1. Iipropathi ezisisiseko ze-HPMC
Hydroxypropyl methylcelculose (hpmc)Ngaba i-selsulose ye-unicose isetyenziswe ngokubanzi kwizinto zokwakha, amayeza, ukutya, i-cosmetics kunye namanye amashishini. Iipropathi zayo ezikhethekileyo ze-procerictives, ezinjengokungabizi, ukonakalisa, ukwenza ifilimu kunye neepropathi zokungalawulekiyo zefilimu, zenze isithako esiphambili kwizicelo ezininzi zemveliso. Temperature is one of the main factors affecting the performance of HPMC, especially in terms of solubility, viscosity, thermal gelation and thermal stability.
2. Isiphumo seqondo lobushushu kwi-sloubing ye-HPMC
I-HPMC yi-polly pollemer enganyibiliki, kwaye i-solubance yayo itshintsha ngamaqondo obushushu:
Iqondo lobushushu elisezantsi (amanzi abandayo): i-HPMC inyibilika ngokulula emanzini abandayo, kodwa iya kufaka amanzi kwaye idumbe xa kuqala inxibelelana namanzi ukwenza amasuntswana. Ukuba i-skirring ayonelanga, amaqhuma anokwenziwa. Ke ngoko, ihlala icetyiswa ukongeza i-HPMC kancinci ngelixa ikhuthaza ukukhuthaza ukusasazeka.
Iqondo lobushushu eliphakathi (20-40 ℃): Kolu luhlu lobushushu, i-HPMC inomelele kwaye ilungele ukubonwa okuphezulu, kwaye ilungele iinkqubo ezahlukeneyo ezifuna ukuqina okanye ukuzinza.
Iqondo lokushisa eliphezulu (ngaphezulu kwe-60 ° C): I-HPMC inomdla wokwenza ijeli eshushu kubushushu obuphezulu. Xa iqondo lobushushu lifikelela kubushushu be-gene elithile, isisombululo siya kuba yi-opaque okanye sivakalise, sichaphazela isiphumo sesicelo. Umzekelo, ekwakhiweni kwezinto ezinje ngodaka okanye ubushushu bamanzi, ukuba amaqondo obushushu amanzi aphezulu kakhulu, i-HPMC inokutshitshiswa ngokufanelekileyo, oko kuchaphazela umgangatho wokwakha.
3. Iziphumo zobushushu kwi-HPMC Viscofity
Uhlobo lwe-HPMC luchaphazeleka kakhulu kubushushu:
Ukwanda kobushushu, ukunciphisa i-viscofity: Uhlobo lwe-viscosity yesisombululo se-HPMC sihlala sincipha ngokukhulisa ubushushu obukhulayo. Umzekelo, uVekyusi wesisombululo esithile se-HPMC sinokuphakama nge-20 ° C, ngelixa u-50 ° C, uVecofity uya kuyehla kakhulu.
Iqondo lokushisa liyancipha, i-viscosity iphinda iphindwe: Ukuba isisombululo se-HPMC sipholile emva kokufudumeza, i-viscofity yayo iya kuba phinda kwakhona, kodwa isenokungabuyi ngokupheleleyo kwimeko yokuqala.
I-HPMC yamabakala ahlukeneyo e-viscosity iziphatha ngendlela eyahlukileyo: I-HPMCIty ye-HPMC ephezulu inovelwano kakhulu kuguquko lweqondo lobushushu, ngelixa i-HPMC ye-HPMC inobungozi obuncinci xa iqondo lobushushu litshintsha. Ke ngoko, kubaluleke kakhulu ukukhetha i-HPMC ngohlobo olufanelekileyo kwimo eyahlukileyo yesicelo.
I-4. Iziphumo zobushushu kwi-thermal ye-thermal ye-HPMC
Inqaku elibalulekileyo le-HPMC lihlazo lobushushu, oko kukuthi, xa iqondo lobushushu liphuma kwinqanaba elithile, isisombululo sayo siza kujika ibe yijeli. Eli qondo lobushushu lidla ngokubizwa ngokuba liqondo lokuhlaselwa. Iindidi ezahlukeneyo ze-HPMC zinamaqondo obushushu ahlukeneyo, ngokubanzi phakathi kwe-50-80 ℃.
