Hydroxypropyl methylcelculose (hpmc) yi-polymer eqhelekileyo esetyenziswa ngamanzi, esetyenziswa ngokubanzi kwiindawo zamayeza, cosmetics, ukutya kunye namasimi osasazo, ngakumbi kumalungiselelo ee-geses. Iipropathi zayo zomzimba kunye nokuziphatha okungapheliyo zinefuthe elibonakalayo ekusebenzeni kakuhle kwezicelo ezahlukeneyo. Ubushushu be-HPMC ye-HPMC yenye yeepropathi zayo eziphambili, ezichaphazela ngokuthe ngqo ukusebenza kwamalungiselelo ahlukeneyo, ezinjengokudityaniswa okulawulwayo, ukwenziwa kweefilimu, uzinzo, njl njl.
1. Ulwakhiwo kunye neepropathi ze-HPMC
I-HPMC yi-polymer ye-itleme ye-solmmer efunyenwe ngokwazisa ezimbini, i-hydroxylpyl kunye ne-methyl, kwi-selselese molekle. Isakhiwo sayo semolekrini sineentlobo ezimbini zezinto ezingena endaweni: i-hydroxypropyl (-C3chohch3) kunye neMethyl (-C3). Izinto ezifana nomxholo we-hydroxypropy, inqanaba le-methylity, kunye nenqanaba le-Polymerization liya kuba nefuthe elibalulekileyo kwi-solidality, indlela yokuziphatha ephelileyo, kunye neepropathi zoomatshini be-HPMC.
Kwizisombululo ezikhutshelwe, iAincelcel®HPMC ye-Colloidal Colloidal Scoolvours ngokwenza iimoleksi ze-hydrogen ngemolekyuli zamanzi kunye nokunxibelelana ne-skeleton esekwe kwiselselese. Xa imeko yangaphandle (efana nobushushu, amandla e-ionic, njl. Njl.) Utshintsho, ukusebenzisana phakathi kweemolekyuli ze-HPMC kuya kutshintsha, kukhokelela kwi-gening.
2. Ingcaciso kunye nokuphembelela izinto zobushushu be-ge
Ubushushu be-Gencoting (iqondo lokuhlambela, i-t_gel) libhekisa kwi-HPMC apho isisombululo se-HPMC siqala ukutshintsha ukusuka kulwelo ukuya kwinqanaba elithile. Kula maqondo obushushu, intshukumo ye-HPMC yeemolekyuli iya kuthintelwa, yenze ubume benethiwekhi ezintathu, okukhokelela kwinto efana nejeli.
Amaqondo obushushu e-HPMC achaphazeleka zizinto ezininzi, enye yezona zinto zibalulekileyo ngumxholo we-hydroxypropy. Ukongeza kumxholo we-hydroxypropy, ezinye izinto ezichaphazela ubushushu be-gel zibandakanya ubunzima bemolekyuli, isisombululo, ixabiso le-pH, uhlobo lwe-SOLVE, njl.
I-3. Isiphumo se-hydroxypropy yomxholo kwi-HPMC GEEL GET
3.1 Ukonyuka komxholo we-hydroxypropy kukhokelela ekunyukeni kubushushu be-gel
Iqondo lokuhlaselwa le-HPMC linxulumene ngokusondeleyo nenqanaba le-hydroxypropy kwimolekyuli yayo. Njengoko umxholo we-hydroxypropy wonyuka, inani leendawo zokugcina izinto ze-hydrophilic kwi-HPMC Calectur, okukhokelela ekuphuculeni unxibelelwano oluphuculweyo phakathi kwemolekyuli kunye namanzi. Olu nxibelelwano lubangela ukubanjiswa kweemolekyuli ukolula ngakumbi, ngaloo ndlela kuncitshiswa amandla okunxibelelana phakathi kweemolekyuli. Kwindawo ethile yoxinzelelo, ukwandisa umxholo we-hydropypropy onceda ukuphucula inqanaba lokuntywila kunye nokukhuthaza ukucwangciswa kwezintshukumo zemolekyuli, ukuze isakhiwo senethiwekhi sinokwenziwa kubushushu obuphezulu. Ke ngoko, amaqondo obushushu ahlabayo ahlala enyuka nge-hydroxypropyl ephakama ngokukhulisa umxholo.
