I-EMARMUCEIL CANISIRYs zinomdla kunye ne-AdgeVANS esetyenziselwa ukuveliswa kwamayeza kunye nemigqaliselo, kwaye yinxalenye ebalulekileyo yamalungiselelo ngamayeza. Njengesibetho sendalo esivela kwi-polymer yendalo, i-Selesese I-Ether ineempawu ze-biodegradiance, ingonakali, kunye nexabiso eliphantsi, enjenge-Sodium Calbosel Methyl Sellulose,I-seluploseezinje nge-hydroxyyetethl seluplose ne-ithyl seluplose inexabiso elibalulekileyo lesicelo kwi-conmariclives. Okwangoku, iimveliso zezona zishishini zeselula zaseSelsulose zaseKhaya ikakhulu zisetyenziswa ikakhulu kwimimandla ephakathi kunye nezantsi yeshishini, kwaye ixabiso elongeziweyo aliphezulu. Ishishini liya kufuneka litshintshe kwaye liphucule kwaye liphucule izicelo eziphezulu zemveliso.
Abanelisiki bemidlalo badlala indima ebalulekileyo kuphuhliso kunye nemveliso yokwenziwa. Umzekelo, kumalungiselelo okukhululwa okuzinzileyo, izixhobo zepolymer ezinje nge-Selessulose e-Seles zisetyenziswa njengamachiza e-Pelmacelical kwi-Pellets, iifom zefomati ezinzileyo, ukukhululwa kweefilimu, kunye nokugcinwa kweziyobisi. Amalungiselelo kunye namalungiselelo olawulo olwenziweyo asetyenziswe ngokubanzi. Kule nkqubo, ii-polymers ezifana ne-Seleulose Teluplose esetyenziswe ngokubanzi njengeenqwelo jikelele zokulawula iziyobisi zeziyobisi emzimbeni womntu, ziyafuneka ukuba zikhululwe kancinci emzimbeni kwixesha elithile lokufezekisa iinjongo zonyango oluthile.
Ngokwezibalo zesebe lokubonisana kunye nophando, kukho iindidi ezingama-300 zezizathu ezikwilizwe lam, kodwa xa kuthelekiswa ne-United States (ngaphezu kwe-European Union (i-3000 ye-European), kukho umahluko omkhulu, kwaye iintlobo zisesincinci. Ilizwe lam lelizwe lamayeza amayeza okuphuhliswa kwentengiso inkulu. Kuyaqondakala ukuba izicaka eziphezulu ze-sumermaces ezikwindawo yam yentengiso ye-gelatinial gelatinial, i-Sunce, i-1,2-proplene, ifilimu, i-hpp, i-hpmc), kunye ne-microcrystalline fibers. Imifuno, i-HPC, iLactose.
"I-Seley Selese yendalo ligama eliqhelekileyo lothotho lwezinto zeselselose eziveliswe yi-alkali se-ilkuli, i-sleuris esetyenziswayo ngamacandelo e-phulls. iikhemikhali. Kuzo zonke iindawo, iimveliso zeBanga eliPhakathi zikuyo iindawo eziphakathi neliphezulu zeli shishini, zinokuveliswa kwenqanaba le-Ether I-Ether. Kunokuthiwa i-Ether ye-Ether idla ngokuyinyaniswa njenge-remermer, i-tertulose ithe isebenza njenge-remerment, i-therix ye-TOEREX iqhele ukongezwa njenge-rearder I-thickener ukwenza iitafile ze-matrix ezikhutshelweyo, izixhobo zokuhlambela ezinyibilikayo, ukukhulula okuzinzileyo ze-microcapsule, ukukhululwa kwezixhobo zefilimu, njl.
I-Sodium Carboxymethyl Selelose (CMC-na) sisisele i-elsulose enesiphumo esikhulu kunye nokusetyenziswa kwekhaya kunye nokuphambuka kwamanye amazwe. Yi-ionic setesulose ekutyuntshele kwikotoni kunye neenkuni nge-alkalization kunye ne-etheriya kunye ne-chlorocetic acid. I-CMC-na yindlela eqhelekileyo esetyenziswayo intsha. Ihlala isetyenziswa njengomqeshwa kumalungiselelo aqinileyo kwaye njengesixhobo esihlekisayo, esinqeni kunye nokumisa iarhente yamalungisa amanzi. Ingasetyenziselwa njengezinto ezinyibilikayo ze-matrix kunye nokwenza ifilimu. Ihlala isetyenziswa njengokukhutshwa kwefilimu yefilimu ye-SECH kunye neThebhusayithi eZinzileyo ye-Matrix kwifomu yokukhupha (elawulwa) ukukhutshwa.
