IHydroxypropyl methylcellulose (HPMC) i-polymer e-soluble esetyenziswa ngokuqhelekileyo emanzini, esetyenziswa ngokubanzi kumachiza, izimonyo, ukutya kunye neendawo zoshishino, ngakumbi ekulungiseleleni iigels. Iimpawu zayo zomzimba kunye nokuziphatha kokutshatyalaliswa kunempembelelo ebalulekileyo ekusebenzeni kwizicelo ezahlukeneyo. Ukushisa kwe-gelation yejeli ye-HPMC yenye yeempawu zayo eziphambili zomzimba, ezichaphazela ngokuthe ngqo ukusebenza kwayo kumalungiselelo ahlukeneyo, njengokukhululwa okulawulwayo, ukubunjwa kwefilimu, ukuzinza, njl.
1. Ubume kunye neepropati ze-HPMC
I-HPMC yipolymer enyibilikayo emanzini efunyenwe ngokuzisa izinto ezimbini, i-hydroxypropyl kunye ne-methyl, kwi-cellulose ye-molecular skeleton. Isakhiwo sayo se-molecular sineentlobo ezimbini ze-substituents: i-hydroxypropyl (-CH2CHOHCH3) kunye ne-methyl (-CH3). Izinto ezifana nomxholo ohlukeneyo we-hydroxypropyl, iqondo le-methylation, kunye neqondo le-polymerization liya kuba nefuthe elibalulekileyo kwi-solubility, ukuziphatha kwe-gelling, kunye neempawu zomatshini ze-HPMC.
Kwizisombululo zamanzi, i-AnxinCel®HPMC yenza izisombululo ezizinzile ze-colloidal ngokwenza iibhondi ze-hydrogen kunye neamolekyu zamanzi kunye nokusebenzisana ne-cellulose-based skeleton. Xa indawo yangaphandle (efana neqondo lokushisa, amandla e-ionic, njl.) utshintsho, ukusebenzisana phakathi kwee-molecule ze-HPMC kuya kutshintsha, kubangele i-gelation.
2. Inkcazo kunye nezinto ezichaphazela ukushisa kwe-gelation
Ubushushu beGelation (Gelation Temperature, T_gel) ibhekisela kwiqondo lokushisa apho isisombululo se-HPMC siqala ukutshintsha ukusuka kulwelo ukuya kwisiqina xa ubushushu besisombululo bunyuka kwinqanaba elithile. Kulo bushushu, ukuhamba kwe-HPMC i-molecular chain chain iya kuthintelwa, yenze isakhiwo senethiwekhi esine-dimensional-dimensional, okubangela ukuba kubekho into efana nejeli.
Ubushushu be-gelation ye-HPMC buchatshazelwa yimiba emininzi, enye yezona zinto zibalulekileyo ngumxholo we-hydroxypropyl. Ukongeza kumxholo we-hydroxypropyl, ezinye izinto ezichaphazela ukushisa kwe-gel ziquka ubunzima be-molecular, i-concentration yesisombululo, ixabiso le-pH, uhlobo lwe-solvent, amandla e-ionic, njl.
3. Impembelelo yomxholo we-hydroxypropyl kwiqondo lokushisa lejeli ye-HPMC
3.1 Ukunyuka komxholo we-hydroxypropyl kukhokelela ekunyuseni kweqondo lokushisa kwe-gel
Ubushushu be-gelation ye-HPMC inxulumene ngokusondeleyo kwiqondo lokutshintshwa kwe-hydroxypropyl kwi-molecule yayo. Njengoko umxholo we-hydroxypropyl usanda, inani le-hydrophilic substituents kwi-HPMC ye-molecular chain chain inyuka, okukhokelela ekusebenzisaneni okuphuculweyo phakathi kwe-molecule kunye namanzi. Olu nxibelelwano lubangela ukuba amatyathanga eemolekyuli anwebe ngakumbi, ngaloo ndlela anciphise amandla onxibelelwano phakathi kwamatyathanga emolekyuli. Ngaphakathi koluhlu oluthile loxinaniso, ukwandisa umxholo we-hydroxypropyl kunceda ukunyusa izinga le-hydration kunye nokukhuthaza ukucwangciswa okufanayo kwamatyathanga eemolekyuli, ukwenzela ukuba isakhiwo sothungelwano sinokubunjwa kwiqondo lokushisa eliphezulu. Ngoko ke, ukushisa kwe-gelation ngokuqhelekileyo kunyuka kunye nokunyuka kwe-hydroxypropyl kunye nomxholo okhulayo.
