Umgangatho wehydroxypropyl methylcelculose (hpmc)inokuvavanywa ngeendlela ezininzi. I-HPMC sisisele esisungulwe ngokubanzi kulwakhiwo, amayeza, ukutya kunye nemizi-mveliso ye-cosmetics, kwaye umgangatho wayo uchaphazela ukusebenza kwemveliso.
I-1. Imbonakalo kunye nobukhulu becala
Ukubonakala kwe-HPMC kufuneka ibe mhlophe okanye i-amornis ye-amorphses emhlophe. Umgubo ophezulu we-HPMC kufuneka ube namasuntswana afanayo, akukho ndawo ye-ageGlomeration, kwaye akukho ziphoso zangaphandle. Ubungakanani kunye nokufana kwamasuntswana kuchaphazela ukonakala kwayo kunye nokusasazeka kwayo. I-HPMC ngamasuntswana amakhulu kakhulu okanye anengxaki ayichaphazeli ukuzomelela, kodwa kunokubangela ukusasazeka okungalinganiyo kwizicelo zokwenyani. Ke ngoko, ubukhulu be-iyunifomu sisiseko sokuvavanya umgangatho wayo.
2. Ukuzalwa kwamanzi kunye nexabiso lokuchitha
Ukuzenzela amanzi i-HPMC yenye yeempawu zayo zomsebenzi. I-HPMP ekumgangatho ophezulu ye-HPMC inyibilikisa ngokukhawuleza emanzini, kwaye isisombululo esichithiweyo kufuneka sibonakale kwaye iyunifomu. Uvavanyo lokunyibilisela amanzi lunokugwetywa ngokongeza isixa esithile se-HPMC ukuya emanzini kwaye ujonge ukuba iyakwazi ukunyibilikisa na kwaye yenza isisombululo esizinzileyo. Isisombululo esicothayo okanye isisombululo esingalinganiyo sinokuthetha ukuba umgangatho wemveliso awuhambelani nomgangatho.
I-3. Iimpawu ze-viscosity
I-viscosity ye-HPMC yenye yeeparamitha ezibalulekileyo zokuvavanya umgangatho wayo. Uhlobo lwayo lwamanzi luhlala lunyuka ngokunyuka kobunzima bemolekyuli. Indlela yokuvavanya i-viscosity ye-viscosity kukusebenzisa i-visment yokuhambisa okanye inqaku lokulinganisa amaxabiso okufana kwezisombululo ezahlukeneyo. Ngokubanzi, i-HPMP ekumgangatho ophezulu kufuneka ibe ne-viscofity elizinzileyo, kwaye utshintsho lwe-viscofity ngokuphucula uxinzelelo kufuneka luthobele umgaqo othile. Ukuba i-viscosity ayizinzanga okanye ingezantsi koluhlu oluqhelekileyo, kunokuthetha ukuba indlela yayo yemolekyuli ayizinzanga okanye iqulethe ukungcola.
4. Umxholo wokufuma
Umxholo wokufuma kwi-HPMC uya kuchaphazela nomgangatho wayo. Ukufuma okungaphezulu kunokubangela ukuba ibumbe okanye inyibilikise ngexesha lokugcina. Umgangatho womxholo wokufuma kufuneka ulawulwe ngaphakathi kwe-5%. Iindlela zovavanyo ezinje ngendlela yokomisa okanye indlela ye-Karl ingasetyenziswa ukumisela umxholo wokufuma. I-HPMP ekumgangatho ophezulu ye-HPMC inomxholo wokufuma ophantsi kwaye ihlala yomile kwaye izinzile.
I-5. Ixabiso lesisombululo
Ixabiso le-pH lesisombululo se-HPMC linokubonakalisa umgangatho walo. Ngokubanzi, ukuxabiseka kwe-PH yesisombululo se-HPMC kufuneka kube phakathi kwe-6.5 kunye ne-8.5. Izisombululo ezingaphezulu okanye ezingaphezulu kakhulu zinokubonisa ukuba imveliso iqulethe izinto zekhemikhali eziphilayo okanye zinyathelwe ngokungafanelekanga ngexesha lenkqubo yemveliso. Ngovavanyo lwe-PH, unokuqonda ngengqondo ukuba umgangatho we-HPMC uhlangabezana neemfuno.
I-6. Umxholo ongathandekiyo
Umxholo we-InPMC uchaphazela ngokuthe ngqo ukusebenza kwayo, ngakumbi kwintsimi yamayeza nokutya, apho ukungcikiva umxholo ongafanelekanga kunokukhokelela kwiimveliso ezingakhuselekanga okanye iziphumo ezimbi. Ukungcola kudla kubandakanya izixhobo ezingasasebenziyo ezixhasiweyo, ezinye iikhemikhali, okanye ingcoliseko eziveliswe ngexesha lenkqubo yemveliso. Umxholo we-InPMC unokufunyanwa ngeendlela ezifana ne-chromatography ye-chromatography (i-HPPC) okanye i-chromatography (GC). I-HPMC ephezulu ye-HPMC kufuneka iqinisekise umxholo ophantsi wokungakhathali kwaye ifezekise imigangatho efanelekileyo.
