Kwityala kunye nemveliso yobuninzi yeetafile ze-nifdipine ezigcinakeleyo, iitafile zokuthintela inzala, iitafile zesisu, iitafile ze-fimaring, i-Buflomelil hydrochloride, njl., Sisebenzisahydroxypropyl methylcelculose (hpmc)Ulwelo, i-HydroxyPOpyl Methylcelcelgalose i-Acid Acid i-Alid Acid i-Alid, Ogodry (ebonelelwe nge-film ehlekisayo, kodwa ihlangane ngempumelelo itekhnoloji yokuthobela i-theyibhile yokuthobela, kodwa idibene neengxaki kwimveliso yelingo kunye nemveliso. Emva kweengxaki ezithile zobugcisa, ngoku sinxibelelana noogxa bethu malunga neengxaki kunye nezisombululo kwifilimu yefilimu.
Kwiminyaka yakutshanje, itekhnoloji yokuthobela ifilimu isetyenziswe ngokubanzi kumalungiselelo aqinileyo. Ukudibana kwefilimu kunokukhusela ichiza ukusuka ekukhanyiseni, ukufuma nomoya ukonyusa uzinzo lwechiza; Imaski yokuncancisa ichiza kunye nokwenza isigulana ukuba siyithathe; lawula indawo yokukhutshwa kunye nokukhupha isantya sechiza; thintela ukutshintsha kwechiza; phucula imbonakalo yecwecwe lecwecwe. Ikwanazo izibonelelo zeenkqubo ezimbalwa, ixesha elifutshane, ukusetyenziswa kwamandla asezantsi, kunye nokufumana ubunzima obuncinci. Umgangatho weetafile ezidityanisiweyo zefilimu ikakhulu ixhomekeke kubume kunye nomgangatho wecwecweli, iyeza lokusebenza kwetafile, ukuqulunqwa kweemeko zokugcina itafile kwaye ibonakalisiwe kakhulu Kwizithako ezisebenzayo zecwecwe lecwecwe, oonontlalontle abahlukeneyo kunye nembonakalo, ubukhali, amaqhekeza obukhulu, kunye nobume betafile. Ukuqulunqwa kolwelo oluhlekisayo kuhlala kunamatye aphezulu e-molerm, iiplasitizeli, iidayisi, izinyibilikisi, njl njl., Njl njl., Njl njl.
I-1.Asion-e-abrashion, umda wefilimu kunye nokuthambisa
Ubunzima bomphezulu wecwecwe kwithebhulethi yeyona nto iphambili, kwaye iphantsi kakhulu ngexesha lenkqubo yokuhlambela, kunye nomgubo oma kwicala elinye okanye amasuntsu aphantsi, kubangela ukuba Ithebhulethi yecwecwe, enxibe i-ofisi yecala elinye, ngakumbi ngefilimu ephawulweyo. Eyona ndawo iphantsi kwefilimu kwithebhulethi enefilimu yingqolowa. Xa i-adhesion okanye amandla efilimu ayonelanga, ukuqhekeza kwaye ukhangelo lwemiphetho yefilimu kunokwenzeka. Oku kungenxa yokuba ukuziqengqeleka kwesinyibilikisi kubangela ukuba ifilimu inyibilike, kunye nokwanda kwefilimu ethandekayo kunye ne-core yonyusa uxinzelelo lwangaphakathi lwefilimu, edlula ifilimu yefilimu.
1.1 Uhlalutyo lwezizathu eziphambili
Ngokubhekisele kwi-chip core, esona sizathu siphambili kukuba umgangatho we-chip core ayilunganga, kwaye ubulukhuni kunye nobuchule buncinci. Ngexesha lenkqubo yokuthuthuzela, icwecwe lecwecwe lifakwe kuxinzelelo olunamandla xa iqengqeleka kwipani yokuhlambela, kwaye kunzima ukumelana nomkhosi onjalo ngaphandle kobunzima obaneleyo, obunokulungiselela. Xa sipakishwe iitafile ze-nifdipine, ngenxa yobunzima obuncinci becwecwe, umgubo wabonakala kwicala elinye, olukhokelela kwiipores, kwaye ifilimu yethebhulethi enamatheko yayingagungqi kwaye yayingabonakali kakubi. Ukongeza, le ntshukumo inesiphene ikwanxulumene nohlobo lwetafile. Ukuba ifilimu ayifaneleki, ngakumbi ukuba ifilimu inelogo kwi-crown, inotyekelo ngakumbi ekunxibelwalweni.
