I-HPMC (Hydroxypropyl Methylcelcelcelose) yi-gicker kwaye i-stabilizer isetyenziswa ngokufuthi kwizinto zokwakha, iingubo, amayeza kunye nokutya. I-HPMC 15 CPS kuthetha ukuba i-vickosity yayo i-15 i-nticupoise, eyinqanaba eliphantsi le-viscosity.
1. Ukunyusa uxinzelelo lwe-HPMC
Eyona ndlela ngokuthe ngqo nesebenzayo yokwandisa i-HPMC kukwandisa uxinzelelo lwayo kwisisombululo. Xa iqhezu le-HPMC linyuswa, uVekyusi wesisombululo uya kwanda. Eyona ndlela yi-HPMC yonyusa i-viscosity yesisombululo ngokwenza ubume benethiwekhi ezintathu. Njengamanani eemolekyuli ze-HPMC kwisisombululo esonyukayo, ukuxinana namandla enethiwekhi kuya kukhulisa, ngaloo ndlela kunyusa ukufakwa kwesisombululo. Nangona kunjalo, kukho umda wokwandisa uxinzelelo. Eyona nto iphambili kwi-HPMC iya kubangela ulwelo lwesisombululo ukuze unciphise, kwaye unokuchaphazela intsebenzo yayo kwizicelo ezithile, njengokwakha kunye nokusebenza.
2. Lawula ubushushu besisombululo
Iqondo lokushisa linempembelelo enkulu kwi-solity kunye nohlobo lwe-HPMC. Kumaqondo obushushu asezantsi, uVekyusi weSisombululo se-HPMC uphezulu; Ngexesha amaqondo obushushu aphezulu, uVenkile yesisombululo se-HPMC uya kuncipha. Ke ngoko, ukunciphisa ubushushu besisombululo ngokufanelekileyo ngexesha lokusetyenziswa kunokunyusa i-HPMC. Kuya kufuneka kuqatshelwe ukuba ukubethwa kwe-HPMC kwisisombululo kwahlukile kubushushu obahlukeneyo. Ihlala ilula ukusasazeka kumanzi abandayo, kodwa kuthatha ixesha elithile lokunyibilikisa ngokupheleleyo. Iyanyibilikisa ngokukhawuleza emanzini afudumeleyo, kodwa i-viscosity iphantsi.
3. Guqula ixabiso le-pH ye-solvent
I-viscosity ye-HPMC ikwanobuthathaka kwixabiso le-pH yesisombululo. Ngaphantsi kweemeko ezingathathi cala okanye ezingathathi cala, ukubonwa kwesisombululo se-HPMC sesona siphezulu. Ukuba ixabiso le-pH lesisombululo liphamsa ukungathathi cala, i-vickosity inokuncipha. Ke ngoko, uVenkile wesisombululo se-HPMC unokonyuswa ngokuhlengahlengiswa ngokufanelekileyo ngexabiso le-pH yesisombululo (umzekelo, ngokudibanisa i-buffer okanye uMlawuli we-Acid-ow). Nangona kunjalo, ngokokwenyani, uhlengahlengiso lwexabiso le-pH kufuneka lube ngumlumki kakhulu, kuba utshintsho olukhulu lunokubangela ukonakaliswa kwe-HPMC okanye ukonakala kwendlela yokusebenza.
4. Khetha i-solvent efanelekileyo
Ukuluka kunye nokubonisa i-HPMC kwiinkqubo ezahlukeneyo zeSolvent zahlukile. Nangona i-HPMC isetyenziswa ikakhulu kwizisombululo ezizenzisimu, ukongezwa kwezinye izinyibilikisi zezinto eziphilayo (ezinje nge-ethanol, i-Iyopropanol, njl. Umzekelo, isixa esincinci seShorlic Solvent sinciphisa ukuphazamiseka kweemolekyuli zamanzi kwi-HPMC, ngaloo ndlela kunyusa ukubonakala kwesisombululo. Kwimisebenzi ethile, kuyimfuneko ukukhetha iinyibilikisi ezifanelekileyo ngokwesicelo.
5. Sebenzisa izixhobo zokubambisa
Ngamanye amaxesha, ezinye izinto ezibalekayo zinokongezwa kwi-HPMC yokufezekisa iziphumo zokwanda kwe-viscosity. I-AIDS isetyenziswayo esetyenziswayo isetyenziswa i-XANAHHY GUM, i-Guar Gum, iCarbomer, njl njl. Ezi zinto zongezwa kwi-gemc molesments ye-HPMC okanye ukwandisa ukumiswa kwesisombululo. Umzekelo, i-chantanhan gum yi-Polysacchaaki yeNdalo enefuthe eliqaqambileyo. Xa isetyenziswa nge-HPMC, ezi zinto zimbini zinokwenza isiphumo esilinganayo kwaye sonyusa kakhulu i-viscofity yenkqubo.