Ukongeza kwi-Sodium Carboxymethyl Selelose ye-conluceutical, i-croscarmelmellose sodium nayo isetyenziswa njengezixhobo zamayeza. Ibhokisi ye-carboxymethyl sedium ye-sodium (ccmc-na) yindawo engenanto yebhokisi ye-carboxymethyl kwisenzo esithile (i-40-80 ° C) phantsi kwesenzo se-inorgadic acid kwaye ihlanjululwe. I-arhente enqamlezileyo inokuba yi-Glyccone ye-propylene, i-succcinic anhydride, i-anhydride, ene-adhydride, kwaye inje. I-Croscarmellose Sodium isetyenziswa njenge-suinterble kwiitafile, iicaphule kunye neegranatis kumalungiselelo omlomo. Ixhomekeke kwi-capillary kunye neempembelelo zokudumba ukuze zifezekise ukwahlula. Inobulungisa obuhle kwaye buyeyona nto inamandla. Izifundo zibonakalise ukuba isidanga esivuyiweyo se-croscarmellose sodium emanzini sikhulu ngakumbi kune-robydymethythyl sebhokisi ye-sodium kunye ne-rocrystalline ye-sodium.
I-Methyl Selelose (MC) yi-Ionic ye-unic selsulose eyenziwe kwikotoni kunye neenkuni nge-alkalization kunye ne-methyl chloride yokuthunga. I-Methyl Selelose inomoya obalaseleyo wamanzi kwaye uzinzile kwi-PH yoluhlu lwe-2.0 ukuya kwi-13.0. Isetyenziswe ngokubanzi kwi-subridels, kwaye isetyenziswa kwiitafile ze-sublical, inaliti ye-intsuramcular, i-Ophthalmic, iicaphus zomlomo, iitafile zomlomo kunye namalungiselelo aphezulu. Ukongeza, kwiifom zokukhutshwa ezizinzileyo, i-MC inokusetyenziswa njenge-hydrophilic ye-gest-gestraphilic ye-gest-yokukhutshwa kwe-gestrix, i-gestric-i-gestric-inyibilikisi ye-microcapsule, yokukhutshwa kwe-microcapsule ye-microcapsule, i-SOTWER.
I-Hydroxypropyl Methylcelcelsulose (HPMC) yi-ionic selsulose exubeneyo eyenziwe kwikotoni kunye neenkuni nge-alkali oxide kunye ne-methyl chloride. Yinto engenatyhafileyo, engenaxabiso, engenatyhefu, inyibiliki emanzini abandayo, kunye neegels emanzini ashushu. I-Hydroxypropyl Methylcelcelcelose yi-selsulose yohlukeneyo ye-Ether exutywe ngokukhawuleza kwimveliso, ukusetyenziswa kunye nomgangatho kule minyaka ili-15 idlulileyo. Yenye yezona zinto zinkulu zamayeza ezisetyenziselwa ekhaya kunye nasephesheya. Isetyenziswe njengokungafuneki kwexesha elimalunga neminyaka engama-50. Iminyaka yembali. Okwangoku, ukusetyenziswa kwe-HPMC kuboniswa ikakhulu kwezi zinto zintlanu zilandelayo:
Enye injenge-binder kwaye intsholongwane. I-HPMC njenge-Binder inokwenza ichiza kulula emanzini, kwaye inokwandisa amakhulu amaxesha emva kokufumana amanzi, ngenxa yoko inokuthi iphucule ukupheliswa okanye ukukhutshwa kwethebhulethi. I-HPMC ine-viscofity eyomeleleyo, kwaye inokuphucula i-vercosic valcosity kwaye iphucule ukutshitshiswa kwezinto ezingafunekiyo nge-crisp okanye i-hard. I-HPMC ene-viscofity ephantsi inokusetyenziswa njenge-binder kwaye i-suintebgran, kunye ne-HPMC isebenzisa i-viscofity ephezulu inokusetyenziswa kuphela njenge-binder.