Kwintsebenzo yokukhuphela, isantya esicothayo kakhulu kunye neqondo elikhulu le-Inset Orlet okanye i-Inch Light Soight iya kukhokelela kwisantya esikhawulezayo, ixesha elisezantsi lefilimu, ixesha elide lokuthetha Okwesibini, uxinzelelo lwe-atomif lube lukhulu, i-viscosity yolwelo oluhlekisayo iphantsi, amathontsi kwiziko elithile leatomizy agxilwe, kwaye i-Soming iguqulelayo emva koxinzelelo lwangaphakathi; Kwangelo xesha, ukungqubana phakathi kwendawo enamacala elinye nayo kukhulisa uxinzelelo lwangaphakathi lwefilimu kwaye ikhawuleze ifilimu. Imiphetho eqhekekileyo.
Ukongeza, ukuba isantya sokujikeleza kwepani yokuphamba sikhawuleza kakhulu okanye ukusetwa kwe-baffle asikho ngqiqweni, amandla angxande kwithebhulethi aya kuba nkulu, kwaye ifilimu iya kuhamba kancinci, nto leyo iya kubangela ukunxiba kwicala elinye.
Ukusuka kulwelo oluhlekisayo, ikakhulu lubangelwa kukhetho lwePolymer ekuqulunqweni nasekufundisweni kwe-viscofity (uxinzelelo) lolwelo oluphantsi (kunye nefilimu ephakathi kwefilimu ehlekisayo kunye nethebhulethi.
1.2 Isisombululo
Inye kukulungelelanisa iyeza okanye inkqubo yemveliso yecwecwe ukuphucula ubunzima betafile. I-HPMC yindawo esetyenziswayo esetyenziswayo. I-Adhesions ye-chendert inxulumene namaqela e-hydroxyl kwiimolekyu ezayo, kwaye amaqela e-hydrogen yenza amaqela e-hydrogen ngamaqela ahambelanayo kwi-HPMCC yokuphelisa i-HPMC ephezulu yokuvelisa i-HPMC ephezulu ye-HPMC yokuvelisa i-HPMC ephezulu yokuvelisa ubumbi bee; Umlinganisi wenziwe buthathaka, kwaye omnye-kwicala kunye nefilimu ehlambileyo ethande ukwahlukana. Inani lamaqela e-hydroxyl kwi-molecular ye-molecular ye-microcrystalline iphezulu, kwaye inamandla amakhulu, kwaye inamacwecwe elungiselelwe iLactose kunye nezinye iiswekile zinemilinganiselo yokunamathela. Ukusetyenziswa kwe-lungisi, ngakumbi i-hydrophogic enje nge-Steric Acid, i-Gonenesis Stearate, i-Glycerl Steate, iya kunciphisa i-hydrogen yesisombululo, esenza ukuba ubiyelwe, Amandla omzimba achuma kancinci. Ngokubanzi, kokukhona isixa se-qubriciernt, kokukhona umlinganisi wenziwe buthathaka. Ukongeza, ekukhetheni uhlobo lwethebhulethi, uhlobo lwetafile yeBiconkex lweBiconzox kufuneka isetyenziswe kangangoko kunokwenzeka ukuba i-cation, enokunciphisa ukuvela kweziphene.
