I-Hydroxypropyl methyl cellulose kunye ne-carboxymethyl cellulose sodium inokuxutywa

I-Hydroxypropyl methyl cellulose (HPMC) kunye ne-carboxymethyl cellulose sodium (CMC) zizinto ezimbini ezisetyenziswa ngokubanzi eziphuma kwiselulosi kumashishini ahlukeneyo ngenxa yeepropathi zazo ezizodwa kunye nokusebenza kwazo. Nangona zombini iipolymers ezisekelwe kwi-cellulose, ziyahluka kwisakhiwo sabo sekhemikhali kunye neempawu, ezibenza bafanelekele izicelo ezahlukeneyo. Nangona kunjalo, kwezinye iimeko, zinokuxutywa ukufikelela kwiimpawu ezithile zokusebenza okanye ukuphucula iimpawu ezithile zemveliso yokugqibela.

IHydroxypropyl methyl cellulose (HPMC), ekwaziwa ngokuba yihypromellose, yi-ether eselulose engeyiyo ionic ephuma kwi-cellulose yepolymer yendalo. Yenziwe ngokusabela kwe-alkali cellulose kunye nepropylene oxide kunye ne-methyl chloride. I-HPMC isetyenziswa kakhulu kumayeza, izinto zokwakha, iimveliso zokutya, kunye nezithambiso ngenxa yendlela egqwesileyo yokwenza ifilimu, ukujiya, ukubopha, kunye neempawu zokugcina amanzi. HPMC ifumaneka kumabanga ahlukeneyo namanqanaba viscosity ezahlukeneyo, nto leyo evumela ukusetyenziswa kwayo kuluhlu olubanzi lwezicelo.

Kwelinye icala, i-carboxymethyl cellulose sodium (CMC) yinto ephuma emanzini enyibilikayo ye-anionic cellulose efunyenwe ngokusabela kweselulosi nge-sodium hydroxide kunye ne-chloroacetic acid. I-CMC yaziwa ngomthamo wayo ophezulu wokugcina amanzi, amandla okuqina, iipropati zokwenza ifilimu, kunye nozinzo kuluhlu olubanzi lweemeko ze-pH. Ifumana izicelo kwiimveliso zokutya, amayeza, izithambiso, amalaphu, kunye nokuveliswa kwephepha ngenxa yokuguquguquka kwayo kunye nokuhambelana kwebhayoloji.

Ngelixa i-HPMC kunye ne-CMC zabelana ngeempawu eziqhelekileyo ezifana nokunyibilika kwamanzi kunye nokukwazi ukwenza ifilimu, zikwabonisa iimpawu ezahlukileyo ezizenza zilungele usetyenziso oluthile. Ngokomzekelo, i-HPMC ikhethwa kwiindlela zokuxutywa kwamachiza ezifana neepilisi kunye ne-capsules ngenxa yeempawu zayo ezikhutshwayo ezilawulwayo kunye nokuhambelana nezithako ezisebenzayo zamachiza. Kwelinye icala, i-CMC iqhele ukusetyenziswa kwiimveliso zokutya ezinje ngeesosi, izinxibo, kunye neempahla ezibhakiweyo njengearhente yokujiya kunye nokuzinzisa.

Ngaphandle kweeyantlukwano, i-HPMC kunye ne-CMC zinokuxutywa kunye kwimixube ethile ukuphumeza iziphumo ze-synergistic okanye ukwandisa iipropati ezithile. Ukuhambelana kwe-HPMC kunye ne-CMC kuxhomekeke kwizinto ezininzi ezifana nesakhiwo sabo sekhemikhali, ubunzima bemolekyuli, iqondo lokutshintshwa, kunye neempawu ezifunwayo zemveliso yokugqibela. Xa ixutywe kunye, i-HPMC kunye ne-CMC zinokubonisa ukujiya okuphuculweyo, ukubopha, kunye neempawu zokwenza ifilim xa kuthelekiswa nokusebenzisa nokuba yipolymer yodwa.

Esinye isicelo esiqhelekileyo sokuxuba i-HPMC kunye ne-CMC kukuqulunqa iinkqubo zokuhanjiswa kweziyobisi ezisekelwe kwi-hydrogel. I-Hydrogels zizakhiwo zenethiwekhi ezine-dimensional ezintathu ezikwazi ukufunxa kunye nokugcina amanzi amaninzi, okwenza ukuba afanelekele ukukhutshwa kweziyobisi ezilawulwayo. Ngokudibanisa i-HPMC kunye ne-CMC ngokwemilinganiselo efanelekileyo, abaphandi banokulungelelanisa iipropathi ze-hydrogel ezifana nokuziphatha kokudumba, amandla omatshini, kunye ne-kinetics yokukhutshwa kweziyobisi ukuhlangabezana neemfuno ezithile.

Esinye isicelo sokuxuba i-HPMC kunye ne-CMC kukulungiselela iipeyinti ezisekelwe emanzini kunye neengubo. I-HPMC kunye ne-CMC zihlala zisetyenziswa njengezinto ezityebileyo kunye nezilungisi zerheology kwiipeyinti ezisekelwe emanzini ukuphucula iimpawu zabo zesicelo, ezifana nokuxubha, ukuxhathisa i-sag, kunye nokumelana nokutshiza. Ngokulungelelanisa umlinganiselo we-HPMC kwi-CMC, abaqulunqi banokufikelela i-viscosity efunwayo kunye nokuziphatha okuhambayo kwepeyinti ngelixa begcina uzinzo kunye nokusebenza kwayo ekuhambeni kwexesha.

Ukongeza kumayeza kunye neengubo, imixube ye-HPMC kunye ne-CMC ikwasetyenziswa kushishino lokutya ukuphucula ukuthungwa, ukuzinza, kunye nokuvakala komlomo weemveliso ezahlukeneyo zokutya. Umzekelo, i-HPMC kunye ne-CMC ziqhele ukongeza kwiimveliso zobisi ezifana neyogathi kunye ne-ayisikrimu njengezizinzisi zokuthintela ukwahlukana kwesigaba kunye nokuphucula ubukhrimu. Kwiimpahla ezibhakiweyo, i-HPMC kunye ne-CMC zingasetyenziswa njengezilungisi zentlama ukomeleza iipropati zokuphatha intlama kunye nokwandisa ubomi beshelufu.

ngelixa i-hydroxypropyl methyl cellulose (HPMC) kunye ne-carboxymethyl cellulose sodium (CMC) zimbini ezihlukeneyo ze-cellulose derivatives kunye neempawu ezizodwa kunye nokusetyenziswa, zinokuxutywa kunye kwiindlela ezithile zokuqulunqa ukuphumeza iziphumo ze-synergistic okanye ukunyusa iimpawu ezithile. Ukuhambelana kwe-HPMC kunye ne-CMC kuxhomekeke kwizinto ezahlukeneyo ezifana nesakhiwo sabo sekhemikhali, ubunzima be-molecular, kunye neempawu ezifunwayo zemveliso yokugqibela. Ngokukhetha ngononophelo umlinganiselo kunye nendibaniselwano ye-HPMC kunye ne-CMC, abaqulunqi banokulungelelanisa iipropati zeendlela zabo zokukhawulelana neemfuno ezithile kumachiza, iingubo, iimveliso zokutya, kunye namanye amashishini.