I-HPMC enemixholo ephezulu ye-hydroxypropy (efana ne-HPMC K15m) idla ngokubonisa ubushushu be-gesing ephezulu kugxininiso lomxholo we-chandroxypropy ene-hydroxpy ye-hydroxdpropy ene-HYDMCMC ye-HydroxdPOPLY ye-HYDMCMP ye-hydroxyl kunye ne-HPMC k4m). Kungenxa yokuba umxholo okhulileyo we-hydroxypropy wenza ukuba kube nzima ngakumbi kwiimolekyuli zokunxibelelana kunye neenethiwekhi kumaqondo obushushu asezantsi, afuna amaqondo obushushu asezantsi ayoyisile unxibelelwano lwenethiwekhi. .
3.2 Ulwalamano phakathi komxholo weHydroxypropy kunye noxinzelelo lwesisombululo
Ugxininiso lwesisombululo lukwayinto ebalulekileyo echaphazela ubushushu be-HPMC. Kwisisombululo esiphezulu se-HPMC, unxibelelwano lwe-playcular lunamandla, ke amaqondo okuhlaselwa anokuphakama nokuba umxholo we-hydroxypropy iphantsi. Kwingcinezelo ephantsi, ukusebenzisana phakathi kweemolekyuli ze-HPMC kubuthathaka, kwaye isisombululo senzeka ngakumbi kwi-gel kubushushu obuphantsi.
Xa umxholo we-hydroxypropy wonyuka, nangona i-hydrophility inyuka, iqondo lobushushu ephezulu lisafuneka lenze ijeli. Ngakumbi phantsi kweemeko zoxinaniso ezisezantsi, amaqondo obushushu anyuka kakhulu. Kungenxa yokuba i-HPMC enemixholo ephezulu ye-hydroxypropy inzima kakhulu yokunxibelelana phakathi kweemolekyuli ngotshintsho lobushushu, kwaye inkqubo yokuhambisa ifuna ukoyisa isiphumo se-hydral.
3.3 Iziphumo ze-hydroxypropy kwiNkqubo yokuTyala
Ngaphakathi kuluhlu oluthile lomxholo we-hydroxypropy, inkqubo yokuhlaselwa ilawulwa ngunxibelelwano phakathi kwamanzi amdaka kunye neemolekyuli. Xa umxholo we-hydroxypropy kwi-HPMC Molecule iphantsi, i-hydration ibuthathaka, ukusebenzisana phakathi kweemolekyuli zomelele, kwaye ubushushu obuphantsi kunokukhuthaza ukwenziwa kwejeli. Xa umxholo we-hydroxypropy ukhulile, i-hydration iphuculwe kakhulu, ukusebenzisana phakathi kweemolekyuli ziba buthathaka, kwaye amaqondo obushushu anyukayo ayanda.
Umxholo ophezulu we-hydroxypropy unokukhokelela ekunyukeni kwesisombululo se-HPMC, utshintsho ngamanye amaxesha lunyusa ubushushu be-OPSE ye-OSPT.
Umxholo weHydroxyPOpyl unefuthe elibonakalayo kwiqondo lokuhlaselwa kweI-HPMC. Njengoko umxholo we-hydroxypropy wonyusa, i-hydrophility ye-HPMC inyuswe kunye nokunxibelelana phakathi kwemixokelelwane ye-molecular, ke iqondo lokungcwaba lihlala linyuka. Le phenomenon ingachazwa yindlela yokusebenzisana phakathi kwemixokelelwane ye-hydration kunye neemolekyuli. Ngokuhlengahlengisa umxholo we-HPMCPUPYL ye-HPMC, ulawulo oluchanekileyo lwamaqondo obushushu anokufezekiswa, ngalo lonke ukusebenza kwe-HPMC kwi-HPMC kwindawo yamayeza.
IXESHA LOKUQALA: UJan-04 ukuya ku-525