(1) Intshayelelo kwi-HPMC
I-HydroxyPOpyl Methylcelcelsulose (HPMC) sisiseko esibalulekileyo seselseulose Etherly esetyenziswe ngokubanzi kwizitolo, izinto zokwakha, ukutya, amayeza kunye namanye amayeza. Kwindawo yokuhlamba iimpahla, i-HPMC isetyenziswa njenge-thi choner ukubonelela ngozinzo kunye nokungasebenzi, ukuphucula umlinganiso kunye nokuhlamba isiqwenga sokuhlamba iimpahla. Nangona kunjalo, ukufezekisa i-viscofity efanelekileyo ye-HPMC kwi-HEAURDY STERGENT, kwizinto ezininzi kufuneka ziqwalaselwe, kubandakanya uhlobo, umthamo, iimeko zokuchitheka, ukulandelelana, njl. I-HPMC.
(2) Izinto ezichaphazela i-HPMC Viscofity
1. Iindidi kunye neemodeli ze-HPMC
Ubunzima bemolekyuli kunye nesidanga sokufakwa endaweni (Malunga ne-Hydroxyproplowl) ye-HPMC ichaphazela ngokuthe ngqo i-HPMCIty kunye nePropathi ye-Solkisity. Iindidi ezahlukeneyo ze-HPMC zinee-vings ezahlukeneyo. Ukukhetha imodeli ye-HPMC efuna iimfuno zakho zokwenza impahla yendawo yokuhlala. Ngokubanzi, i-HPMOS ephezulu ye-HPMCS ibonelela ngee-viscofis eziphezulu, ngelixa i-HPMS yesilinganiselo semolekyuzi ibonelela ngeendawo zokundwendwela ezisezantsi.
2. Umthamo we-HPMC
Isixa se-HPMC sinefuthe elibonakalayo kwi-vickosity. Ngokwesiqhelo, i-HPMC yongezwa kwi-0.5% kunye ne-2% kwiziteyitings zempahla yokuhlamba. Umthamo ophantsi kakhulu awuyi kufezekisa isiphumo esithandekayo, ngelixa umthamo ophezulu kakhulu unokukhokelela kwiingxaki ezinje ngobunzima bokuchitheka kunye nokudityaniswa okungahambelaniyo. Ke ngoko, umthamo we-HPMC kufuneka uhlengahlengiswe ngokweemfuno ezithile kunye neziphumo zovavanyo ukuze ufezekise i-viscofity efanelekileyo.
I-3. Iimeko zokuTyeliswa
Iimeko zokuchitha ze-HPMC (iqondo lobushushu, ixabiso le-pH, isantya, njl njl) sinefuthe elibalulekileyo kwi-viscofity yalo:
Iqondo lokushisa: i-HPMC inyibilikisa ngokuthe ngcembe kumaqondo obushushu asezantsi kodwa unokubonelela ngeendawo zokundwendwela eziphezulu. Inyibilikiswe ngokukhawuleza kumaqondo obushushu aphezulu kodwa inophawu oluphantsi. Kucetyiswa ukunyibilikisa i-HPMC phakathi kwe-20-40 ° C yokuqinisekisa uzinzo novissity.
I-HP: I-HPMC yenza kakuhle phantsi kweemeko ezingathathi hlangothi. Ixabiso eligqithisileyo le-pH (i-acidic kakhulu okanye i-alkaline) inokutshabalalisa ubume be-HPMC kwaye inciphise i-viscofity yayo. Ke ngoko, ukulawula ixabiso le-pH lenkqubo yokuhlaselwa kweenyawo phakathi kwe-6-8 kunceda ukugcina uzinzo kunye noVikosity we-HPMC.
Isantya esishukumisayo: Isantya esifanelekileyo sokukhuthaza sinokukhuthaza ukuchitheka kwe-HPMC, kodwa ukuvuselela okungaphezulu kunokwazisa iibhubhu kwaye kuchaphazele ukufana kwesisombululo. Kuyacetyiswa ukusebenzisa isantya esicothayo kunye nokuba nesikhubekiso sokuphelisa i-HPMC.
4. Yongeza i-odolo
I-HPMC ngokulula i-Aggomerate in Sombuls, ichaphazela intsebenzo yayo kunye ne-viscofity. Ke ngoko, iodolo apho kongezwa i-HPMC ibalulekile:
Ukudibanisa kwangaphambili: Hlanganisa i-HPMC kunye nezinye iipowuti ezomileyo kwaye emva koko zizongeze emanzini, ezinokuthintela ukuqunjelwa kweziqwengana kunye nokunceda ngokulinganayo.