Okwesibini kukuhlengahlengisa amayeza olwelo, unyuse umxholo oqinileyo kwi-flayley yolwelo okanye i-viscosity yolwelo oluhlekisayo, kwaye uphucule ifilimu ehlekisayo, eyindlela elula ukusombulula ingxaki. Ngokubanzi, umxholo oqinileyo kwinkqubo yokuhamba kwe-actarational yi-12%, kwaye umxholo oqinileyo kwiNkqubo yeSholvent Systent yi-5% ukuya kwi-8%.
Umahluko kwi-vickosity ye-viscosity ye-fayiling udaka ichaphazela isantya kunye nesidanga sokungena kolwelo olunomtsalane kwithebhulethi. Xa kuncinci okanye kungabikho mbini, i-adhesion iphantsi kakhulu. Uhlobo lolwelo oluhlekisayo kunye neepropathi zefilimu ehloniphayo zihambelana nobunzima bemolekyuli yemolekyuli kwi-polymer ekuqulunqweni. Ukuphakama komgangatho ophakathi kwemolekyuli, okukhulu kakhulu kwifilimu ehlekisayo, i-elasticastity encinci kunye nokunganyangeki. Umzekelo, okufumaneka i-HPMC ye-HPMC eyahlukeneyo yokhetho lokukhetha ngenxa yomahluko kubunzima obuqhelekileyo bemolekyuli. Ukongeza kwimpembelelo ye-polymer, eyongeza iiplastiki okanye ukwandisa umxholo we-TATC unokunciphisa isimo sefilimu, kodwa ukongezwa kweefilimu zefilimu, ke kufanele kube njalo isetyenziswe ngokumodareyitha.
Okwesithathu, ekwenzeni umsebenzi wokutshutshiswa, kuyimfuneko ukwandisa isantya sokutshiza, ngakumbi xa ukuqeshwa kuqala, isantya sokutshiza kufanele ukuba sikhawuleze, ukuze itafile yetafile igubungele ifilimu yexesha elifutshane, nto leyo Idlala indima yokukhusela itafile ephambili. Ukunyusa umgangatho we-Spray kunokunciphisa iqondo lobushushu bebhedi, inqanaba lokuphuma kwi-levation kunye neqondo lefilimu, ukunciphisa uxinzelelo lwangaphakathi, kwaye kunciphisa imeko yefilimu. Kwangelo xesha, lungisa isantya sokujikeleza kwepani yokuthoba yeyona ndawo ilungileyo, kwaye usete i-baffle kusenokwenzeka ukuba inciphise ukuxabana nokunxiba.
2.adhesion kunye nokufakelwa
Kwinkqubo yokuthobela, xa ukuhlangana konxibelelwano phakathi kwamanqanaba amabini mkhulu kunemikhosi yemolekyuli, amaqhekeza amaninzi (amasuntswana amaninzi) aya kwahlula-hlula. Xa ibhalansi phakathi kokutshiza kunye nokomisa akulunganga, ifilimu imanzi kakhulu, ifilimu iyakunamathela eludongeni lwembiza okanye inamathele kwelinye ifilimu kwindawo yokutsala; Kwisitshizi, xa amacotha awomileyo, amathole angapheliyo aya kuhlala kwifilimu ehlambulukileyo, kukho amaqabu amancinci, enze i-bubble yomanzi, i-biedble ibonakala imibhobho.
2.1 Uhlalutyo lwezizathu eziphambili
Ubungakanani kwaye bubuchule bokuthambeka kwesinambuzane bubangelwa ikakhulu kwiimeko zokusebenza zokusebenza, ukungalingani phakathi kokutshiza kunye nokomisa. Isantya sokutshiza singxama kakhulu okanye ivolumu yerhasi yeatomid inkulu kakhulu. Isantya esomalayo sicotha ngenxa yevolumu ye-moya ephantsi okanye iqondo lokushishina lomoya eliphantsi kunye neqondo lokushisa elisezantsi lebhedi. Iphepha alikho tuers olwenziwe ngexesha kunye namabi okanye iibhubhu zesenzeka. Ukongeza, ngenxa ye-angle engalunganga okanye umgama, ikhonkco lenziwe ngesitshizi lincinci, kwaye ulwelo olunamanzi lugxile kwindawo ethile, kukhokelela ekubeni. Kukho imbiza ehamba kancinci, amandla e-Centrifugal incinci kakhulu, ukuntywila kwefilimu akulunganga kuya kuvelisa kwakhona.
