(1) Intshayelelo kwi-HPMC
I-Hydroxypropyl Methylcellulose (HPMC) i-ether ebalulekileyo ye-cellulose ye-nonionic esetyenziswa kakhulu kwi-detergents, izinto zokwakha, ukutya, amayeza kunye nezinye iindawo. Kwisephu yokuhlamba impahla, i-HPMC isetyenziswa njengento engqindilili ukunika uzinzo olugqwesileyo lokunqunyanyiswa kunye nokunyibilika, ukomeleza ukuncamathela kunye nesiphumo sokuvasa isicoci sempahla. Nangona kunjalo, ukufezekisa eyona viscosity ye-HPMC kwisicoci sempahla yokuhlamba impahla, izinto ezininzi kufuneka ziqwalaselwe, kubandakanywa uhlobo, idosi, iimeko zokuchithwa, ulandelelwano lokongezwa, njl njl. ye-HPMC.
(2) Izinto ezichaphazela i-HPMC viscosity
1. Iintlobo kunye neemodeli ze-HPMC
Ubunzima bemolekyuli kunye neqondo lokutshintshwa (i-methoxy kunye ne-hydroxypropyl substitution) ye-HPMC ichaphazela ngokuthe ngqo i-viscosity yayo kunye neempawu zokunyibilika. Iindidi ezahlukeneyo ze-HPMC zineendawo ezahlukeneyo ze-viscosity. Ukukhetha imodeli ye-HPMC ehambelana neemfuno zakho zokwenziwa kwesicoci sempahla ngundoqo. Ngokuqhelekileyo, ubunzima be-molecular HPMCs bubonelela ngee-viscosities eziphezulu, ngelixa ubunzima be-molecular HPMCs bubonelela ngee-viscosities ezisezantsi.
2. Umthamo we-HPMC
Isixa se-HPMC sinempembelelo ebalulekileyo kwi-viscosity. Ngokwesiqhelo, i-HPMC yongezwa ngokwemali phakathi kwe-0.5% kunye ne-2% kwizicoci zokuhlamba impahla. Idosi ephantsi kakhulu ayiyi kufezekisa umphumo ofunekayo wokuqina, ngelixa i-dosage ephezulu kakhulu inokukhokelela kwiingxaki ezinjengobunzima bokutshatyalaliswa kunye nokuxuba ukungalingani. Ke ngoko, idosi ye-HPMC kufuneka ihlengahlengiswe ngokweemfuno ezithile kunye neziphumo zovavanyo ukufezekisa i-viscosity efanelekileyo.
3. Iimeko zokuchithwa
Iimeko zokuchithwa kwe-HPMC (ubushushu, ixabiso le-pH, isantya esishukumisayo, njl.) zinempembelelo ebalulekileyo kwi-viscosity yayo:
Ubushushu: I-HPMC inyibilika kancinci kumaqondo obushushu asezantsi kodwa inokubonelela ngee-viscosities eziphezulu. Inyibilika ngokukhawuleza kumaqondo obushushu aphezulu kodwa ine-viscosity esezantsi. Kunconywa ukunyibilikisa i-HPMC phakathi kwe-20-40 ° C ukuqinisekisa ukuzinza kwayo kunye ne-viscosity.
pH: I-HPMC isebenza kakuhle phantsi kweemeko ezingathathi hlangothi. Amaxabiso e-pH aphezulu kakhulu (i-acidic kakhulu okanye i-alkaline kakhulu) inokutshabalalisa ubume be-HPMC kwaye inciphise i-viscosity yayo. Ngoko ke, ukulawula ixabiso le-pH yenkqubo yokuhlamba impahla phakathi kwe-6-8 inceda ukugcina uzinzo kunye ne-viscosity ye-HPMC.
Isantya esishukumisayo: Isantya esifanelekileyo sokuvuselela sinokukhuthaza ukuchithwa kwe-HPMC, kodwa ukuvuselela okugqithisileyo kunokwazisa amaqamza kwaye kuchaphazele ukufana kwesisombululo. Kucetyiswa ngokubanzi ukusebenzisa isantya esicothayo kwaye nkqu nokushukumisa ukunyibilikisa ngokupheleleyo i-HPMC.
4. Yongeza iodolo
I-HPMC yenza i-agglomerate ngokulula kwisisombululo, echaphazela ukuchithwa kwayo kunye nokusebenza kwe-viscosity. Ke ngoko, ulandelelwano apho i-HPMC yongezwa lubalulekile:
Ukuxuba kwangaphambili: Xuba i-HPMC kunye nezinye ii powders ezomileyo ngokulinganayo uze udibanise ngokuthe ngcembe emanzini, oko kunokuthintela ukubunjwa kwe-clumps kunye nokunceda ukunyibilika ngokulinganayo.