Okwesibini, isetyenziswa njengezinto zokuzinza ezizinzileyo nezilawulwayo zokulungiselela ngomlomo. I-HPMC yi-Hydrogel Matrix yeMatrix yeZilungiselelo eziZinzileyo. I-HPMC yeBanga le-Viscosity ephantsi (i-5 ~ 50Mparo) inokusetyenziswa njengendawo yokubhabha, i-viscosity eyandayo iarhente yenqanaba le-farix ender kunye ne-bitmpas ye-biptules ye-capsules kunye neetafile ze-hydrophilic ze-thtrix ezigcinakalayo. I-HPMC inyibilikisi kwi-Gastrointentinal fluid, inezibonelelo zokungcola ezilungileyo, ulwelo oluhle, umthamo onamandla weziyobisi kunye neempawu zokukhupha iziyobisi ezingachaphazelekanga yi-PH. Yinto ebaluleke kakhulu yokuthwala i-hydrophilic ye-hydrophilic kwiinkqubo zokulungiselela ezinzileyo kwaye ihlala isetyenziswa njenge-hydrophilic ges matrix kunye nezinto eziqengqelekayo zamalungiselelo okukhutshwa, kwaye isetyenziswe kwi-Gostric Aulting Syssociences.
Elesithathu linjengearhente yefilimu yokwakha ifilimu.I-HPMCinepropathi efanelekileyo yefilimu. Ifilimu eyenziwe ngayo yiyunifomu, elubala, kwaye inzima, kwaye akukho lula ukulandela ngqo ngexesha lemveliso. Ngokukodwa amachiza alula ukuyifumana umswakama kwaye angazinzanga, ayisebenzisa njengokuphucula ungqingqwa. I-HPMC ineendlela ezahlukeneyo zokufakelwa. Ukuba ikhethiwe ngokufanelekileyo, umgangatho kunye nokubonakala kweetafile ezinamaphepha angcono kunezinye izinto, kwaye uxinzelelo lwalo luyi-2% ukuya kwi-10%.
Ezine zisetyenziswa njengesixhobo se-capsule. Kwiminyaka yakutshanje, ngokuqhambuka okuqhubekayo kwesilwanyana sasehlabathini, xa kuthelekiswa ne-gelatin capsules, iicapsules ezityalonile ziye zaba sisithandwa esitsha samayeza kunye nokutya. I-Pfizer ikhuphe ngempumelelo i-HPMC kwizityalo zendalo kunye ne-vcaps elungisiweyo ye-vcaptm. Xa kuthelekiswa ne-gelatini yendabuko ye-gelatini, iicaphu zemifu yemifuno zinezinto eziluncedo kakhulu, akukho mngcipheko wokuphendula ngokudibeneyo, kunye nokuzinza okuphezulu. Ireyithi yokukhupha iziyobisi ihleli, kwaye umahluko umntu mncinci. Emva kokuhluma komzimba womntu, ayikhutshwa kwaye inokukhutshwa. Ikhutshiwe emzimbeni. NgokweMeko yokuGcina, emva kovavanyo oluninzi, luphantse lungabi lubanzi phantsi kweemeko zokufuma okuphantsi, kwaye iipropathi zeqokobhe le-capsule zisazinza phantsi komswakazi ophezulu, kunye nezihloko ezahlukeneyo zezityalo eziphantsi kweemeko zokugcina eziphezulu azichaphazelekanga. Ukuqonda kwabantu iicapbules zezityalo kunye notshintsho lwamayeza oluntu ekhaya nasephesheya, imfuno yentengiso ye-capsules yokutyala iya kukhula ngokukhawuleza.
Isihlanu sinjengearhente yokumisa. Uhlobo lokumiswa kwenkqubo yolwelo yindlela eqhelekileyo yeKlinikhi yeKlinikhi, eyinkqubo yokusasazeka ye-Heterogeneneous apho kunzima ukunyibilika kuchithwayo. Ukuzinza kwenkqubo kumisela umgangatho wokumiswa kwamanzi. Isisombululo se-HPMC Colloidal sinokunciphisa uxinzelelo oluqinileyo olunamandla, ukunciphisa amandla asimahla samasuntswana amasuntswana, kwaye uzinzile inkqubo ye-heterogeneous yokusasazeka. Yiarhente enokumisa kakhulu. I-HPMC isetyenziswa njenge-thickener yehla, ngomxholo we-0.45% ukuya kwi-1,0%.
