IHydroxypropyl methylcellulose (HPMC)isetyenziswa njengenye yezona zinto zinceda amayeza ekhaya naphesheya. I-HPMC ingasetyenziswa njenge-ejenti yokwenza ifilimu, i-adhesive, i-ejenti yokukhululwa eqhubekayo, i-arhente yokunqunyanyiswa, i-emulsifier, i-agent ehlukanisayo, njl.
Abancedisi bamachiza bayingxenye ebalulekileyo yamalungiselelo amayeza, kwaye indima yabo kukuqinisekisa ukuba izidakamizwa zihanjiswa ngokukhethiweyo kwiiscuphe ngendlela ethile kunye nenkqubo, ukwenzela ukuba izidakamizwa zikhutshwe emzimbeni ngesantya esithile kunye nexesha. Ngoko ke, ukukhethwa kwabancedisi abafanelekileyo ngenye yezinto eziphambili kwimpembelelo yonyango yamalungiselelo amayeza.
Iipropati ezi-1 ze-HPMC
I-HPMC ineempawu ezininzi ezinye ii-excipients ezingenazo. Inonyibiliko olugqwesileyo lwamanzi kumanzi abandayo. Ngethuba nje ifakwe emanzini abandayo kwaye ixutywe kancinane, inokunyibilika kwisisombululo esicacileyo. Ngokuchasene noko, ayinyibiliki kumanzi ashushu ngaphezulu kwe-60E kwaye inokunyibilika kuphela. Ngaba i-ether ye-cellulose engekho i-ionic, isisombululo sayo asinayo i-ionic intlawulo, kunye neetyuwa zetsimbi okanye i-ionic organic compounds, ukwenzela ukuba kuqinisekiswe ukuba i-HPMC ayifuni kunye nezinye izinto eziluhlaza kwinkqubo yokuvelisa imveliso. Ngokuchasene ne-anti-sensitivity enamandla, kunye nokwanda kwesakhiwo se-molecular of the degree of substitution, anti-sensitivity nayo iphuculwe, isebenzisa i-HPMC njengeziyobisi ezincedisayo, ngokumalunga nokusetyenziswa kwamanye ama-adjuvants endabuko (isitashi, i-dextrin, i-powder powder) iziyobisi, umgangatho wexesha elisebenzayo uzinzile ngakumbi. Ine-inertia ye-metabolic. Njengezinto ezincedisayo zamachiza, ayinakuxutywa okanye ifakwe, ngoko ayiboneleli ngeekhalori kwiyeza kunye nokutya. Inokusebenza okuyingqayizivele kwixabiso eliphantsi le-calorific, iyeza elingenatyuwa kunye ne-non-allergenic kunye nokutya okufunwa ngabantu abanesifo sikashukela. I-HPMC izinzile ngakumbi kwi-asidi kunye ne-alkali, kodwa ukuba idlula i-pH2 ~ 11 kwaye ixhomekeke kwiqondo lokushisa eliphezulu okanye ixesha lokugcina lide, i-viscosity iya kuncitshiswa. Isisombululo esinamanzi sibonelela ngomsebenzi ongaphezulu kwaye sibonisa ukuxinana komphezulu ophakathi kunye namaxabiso oxinzelelo phakathi kobuso. Ine-emulsification esebenzayo kwinkqubo yesigaba sesibini kwaye ingasetyenziswa njenge-stabilizer esebenzayo kunye ne-colloid ekhuselayo. Isisombululo se-Aqueous sineempawu ezibalaseleyo zokwenza ifilimu kwaye yinto efanelekileyo yokugqoka iipilisi kunye neepilisi. Ifilimu eyenziwe yiyo ayinambala kwaye inzima. Iplastiki yayo inokwandiswa ngokudibanisa i-glycerol.
2.Ukusetyenziswa kwe-HPMC kwimveliso yethebhulethi
2.1 Ukuphucula ukupheliswa
Ukusebenzisa isisombululo se-ethanol se-HPMC okanye isisombululo samanzi njenge-arhente yokumanzisa i-granulation, ekuphuculeni ukuchithwa kwamacwecwe, umphumo uyamangalisa, kwaye ucinezelekile kwifilimu yobulukhuni bungcono, imbonakalo egudileyo. Ukunyibilika kwethebhulethi yeRenimodipine: ukunyibilika kwe-adhesive kwaba yi-17.34% kunye ne-28.84% xa i-adhesive yi-40% ethanol, 5% ye-polyvinylpyrrolidone (40%) isisombululo se-ethanol, i-1% ye-sodium dodecyl sulfate (40%) isisombululo se-ethanol kwi-MC I-10% ye-starch pulp, i-3% ye-HPMC isisombululo, 5% HPMC isisombululo, ngokulandelanayo. 30.84%, 75.46%, 84.5%, 88%. Izinga lokuchithwa kweepilisi ze-piperic acid: xa i-adhesive yi-12% ethanol, 1% HPMC (40%) isisombululo se-ethanol, 2% HPMC (40%) isisombululo se-ethanol, 3% HPMC (40%) isisombululo se-ethanol, izinga lokuchithwa yi-80.94% , 86.23%, 90.45%, 99.88%, ngokulandelanayo. Izinga lokuchithwa kweepilisi ze-Cimetidine: xa i-adhesive yi-10% ye-starch slurry kunye ne-3% ye-HPMC (40%) isisombululo se-ethanol, izinga lokuchithwa laliyi-76.2% kunye ne-97.54%, ngokulandelanayo.
Ukususela kule datha ingentla, kunokubonwa ukuba isisombululo se-ethanol kunye nesisombululo se-aqueous se-HPMC sinesiphumo sokuphucula ukuchithwa kwamachiza, eyona nto isiphumo sokumiswa kunye nomsebenzi womphezulu we-HPMC, ukunciphisa ukuxinana komphezulu phakathi kwesisombululo kunye iziyobisi eziqinileyo, ukwandisa ukufuma, okulungele ukuchithwa kweziyobisi.
2.2 Ukuphucula umgangatho wokugquma
I-HPMC njengento yokwenza ifilimu, xa kuthelekiswa nezinye izinto zokwenza ifilimu (i-acrylic resin, i-polyethylene pyrrolidone), inzuzo enkulu kukunyibilika kwayo kwamanzi, ayifuni i-solvents eziphilayo, ukusebenza ngokukhuselekileyo, kulungele. KwayeHPMCineentlobo ngeentlobo zenkcazo ye-viscosity, ukhetho olufanelekileyo, umgangatho wefilimu yokugqoka, imbonakalo ingcono kunezinye izinto. Iipilisi zeCiprofloxacin hydrochloride ziipilisi ezimhlophe ezingenanto ezinombhalo omacala amabini. Ezi pilisi zokugquma ifilimu ebhityileyo kunzima, ngovavanyo, khetha i-viscosity ye-50 mpa # s ye-plasticizer enyibilikayo yamanzi, inokunciphisa uxinzelelo lwangaphakathi lwefilimu ebhityileyo, i-tablet yokwambathisa ngaphandle kwebhulorho / ukubila 0, 0, 0, 0 / i-orenji. i-oyile / i-oyile yokungena, i-0 / i-crack, njengengxaki yomgangatho, ukugquma ifilimu yolwelo, ukunamathela okulungileyo, kunye nokuzisa umda wamagama ngaphandle kokuvuza, kuyafundeka, enye - icala eqaqambileyo, mhle. Xa kuthelekiswa nolwelo lokutyabeka lwemveli, lo myalelo ulula kwaye unengqiqo, kwaye iindleko ziyancipha kakhulu.
Ixesha lokuposa: Apr-25-2024