Kwimizi-mveliso yokutya kunye namashishini amayeza, olu phawu lwe-HPMC lusetyenziselwa ukulungiselela amachiza akhuselekileyo okanye i-colloids yokutya.
Kwizicelo zokwakha, ezinje ngodaka lwamancedo, ukulawulwa kwe-HPMC kunokubonelela ngokugcinwa kwamanzi, kodwa ukuba iqondo lobushushu lokwakha liphezulu kakhulu, ukuhlutha kunokuchaphazela ukusebenza kwendalo.
I-5. Iziphumo zobushushu kwi-shirmal yezinza kwe-HPMC
Isakhiwo sekhemikhali se-HPMC sizinzile kuluhlu olufanelekileyo lobushushu, kodwa ukuvezwa kwexesha elide kubushushu obuphezulu kunokubangela ukonakaliswa.
Iqondo lokushisa elifutshane elifutshane (elinjengokufudumeza ngokukhawuleza ngaphezulu kwe-100 ℃): Isenokungachaphazeli ipropathi yekhemikhali ye-HPMC, kodwa inokubangela utshintsho kwiimpawu ezihlaselweyo.
Iqondo lokushisa ixesha elide (njengokufudumeza okuqhubekayo ngaphezulu kwe-90 ℃): kunokubangela i-molecular thein ye-HPMC yokwaphula umthetho, echaphazela iipropathi zefilimu kunye nefilimu.
Iqondo lokushisa eliphezulu (ngaphezulu kwe-200 ℃): I-HPMC inokubangela ukuba kubekho i-therimoal, ukukhulula izinto eziguqukayo njengee-methanol kunye ne-propanol, kwaye zibangele ukubamba.
6. Iingcebiso zesicelo se-HPMC kwiindawo ezahlukeneyo zobushushu
Ukwenzela ukunika umdlalo opheleleyo kwintsebenzo ye-HPMC, amanyathelo afanelekileyo kufuneka athathwe ngokwemimandla yobushushu eyahlukeneyo:
Kwimeko yobushushu obuphantsi (0-10 ℃): I-HPMC inyibilikisa kancinci, kwaye kuyacetyiswa ukuba ichithe inyibilikise emanzini afudumeleyo (20-40 ℃) ngaphambi kokusetyenziswa.
Kwimeko yobushushu obuqhelekileyo (i-10 ukuya kwengama-100 ℃): I-HPMC inendlela yokusebenza ngokuzinzileyo kwaye ilungele ukusetyenziswa kwezicelo ezininzi, ezinjengeengubo, izilwanyana, ukutya kunye nabanelisikisi.
Kwimeko yobushushu obuphezulu (ngentla kwe-40 ℃): Kulumkele ukongeza i-HPMC ngqo kwiqondo lokushisa eliphezulu. Kuyacetyiswa ukuba ichithiwe kumanzi abandayo ngaphambi kokufudumeza, okanye ukhethe i-HPMC yobushushu i-HPMC ukunciphisa ifuthe lokungabikho kwe-shirmal kwisicelo.
Iqondo lokushisa linefuthe elibonakalayo kwi-solidality, i-viscosity, ukurhafiswa kwe-thermal kunye nokuzinza kwe-thermal yeI-HPMC. Ngexesha lenkqubo yokufaka isicelo, kuyimfuneko ukuba ukhethe ngokufanelekileyo ukuba ukhethe imodeli kunye nendlela yokusetyenziswa kwe-HPMC ngokwemigaqo yobushushu obuthile ukuqinisekisa ukusebenza kwayo kakuhle. Ukuqonda imvakalelo yobushushu ye-HPMC ayinakuphucula umgangatho wemveliso kuphela, kodwa kukuphepha ilahleko engafunekiyo ebangelwa kukuguqula ubushushu kunye nokuphucula ukusebenza kwemveliso kunye nezibonelelo zoqoqosho.
Ixesha lokuphumla: Mar-21 ukuya kwi-4025