Ukulungiselela i-hydroxypropyl methylcelsele (i-HPMC) yenkqubo esisiseko yenkqubo yamayeza kunye nokutya. I-HPMC yi-polymer eqhelekileyo esetyenziswayo kwiforati yokutsala umdla ngenxa yeepropathi zayo ezilungileyo zefilimu, uzinzo, kunye nokuhambelana nezithako ezahlukeneyo. Izisombululo ezikhanyayo zisetyenziselwa ukudlulisela izazisi ezikhuselayo, iiprofayili zolawulo, kunye nokuphucula ukubonakala kunye nokusebenza kweetafile, iicapbules, kunye nezinye iifom zedosi eqinileyo.
1. Izixhobo ezifunekayo:
Hydroxypropyl methylcelculose (hpmc)
Isinyibilikisi (ngokwesiqhelo amanzi okanye umxube wamanzi notywala)
Iplastikhi (ngokuzithandela, ukuphucula ukuguquguquka kwefilimu)
Ezinye iisayindi (ngokuzithandela, njengabakhweli, ii-opacifiers, okanye iiarhente zokuchasa)
2. Izixhobo ezifunekayo:
Ukuxuba inqanawa okanye isitya
I-stirrer (umatshini okanye imagnetic)
Ukulinganisa ukulingana
Umthombo wokufudumeza (ukuba uyafuneka)
SEEN (ukuba kukho imfuneko yokususa amagqabi)
I-ph meter (ukuba i-PH yohlengahlengiso iyimfuneko)
Igiya yokhuseleko (iigloves, i-goggles, idyasi yelebhu)
3. Inkqubo:
Inyathelo loku-1: Ukulinganisa izithako
Linganisa inani elifunekayo le-HPMC usebenzisa ibhalansi yobunzima. Imali inokwahluka ngokuxhomekeka kuxinzelelo olufunekayo lwesisombululo sokuzihlaziya kunye nobungakanani be-batch.
Ukuba usebenzisa iplastiki okanye ezinye izongezelelo, ulinganise inani elifunekayo.
Inyathelo 2: Ukulungiswa kweShorvent
Chonga uhlobo lwe-solvent eza kusetyenziswa ngokusekwe kwisicelo kunye nokuhambelana nezithako ezisebenzayo.
Ukuba usebenzisa amanzi njengeSolvent, qinisekisa ukuba icocekile kwaye kukhethwe okanye i-Deodwety.
Ukuba usebenzisa umxube wamanzi notywala, chonga umyinge ofanelekileyo ngokusekwe kwi-smobility ye-HPMC kunye neempawu ezinqwenelekayo zesisombululo esihlekisayo.
Inyathelo 3: Ukuxuba
Beka inqanawa yokuxuba kwi-stirrer kwaye yongeza i-solvent.
Qala ukuvuselela isinyibilikisi ngesantya esiphakathi.
Ngokuthe ngcembe yongeza i-HPMP ye-HPMC ye-HPMC ye-HPMC kwi-starvent eshukumisayo ukuthintela ukungqubana.
Qhubeka nokuvuselela de i-HPMC POPLER ichithwe ngokungafaniyo kwisinyibilikisi. Le nkqubo inokuthatha ixesha, kuxhomekeka kuxinzelelo lwe-HPMC kunye nokusebenza kakuhle kwezixhobo ezivuselelayo.
Inyathelo 4: Ukufudumeza (ukuba kuyafuneka)
Ukuba i-HPMC ayiyi kunyibilikisa ngokupheleleyo kubushushu begumbi, ukufudumeza kunokuba yimfuneko.
Fudumeza umxube ngelixa ushukumisa de i-HPMC ichithwe ngokupheleleyo. Lumka ungabi nakukuphela, njengoko ubushushu obukhulu bungadekisi i-HPMC okanye ezinye izinto zesisombululo.
Inyathelo lesi-5: Ukuveliswa kweplastiki kunye nezinye izinto ezongeziweyo (ukuba ziyasebenza)
Ukuba usebenzisa iplastiki, yongeze kwisisombululo esiphumelele kancinci ngelixa sikhuthaza.
Ngokufanayo, yongeza naziphi na ezinye iizongezo ezinqwenelekayo ezifana nezikolo okanye ii-opacifiriers kweli nqanaba.
Inyathelo 6: I-PH yohlengahlengiso (ukuba kukho imfuneko)
Jonga i-pH yesisombululo esikrakra usebenzisa imitha ye-pH.
Ukuba i-pH ingaphandle koluhlu olufunayo okanye izizathu zokungqinisisa, zilungelelanise ngokongeza isixa esincinci se-acidic okanye izisombululo ezisisiseko ngokufanelekileyo.
Shuma isisombululo emva nje kokudityaniswa nganye kwaye uphinde uphinde uphinde uphinde pp de ube kwinqanaba elifunayo.
Inyathelo 7: Ukuxuba kokugqibela kunye nokuvavanywa
Nje ukuba onke amanye amanye amanyeko ayongezwa kwaye adityaniswe ngokupheleleyo, qhubeka ushukumisa imizuzu embalwa ukuqinisekisa i-homogeneity.
Yenza naluphi na uvavanyo lomgangatho oluyimfuneko onjengemilinganiselo yokubonisa i-viscofity okanye uhlolo olubonakalayo lwazo naziphi na iimpawu zokwahlulahlula okanye ukwahlulwa kwesigaba.
Ukuba iyafuneka, dlulisela isisombululo kwi-sieve ukuze ususe nayiphi na i-limps eshiyekileyo okanye amasuntswana aluhlaza.
Inyathelo 8: Ukugcinwa kunye nokupakisha
Dlulisela isisombululo esilungiselelwe i-HPMC esilungiselelwe i-HPMC kwizikhongozelo zogcino olufanelekileyo, ngokukhethekileyo iibhotile zeglasi ye-Amber okanye izikhongozeli eziphezulu zeplastiki.
Faka iilebheli izikhongozeli zolwazi olufanelekileyo ezinje ngenombolo ye-batch, umhla wokulungiselela, uxinzelelo kunye neemeko zokugcina.
Gcina isisombululo kwindawo epholileyo, eyomileyo ekhuselweyo ukusuka kokukhanya kunye nokufuma ukuze uhlale uzinzo nobomi beshelufa.
4. Iingcebiso kunye nokuqwalaselwa:
Soloko ulandela iindlela zokusebenza zelebhu kunye nezikhokelo zokhuseleko xa ziphatha iikhemikhali nezixhobo.
Gcina ucoceko kunye nokungasebenzi kakuhle kuyo yonke inkqubo yokulungiselela ukunqanda ungcoliseko.
Vavanya ukuhambelana kwesisombululo esihlekisayo kunye ne-substied ecetywayo (iitafile, i-capsules) ngaphambi kwesicelo esikhulu.
Ukuqhutywa kwezifundo zokuzincama ukuvavanya intsebenzo yexesha elide kunye neemeko zokugcina isisombululo sokuthomala.
Xela inkqubo yokulungiselela kwaye ugcine iirekhodi zeenjongo zolawulo lomgangatho kunye nokuthotyelwa komthetho.
IXESHA LOKUQALA: UMar-07-2024