7. Ukungafihlisi kunye nokuzinza kwesicombululo
Ukudluliselwa kwesisombululo se-HPMC sikwisalathisi esiqhelekileyo esemgangathweni. Isisombululo esinobala oluphezulu kunye nokuzinza kudla ngokuthetha ukuba i-HPMC icocekile kwaye inezinto ezimbalwa ezingcolileyo. Isisombululo kufuneka sihlale sicacile kwaye sibonakale ngexesha lokugcina ixesha elide, ngaphandle kokuqina okanye i-turbidity. Ukuba isisombululo se-HPMC sibonisa okanye sibe yi-turbid ngexesha lokugcina, ibonisa ukuba inokuthi iqulethe izinto ezingekho ngqiqweni okanye ukungcola.
8. Uzinzo lwe-thermal kunye neqondo lokugcina i-thermal
Uvavanyo lozinzo lozinzo luhlala lwenziwa ngohlalutyo lwe-thermogramelimpric (i-TGA). I-HPMC kufuneka ibe nokuzinza okufanelekileyo kwe-shirm kwaye akufuneki ibole amaqondo obushushu aqhelekileyo. I-HPMC eneqondo lokungalunganga eliphantsi eliphantsi liya kudibana ne-Deparadotion yentsebenzo kwizicelo eziphezulu zokusetyenziswa kweqondo lokushisa, ukuqina okufanelekileyo kukuqina okufanelekileyo kwe-HPMC ekumgangatho ophezulu we-HPMC.
9. Isisombululo sobunzima kunye noxinzelelo lomphezulu
Uxinzelelo lomphezulu we-HPMC lunokuchaphazela ukusebenza kwalo lesicelo, ngakumbi kwi-cayishini kunye nezinto zokwakha. Umgangatho ophezulu we-HPMC unombhobho womhlaba ophantsi emva kokutya, okunceda ukuphucula ukusasazeka kwayo kunye nolwelo kwimithombo yeendaba ezahlukeneyo. Uxinzelelo lwayo oluphezulu lunokuvavanywa ngumgama ophantsi komhlaba. Isisombululo esifanelekileyo se-HPMC kufuneka sibe noxinzelelo oluphantsi noluzinzileyo.
10. Uzinzo kunye nokugcinwa
Ukugcinwa kokuzinza kwe-HPMC kunokubonakalisa umgangatho wayo. I-HPMC ekumgangatho ophezulu i-HPMC kufuneka ikwazi ukugcinwa ngokutshekiyo ixesha elide ngaphandle kokwesiphako okanye ukonakala kwentsebenzo. Xa uqhuba uhlolo olusemgangathweni, ukuzinza kwalo kungavavanywa ngokugcina iisampulu ixesha elide kwaye uvavanyele ukusebenza rhoqo. Ingakumbi kwiindawo ezinomswakama ophezulu okanye utshintsho lobushushu obukhulu, i-HPMC ekumgangatho ophezulu kufuneka ikwazi ukugcina izibonelelo zomzimba kunye neekhemikhali.
11. Thelekisa iziphumo zovavanyo ezinemigangatho yeshishini
Okokugqibela, enye yeendlela ezinomdla zokuchonga umgangatho we-HPMC kukuthelekisa nemigangatho yeshishini. Kuxhomekeka kwicandelo lesicelo (njengolwakhiwo, amayeza, ukutya, njl.njl), imigangatho esemgangathweni ye-HPMC yahlukile. Xa ukhetha i-HPMC, ungabhekisa kwimigangatho efanelekileyo kunye neendlela zovavanyo kwaye udibanise iziphumo zovavanyo ukuze ugwebe umgangatho wayo.
Uvavanyo lweI-HPMCkufuneka uqwalasele izinto ezininzi, kubandakanya izinto, ukuntywila, umxholo we-pl, umxholo, umnyhadala, umgangatho we-HPMC unokugwetywa ngokungathandabuzekiyo. Ngeemfuno zemimandla eyahlukeneyo yesicelo, ezinye izambatho zomsebenzi ezithile zinokufuneka ziqwalaselwe. Ukukhetha iimveliso ze-HPMC ezihlangabezana nemigangatho efanelekileyo kunokuqinisekisa umgangatho kunye nokuzinza kwemveliso yokugqibela.
IXESHA LOKUQALA: I-DEC-19 ukuya ku-2004