I-Hydroxypropyl seluplose (HPC) yi-Ionic selsulose Monoter eyenziwe kwikotoni kunye neenkuni nge-alkalition kunye ne-proplenene oxide. I-HPC ihlala inyibiliza emanzini ngezantsi kwe-40 ° C kunye nexabiso elikhulu le-polar, kwaye intsebenzo yayo inxulumene nomxholo we-hydroxypropy kunye nenqanaba le-polymerization. I-HPC inokuthi ihambelane namachiza ahlukeneyo kwaye inobutyebi obuhle.
I-hydroxypropy ye-hydroxyl(L-HPC)isetyenziswa ikakhulu njengecwecwe lecwecwe kunye ne-binder. Iimpawu zayo zezi: Kulula ukucinezela kunye nokwenza isicelo, kokuphathwa komhlaba, ngakumbi kunzima ukwenza ithebhulethi, kwaye kukwenza ukuba ithebhulethi yemveliso, kwaye iphucule umgangatho wangaphakathi wecwecwe, kwaye uphucule isiphumo soqobo.
I-Hydroxypropyl ye-Hydroplopy ye-Hydroplopy ye-SHYDROSE I-H-HPC inepropathi ebalaseleyo yefilimu, kwaye ifilimu enokubakho inzima kwaye ine-elastiki, enokuthelekiswa neplastiki. Ngokuxubana nezinye iiarhente zokuhlambela ezinamanzi, ukwenziwa kwefilimu kunokuphuculwa ngakumbi, kwaye kuhlala kusetyenziswa njengezinto zokuhamba ngefilimu kwiitafile. I-H-HPC inokusetyenziswa njengezixhobo ze-matrix ukulungiselela iitafile ze-matrix ezigcinakileyo, iipelethi ezikhutshelweyo ezikhutshelweyo kunye neetafile ze-windows ezimbini.
I-HydroxyEtheetheetheetheethl seluplose (hec) i-unic ye-unic selsulose ye-monoter eyenziwe kwikotoni kunye neenkuni nge-alkalization kunye ne-englone oxide. I-hec isetyenziswa ikakhulu njengearhente yokukhusela i-tickener, iarhente yokhuselo, inamathela, ihlazo, iarhente, iarhente yokumisa ifilimu, iarhente yefilimu yefilimu kunye nempahla yokukhupha kancinci kwicandelo lezonyango. Ingasetyenziselwa ukuvela kwi-eulsions, ii-oyile, kunye nehlay yeliso lamehlo amayeza aphezulu. Ulwelo lomlomo, iitafile eziqinileyo, iicapbules kunye nezinye iifom zedosi. I-HydroxyEtheetheetheetheetheethy ifakiwe kwi-pharmacopoeia / i-US yeSomtha yaseMelika kunye ne-European Pharmacopoeia.
I-Ethyl Selelose (EC) yenye yezona zinto zisetyenziswa kakhulu zesekela. I-EC ayinatyhefu, izinzile, i-infline emanzini, i-acid okanye isisombululo se-alkaline, kwaye inyibilikisi kwiinyibiliki ezifana ne-ethanol kunye ne-methanol. I-Solvent esetyenziswayo isetyenziselwa ukunyibilikiswa okuxubileyo kwe-toluene / ethanol 4/1 (ubunzima). I-EC isebenzisa uninzi lwamalungiselelo okukhutshwa kwechiza, kwaye isetyenziswa ngokubanzi njengomphathi kunye nezixhobo zokwenza iifilimu, njl njl. ukucaciswa kwezinto ezincedisayo ukulungiselela ii-microcaps ezizinzileyo zokukhutshwa; Ingasetyenziswa ngokubanzi njengomcimbi ophetheyo osetyenziselwa ukulungiselela ukusasazeka okuqinileyo; Ingasetyenziswa ngokubanzi kwitekhnoloji yamayeza njengento yokwenza ifilimu kunye nokukhusela i-filtive, kwaye inokusetyenziswa njenge-binder kunye nefilitha. Njengomntu okhuselayo obandayo kwiitafile, inokunciphisa ubuntununtunu beetafile ukuya kuthi ga ngomswakama kwaye kuthintele amachiza ekubeni achithelwe kwaye awehliswa ngumswakama; Ikwanokwenza i-glue yokukhutshwa kancinci ye-glue kunye ne-microncalling i-polymer yokuqhuba ngokuqhubekayo isiphumo seziyobisi.
