukutshitshiswa ngokukuko nangokhethiweyo.
I-6. Ukuqala ngaphambi kokupheliswa
Ukuze uphepheI-HPMCI-AgeGlomeration okanye ubunzima bokuthimba, ezinye iindlela zokwenza izinto zinokusetyenziswa, njengokuxuba i-HPMC ngenani elincinci lezinye izinyibilikisi (njenge-gelycerol), iloma i-HPMC ngaphambi kokuba yongeze i-Solvent. La manyathelo okhuseleko anokuphucula ngokufanelekileyo ukunyibilikisa i-HPMC.
Zininzi iindlela zokunyibilikisa i-HPMC. Ukukhetha indlela efanelekileyo yokufaka Indlela yokuhlaselwa kwamaqondo obushushu igumbi ilungele indawo enomtya, indlela eshushu yamanzi inokukhawulezisa inkqubo yokuphelisa, kwaye indlela yokuphelisa intetho yotywala kunye nendlela yokuchithwa kwamanzi ahambelana ne-SOLTIT INDLELA YOKUGCINWA KWAMANQAKU AMANZI ALUSETYENZISIWEYO. Indlela yokuchithwa kwe-Ultrasonic-incedise ekusombululeni ukusombulula ukuphathwa ngokukhawuleza kwe-HPMC enkulu. Ngokweemfuno ezithile zesicelo, ukukhetha ukutshintsha kwendlela efanelekileyo yokufaka isondo kunokuqinisekisa ukuba kweyona ndlela ilungileyo ye-HPMC kwimimandla eyahlukeneyo.
IXESHA LOKUQALA: I-DEC-19 ukuya ku-2004