I-HPMC (i-hydroxypropyl methylcellulose) yimpahla yepolymer e-soluble yamanzi esetyenziswa ngokubanzi kwimimandla yokwakha, amayeza, ukutya kunye neekhemikhali zemihla ngemihla. Inokuqina okulungileyo, i-emulsification, ifilimu-ifom, i-colloid yokukhusela kunye nezinye iipropati. Kwiinkqubo ze-emulsion, i-HPMC inokulawula i-viscosity ye-emulsion ngeendlela ezahlukeneyo.
1. Ubume bemolekyuli ye-HPMC
I-viscosity ye-HPMC ichaphazeleka ubukhulu becala bubunzima bayo bemolekyuli kunye neqondo lokuthatha indawo. Ubukhulu be-molecular weight, buphezulu i-viscosity yesisombululo; kunye neqondo lokutshintshwa (oko kukuthi, iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methoxy) kuchaphazela ukunyibilika kunye neempawu ze-viscosity ze-HPMC. Ngokukodwa, iqondo eliphezulu lokutshintshwa, ngcono ukunyibilika kwamanzi kwe-HPMC, kwaye i-viscosity iyanda ngokufanelekileyo. Abavelisi badla ngokubonelela ngeemveliso ze-HPMC ezinobunzima obuhlukeneyo bemolekyuli kunye nezidanga zokutshintsha ukuze kuhlangatyezwane neemfuno zezicelo ezahlukeneyo.
2. Sebenzisa ingqondo
Ukuxinwa kwe-HPMC kwisisombululo se-aqueous yenye yezinto eziphambili ezichaphazela i-viscosity. Ngokuqhelekileyo, ukuphakama kwe-HPMC ephezulu, i-viscosity enkulu yesisombululo. Nangona kunjalo, i-viscosity yeentlobo ezahlukeneyo ze-HPMC ekugxininiseni okufanayo kunokwahluka kakhulu. Ke ngoko, kwizicelo ezisebenzayo, kuyafuneka ukuba ukhethe ugxininiso olufanelekileyo lwesisombululo se-HPMC ngokweemfuno ezithile ze-viscosity. Ngokomzekelo, kwizicelo zokwakha, ukuxinwa kwe-HPMC ngokuqhelekileyo kulawulwa phakathi kwe-0.1% kunye ne-1% ukubonelela nge-viscosity efanelekileyo yokusebenza kunye nokusebenza kokwakha.
3. Indlela yokuphelisa
Inkqubo yokuchithwa kwe-HPMC nayo inempembelelo ebalulekileyo kwi-viscosity yokugqibela. HPMC kulula ukusasaza emanzini abandayo, kodwa izinga lokuchithwa licotha; inyibilika ngokukhawuleza emanzini ashushu, kodwa kulula ukuba agglomerate. Ukuze uthintele i-agglomeration, indlela yokongeza ngokuthe ngcembe ingasetyenziswa, oko kukuthi, qala ngokucotha ukongeza i-HPMC kumanzi abandayo ukuwachithachitha, emva koko shushu kwaye ushukumise de unyibilike ngokupheleleyo. Ukongeza, i-HPMC inokuxutywa kwangaphambili kunye nezinye ii powders ezomileyo kwaye zongezwe emanzini ukuze zinyibilike ukuphucula ukusebenza kakuhle kokunyibilika kunye nokuzinza kwe-viscosity.
4. Ubushushu
Ubushushu bunempembelelo ebalulekileyo kwi-viscosity yezisombululo ze-HPMC. Ngokubanzi, i-viscosity yesisombululo se-HPMC iyancipha njengoko ubushushu bukhula. Oku kungenxa yokuba ukunyuka kwamaqondo obushushu kuya kukwenza buthathaka ukudityaniswa kwe-hydrogen phakathi kweemolekyuli, okwenza ikhonkco lemolekyuli ye-HPMC isilayidi ngokulula, ngaloo ndlela inciphisa i-viscosity yesisombululo. Ke ngoko, kwizicelo ezifuna i-viscosity ephezulu, izisombululo ze-HPMC zihlala zisetyenziswa kumaqondo obushushu asezantsi. Ngokomzekelo, kwizicelo zamachiza, izisombululo ze-HPMC zihlala zisetyenziselwa ubushushu begumbi ukuqinisekisa ukuzinza kunye nokusebenza kwechiza.
5. ixabiso le-pH
I-viscosity yesisombululo se-HPMC nayo ichatshazelwa yixabiso le-pH. I-HPMC ineyona viscosity iphezulu phantsi kweemeko ezingathathi hlangothi kunye ne-asidi ebuthathaka, ngelixa i-viscosity iya kuncipha kakhulu phantsi kweemeko ezinamandla ze-acidic okanye i-alkaline. Oku kungenxa yokuba amaxabiso e-pH agqithisileyo aya kutshabalalisa ubume bemolekyuli ye-HPMC kwaye yenze buthathaka isiphumo sayo sokuqina. Ngoko ke, kwizicelo eziphathekayo, ixabiso le-pH lesisombululo kufuneka lilawulwe kwaye ligcinwe ngaphakathi koluhlu oluzinzile lwe-HPMC (ngokuqhelekileyo i-pH 3-11) ukuze kuqinisekiswe umphumo wayo wokuqina. Umzekelo, kwizicelo zokutya, i-HPMC ihlala isetyenziswa kukutya okuneasidi okufana neyogathi kunye nejusi, kwaye i-viscosity efanelekileyo inokufumaneka ngokulungelelanisa ixabiso le-pH.
6. Ezinye izongezo
Kwiinkqubo ze-emulsion, i-viscosity ye-HPMC nayo ingahlengahlengiswa ngokudibanisa ezinye ii-thickeners okanye izinyibilikisi. Ngokomzekelo, ukongeza inani elifanelekileyo leetyuwa ze-inorganic (ezifana ne-sodium chloride) kunokunyusa i-viscosity yesisombululo se-HPMC; ngelixa ukongeza izinyibilikisi eziphilayo ezifana ne-ethanol kunokunciphisa i-viscosity yayo. Ukongezelela, xa isetyenziswe ngokudibanisa nezinye i-thickeners (ezifana ne-xanthan gum, i-carbomer, njl.), i-viscosity kunye nokuzinza kwe-emulsion kunokuphucula kakhulu. Ke ngoko, kuyilo lwefomula yokwenyani, izongezo ezifanelekileyo zinokukhethwa njengoko zifuneka ukuze kuphuculwe i-viscosity kunye nokusebenza kwe-emulsion.
I-HPMC inokufikelela kulawulo oluchanekileyo lwe-emulsion viscosity ngokusebenzisa i-molecular structure, i-concentration yokusetyenziswa, indlela yokutshatyalaliswa, ubushushu, ixabiso le-pH kunye nezongezo. Kwizicelo ezisebenzayo, le miba kufuneka iqwalaselwe ngokubanzi ukukhetha uhlobo olufanelekileyo lwe-HPMC kunye neemeko zokusetyenziswa ukufezekisa isiphumo esifanelekileyo sokuqina. Ngoyilo lwefomula yesayensi kunye nolawulo lwenkqubo, i-HPMC inokudlala indima ebalulekileyo kwiinkalo zokwakha, amayeza, ukutya kunye neekhemikhali zemihla ngemihla, zibonelela ngokusebenza okugqwesileyo kunye namava omsebenzisi.
Ixesha lokuposa: Jul-17-2024