Ukuphatha i-fetrosity yolwelo kuyinto enkulu kakhulu, ikwayenye yezizathu. I-viscosity yempahla yokunxiba inkulu, kulula ukwenza i-rog enkulu yehla, amandla ayo okungena esitratweni alinaxesha elinye, kwangaxeshanye, ubuninzi befilimu bungalunganga, amaqabunga amaninzi. Kodwa oku akunampembelelo kakhulu kumanye amanyeneyo.
Ukongeza, udidi lwefilimu engalunganga luya kubonakala ngathi lubethelela. Ukuba ifilimu ethe tyaba kwindawo yokuhamba iqengqeleka ayilunganga, iya kuba ngaphezulu, kulula ukuba ibangele ifilimu ephindwe kabini okanye yefilimu eninzi. Kwimveliso yethu yokuvavanywa kweetafile ze-hydrochlorider, uninzi lwamaqhekeza olugqithisileyo luvele kwi-chestnuts enamanzi ahlukeneyo okuba nokuhla kwentloko.
2.2 Izisombululo
Kuyinto enokuhlengahlengisa isitshizi kunye nesantya esomileyo sokufezekisa ibhalansi eguqukayo. Ukucutha isantya sokutshiza, ukunyusa ivolumu yomoya kunye neqondo lobushushu lomoya, ukunyusa ubushushu bebhedi kunye nesantya esomileyo. Ukonyusa indawo yokugubungela yokutshiza, ukunciphisa ubungakanani be-suricle ye-screples okanye uhlengahlengise umgama phakathi kompu kunye nendawo yokulala ye-ferheen, ukuze isithuba somgama sinciphisa umgama phakathi kwe-Spray kunye neBhodi.
Hlengahlengisa isisombululo sokudibanisa isisombululo, ukwandisa umxholo wesisombululo esiqinileyo kwisisombululo esikhawulezayo, ukunciphisa isixa sesolvent okanye ukonyusa ukugxininiswa kwe-ethanol ngokufanelekileyo kuluhlu lwe-vikosity; Ukuhlaselwa okuchasene nokongezwa ngokufanelekileyo, njenge-talcum powder, i-magnesium stearate, i-silica gel powder okanye i-oxide peptder. Inokuphucula ngokufanelekileyo isantya sembiza yokuthuka, yonyusa amandla e-centrifugal yebhedi.
Khetha iphepha elifanelekileyo lokudibana. Nangona kunjalo, kwimakhishithi ethe tyaba, enjengeetafile ze-typlomeric ye-hydrochloride, ukungqubana kwaqhutywa ngempumelelo emva koko usebenzisa i-pan yokuthoba i-piff okanye ngokufaka i-vaffle kwipani yokukhuthaza iphepha.
3.USondle-kwicala elinamacala aphezulu kunye nolusu olucekeceke
Kwinkqubo yokuthoba, kuba i-rayid ulwelo alusasazeki, ipolymer eyomileyo ayisasazwanga, i-pollredition engaqhelekanga okanye i-adhedhenter okanye i-adhesion engaphezulu kwefilimu, ekhokelela kumbala ongalinganiyo kunye nombala ongalinganiyo. Ulusu olucekeceke luhlobo lomgangatho oqinileyo, lubonakale kakhulu ukubonisa.
3.1 Uhlalutyo lwezizathu eziphambili
Eyokuqala inxulumene ne-Chip Core. Ukuphakathi komphezulu womhlaba wokuqala we-core, kukhuselo olukhulu lwemveliso edityanisiweyo.
