Okwangoku, izixhobo ezivuthiweyo zezityalo ze-capsules ziyi-hydroxypropyl methylcellulose (HPMC) kunye ne-pululan, kunye ne-hydroxypropyl starch nayo isetyenziswa njengezinto eziluhlaza.
Ukususela ekuqaleni koo-2010,HPMCisetyenziswe kwishishini lokuvelisa i-capsule yesityalo saseTshayina, kwaye ngokusekelwe ekusebenzeni kwayo kakuhle, ii-capsules ezingenanto ze-HPMC ziye zahlala ngokuqinileyo kwindawo yemarike ye-capsule, ebonisa imfuno eqinile kwiminyaka elishumi edlulileyo yokwanda.
Ngokwedatha yeshishini, ngo-2020, umthamo wentengiso yasekhaya yee-capsules ezinzima ezingenanto iya kuba malunga ne-200 yeebhiliyoni zee-capsules (imveliso yamayeza kunye nemveliso yezempilo idityanisiwe), apho umthamo wentengiso yee-capsules ze-HPMC iya kuba malunga ne-11.3 yeebhiliyoni zee-capsules (kubandakanywa nokuthunyelwa ngaphandle) , ukwanda kwe-4.2% ngaphezu kowama-2019. %, ebalelwa malunga ne-5.5%. I-akhawunti ye-non-pharmaceutical industry i-93.0% yokusetyenziswa kwee-capsules ze-HPMC e-China, kunye nokukhula kwemveliso yokunakekelwa kwezempilo kuqhuba ukuthengiswa kwee-capsules ze-HPMC.
Ukususela ngo-2020 ukuya ku-2025, i-CAGR yee-capsules ze-HPMC kunye ne-gelling agents kulindeleke ukuba ibe yi-6.7%, ephezulu kunezinga lokukhula kwe-3.8% ye-gelatin capsules. Ngapha koko, imfuno yee-capsules ze-HPMC kwishishini lemveliso yokhathalelo lwempilo yasekhaya iphezulu kunaleyo ikwishishini lamayeza.HPMCIicapsules zinokunceda zombini ngemingeni kagqirha kwaye zivumelane nenkcubeko kunye nokutya okukhethwa ngabathengi kwihlabathi liphela. Nangona imfuno yangoku yee-capsules ze-HPMC isengaphantsi kakhulu kunee-gelatin capsules, izinga lokukhula kwemfuno liphezulu kunelo le-gelatin capsules.
1) Ukuqulunqwa kokuphumelela kunye nenkqubo, ngaphandle kwe-gelling agent; ine-solubility engcono, ukuziphatha okungaguqukiyo kokuchithwa kwimidiya eyahlukeneyo, engachatshazelwa yi-pH kunye namandla e-ionic, kwaye ihlangabezana neemfuno ze-pharmacopoeia zamazwe amakhulu kunye nemimandla;
I-2) Ngomxholo we-alkaline obuthathaka, phucula i-bioavailability kunye nokuphucula i-dosage form optimization;
3) Ukubonakala kuhle, kwaye ukhetho lombala luninzi kakhulu.
I-capsule ethambileyo lulungiselelo olwenziwe ngokutywinwa kweoli okanye ukunqunyanyiswa kwe-oyile kwiqokobhe le-capsule, kwaye imilo yayo ingqukuva, imile okwe-olive, imile okwentlanzi encinci, imile okwethontsi, njl. njl. ioli, enokuqala ngokukhawuleza kwesenzo kunye ne-bioavailability ephezulu kunokwenza isithako esisebenzayo esifanayo kwiipilisi, kwaye isetyenziswe ngokubanzi ekulungiseleleni iimveliso zempilo kunye namayeza. Kule mihla, iicapsules ezithambileyo ezineempawu ezahlukeneyo ezinje nge-enteric-coated, chewable, impompo ye-osmotic, ukukhutshwa okuzinzileyo, kunye neesuppositories ezithambileyo sele zithengisiwe. Igobolondo ye-capsule ethambileyo yenziwe nge-colloid kunye nezongezo ezincedisayo. Phakathi kwabo, i-colloids efana ne-gelatin okanye i-gum yemifuno yizona zinto ziphambili, kwaye umgangatho wabo uchaphazela ngokuthe ngqo ukusebenza kwee-capsules ezithambileyo. Ngokomzekelo, ukuvuza kwegobolondo le-capsule, ukunamathela, ukufuduka kwezinto eziphathekayo, ukuchithwa kancinci, kunye nokuchithwa kwee-capsules ezithambileyo zenzeka ngexesha lokugcinwa Iingxaki ezifana nokungahambelani zihambelana nayo.
Okwangoku, uninzi lwezixhobo ze-capsule ze-capsules ezithambileyo kwilizwe lam yi-gelatin yezilwanyana, kodwa ngophuhliso olunzulu kunye nokusetyenziswa kwe-gelatin capsules ezithambileyo, ukusilela kwayo kunye nokusilela kuye kwabonakala ngakumbi, njengemithombo enzima yezinto eziluhlaza, kunye nokuphendula okulula okuxhamlayo kunye neengxube ze-aldehyde Iingxaki zomgangatho ezifana nexesha elifutshane lokugcina kunye "nenkunkuma emithathu" eveliswe kwinkqubo yokucoca i-gelatin inempembelelo enkulu ekukhuselweni kwendalo. Ukongezelela, kukho kwakhona ingxaki yokuqina ebusika, enefuthe elibi kumgangatho wokulungiselela. Kwaye imifuno gum capsules ezithambileyo zinempembelelo encinane kwindawo engqongileyo. Ngokuqhambuka okulandelelanayo kwezifo ezosulelayo zemvelaphi yezilwanyana kwihlabathi liphela, uluntu lwamazwe ngamazwe luzikhathaza ngakumbi ngokhuseleko lweemveliso zezilwanyana. Xa kuthelekiswa nezilwanyana ze-gelatin capsules, iipilisi zezityalo zineenzuzo ezibalaseleyo ngokubhekiselele ekusebenziseni, ukhuseleko, ukuzinza kunye nokukhuselwa kwendalo.
Yongezaihydroxypropyl methylcelluloseukumanzisa kunye nokusabalalisa ukufumana isisombululo A; yongeza i-ejenti ye-gelling, i-coagulant, i-plasticizer, i-opacifier kunye ne-colorant emanzini kwaye usasaze ukufumana isisombululo B; xuba izisombululo ze-A kunye ne-B, kunye nokufudumala ukuya kwi-90 ~ 95 ° C, ugxobhoze kwaye uhlale ufudumele kwi-0.5 ~ 2h, upholile phantsi ukuya kwi-55 ~ 70 ° C, gcina ukufudumala kwaye ume ukuhlambalaza ukufumana iglue;
Indlela yokufumana ngokukhawuleza ulwelo lweglue, inkqubo ngokubanzi kukufudumala kancinci kwi-kettle yokusabela ixesha elide,
Abanye abavelisi badlula ngokukhawuleza kwi-colloid mill ngokusebenzisa iglue yekhemikhali
Ixesha lokuposa: Apr-25-2024