Umgangatho weihydroxypropyl methylcellulose (HPMC)inokuvavanywa ngokusebenzisa izikhombisi ezininzi. I-HPMC yi-derivative cellulose esetyenziswa ngokubanzi kumashishini okwakha, amayeza, ukutya kunye nezithambiso, kwaye umgangatho wayo uchaphazela ngokuthe ngqo ukusebenza kwemveliso.
1. Ukubonakala kunye nobukhulu beqhekeza
Ukubonakala kwe-HPMC kufuneka ibe mhlophe okanye i-off-white amorphous powder. Umgangatho ophezulu we-HPMC powder kufuneka ube neengqungquthela ezifanayo, akukho agglomeration, kwaye akukho kungcola kwamanye amazwe. Ubungakanani kunye nokufana kweengqungquthela zichaphazela ukunyibilika kwayo kunye nokusabalalisa. I-HPMC enamasuntswana amakhulu kakhulu okanye adityanisiweyo ayichaphazeli kuphela ukunyibilika, kodwa inokubangela iziphumo zokusasazwa okungalinganiyo kwizicelo zokwenyani. Ngoko ke, ubungakanani bamasuntswana afanayo sisiseko sokuvavanya umgangatho walo.
2. Ukunyibilika kwamanzi kunye nesantya sokuchithwa
Ukunyibilika kwamanzi kwe-HPMC yenye yezalathi zayo ezibalulekileyo zokusebenza. Umgangatho ophezulu we-HPMC unyibilika ngokukhawuleza emanzini, kwaye isisombululo esichithwayo kufuneka sibe sobala kwaye sifane. Uvavanyo lokunyibilika kwamanzi lunokugwetywa ngokongeza umlinganiselo othile we-HPMC emanzini kunye nokujonga ukuba inganyibilika ngokukhawuleza kwaye yenze isisombululo esizinzile. Unyiso olucothayo okanye isisombululo esingalinganiyo sinokuthetha ukuba umgangatho wemveliso awuhambelani nomgangatho.
3. Iimpawu zeViscosity
I-viscosity ye-HPMC yenye yeeparamitha ezibalulekileyo zokuvavanya umgangatho wayo. I-viscosity yayo emanzini idla ngokunyuka ngokunyuka kobunzima bayo be-molecular. Indlela eqhelekileyo yovavanyo lwe-viscosity kukusebenzisa i-viscometer ejikelezayo okanye i-viscometer ukulinganisa amaxabiso e-viscosity yezisombululo zokugxilwa okwahlukeneyo. Ngokuqhelekileyo, umgangatho ophezulu we-HPMC kufuneka ube ne-viscosity ezinzileyo, kwaye utshintsho lwe-viscosity kunye nokwanda koxinzelelo kufuneka luhambelane nomgaqo othile. Ukuba i-viscosity ayizinzile okanye ingaphantsi komgangatho oqhelekileyo, kunokuthetha ukuba isakhiwo sayo se-molecular asizinzile okanye siqulethe ukungcola.
4. Umxholo wokufuma
Isiqulatho sokufuma kwi-HPMC siya kuchaphazela nomgangatho wayo. Ukufuma okugqithisileyo kunokubangela ukuba ibumbe okanye yonakale ngexesha lokugcinwa kwayo. Umgangatho wesiqulatho sokufuma kufuneka uqhele ukulawulwa ngaphakathi kwe-5%. Iindlela zovavanyo ezifana nendlela yokomisa okanye indlela yeKarl Fischer inokusetyenziselwa ukumisela isiqulatho sokufuma. Umgangatho ophezulu we-HPMC unomxholo ophantsi wokufuma kwaye uhlala womile kwaye uzinzile.
5. ixabiso le-pH lesisombululo
Ixabiso le-pH lesisombululo se-HPMC lingabonakalisa kwakhona umgangatho walo. Ngokuqhelekileyo, ixabiso le-pH lesisombululo se-HPMC kufuneka libe phakathi kwe-6.5 kunye ne-8.5. Izisombululo ze-acidic ezigqithisileyo okanye ezigqithisiweyo ze-alkaline zingabonisa ukuba imveliso iqulethe amacandelo ekhemikhali angcolileyo okanye iphathwe ngokungafanelekanga ngamachiza ngexesha lenkqubo yokuvelisa. Ngovavanyo lwe-pH, unokuqonda ngokuqonda ukuba umgangatho we-HPMC uyahlangabezana neemfuno.
6. Umxholo wokungcola
Umxholo ongcolileyo we-HPMC uchaphazela ngokuthe ngqo ukusebenza kwayo, ngokukodwa kwintsimi yeyeza kunye nokutya, apho umxholo wokungcola ongafanelekanga unokukhokelela kwiimveliso ezingakhuselekanga okanye iziphumo ezimbi. Ukungcola ngokuqhelekileyo kubandakanya izinto ezingaphendulwanga ezingaphelelanga, ezinye iikhemikhali, okanye ungcoliseko oluveliswe ngexesha lenkqubo yokuvelisa. Umxholo wokungcola kwi-HPMC unokubonwa ngeendlela ezifana ne-high-performance liquid chromatography (HPLC) okanye i-chromatography yegesi (GC). Umgangatho ophezulu we-HPMC kufuneka uqinisekise umxholo ophantsi wokungcola kwaye uhlangabezane nemigangatho efanelekileyo.
