IHydroxypropyl methylcellulose (HPMC)yikhompawundi yepolymer enyibilikayo esetyenziswa ngokuqhelekileyo emanzini, esetyenziswa kakhulu kumayeza, ukutya, izinto zokwakha, izinto zokuthambisa kunye nezinye iinkalo. I-HPMC ineempawu ezintle zokunyibilika kunye ne-viscosity kwaye inokwenza isisombululo se-colloidal esizinzileyo, ngoko ke idlala indima ebalulekileyo kwizicelo ezininzi. Ukuze unikeze umdlalo opheleleyo ekusebenzeni kwe-HPMC, indlela yokuphelisa echanekileyo ibaluleke kakhulu.
1. Indlela yokuchithwa kwamanzi obushushu obuqhelekileyo
I-HPMC inokunyibilika emanzini abandayo, kodwa ngokuqhelekileyo ezinye izakhono ziyafuneka ukunqanda i-agglomeration yayo. Ukuphucula umphumo wokutshatyalaliswa, la manyathelo alandelayo angasetyenziswa:
Inyathelo 1: Yongeza i-HPMC emanzini
Kwiqondo lobushushu begumbi, qala ufefe iHPMC ngokulinganayo kumphezulu wamanzi ukunqanda ukugalela isixa esikhulu seHPMC emanzini ngaxeshanye. Ngenxa yokuba i-HPMC yikhompawundi yepolymer, ukongeza ngokuthe ngqo isixa esikhulu se-HPMC kuya kubangela ukuba ifunxe amanzi kwaye idumbe ngokukhawuleza emanzini ukwenza into efana nejeli.
Inyathelo lesi-2: Ukuvuselela
Emva kokongeza i-HPMC, qhubeka uvuselela ngokulinganayo. Ngenxa yokuba i-HPMC inamasuntswana amahle, iya kudumba emva kokufunxa amanzi ukwenza into efana nejeli. Ukuvuselela kunceda ukuthintela i-HPMC ukuba idibanise ibe yimbumba.
Inyathelo lesi-3: Yima kwaye uqhube ngakumbi
Ukuba i-HPMC ayichithwanga ngokupheleleyo, isisombululo sinokushiywa ukuze sime ixesha elithile kwaye siqhubeke sishukumisa. Ngokuqhelekileyo iya kuchithwa ngokupheleleyo kwiiyure ezimbalwa.
Le ndlela ifanelekile kwizihlandlo apho ukufudumeza kungafunwa, kodwa kuthatha ixesha elide ukuqinisekisa ukuba i-HPMC ichithwe ngokupheleleyo.
2. Indlela yokuchithwa kwamanzi ashushu
I-HPMC inyibilika ngokukhawuleza kumanzi afudumeleyo, ngoko ke ukufudumeza ubushushu bamanzi kunokunyusa kakhulu inkqubo yokupheliswa. Ubushushu bamanzi obuqhelekileyo obusetyenziswayo yi-50-70℃, kodwa ubushushu obuphezulu kakhulu (obufana nobushushu obungaphezulu kwe-80℃) bunokubangela ukuba i-HPMC yehle, ngoko ke kufuneka ubushushu bulawuleke.
Inyathelo 1: Ukufudumeza amanzi
Fudumeza amanzi ukuya kwi-50℃ kwaye uwagcine engatshintshi.
Inyathelo 2: Yongeza i-HPMC
Ufefe iHPMC kancinci emanzini ashushu. Ngenxa yobushushu bamanzi aphezulu, HPMC iya kunyibilika lula ngakumbi, ukunciphisa agglomeration.
Inyathelo lesi-3: Ukuvuselela
Emva kokongeza i-HPMC, qhubeka ushukumisa isisombululo esimanzi. Ukudibanisa ukufudumeza kunye nokuvuselela kunokukhuthaza ukuchithwa ngokukhawuleza kwe-HPMC.
Inyathelo 4: Gcina ubushushu kwaye uqhubeke uvuselela
Ungagcina ubushushu obuthile kwaye uqhubeke uvuselela de i-HPMC ichithwe ngokupheleleyo.
3. Indlela yokuNcitshiswa koTywala
I-HPMC inokunyibilika kungekuphela nje emanzini, kodwa nakwezinye izinyibilikisi zotywala (ezifana ne-ethanol). Inzuzo ephambili yendlela yokuchithwa kotywala kukuba inokuphucula ukunyibilika kunye nokuchithwa kwe-HPMC, ngakumbi kwiinkqubo ezinomxholo ophezulu wamanzi.
Inyathelo 1: Khetha isinyibilikisi esifanelekileyo sotywala
Izinyibilikisi zotywala ezifana ne-ethanol kunye ne-isopropanol zihlala zisetyenziselwa ukunyibilikisa i-HPMC. Ngokuqhelekileyo, isisombululo se-ethanol se-70-90% sinesiphumo esingcono sokunyibilikisa i-HPMC.
Inyathelo lesi-2: Ukupheliswa
Kancinci ufefe i-HPMC kwisinyibilikisi sotywala, uvuselela ngelixa udibanisa ukuqinisekisa ukuba i-HPMC isasazwe ngokupheleleyo.
