Ngaba i-hydroxypropyl methylcelcelgalose

I-HydroxyPOpyl Methylcelcelgalose (HPMC) yi-polymer eguquguqukayo isetyenziswe ngokubanzi kwifomu yamayeza njenge-binder, phakathi kweminye imisebenzi. Iibhidi zidlala indima ebalulekileyo ekuphumezeni amachiza amachiza, uqinisekisa ubumbano bemigudi ngexesha lokucinezelwa kwiifom zedosi eziqinileyo.

1. Indlela yokuBopha:

I-HPMC inepropathi ye-hydrophilic kunye ne-hydrophobic ngenxa yesakhiwo sayo semichiza, esiquka i-methyl kunye namaqela e-hydropypropy eqhotyoshelwe kwi-selsulose. Ngexesha lokucinezelwa kwethebhulethi, i-HPMC yenza ifilimu enamathelayo, ifilimu ekuvezeni amanzi okanye izisombululo ezizenziweyo, ngokwenza oko ukubopha izithako ezinamafutha kunye. Le ndalo ivelayo ivela kwi-hydrogen ye-hydrogen ye-hydroxyl kwi-HPMC, eqhuba unxibelelwano nezinye iimolekyuli.

I-2. Actual Aglomeration:

I-HPMMC ye-AIDS ekususweni kwe-Agglomerates ngokudala iibhulorho phakathi kwamasuntswana athile. Njengoko iigranati zetafile zicinezelwe, iimolekyuli ze-HPMC zadlulisa kwaye zingene phakathi kwamasuntswana, ukukhuthaza i-pauntercle-to-surcheicle. Olu lwantu luphucula amandla obuchwephesha kunye nengqibelelo yecwecwe.

3. Ukulawulwa kwenqanaba lokuchithwa:

Uhlobo lwesisombululo se-HPMC sefutha inqanaba lokungasebenzi kwetafile kunye nokukhutshwa ngamachiza. Ngokukhetha inqanaba elifanelekileyo kunye ne-HPMC, iifomulators zinokulungelelanisa iprofayili yokugqanyenisa itafile yokufezekisa i-kinetics yokukhutshwa kweziyobisi. Amabanga aphezulu e-HPMC aqhumayo akhokelela kumaxabiso acociweyo acotweyo ngenxa yokwanda kwejeli.

I-4. Ukuhanjiswa kwe-UNIFORM:

I-HPMC ye-AIDS kwindawo yokuhanjiswa kwe-iyunifomu ye-Pmermaceutical Active (APIS) kunye ne-wancript matrix. Ngesenzo sayo esibophelelayo, i-HPMC inceda ukukhusela ukwahlula-hlulwa, ukuqinisekisa ukusasazwa kweHomogeneous kunye noMxholo weziyobisi oguqukayo kwithebhulethi nganye.

I-5. Ukuhambelana nezithako ezisebenzayo:

I-HPMC i-Inert ye-chemic kwaye ihambelana noluhlu olubanzi lweethafa ezisebenzayo zamayeza, zenza ilungele ukwenziwa kweemveliso ezahlukeneyo zeziyobisi. Ayisabelanga okanye ikhuphe iziyobisi ezininzi, igcine uzinzo lwazo kunye nokusebenza kwawo kubomi beshelufu yetafile.

I-6. Ukucuthwa kokuthula:

Ngexesha lokucinezelwa kwethebhulethi, i-HPMC inokuthatha amanyathelo njengonxibelelwano, ukunciphisa isizukulwane sabantu abahamba ngenqwelomoya. Le propati yokuphucula ukhuseleko lokusebenzisa kwaye igcina indawo yokucoca imveliso.

7. Ukudumba ngokuxhomekeka kwe-PH:

I-HPMC ibonisa indlela yokuhamba ixhomekeka kwi-PH-PH, apho amanzi ayo aqala khona kwaye i-gell ye-gell yenziwa i-PH. Olu phawu lunokuba luncedo xa kusenziwa iifomu zokukhupha ezilawulwayo eziyilelwe ukukhupha ichiza kwiindawo ezithile ecaleni kwe-gestrointenal phecanal.

I-8. Ukwamkelwa kolawulo:

I-HPMC yamkelwe ngokubanzi ziiarhente zolawulo ezinjengokulawulwa kwe-US kunye nolawulo lweziyobisi (i-FDA) kunye ne-Arhente yaseYurophu yaseYurophu (i-EMA) yokusetyenziswa kwamayeza. Idweliswe kwi-pharmacopeaias eyahlukeneyo kwaye ihambelana nemigangatho yobuqhetseba, ukuqinisekisa ukhuseleko lwemveliso kunye nokusebenza ngempumelelo.

9. Ukuguquguquka kulwakhiwo:

I-HPMC ibonelela ngokuguquguquka, njengoko inokusetyenziswa bodwa okanye ngokudibeneyo kunye nabanye ababi beebhanti, iifilitha, kunye neenkampani zokufezekisa iipropathi zetafile ezinqwenelekayo. Ukuqulunqa kuvumela iifomula ukuba zisebenzele ukulungisa iimfuno ezithile zokuhambisa iziyobisi.

I-10. I-BioMPiatisiatise kunye nokhuseleko:

I-HPMC iyityhefu, engenatyhefu, engenabungozi, iyenza ilungele iifom zomlomo. Ihlala ichithwe ngokukhawuleza kwiphecana le-gestrointenal ngaphandle kokubangela ukuba umsindo okanye iziphumo ezibi, negalelo kwiprofayili yokhuseleko iyonke yeetafile zamachiza amachiza.

I-Hydroxypropyl Methylcelcelse Modles Iipropathi zayo ezizodwa zenza ukuba kubekho isithako esifanelekileyo kuphuhliso lweetafile ezisemgangathweni eziphezulu zokuhanjiswa kweziyobisi ngomlomo.