Iimpawu zeHPMC kunye nemisebenzi

I-Hydroxypropyl methylcellulose (HPMC) i-polymer esebenzayo kunye nezicelo ezibanzi kumashishini ahlukeneyo afana namayeza, ukwakhiwa, ukutya, izithambiso, njl. Nalu uphononongo olunzulu lwe-HPMC:

1. Iimpawu ze-HPMC:

Ulwakhiwo lweMichiza: I-HPMC ithathwe kwi-cellulose, ipholima yendalo efumaneka kwizityalo. Idityaniswe ngokuguqula iikhemikhali zeselulosi ngepropylene oxide kunye nemethyl chloride. Iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methoxy amisela iimpawu zayo.

Ukunyibilika: I-HPMC iyanyibilika emanzini kuluhlu olubanzi lobushushu. Ukunyibilika kuxhomekeke kwinqanaba lokutshintshwa kunye nobunzima bemolekyuli yepolymer. Amanqanaba aphezulu okutshintsha akhokelela ekwandeni kokunyibilika kwamanzi.

I-Viscosity: I-HPMC ibonisa ukuziphatha kwe-pseudoplastic okanye i-shear-thinning, oku kuthetha ukuba i-viscosity yayo iyancipha phantsi koxinzelelo lwe-shear. I-viscosity yezisombululo ze-HPMC zinokuhlengahlengiswa ngokulungelelanisa iiparamitha ezifana nobunzima bemolekyuli, iqondo lokutshintshwa, kunye nokugxininiswa.

Ukwenziwa kweFilimu: I-HPMC yenza iifilimu ezicacileyo neziguquguqukayo xa zifakwe kwisisombululo. Iimpawu zefilimu zinokuguqulwa ngokulungelelanisa ukugxininiswa kwepolymer kunye nobukho beplastiki.

Uzinzo lwe-Thermal: I-HPMC inozinzo oluhle lwe-thermal, kunye namaqondo okushisa okubola ahlala engaphezulu kwe-200 ° C. Oku kuyenza ilungele iindlela ezahlukeneyo zokusetyenzwa, kubandakanya i-extrusion eshushu yokunyibilika kunye nokubumba inaliti.

I-Hydrophilicity: Ngenxa yobume bayo be-hydrophilic, i-HPMC inokufunxa kwaye igcine isixa esikhulu samanzi. Le propati inenzuzo kwizicelo ezifana nokuhanjiswa kweziyobisi ezilawulwayo kunye ne-agent eqina kwiinkqubo ezinamanzi.

Ukuhambelana: I-HPMC iyahambelana nezinye izinto ezahlukeneyo, kubandakanywa nezinye iipolymers, iiplastiki, kunye nezithako ezisebenzayo zamachiza (APIs). Oku kuhambelana kuvumela iinkqubo ezintsonkothileyo ukuba ziqulunqwe kunye neempawu ezilungiselelwe.

IiPropati ezingezizo i-ionic: I-HPMC yipolymer engeyiyo ionic, oku kuthetha ukuba ayithwali nayiphi na intlawulo yombane. Le propati inciphisa intsebenziswano kunye neentlobo ezihlawuliswayo ekuqulunqweni kwaye ikhulise ukuzinza kwayo kwisisombululo.

2.HPMC imisebenzi:

Izibophelelo: Kwimiqulu yethebhulethi, i-HPMC isebenza njenge-binder, ikhuthaza ukunamathela phakathi kwamaqhekeza kunye nokwandisa amandla omatshini wethebhulethi. Kwakhona kunceda iipilisi ukuba ziqhekeke emva kokungena.

I-Film Coating: I-HPMC isetyenziswa ngokubanzi njenge-ejenti yokugquma ifilimu kwiipilisi kunye nee-capsules. Yenza i-uniform, i-coating ekhuselayo efihla incasa kunye nevumba lechiza, iphakamisa uzinzo, kwaye iququzelele ukuginya.

Ukukhululwa okuzinzileyo: I-HPMC ingasetyenziselwa ukulawula izinga lokukhululwa kwamachiza kwiifom zedosi yonyango. Ngokufaka amanzi ukwenza umaleko wejeli, i-HPMC inokulibazisa ukukhutshwa kweziyobisi kwaye ibonelele ngeziphumo zonyango ezizinzileyo.

I-Viscosity Modifier: Kwiinkqubo zamanzi, i-HPMC isebenza njenge-viscosity modifier okanye i-thickener. Inika ukuziphatha kokuhamba kwe-pseudoplastic, ukuphucula ukuzinza kunye nokusebenza kwesicelo sokuqulunqwa njengama-creams, i-lotions kunye neegels.

I-arhente yokumisa: I-HPMC isetyenziselwa ukuzinzisa ukumiswa kwamasuntswana anganyibilikiyo kulwelo. Ikhusela ukuhlalisa ngokunyusa i-viscosity yesigaba esiqhubekayo kunye nokuphucula i-particle dispersion.

I-Emulsifier: Ekuqulunqweni kwe-emulsion, i-HPMC izinzisa i-interface phakathi kwezigaba zeoli kunye namanzi, ukuthintela ukuhlukana kwesigaba kunye ne-emulsification. Iphucula uzinzo kunye nobomi beshelufu yeloshini kwiimveliso ezifana nekhrimu, i-ointments kunye neloshini.

Ukubunjwa kweHydrogel: I-HPMC inokwenza ii-hydrogels xa ifakwe emanzini, iyenza ibe luncedo ekubopheni amanxeba, iilensi zoqhagamshelwano, kunye neenkqubo zokuhanjiswa kweziyobisi. Ezi hydrogels zibonelela ngemekobume efumileyo yokuphulukisa isilonda kwaye zinokulayishwa ngamachiza okuhanjiswa kwendawo.

I-Agent etyebisayo: I-HPMC iqhele ukusetyenziswa njenge-arhente yokutyebisa kwiimveliso zokutya ezifana neesosi, izinxibo kunye nezimuncumuncu. Inika ukuthungwa okugudileyo kwaye yongeza incasa ngaphandle kokuguqula incasa okanye umxholo wesondlo.

Izongezo zokwakha: Kushishino lokwakha, i-HPMC isetyenziswa njenge-arhente yokugcina amanzi kwi-samente-based mortars kunye ne-plasters. Iphucula ukusebenza, ukunamathela, kunye nokunciphisa ukuqhekeka ngokucotha ukuvela kwamanzi.

Isilungisi soMphezulu: I-HPMC inokuguqula iipropathi zomphezulu we substrates eziqinileyo ezifana nephepha, amalaphu kunye neeseramikhi. Iphucula ukuprintwa, ukunamathela kunye neempawu zokuthintelwa kweengubo kunye neefilimu.

IHydroxypropylmethylcellulose (HPMC) yipolymer eguquguqukayo eneempawu ezahlukeneyo kunye nemisebenzi. Ukunyibilika kwayo, i-viscosity, isakhono sokwenza ifilim kunye nokuhambelana kwayo kuyenza ibe sisithako esibaluleke kakhulu kwizicelo ezininzi kuwo wonke amashishini. Ukusuka kumayeza ukuya kulwakhiwo, ukutya ukuya kwizinto zokuthambisa, i-HPMC iyaqhubeka nokudlala indima ebalulekileyo ekuphuculeni ukusebenza kwemveliso kunye nomgangatho. Njengoko uphando kunye nobuchwephesha buhambela phambili, ukuguquguquka kunye nokusetyenziswa kwe-HPMC kunokwandisa ngakumbi, ukuqhuba ukuqalwa kokuyila koyilo kunye nophuhliso lwemveliso.