Inyathelo lesi-3: Ukuma nokushukumisa
Inkqubo yokunyibilikisa isinyibilikisi sotywala i-HPMC ikhawuleza kakhulu, kwaye idla ngokuthatha imizuzu embalwa ukufezekisa ukunyibilika ngokupheleleyo.
Indlela yokutshatyalaliswa kotywala idla ngokusetyenziswa kwiimeko zesicelo ezifuna ukuchithwa ngokukhawuleza kunye nomxholo ophantsi wamanzi.
4. Indlela yonyibiliko oluxutyiweyo lwamanzi axutyiweyo
Ngamanye amaxesha i-HPMC inyibilika kumxube womlinganiselo othile wamanzi kunye nesinyibilikisi. Le ndlela ifaneleke ngokukodwa kwiimeko apho i-viscosity yesisombululo okanye izinga lokuchithwa lifuna ukulungiswa. Izinyibilikisi eziqhelekileyo ziquka i-acetone, i-ethanol, njl.
Inyathelo 1: Lungisa isisombululo
Khetha umlinganiselo ofanelekileyo wesinyibilikisi namanzi (umzekelo, i-50% yamanzi, i-50% yesinyibilikisi) kunye nobushushu obufanelekileyo.
Inyathelo 2: Yongeza i-HPMC
Ngelixa uvuselela, yongeza kancinci i-HPMC ukuqinisekisa ukupheliswa okufanayo.
Inyathelo lesi-3: Olunye uhlengahlengiso
Njengoko kufuneka, umlinganiselo wamanzi okanye i-solvent inokunyuswa ukulungisa ukunyibilika kunye ne-viscosity ye-HPMC.
Le ndlela ifanelekile kwizihlandlo apho i-solvents ye-organic yongezwa kwisisombululo samanzi ukuphucula izinga lokuchithwa okanye ukulungelelanisa iimpawu zesisombululo.
5. Indlela yokuchithwa kwe-Ultrasonic
Ukusebenzisa i-high-frequency oscillation effect ye-ultrasound, i-ultrasonic-assisted dissolution method inokukhawuleza inkqubo yokuchithwa kwe-HPMC. Le ndlela ifaneleke ngokukodwa izixa ezikhulu ze-HPMC ezifuna ukuchithwa ngokukhawuleza, kwaye inokunciphisa ingxaki ye-agglomeration enokuthi yenzeke ngexesha lokuvuselela kwendabuko.
Inyathelo 1: Lungisa isisombululo
Yongeza i-HPMC kwisixa esifanelekileyo samanzi okanye isisombululo esixubileyo samanzi.
Inyathelo 2: Unyango lwe-ultrasonic
Sebenzisa isicoci se-ultrasonic okanye i-disolver ye-ultrasonic kwaye uyiphathe ngokwamandla abekiweyo kunye nexesha. Impembelelo ye-oscillation ye-ultrasound inokukhawulezisa kakhulu inkqubo yokuchithwa kwe-HPMC.
Inyathelo lesi-3: Jonga isiphumo sokupheliswa
Emva konyango lwe-ultrasonic, khangela ukuba isisombululo sichithwa ngokupheleleyo. Ukuba kukho inxalenye engachithwanga, unyango lwe-ultrasonic lunokwenziwa kwakhona.
Le ndlela ifanelekile kwizicelo ezifuna ukuchithwa okusebenzayo kunye nokukhawuleza.
6. Unyango ngaphambi kokuchithwa
Ukuze uphepheHPMCagglomeration okanye ubunzima ekunyibilikeni, ezinye iindlela pretreatment zingasetyenziswa, ezifana ukuxuba HPMC kunye isixa esincinci ezinye izinyibilikisi (ezifana glycerol), yomisa kuqala, okanye ukumanzisa HPMC phambi kokuba wongeze isinyibilikisi. La manyathelo onyango anokuphucula ngokufanelekileyo ukunyibilika kwe-HPMC.
Zininzi iindlela zokunyibilikisa i-HPMC. Ukukhetha indlela efanelekileyo yokutshatyalaliswa kunokuphucula kakhulu ukusebenza kakuhle kokutshatyalaliswa kunye nomgangatho wemveliso. Indlela yokuchithwa kweqondo lokushisa kwegumbi ifanelekile kwindawo epholileyo, indlela yokuchithwa kwamanzi ashushu inokukhawulezisa inkqubo yokutshatyalaliswa, kunye nendlela yokutshatyalaliswa kotywala kunye nendlela yokuchithwa kwe-solvent-water mixed dissolution ifanelekile ukuchithwa kunye neemfuno ezikhethekileyo. I-ultrasonic-assisted dissolution method yindlela esebenzayo yokusombulula ukuchithwa ngokukhawuleza kwenani elikhulu le-HPMC. Ngokweemfuno ezithile zesicelo, ukhetho oluguquguqukayo lwendlela efanelekileyo yokutshatyalaliswa kunokuqinisekisa ukusebenza kakuhle kwe-HPMC kwiinkalo ezahlukeneyo.
Ixesha lokuposa: Dec-19-2024