Okwesibini, inolwalamano olukhulu kunye nonyango lwesisombululo esihlekisayo. Kuyakholelwa ngokubanzi ukuba ubunzima bemolekyuli, uxinzelelo kunye nokongezwa kwePolymer kwiSisombululo sokuCoca kunxulumene nobunzima befilimu. Benza ngokuchaphazela i-viscofity yesisombululo esihlekisayo, kwaye uburharha bokudibana kwefilimu kuqwentwa ngohlobo lwesisombululo esihlekisayo, ukwanda kokunyuka kwe-vickosity. Eyona nto ininzi kakhulu kwisisombululo sokukhathalela inokubangela lula ukubambisa ngamehlo.
Okokugqibela, inxulumene nentsebenziswano. Isantya se-atomisid siphantsi kakhulu okanye siphezulu kakhulu (isiphumo se-atomisis ayilunganga), engakhange inganele ukusasaza inkungu kwaye ibeke ulusu olunamacala odwa. Kwaye ivolumu egqithisileyo yomoya owomileyo (umoya ophumeleleyo kakhulu) okanye ubushushu obukhulu, iqondo lokuphuma ngokukhawuleza, ngakumbi ukuhamba komoya, kuphelisa i-Eddy Oppes, yenza ukuba isantya se-roddy asilungile.
3.2 Izisombululo
Eyokuqala kukuphucula umgangatho we-core. Kwindawo yokuqinisekisa umgangatho wezinto ezisisiseko, hlengahlengisa isisombululo sokucoca isisombululo kwaye unciphise i-viscofity (uxinzelelo) okanye umxholo oqinileyo wesisombululo sokuqaqamba. Isisombululo esinyibilikayo sotywala okanye isisombululo sokukhathalela amanzi esi-2 sinokukhethwa. Emva koko lungisa iimeko zokusebenza, phucula ngokufanelekileyo isantya sembiza yokuthuka, yenza ifilimu irola ngokulinganayo, yenyusa ukuxabana, ukukhuthaza ukusasazeka kolwelo oluhlambileyo. Ukuba amaqondo obushushu ebhedi aphezulu, nciphisa ivolumu yokuthathwa kwenkunkuma kunye nokuthatha iqondo lobushushu lomoya. Ukuba kukho izizathu zokutshiza, uxinzelelo lwe-atomizetion kufuneka lunyuswe ukukhawulezisa isantya se-SPRAY, kwaye i-Atomitizetion Deed kunye ne-SPRAY KUNYE NOKUGQIBELA I-SPG kufuneka iphuculwe ukwenza i-FOG yehla kwi-titness emqolo I-avareji ye-avareyiti kwaye ikhusele ukuvela kwenkungu enkulu yehla, ingakumbi ekuphathweni kolwelo olukhulu. Umgama phakathi kompu wokutshiza kunye nephepha lokulala linokuhlengahlengiswa. I-Spray umpu ene-nozzle ye-nozzlere (015 mm ~ 1.2 mm) kunye nenqanaba lokuqala lokuhamba kwe-atoming likhethiwe. Imilo yokutshiza ihlengahlengiswa kuluhlu olubanzi lwe-cone ye-cone ye-cone ye-cone, ukuze amasele asasazeke kwindawo enkulu.
4. Chaza ibhulorho
4.1 Uhlalutyo lwezizathu eziphambili
Oku kwenzeka xa umphezulu wefilimu uphawulwe okanye uphawulelwe. Ngenxa yokuba impahla ye-membrane ye-membrane ye-ofisi yendlela, efana ne-elaistity ephezulu, amandla efilimu ihlwempu, i-Dells, kwi-Mbrane yomisa umphezulu we-membrane, i-membrane ivele, yenzeka I-notch esecaleni yanyamalala okanye i-logo ayicacanga, izizathu zele phenomeno ilele ekuqeqesheni i-fluid fluid fluid.
