Yenziwe njani i-hypromellose?

I-Hypromellose, ekwabizwa ngokuba yi-hydroxypropyl methylcelcelcelse (i-HPMC), yi-seslynthetic Polymer ethathwe kwi-sellyulose, i-polysacchacchaacchaacchaacchaacchaacchaacchaacchaacchaacchaackacchaacchaacchaaccharide efumaneka kwiindonga zeseli. Ukuveliswa kwe-hypromellose kubandakanya amanyathelo aliqela, kubandakanya i-ether kunye nokucocwa. Nantsi isishwankathelo sendlela yenziwe ngayo i-hypromellose:

1. Ukufunyanwa kwe-Selsulose: Inkqubo iqala ngokufumana i-selsulose, enokufumaneka kwimithombo yolwazi eyahlukeneyo efana ne-pulp yenkuni, imicu yekotoni, okanye ezinye izityalo ezinamaqhina. I-seluplose idla ngokukhutshwa kule mithombo ngothotho lweenkqubo zekhemikhali kunye noomatshini bokufumana izinto zesekofi.
2. Isiseko: Isisele esihlanjululwe phantsi kwenkqubo yokuhlengahlengiswa kwekhemikhali ebizwa ngokuba yi-etheriya, apho i-hydroxypropy ye-hydropyl kunye namaqela e-methyl izizwe zaziswa kwi-SellXose. Olu hlengahlengiso lufezekisiwe ngokuphendula kwiseluplose nge-proplone oxide (ukwazisa i-hydroxypropy) kunye ne-methyl chloride (ukwazisa amaqela e-methyl) phantsi kweemeko ezilawulwayo.
3. Ukucocwa: Emva kokuthengiswa kwe-ether, imveliso yesiphumo ihlambulukuqa ukucoca ukususa ukungcola kunye neemveliso ezivela kwimpendulo. Oku kunokubandakanya ukuhlamba, ukufihlakala, kunye nezinye iindlela zokwahlula ukuze ufumane imveliso esulungekileyo ye-hypromellose.
4. Ukomisa kunye nokugaya: I-Hulpromellose ihlanjululwe iyomisiwe yokususa umswakama ogqithisileyo kwaye igcinwe kumgubo ococekileyo okanye igranti. Ubungakanani be-suricle kunye ne-morphology ye-hypromellose powder inokulawulwa kwiimfuno ezithile kwizicelo ezahlukeneyo.
5. Ulawulo loMgangatho: Ngalo lonke inkqubo yokuphuhlisa, amanyathelo olawulo esemgangathweni amiliselwe ukuqinisekisa ubunyulu, ukungangqinelani, kunye nokusebenza kwemveliso ye-hypromellose. Oku kubandakanya uvavanyo lweeparamitha ezinje ngobunzima bemolekyuli, i-viscosity, ukuluka, kunye nezinye iipropathi zomzimba.
6. Ukupakishwa kunye nokuhanjiswa: Nje ukuba imveliso ye-hypromellose ihlangabezane nemigangatho yomgangatho, ipakishwe kwizitya ezifanelekileyo kwaye ihanjiswa kumashishini ahlukeneyo okusetyenziswa kwiindawo zamayeza, iimveliso zokutya, kunye nezinye iinkqubo.

Lilonke, ukuveliswa kwe-hypromellose kubandakanya uthotho lwezinto ezicwangcisiweyo kunye nezigqibo ezisetyenzisiweyo kwiselpulose, ezikhokelela kwi-polymer esetyenziswe enesitayile kunye nezixhobo ezahlukileyo kwimizi-mveliso eyahlukeneyo.