I-HPMC ilawula njani i-viscosity ye-emulssion?

I-HPMC (i-hydroxypropyl methylcelcelsulose ye-polymer ye-polymer isetyenziswe ngokubanzi kwicandelo lokwakha, amayeza, ukutya kunye nemichiza yemihla ngemihla. Inesisu esihle, ukwenziwa kwe-enulsation, ukwenza ifilimu, i-colloid ekhuselweyo kunye nezinye iipropathi. Kwiinkqubo ze-emulsion, i-HPMC inokulawula i-viulsion ye-emulsion ngeendlela ezahlukeneyo.

1. Ubume bemolekyuli ye-HPMC
I-viscosity ye-HPMC ichaphazeleka ikakhulu kukulinganiswa kwemolekyuli kunye nenqanaba lokufakwa endaweni. Ukukhulu ubunzima bemolekyuli, ukuphakama kwe-viscosity yesisombululo; Kwaye inqanaba lokufaka endaweni (oko kukuthi, inqanaba lokufakwa endaweni ye-hydroxylpropy ye-hydroxypropy kunye namaqela e-AFGISY) ichaphazela ukonakala kunye neepropathi ze-HPMC. Ngokukodwa, ukuphakama kwenqanaba lokufakwa endaweni, kungcono ukubethwa kwamanzi kwe-HPMC, kwaye i-viscosity yonyuka ngokufanelekileyo. Abavelisi badla ngokubonelela ngeemveliso ze-HPMC ezinamatye ahlukeneyo eemolekyuli kunye nezigameko zokufezekisa iimfuno zezicelo ezahlukeneyo.

2. Sebenzisa uxinzelelo
Ukuxinezeleka kwe-HPMC kwisisombululo esinamandla yenye yezinto eziphambili ezichaphazela uVeksisity. Ngokubanzi, ukugxininiswa okuphezulu kwe-HPMC, kokukhona i-viscosity yesisombululo. Nangona kunjalo, uVekyusi weentlobo ezahlukeneyo ze-HPMC ngoxinzelelo olufanayo lunokwahluka kakhulu. Ke ngoko, kwizicelo ezenziwayo, kubalulekile ukukhetha ukugxininiswa okufanelekileyo kwesisombululo se-HPMC ngokweemfuno ezithile ze-viscosity. Umzekelo, kwizicelo zokwakha, ukugxininiswa kwe-HPMC kuhlala kulawulwa phakathi kwe-0.1% ne-1% ukubonelela nge-viscofity efanelekileyo kunye nokusebenza ngokwakhiwa.

I-3. Indlela yokuphelisa
Inkqubo yokupheliswa kwe-HPMC ikwanempembelelo ebalulekileyo kwi-viscofity yokugqibela. I-HPMC kulula ukusasazeka kumanzi abandayo, kodwa ireyithi yokuchithwa icotha; Iyayinyibilikisa ngokukhawuleza emanzini ashushu, kodwa kulula ukuyigcuma. Ukwenzela ukunqanda ukwahluka, indlela yokudibanisa kancinci inokusetyenziswa, oko kukuthi, kuqala ukongeza i-HPMC kubanda ukuya kwi-SPIRE, emva koko ubushushu bude buchithwe ngokupheleleyo. Ukongeza, i-HPMC inokuba yinxalenye ye-powders eyomileyo kwaye yongezwe emanzini ukunyibilikisa ukuphucula ukusetyenziswa kwempumelelo kunye nokuzinza kwe-viscofity.

4. Ubushushu
Iqondo lokushisa linempembelelo ebonakalayo kuhlobo lwe-HPMC. Ngokubanzi, isisombululo se-HPMC sincipha njengoko iqondo lobushushu liyanda. Oku kungenxa yokuba iqondo lobushushu liya kuyenza buthathaka i-hydrogen birs phakathi kweemolekyuli, esenza i-HPMC ye-HPMC Molecular Slide ngokulula, ngaloo ndlela kuncitshiswa i-viscosity yesisombululo. Ke ngoko, kwizicelo ezifuna i-viscofity ephezulu, izisombululo ze-HPMC zihlala zisetyenziswa kumaqondo obushushu asezantsi. Umzekelo, kwizicelo zamayeza, izisombululo ze-HPMC zihlala zisetyenziswa kubushushu begumbi ukuqinisekisa uzinzo kunye nokusebenza kweziyobisi.

I-5. Ixabiso le-pH
Uhlobo lwesisombululo se-HPMC siyachaphazeleka kwixabiso eli-pH. I-HPMC inolona vimba luphezulu lungathathi cala kwezopolitiko nangokungathathi cala, ngelixa i-viscosity iya kunciphisa kakhulu phantsi kweemeko ze-acidic okanye i-alkaline. Kungenxa yokuba amaxabiso e-pH egqithisileyo aya kutshabalalisa isakhiwo se-HPMC kwaye siyenza buthathaka isiphumo sayo. Ke ngoko, kwizicelo ezisebenzayo, ukuxabiseka kwesisombululo kufuneka kulawulwe kwaye kugcinwe ngaphakathi kuluhlu oluzinzileyo lwe-HPMC (i-PH 3-11) ukuqinisekisa ukusebenza kwayo. Umzekelo, kwizicelo zokutya, i-HPMC ihlala isetyenziswa ngokutya nge-acidic efana ne-yoghurt kunye nejusi, kwaye ijusi efanelekileyo inokufunyanwa ngokulungelelanisa ixabiso le-pH.

I-6. Ezinye izongezo
Kwiinkqubo ze-emulsion, i-viscosity ye-HPMC inokuhlengahlengiswa ngokwenza ezinye ii-thi chunga okanye izinyibilikisi. Umzekelo, ukongeza isixa esifanelekileyo se-inorganic ye-inorganic (efana ne-sodium chloride) inokunyusa isisombululo se-HPMC; Ngelixa ukongeza izinyibilikisi zezinto eziphilayo ezinjenge-ethanol kunokunciphisa i-viscofity yayo. Ukongeza, xa isetyenziswa ngokudibeneyo kunye nezinye iintonga (ezinjenge-XANHAn Gum, iCarbomer, njl.njl.), I-viscomes, njl njl. Ke ngoko, ngoyilo lwefomula, oongezo olufanelekileyo banokukhethwa njengoko kufuneka njalo ukuze kuqinisekiswe i-viscofity kunye nokusebenza kwe-emulsion.

I-HPMC inokufikelela kulawulo oluchanekileyo lwe-eulsion vissosity yemolekyuli, ukusetyenziswa kwendlela yokusetyenziswa, indlela yokuphelisa, ubushushu, ixabiso le-pH kunye nokongezwa. Kwizicelo ezisebenzayo, ezi zinto kufuneka zithathelwe ingqalelo ngokupheleleyo kukukhetha uhlobo olufanelekileyo lwe-HPMC kunye nemeko yokusetyenziswa yokufezekisa isiphumo esifanelekileyo. Ngoyilo lwendlela yoyilo lwendlela kunye nolawulo lwenkqubo, i-HPMC inokudlala indima ebalulekileyo kumasimi ezokwakha, amayeza, ukutya kunye nemichiza yemihla ngemihla, ukubonelela ngamava abasebenzisi kunye namava abasebenzisi.