Ngesishwankathelo, i-sodium ye-sodium ye-sodium ye-sodium ye-sodboxymethyl seluplose, methyl seluplopyl methulose, i-HydroxyEylSelsel seluplose isetyenziswa kwimveliso yemveliso esetyenziswayo kwiimpawu zemveliso. Izinto zokuzibandakanya, ukutya okuzinzileyo nokulawulwa kwezixhobo zokulungiselela ngomlomo, ii-arhente zokwenza iifilimu zefilimu, izixhobo zecaphule kunye neearhente zokumisa. Ukujonga umhlaba, iinkampani ezininzi zelizwe lasekhaya (i-shin-essu yaseJapan, i-Dow Wolfland) ifumene imakethi enkulu kwi-CLMACEOS kwi-CLMACEOS kwi-CLMACEOS kwi-CLERMACEOF kwi-CHINA kwi-CHEMA kwi-CREMATION kwi-chilla kule ndawo. Utyalomali kwisicelo. UDow Wolff uxele ukuba iya kukhulisa ingqalelo yayo ekuqulunqweni, izithako kunye neemfuno zemakethi yamachiza amachiza amachiza amayeza, kwaye uphando lwalo lwesicelo luya kuzama ukusondela kwintengiso. Indawo ye-Wolff sellose ye-Dow Shemical Cormical Corporation ye-United States yaseka i-United Staterication Alliance Alligaly kwihlabathi jikelele. Inabasebenzi abangaphezu kwe-1,200 kwizixeko ezili-15, amaziko ali-15 ee-Asethi kunye neenkampani ezi-6 ze-GPP. Iingcali zophando ezisetyenzisiweyo zibonelela ngeenkonzo kubaxumi bamazwe ali-160. I-Ashland ineziseko zemveliso eBeijing, eTianjin, Shanghai, Nunnjing, Changzhana, Kunshan noJunhan, i-Jintangmen, kwaye ihlawulwe kumaziko amathathu eetekhnoloji yaseShanghai naseMjezing.
Ngokweenkcukacha-manani kwiwebhusayithi yombutho wase China seSelsulose, ngo-2017, imveliso yasekhaya ye-Telulose Ethe yayiyiitoni ezingama-373,000 kunye nevolumu yentengiso yayingama-360 amatoni amathole. Ngo-2017, ivolumu yokuthengisa i-IonicCmcyayingama-234,000 iitoni, ukunyuka kwe-18.61% ngonyaka, kwaye ivolumu yentengiso ye-ionic ye-126,000, ukwanda kwe-8.2% ngonyaka. Ukongeza kwi-HPMC (yeBanga leZinto eziSebenzayo) le-Ionic,I-HPMC. I-Selese yasekhaya ikhula ngokukhawuleza iminyaka engaphezu kweshumi, kwaye iziphumo zibe zehlabathi kuqala. Nangona kunjalo, uninzi lweemveliso ze-Elet Setheli I-Elet Sether isetyenziswa ikakhulu embindini nakwizixhobo eziphantsi zeshishini, kwaye ixabiso elongeziweyo aliphezulu.
Okwangoku, uninzi lweshishini le-esupese zasekhaya likwixesha elinzima lenguqu kunye nophuculo. Kuya kufuneka baqhubeke nokonyusa uphando lweMveliso kunye neenzame zophuhliso, ngokuqhubekayo zisebenzisa i-china, imakethi enkulu yehlabathi, kunye nokwandisa iinzame zokuphuhlisa ngokukhawuleza. Gqibezela inguqu kunye nokuphucula, faka isiphelo esiphakathi kwishishini, kwaye ufezekise uphuhliso oluluhlaza noluhlaza.
Ixesha leposi: Apri-25 ukuya ku-2424