Ukwenza i-curisting: Ngaphambi kongeza i-HPMC ukuya kwisisombululo sokuhlaselwa kwempahla, ungaqala ukuyitywina ngesantya esincinci samanzi abandayo, uze wongeza amanzi ashushu ukuyichitha. Oku kunokuphucula ukugqitywa kokucotswaniso kunye nokubonakala kwe-HPMC.
(3) amanyathelo okwenza i-HPMC Viscosity
1. Uyilo lweFomula
Khetha imodeli ye-HPMC efanelekileyo kunye nedosi esekwe kwisiphelo sephepha kunye neemfuno zendlela yokuhlamba iimpahla. Ukucocwa kweendawo zokucoca iimpahla eziphezulu kunokufuna i-HPMC ephezulu ye-HPMC, ngelixa iimveliso zokucoca ngokubanzi zinokukhetha i-HPMMC ephantsi ye-HPMC.
2. Uvavanyo lovavanyo
Ukuqhutywa kweemvavanyo ze-batch ezincinci ukuze kujongwe ifuthe kwi-viscosity ye-viscosity ye-viscosity yokutshintsha kwethamo, iimeko zokuchitha, i-HPMC. Rekhoda iiparameter kunye neziphumo zovavanyo ngalunye ukufumanisa ukudityaniswa okufanelekileyo.
3. Uhlengahlengiso lwenkqubo
Faka isicelo seendlela zokupheka zelebhu kunye neemeko zenkqubo kumgca wemveliso kwaye uzihlengahlengise kwimveliso yamakhaka. Ukuqinisekiswa kokusasazwa kweyunifomu kunye nokuchithwa kwe-HPMC ngexesha lenkqubo yokuvelisa ukunqanda iingxaki ezinje ngeziqwengana kunye nokuchithwa kakubi.
4. Ulawulo olusemgangathweni
Ngeendlela zokuvavanywa okusemgangathweni, ezinje ngomgangatho wokubonisa, ubungakanani be-suricle, njl njl, njl. Yenza uhlolo lwenqanaba lomgangatho rhoqo kunye nokulungelelanisa ngokukhawuleza iinkqubo kunye neefomula ukuba zifunyenwe iingxaki.
(4) Imibuzo ebuzwa rhoqo kunye nezisombululo
1. Ukuchithwa okungalunganga kwe-HPMC
Izizathu: Iqondo lokushisa elingafanelekanga, ikhawuleza kakhulu okanye isantya esicotha kakhulu, i-odolo engalunganga, njl.
Isisombululo: Lungisa iqondo lobushushu ukuya kwi-20-40 ° 2 ° C, sebenzisa isantya esicothayo kwaye sivuselele, kwaye sichaze ukulandelelana kongezwa.
I-2. I-HPMC Viscosity ayikho kumgangatho
Izizathu: Imodeli ye-HPMC ayifanelekanga, idosi ayonelanga, ixabiso le-pH liphezulu kakhulu okanye liphantsi kakhulu, njl.
Isisombululo: Khetha imodeli ye-HPMC efanelekileyo kunye ne-dosage, kwaye ulawule ixabiso le-pH yenkqubo yokuhlaselwa kwempahla phakathi kwe-6-8.
I-3. I-HPMC ye-HPMP
Isizathu: I-HPMC yongezwa ngokuthe ngqo kwisisombululo, iimeko ezifanelekileyo zokuchitha, njl. Njl.
Isisombululo: Sebenzisa indlela yokudibanisa, qala umxube we-HPMC kunye nezinye iipowuti ezizomileyo, kwaye ngokuthe ngcembe woyila emanzini ukuze unyibilike.
Ukufezekisa i-viscosity efanelekileyo ye-HPMC kwi-HEAURDY STERGENT, imiba enjengohlobo, umthamo, iimeko zokuchitheka, kunye nokulongeka kwe-HPMC kufuneka kuthathelwe ingqalelo ngokufanelekileyo. Ngoyilo lwendlela yenzululwazi, uvavanyo lovavanyo kunye nohlengahlengiso lwenkqubo, ukuSebenza kwenkqubo ye-HPMC kunokuphumeza ngokufanelekileyo, ngaloo ndlela kuphuculwe ukusebenza kwempahla kunye nokhuphiswano lokuhlamba iimpahla.
Ixesha lokuphumla: Jul-08-2024