Isetyenziswa njani iHypromellose (HPMC) kwiipilisi zematrix zokukhululwa okwandisiweyo?

Kwishishini lamachiza, i-hypromellose (HPMC, METHOCEL™) ingasetyenziswa njenge-filler, i-binder, i-tablet yokugqoka i-polymer kunye ne-excipient ephambili yokulawula ukukhutshwa kweziyobisi. I-Hypromellose isetyenziswe kwiipilisi ngaphezu kweminyaka engama-60 kwaye i-excipient ephambili esetyenziswa ngokubanzi kwiipilisi ze-hydrophilic gel matrix.

Iinkampani ezininzi zamachiza zisebenzisa i-hypromellose yokukhutshwa kweyeza elilawulwayo, ngakumbi kwi-hydrophilic gel matrix tablet formulations. Xa kuziwa kwiimveliso ze-hypromellose, usenokuba uyazibuza ukuba ungalwenza njani ukhetho- ngakumbi ukuba ujonge into ebhalwe ngokufanelekileyo kwaye ezinzileyo ukuze ithengiswe kubathengi bakho. Kwesi sikhokelo, siza kuthetha ngezinto eziphambili ekufuneka uzazi malunga ne-hypromellose.

Yintoni i-hypromellose?

Hypromellose, eyaziwa ngokubaihydroxypropyl methylcellulose (HPMC), i-polymer esetyenziswa njenge-excipient yamachiza ukulawula ukukhutshwa kwamachiza kwi-oral hydrophilic gel matrix tablets.

I-Hypromellose yimathiriyeli ye-semi-synthetic ephuma kwi-cellulose, eyona polymer ininzi kwindalo. Ezinye zeempawu zayo eziqhelekileyo ziquka:

. inyibilika emanzini abandayo

. enganyibilikiyo emanzini ashushu

. Nonionic

. Ngokukhethekileyo inyibilika kwizinyibilikisi eziphilayo

. Ukuguqulwa, iipropati ze-thermal gel

. I-Hydration kunye ne-viscosity ezimeleyo kwi-pH

. I-surfactant

. non-toxic

. Ukungcamla kunye nevumba liphakathi

. Ukuxhathisa i-enzyme

. pH (2-13) uzinzo loluhlu

. Ingasetyenziswa njenge-thickener, i-emulsifier, i-binder, i-rate regulator, ifilimu yangaphambili

Yintoni iHydrophilic Gel Matrix Tablet?

Ithebhulethi ye-Hydrophilic gel matrix yifomu yedosi enokulawula ukukhutshwa kwechiza kwithebhulethi ixesha elide.

Ukulungiswa kwethebhulethi ye-Hydrophilic gel matrix:

. ilula noko

. Ifuna kuphela isixhobo esiqhelekileyo sokucinezela ithebhulethi

. Thintela ukulahlwa kwedosi yeziyobisi

. Ayichatshazelwa bubulukhuni bethebhulethi okanye amandla oxinzelelo

. Ukukhutshwa kweziyobisi kunokulungiswa ngokwexabiso lezinto ezincedisayo kunye neepolymers

Ukusetyenziswa kwe-hypromellose kwi-hydrophilic gel-matrix tablets ifumene imvume ebanzi yokulawula, kwaye i-hypromellose ikulungele ukusebenzisa kwaye inerekhodi elikhuselekileyo lokhuseleko, eliye labonakaliswa ngezifundo ezininzi. I-Hypromellose iye yaba lolona khetho lulungileyo kwiinkampani zamachiza ukuphuhlisa nokuvelisa iipilisi ezikhutshwa ngokuzinzileyo.

Izinto ezichaphazela ukukhutshwa kweziyobisi kwiMatrix Tablets:

Xa uyila ithebhulethi yokukhululwa okwandisiweyo, kukho izinto ezimbini eziphambili ekufuneka ziqwalaselwe: ukuqulunqwa kunye nokucubungula. Kukwakho nemiba engezantsi ekufuneka iqwalaselwe xa kumiselwa iprofayili yokwenziwa kunye nokukhutshwa kwemveliso yechiza lokugqibela.

Ifomula:

Imiba ephambili ekufuneka iqwalaselwe kuphuhliso lwangethuba:

1. Ipolymer (uhlobo lokutshintsha, i-viscosity, isixa kunye nobukhulu bamasuntswana)

2. Amachiza (ubungakanani besuntswana kunye nokunyibilika)

3. Iiarhente zokukhupha izinto ezininzi (i-solubility kunye nedosi)

4. Ezinye izincedisi (izinzinzi kunye nezithinteli)

Ubugcisa:

Ezi zinto zinxulumene nendlela ichiza elenziwa ngayo:

1. Iindlela zokuvelisa

2. Ubungakanani beThebhulethi kunye neMilo

3. Amandla etafile

4. indawo ye-pH

5. Ukugquma ifilimu

Zisebenza njani iitshiphu zamathambo:

I-Hydrophilic gel matrix tablets inokulawula ukukhutshwa kweziyobisi ngokusebenzisa i-gel layer, kubandakanywa neendlela ezimbini zokusasazwa (izithako ezidibeneyo ezixutywayo) kunye nokhukuliseko (izithako ezisebenzayo ezingenayo i-insoluble), ngoko i-viscosity ye-polymer inempembelelo enkulu kwiprofayili yokukhululwa. Ukusebenzisa i-hypromellose, iinkampani zamachiza zinokusebenzisa itekhnoloji yethebhulethi ye-hydrophilic gel matrix ukulungelelanisa iprofayili yokukhutshwa kweyeza, ukubonelela ngedosi esebenzayo ngakumbi kunye nokuthotyelwa kwesigulane esingcono, ngaloo ndlela ukunciphisa umthwalo wamayeza kwizigulana. Indlela yokuthatha iyeza kanye ngemini ngokuqinisekileyo ingcono kunamava okuthatha iipilisi ezininzi amaxesha amaninzi ngemini.