7. Ukungafihli kunye nokuzinza kwesisombululo
Ukuhanjiswa kwesisombululo se-HPMC kwakhona sisalathisi somgangatho esisetyenziswa ngokuqhelekileyo. Isisombululo esinokucaca okuphezulu kunye nokuzinza ngokuqhelekileyo kuthetha ukuba i-HPMC inobunyulu obuphezulu kwaye inobumdaka obumbalwa. Isisombululo kufuneka sihlale sicacile kwaye sicacile ngexesha lokugcinwa kwexesha elide, ngaphandle kwemvula okanye i-turbidity. Ukuba isisombululo se-HPMC siyakhawuleza okanye sibe nesiphithiphithi ngexesha logcino, oko kubonisa ukuba sinokuqulatha iinxalenye ezininzi ezingaphendulwanga okanye ukungcola.
8. Ukuzinza kwe-thermal kunye neqondo lokushisa lokubola kwe-thermal
Uvavanyo lokuzinza kwe-thermal ngokuqhelekileyo lwenziwa ngohlalutyo lwe-thermogravimetric (TGA). I-HPMC kufuneka ibe nozinzo olululo lwe-thermal kwaye ingaboli kumaqondo obushushu obuqhelekileyo besicelo. I-HPMC enobushushu obuphantsi bokubola kwe-thermal iya kudibana nokuthotywa kokusebenza kwizicelo zobushushu obuphezulu, ngoko ke uzinzo oluhle lwe-thermal luphawu olubalulekileyo lwe-HPMC ekumgangatho ophezulu.
9. Ukugxininiswa kwesisombululo kunye noxinzelelo lwangaphandle
Uxinzelelo oluphezulu lwesisombululo se-HPMC sinokuchaphazela ukusebenza kwayo kwesicelo, ngakumbi kwiingubo kunye nezinto zokwakha. Umgangatho ophezulu we-HPMC unobunzima obuphantsi komhlaba emva kokuchithwa, okunceda ukuphucula ukuchithwa kwayo kunye nobuninzi kwimidiya eyahlukeneyo. Ukunyanzeliswa kwayo komphezulu kunokuvavanywa ngemitha yoxinzelelo lomphezulu. Isisombululo esifanelekileyo se-HPMC kufuneka sibe noxinzelelo olusezantsi kunye nozinzile.
10. Ukuzinza kunye nokugcinwa
Uzinzo lokugcina lwe-HPMC lunokubonakalisa umgangatho walo. Umgangatho ophezulu we-HPMC kufuneka ikwazi ukugcinwa ngokuzinzileyo ixesha elide ngaphandle kokuwohloka okanye ukuthotywa kokusebenza. Xa uqhuba ukuhlolwa komgangatho, ukuzinza kwayo kunokuvavanywa ngokugcina iisampuli ixesha elide kunye nokuvavanya ukusebenza kwazo rhoqo. Ngokukodwa kwiindawo ezinomswakama ophezulu okanye utshintsho olukhulu lobushushu, i-HPMC ephezulu kufuneka ikwazi ukugcina iipropati ezizinzileyo zomzimba kunye neekhemikhali.
11. Ukuthelekiswa kweziphumo zovavanyo kunye nemigangatho yoshishino
Okokugqibela, enye yezona ndlela zibonakalayo zokumisela umgangatho we-HPMC kukuthelekisa kunye nemigangatho yoshishino. Ngokuxhomekeke kwintsimi yesicelo (njengokwakhiwa, amayeza, ukutya, njl.), Imigangatho yomgangatho we-HPMC iyahluka. Xa ukhetha i-HPMC, ungabhekisa kwimigangatho efanelekileyo kunye neendlela zovavanyo kwaye udibanise iziphumo zovavanyo ukuze ugwebe ngokupheleleyo umgangatho wayo.
Uvandlakanyo lomgangatho weHPMCkufuneka kuthathelwe ingqalelo izinto ezininzi, kubandakanywa inkangeleko, ukunyibilika, i-viscosity, umxholo wokungcola, ixabiso le-pH, umxholo wokufuma, njl njl. Ngoluhlu lweendlela zokuvavanya ezisemgangathweni, umgangatho we-HPMC unokugwetywa ngakumbi nge-intuitive. Ngeemfuno zemimandla eyahlukeneyo yesicelo, ezinye izalathisi ezithile zokusebenza zinokufuna ukuhoywa. Ukukhetha iimveliso ze-HPMC ezihlangabezana nemigangatho efanelekileyo kunokuqinisekisa umgangatho kunye nokuzinza kwemveliso yokugqibela.
Ixesha lokuposa: Dec-19-2024