6. Guqula inqanaba lokufakwa endaweni ye-HPMC
I-viscosity ye-HPMC ikwanxulumene nenqanaba lokufakwa endaweni yendlela yayo ye-fhydroxypropoxy. Inqanaba lokufaka ichaphazela ukwahlukana kwalo kunye nohlobo lwesisombululo. Ngokukhetha i-HPMC ngamanqanaba ahlukeneyo okufaka endaweni, uVekyusi wesisombululo unokuhlengahlengiswa. Ukuba i-HPMC ephezulu ye-HPMC iyafuneka, imveliso enomxholo ophezulu onokukhethwa, kuba ukuphakama komxholo wendlela, ukomelela kwe-hpmcro fition ye-HPMC, kunye nohlobo lwe-viscofity emva kokupheliswa kuphezulu.
7. Yandisa ixesha lokuchithwa
Ixesha apho i-HPMC i-HPMC iyakwazi ukuchaphazela i-viscofity yayo. Ukuba i-HPMC ayichithi ngokupheleleyo, i-viscosity yesisombululo ayizukufikelela kwimeko efanelekileyo. Ke ngoko, ukwandisa ngokufanelekileyo ixesha lokuchithwa kwe-HPMC emanzini ukuqinisekisa ukuba i-HPMC i-hpmc i-hydd) i-hyddy inokuthi inyuse i-viscomosity yesisombululo. Ingakumbi xa inyibilikisiwe kumaqondo obushushu asezantsi, inkqubo yokutya kwe-HPMC inokucotha, kwaye yandise ixesha kubalulekile.
8. Guqula iimeko zeShear
Uhlobo lwe-HPMC luhambelana neShericar Prece ifakwe ngexesha lokusetyenziswa. Phantsi kweemeko zeHerical Shear, i-viscosity yesisombululo se-HPMC iya kuncipha okwethutyana, kodwa xa i-shear ima, i-vickosity iya kuphila. Kwiinkqubo ezifuna i-viscofity eyandiswayo, amandla eShear apho isisombululo siphantsi sinokuncitshiswa, okanye sinokusebenza phantsi kweemeko zonxweme ezisezantsi ukugcina i-viscofity ephezulu.
9. Khetha ubunzima bemolekyuli elungileyo
Ubunzima bemolekyuli ye-HPMC buchaphazela ngokuthe ngqo i-viscofity yayo. I-HPMC enemozulu enkulu yemolekyuli yenze umsebenzi omkhulu wenethiwekhi kwisisombululo, okukhokelela kwi-viscofity ephezulu. Ukuba ufuna ukwandisa i-HPMC, unokukhetha iimveliso ze-HPMC kunye nobunzima obuphezulu bemolekyuli. Nangona i-HPMC 15 CPs yimveliso ye-viscofity ye-viscosity, i-viscosity inokonyuswa ngokukhetha i-molecular ephezulu yemoyari eyahlukileyo kwimveliso efanayo.
10. Cinga ngezinto zokusingqongileyo
Izinto zokusingqongileyo ezinje ngokufudumala kunye noxinzelelo zinokuba nefuthe elithile kuhlobo lwe-HPMC. Kwimeko ephezulu yokufuma, i-HPMC inokufumana umswakama emoyeni, ibangela ukuba kumiliselwe. Ukuthintela oku, iimeko zokusingqongileyo zemveliso okanye indawo yokusebenzisa inokulawulwa ngokufanelekileyo ukugcina indalo yome kwaye kuxinzelelo olufanelekileyo lokugcina i-viscofity yesisombululo se-HPMC.
Zininzi iindlela zokwandisa i-HPMC ye-HPMC 15 CPS, kubandakanya ukwanda kwengxilongo, ukulawula i-PH, kusetyenziswa isilinganiselo se-PH, sikhetha isilinganiselo esifanelekileyo, i-molecular ubunzima obuthile kuxhomekeke kwimo yesicelo kunye neemfuno zenkqubo. Ngokwenene, kuhlala kuyimfuneko ukuqwalasela izinto ezininzi kwaye wenze uhlengahlengiso olusengqiqweni kunye nethemba lokuqinisekisa ukusebenza kakuhle kwesisombululo se-HPMC kwizicelo ezithile.
I-Post Time: Oct-16 ukuya ku-2004