I-HPMC Solubity

I-HydroxyPOpyl Methyl Selelose (i-HPMC), ekwabizwa ngokuba yi-Hyprelllose, ibonise iimpawu zomhlaba ezixhomekeke kwinqanaba layo lokufaka endaweni, kunye neemeko ezisetyenziswayo. Ngokubanzi, i-HPMC inyibilikiswa yamanzi, eyinto ephambili ebangela ukuba ibe negalelo kwizicelo ezahlukeneyo. Nangona kunjalo, ukuluka kunokuchukunyiswa zizinto ezinjengoxinzelelo kunye nobushushu. Nazi ezinye izikhokelo ngokubanzi:

1. I-Solity yaManzi:
   • I-HPMC inyibilikiswa emanzini, yenze izisombululo ezicacileyo nezicacileyo. Esi sonyi sivumela ukubandakanywa ngokulula kwiziko elinamanzi anjengeeglasi, iikhrim, kunye neengubo.
2. Ukuxhomekeka kubushushu:
   • Ukunyibilika kwe-HPMC emanzini kunokubangelwa bubushushu. Amaqondo obushushu aphezulu anyusa uninzi lomoya, kwaye izisombululo ze-HPMC zinokuba yi-vikous kumaqondo obushushu aphakamileyo.
3. Iziphumo zoxinzelelo:
   • I-HPMC ihlala inyibilika emanzini ngendlela ephantsi. Nangona kunjalo, njengoko uxinzelelo luyenyuka, uVekyusi wesisombululo uyanda. Olu nxibelelwano luxhomekeke kugxilwe luxhomekeke kwizicelo ezahlukeneyo, kubandakanya nolawulo lweepropathi ze-ROOOOOOOCTERPRTERORKICATIONs kunye nezixhobo zokwakha.
4. Imvakalelo ye-PH:
   • Ngelixa i-HPMC ihlala izinzile ngaphezulu kwe-PH ye-PH, okanye iphantsi kakhulu okanye ixabiseke kakhulu okanye i-EPHE ichaphazele ukubenzela i-smoubiolity kunye nokusebenza kwayo. Iqhelekile isetyenziselwa ukwenza ifomu kunye ne-PH Uluhlu lwe-3 ukuya kwi-11.
5. Amandla e-Ionic:
   • Ubukho bee-ions kwisisombululo kunokuba nefuthe ku-slobing ye-HPMC. Ngamanye amaxesha, ukongezwa kweetyiwa okanye ezinye ii-ION zinokuba nefuthe ekuhambeni kwezisombululo ze-HPMC.

Kubalulekile ukuba uqaphele ukuba iBakala elithile kunye nohlobo lwe-HPMC, kunye nesicelo esicetywayo, sinokuchaphazela iimpawu zayo zomelele. Abavelisi bahlala benikezela ngesikhokelo kunye neenkcazo zokuzenzela izilwanyana zeemveliso zabo ze-HPMP ngokusekwe kwezi zinto.

Ngolwazi oluchanekileyo malunga nokubelelwa kwinqanaba elithile le-HPMC kwisicelo esithile, kuyacetyiswa ukuba kuhlolwe iphepha ledatha lemveliso yobugcisa okanye ukunxibelelana nomvelisi wolwazi oluneenkcukacha.