4.2 Isisombululo
Lungisa amayeza okubhala. Sebenzisa ii-polymers eziphantsi zemolekyuli okanye izixhobo zokwenza ifilimu eziphezulu; Ukonyusa inani le-solvent, ukunciphisa i-viscosity yesisombululo sokuqaqamba; Yandisa inani lesiqwengana, ukunciphisa uxinzelelo lwangaphakathi. Iziphumo zeplastiki ezahlukeneyo zahlukile, i-Polythylene Glycol 200 ibhetele kune-propylene glycone, i-glyrin. Inokunciphisa isantya sokutshiza. Yandisa iqondo lokushisa lomoya, lunyusa ubushushu bephepha ebhedini, ukuze kwenziwe i-caing yomelele, kodwa kukuthintela ukuqhekeka. Ukongeza, kuyilo lokufa okhethiweyo, kufuneka sinikele ingqalelo kububanzi be-engile yokusika kunye namanye amanqaku amahle, kangangoko kunokwenzeka ukuthintela ukwenzeka kweBridge Gunomenon.
5.Ukutya okune-chromatism
5.1 Uhlalutyo lwezizathu eziphambili
Kwizisombululo ezininzi zokukhathalela ukuba kukho ii-pigments okanye ii-Dyees ezinqunyanyisiwe kwisisombululo esikhawulezayo kwaye ngenxa yokuhanjiswa kophawu olungafanelekanga, ukuhanjiswa kombala akuveli phakathi kwamaqhinga okanye kwiindawo ezahlukeneyo zamaqhina. Esona sizathu kukuba isantya sembiza yokuthuka sicotha kakhulu okanye ukudibanisa ukusebenza kakuhle kulihlwempu, kwaye ifuthe le-iyunifomu alinakufezekiswa phakathi kwexesha eliqhelekileyo eliqhelekileyo; Ukuxinana kwe-pigment okanye idayi kwi-flaid flounks iphezulu kakhulu okanye umxholo oqinileyo uphakame kakhulu, okanye isantya sokutshiza siphezulu kakhulu, iqondo lobushushu lokulala liphezulu ngaphandle ngexesha; Ubembelele kwifilimu nokuba kungenziwa; Ubume besiqwenga akulunganga, njengento ende, i-capsule yenziwe iqhekeza, ngenxa yokuqengqeleka njengesiqwenga somjikelo, siya kubangela umahluko wombala.
5.2 Isisombululo
Yongeza isantya sepani yokuthoba okanye inani le-baffle, luhlengahlengise kwimeko efanelekileyo, ukuze iphepha lephepha le-pan liqengqeleka. Ukucutha isantya sokutshiza i-pieling flory flory, ukunciphisa ubushushu bebhedi. Kwindlela yokuyila i-proous enomtsalane, idosi okanye umxholo oqinileyo wokuqina okanye idayi kufuneka incitshiswe, kwaye i-pigment yesigqubuthelo esomeleleyo kufuneka ikhethwe. I-pigment okanye idayi kufuneka icoceke kwaye amasuntswana afanele abe mncinci. I-DYES yamanzi i-i-InOlin ilunge ngakumbi kune-dyes ye-dayling, i-i-insullen ye-insulen ayifuduki namanzi ngokulula, kunye nokuncitshiswa kwe-vapor, kunye nokuncitshiswa kwe-vally yefilimu kungcono kune-dyes enyibilikisi. Khetha udidi olufanelekileyo. Kwinkqubo yokuthobela ifilimu, kusoloko kukho iingxaki ezahlukeneyo, kodwa nokuba zeziphi iingxaki, izinto ezininzi zininzi, zinokusonjululwa ngokuphucula umlinganiso wezinto ezihambayo, hlengahlengisa, ukuze kufezekiswe isicelo esiguqukayo kunye nokusebenza kwe-dialegical. Ngolwazi lwetekhnoloji yokuthobela, uphuhliso kunye nokusetyenziswa koomatshini obutsha bokuzithoba kunye nezinto zokuhamba ngefilimu, itekhnoloji yokuhamba ngefilimu iya kuphuculwa kakhulu, ukudibana kwefilimu kuya kuba nophuhliso olukhawulezileyo.
Ixesha leposi: Apri-25 ukuya ku-2424