Umahluko wemodeli yeHydroxypropyl methylcellulose

IHydroxypropyl methylcellulose (HPMC)yikhompawundi eguquguqukayo esetyenziswa kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye nokwakha. Iimpawu zayo kunye nokusetyenziswa kwayo kuyahluka ngokuxhomekeka kwisakhiwo sayo se-molecular, esinokuguqulwa ukuze sihambelane neemfuno ezithile.

Ulwakhiwo lweMichiza:

I-HPMC iphuma kwi-cellulose, ipholima yendalo efumaneka kwizityalo.
I-hydroxypropyl kunye ne-methyl substituents zifakwe kumaqela e-hydroxyl ye-cellulose backbone.
Umlinganiselo waba babambeli umisela iipropati ze-HPMC, ezifana nokunyibilika, i-gelation, kunye nokukwazi ukwenza ifilimu.

Isidanga soTshintsho (DS):

I-DS ibhekisa kwi-avareji yenani lamaqela abambeleyo kwiyunithi nganye yeglucose kwi-cellulose backbone.
Amaxabiso aphezulu e-DS akhokelela ekwandeni kwe-hydrophilicity, ukunyibilika, kunye nomthamo we-gelation.
I-DS HPMC ephantsi izinzile ngakumbi kwi-thermal kwaye inokumelana nokufuma okungcono, iyenza ilungele usetyenziso kwizinto zokwakha.

Ubunzima beMolekyuli (MW):

Ubunzima bemolekyuli buchaphazela i-viscosity, isakhono sokwenza ifilimu, kunye neempawu zoomatshini.
Ubunzima obuphezulu bemolekyuli i-HPMC idla ngokuba ne-viscosity ephezulu kunye neempawu ezingcono zokwenza ifilim, nto leyo eyenza ukuba ilungele ukusetyenziswa kwimixube yonyango ekhutshwa ngokuzinzileyo.
Ukwahluka kobunzima beemolekyuli ezisezantsi zikhethwa kwizicelo apho i-viscosity esezantsi kunye nonyibiliko olukhawulezayo zifunwayo, njengeengubo kunye nokuncamathelisa.

Ubungakanani beNcam:

Ubungakanani besuntswana buphembelela iipropathi zokuqukuqela komgubo, izinga lokunyibilika, kunye nokufana kwimixube.
Ubungakanani bamasuntswana alungileyo I-HPMC isasazeke ngokulula kwizisombululo ezinamanzi, ezikhokelela kumanzi okukhawulezayo kunye nokwakheka kwejeli.
Amasuntswana arhabaxa anokubonelela ngeempawu zokuqukuqela ngcono kwimixube eyomileyo kodwa anokufuna amaxesha amade okugalela amanzi.

Ubushushu beGelation:

Ubushushu beGelation bubhekisa kwiqondo lobushushu apho izisombululo zeHPMC zingena kwinguqu yesigaba ukusuka kwisisombululo ukuya kwijeli.
Amanqanaba aphezulu okutshintshela kunye nobunzima beemolekyuli ngokubanzi bukhokelela ekunciphiseni amaqondo obushushu be-gelation.
Ukuqonda ubushushu be-gelation kubalulekile ekuqulunqeni iinkqubo zokuhanjiswa kweziyobisi ezilawulwayo kunye nokuveliswa kweejeli zokusetyenziswa kwezihloko.

Iinkcazelo ngeThermal:

Ukuzinza kwe-thermal kubalulekile kwizicelo apho i-HPMC iphantsi kobushushu ngexesha lokucubungula okanye ukugcinwa.
I-DS HPMC ephezulu inokubonisa uzinzo oluphantsi lwe-thermal ngenxa yobukho bama-labile substituents.
Iindlela zokuhlalutya i-thermal ezifana ne-different scanning calorimetry (DSC) kunye nohlalutyo lwe-thermogravimetric (TGA) zisetyenziselwa ukuvavanya iimpawu ze-thermal.

Ukunyibilika kunye nokuDumba:

Ukunyibilika kunye nokuziphatha kokudumba kuxhomekeke kwi-DS, ubunzima bemolekyuli, kunye nobushushu.
I-DS ephezulu kunye nokwahluka kobunzima bemolekyuli ngokuqhelekileyo kubonisa ukunyibilika okukhulu kunye nokudumba emanzini.
Ukuqonda ukunyibilika kunye nokuziphatha kokudumba kubalulekile ekuyileni iinkqubo zokuhanjiswa kweziyobisi ezilawulwayo kunye nokuqulunqa ii-hydrogel kwizicelo ze-biomedical.

Iinkcazelo ngeRheological:

Iimpawu zeRheological ezifana ne-viscosity, i-shear thinning behavior, kunye ne-viscoelasticity zibalulekile kwizicelo ezahlukeneyo.
HPMCIzisombululo zibonisa ukuziphatha kwepseudoplastic, apho i-viscosity iyancipha ngokunyuka kwesantya sokucheba.
Iimpawu ze-rheological ze-HPMC zinempembelelo ekusebenzeni kwayo kumashishini afana nokutya, izinto zokuthambisa, kunye namayeza.

Umahluko phakathi kweemodeli ezahlukeneyo ze-HPMC zivela kwiiyantlukwano kubume bekhemikhali, isidanga sokutshintsha, ubunzima bemolekyuli, ubungakanani bamasuntswana, ubushushu be-gelation, iipropathi ezishushu, ukunyibilika, ukuziphatha ukudumba, kunye neempawu zerheological. Ukuqonda lo mahluko kubalulekile ekukhetheni ukwahluka okufanelekileyo kwe-HPMC kwizicelo ezithile, ukusuka kwimixube yamayeza ukuya kwimathiriyeli yokwakha.