I-HPMC enomxholo ophezulu we-hydroxypropyl (efana ne-HPMC K15M) ithande ukubonisa ubushushu obuphezulu be-gelation kwi-concentration efanayo kune-AnxinCel®HPMC enomxholo ophantsi we-hydroxypropyl (efana ne-HPMC K4M). Oku kungenxa yokuba umxholo ophezulu we-hydroxypropyl wenza kube nzima ngakumbi ukuba iimolekyuli zidibanise kwaye zenze uthungelwano kumaqondo obushushu aphantsi, afuna amaqondo obushushu aphezulu ukuba anqobe le hydration kunye nokukhuthaza ukusebenzisana kwe-intermolecular ukwenza isakhiwo senethiwekhi esine-dimensional-dimensional network. .
3.2 Ubudlelwane phakathi komxholo we-hydroxypropyl kunye nokugxilwa kwesisombululo
Ugxininiso lwesisombululo lukwayinto ebalulekileyo echaphazela ukushisa kwe-gelation ye-HPMC. Kwizisombululo ze-HPMC eziphezulu, ukusebenzisana kwe-intermolecular kunamandla, ngoko ukushisa kwe-gelation kunokuba phezulu nokuba umxholo we-hydroxypropyl uphantsi. Kwiindawo eziphantsi, ukusebenzisana phakathi kwee-molecule ze-HPMC kubuthathaka, kwaye isisombululo sinokuthi senze i-gel kumaqondo aphantsi.
Xa umxholo we-hydroxypropyl ukhula, nangona i-hydrophilicity inyuka, ukushisa okuphezulu kusafuneka ukwenza i-gel. Ngokukodwa phantsi kweemeko eziphantsi zoxinzelelo, ukushisa kwe-gelation kwandisa kakhulu. Oku kungenxa yokuba i-HPMC enomxholo ophezulu we-hydroxypropyl inzima kakhulu ukukhuthaza ukusebenzisana phakathi kwamatyathanga eemolekyuli ngotshintsho lobushushu, kwaye inkqubo ye-gelation idinga amandla ongezelelweyo obushushu ukuze boyise isiphumo se-hydration.
3.3 Impembelelo yomxholo we-hydroxypropyl kwinkqubo ye-gelation
Ngaphakathi koluhlu oluthile lomxholo we-hydroxypropyl, inkqubo ye-gelation ilawulwa yintsebenziswano phakathi kwe-hydration kunye ne-molecular chain. Xa umxholo we-hydroxypropyl kwi-molecule ye-HPMC iphantsi, i-hydration ibuthathaka, ukusebenzisana phakathi kwama-molecule kunamandla, kwaye ukushisa okuphantsi kunokukhuthaza ukubunjwa kwejel. Xa umxholo we-hydroxypropyl uphezulu, i-hydration iphuculwe kakhulu, intsebenziswano phakathi kwamakhonkco e-molecular iba buthathaka, kwaye ukushisa kwe-gelation kuyanda.
Umxholo ophezulu we-hydroxypropyl unokukhokelela ekunyuseni kwe-viscosity yesisombululo se-HPMC, utshintsho oluthi ngamanye amaxesha lukhulise ukushisa kokuqala kwe-gelation.
Umxholo weHydroxypropyl unempembelelo enkulu kwiqondo lokushisa le-gelationHPMC. Njengoko umxholo we-hydroxypropyl usanda, i-hydrophilicity ye-HPMC iyanda kwaye intsebenziswano phakathi kwamakhonkco eemolekyuli iyancipha, ngoko ukushisa kwayo kwe-gelation kudla ngokunyuka. Le nto inokuchazwa yindlela yokusebenzisana phakathi kwe-hydration kunye ne-molecular chain. Ngokulungelelanisa umxholo we-hydroxypropyl we-HPMC, ukulawulwa ngokuchanekileyo kobushushu be-gelation kunokufezekiswa, ngaloo ndlela kuphuculwe ukusebenza kwe-HPMC kumachiza, ukutya kunye nezinye izicelo zoshishino.
Ixesha lokuposa: Jan-04-2025