Ukufumisa: Phambi kokuba wongeze i-HPMC kwisisombululo sesicoci sempahla, ungaqala usinyakamise ngentwana yamanzi abandayo, uze ugalele amanzi ashushu ukuze uwanyibilikise. Oku kunokuphucula ukusebenza kakuhle kokupheliswa kunye ne-viscosity ye-HPMC.
(3) Amanyathelo okwandisa i-HPMC viscosity
1. Uyilo lwefomula
Khetha imodeli efanelekileyo ye-HPMC kunye nedosi esekwe kusetyenziso lokugqibela kunye neemfuno zesicoci sempahla. Izinto zokucoca iimpahla zokucoca ezikumgangatho ophezulu zinokufuna i-viscosity ephezulu ye-HPMC, ngelixa iimveliso zokucoca ngokubanzi zinokukhetha okuphakathi ukuya kwi-viscosity ephantsi ye-HPMC.
2. Uvavanyo lovavanyo
Ukuqhuba iimvavanyo zeebhetshi ezincinci kwibhubhoratri ukujonga impembelelo yayo kwi-viscosity yesicoci sokuhlamba impahla ngokuguqula idosi, iimeko zokuchithwa, umyalelo wokongezwa, njl njl. ye-HPMC. Rekhoda iiparamitha kunye neziphumo zovavanyo ngalunye ukumisela eyona ndibaniselwano ilungileyo.
3. Uhlengahlengiso lwenkqubo
Faka iiresiphi ezingcono zelabhoratri kunye neemeko zenkqubo kumgca wemveliso kwaye ulungelelanise imveliso enkulu. Ukuqinisekisa ukuhanjiswa okufanayo kunye nokuchithwa kwe-HPMC ngexesha lenkqubo yokuvelisa ukuphepha iingxaki ezifana ne-clumps kunye nokuchithwa kakubi.
4. Ulawulo lomgangatho
Ngokusebenzisa iindlela zokuvavanya umgangatho, ezifana nokulinganisa i-viscometer, uhlalutyo lwesayizi ye-particle, njl., ukusebenza kwe-HPMC kwi-detergent yokuhlamba impahla kuhlolwa ukuqinisekisa ukuba ifezekisa i-viscosity elindelekileyo kunye nokusetyenziswa kwesiphumo. Ukuhlola umgangatho rhoqo kwaye uhlengahlengise iinkqubo kunye neefomyula ngokukhawuleza ukuba iingxaki zifunyenwe.
(4) Imibuzo edla ngokubuzwa nezisombululo
1. Ukupheliswa kakubi kwe-HPMC
Izizathu: Ubushushu obungafanelekanga bokupheliswa, isantya esikhawulezileyo okanye esicothayo kakhulu, isantya sokongeza esingafanelekanga, njl.
Isisombululo: Lungisa iqondo lokushisa lokunyibilika ukuya kwi-20-40 ° C, sebenzisa isantya esicothayo kunye nesokushukumisa, kwaye ulungise ulandelelwano lokongeza.
2. I-HPMC viscosity ayikho kumgangatho
Izizathu: Imodeli ye-HPMC ayifanelekanga, i-dosage ayinelanga, ixabiso le-pH liphezulu kakhulu okanye liphantsi kakhulu, njl.
Isisombululo: Khetha imodeli efanelekileyo ye-HPMC kunye nedosi, kwaye ulawule ixabiso le-pH yenkqubo yokuhlamba impahla phakathi kwe-6-8.
3. Ukwenziwa kwe-HPMC clump
Isizathu: I-HPMC yongezwa ngokuthe ngqo kwisisombululo, iimeko ezingafanelekanga zokuchithwa, njl.
Isisombululo: Sebenzisa indlela yokuxuba kwangaphambili, xuba kuqala i-HPMC kunye nezinye ii powders ezomileyo, kwaye ngokuthe ngcembe udibanise emanzini ukuze unyibilike.
Ukufezekisa eyona viscosity ye-HPMC kwisicoci sempahla, imiba efana nohlobo, idosi, iimeko zokuchithwa, kunye nomyalelo wokongezwa kwe-HPMC kufuneka iqwalaselwe ngokubanzi. Ngoyilo lwefomula yesayensi, uvavanyo lovavanyo kunye nohlengahlengiso lwenkqubo, ukusebenza kwe-viscosity ye-HPMC kunokuphuculwa ngokufanelekileyo, ngokwenjenjalo kuphuculwe isiphumo sokusetyenziswa kunye nokhuphiswano lwentengiso lwesicoci sempahla.
Ixesha lokuposa: Jul-08-2024