I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-polymer eguquguqukayo esetyenziswa ngokubanzi kumzi mveliso wamayeza, ngakumbi kwifomu yetafile. Njengesifo se-seluplose, i-HPMC inoluhlu lweepropathi ezisebenzayo ezifaka isandla kwi-tabyct yetafile. I-complate isuselwa kwiselfowuni ngothotho lwezinto eziguqulweyo zekhemikhali, ezikhokelela kwiimveliso ezinepropathi ezahlukileyo ezifanelekileyo kwizicelo ezahlukeneyo. Kwimigaqo yetafile, i-HPMC ineentlobo ngeentlobo zokusetyenziswa, kubandakanya ukulawula ukukhutshwa kweziyobisi, ukuphucula ubumbano lwetafile, kunye nokuphucula uzinzo lwemosi yedosi.
I-1. Iibhedi kunye neearhente zokungena:
I-HPMC isebenza njenge-binder kwifomu yecwecwe, incedisa ukubopha izithako kunye nokuthintela ukwahlula-hlulwa kwangaphambili. Ikwasetyenziswa njenge-arhente yokufunyanwa kwenkqubo yenkqubo yokwenziwa, enceda umxube weziyobisi kunye nomxube onyanisekileyo ukuze wenze igranules.
I-2. I-Matrix yeFowuni yokuFumaneka kweMatrix yokukhululwa okulawulwayo:
Enye yezona zinto zibalulekileyo zokusebenzisa i-HPMC kwifomu yecwecwe kukukwazi ukulawula ukukhutshwa kweziyobisi. Xa isetyenziswa njenge-matrix yangaphambili, i-HPMC ichaza i-matrix-njenge-matrix ekunxibelelaneni namanzi, ivumela ukukhutshwa okuzinzileyo kunye nokulawulwa kwechiza. Oku kubaluleke kakhulu ngeziyobisi ngeefestile ezinqabileyo okanye ezifuna isenzo sexesha elide.
I-3. Intsholongwane:
Ukongeza kwindima yayo njenge-binder, i-HPMC ikwasebenza njenge-suinterble kwifom yetafile. Xa ithebhulethi inxibelelana nejusi ye-gastric, i-HPMC ishukumile kwaye iphazamise ubume bethebhulethi, ukukhuthaza ukukhutshwa ngamachiza okukhawulezayo. Oku kuluncedo ngakumbi kwifom yokukhutshwa kwangoko.
4. Ifilimu yefilimu:
I-HPMC isetyenziselwa ukusetyenziswa kwefilimu yefilimu. Iifayile ze-HPMC ezivelisa ukubonakala kweetafile, zibonelela ngokhuseleko kwizinto zokusingqongileyo, kwaye zinokusetyenziselwa ukungcamla imaski. Inkqubo yokuthobela ifilimu kukusebenzisa isisombululo se-HPMC kumphezulu weetafile kwaye senze iyunifomu kwaye icace gca emva komile.
I-5. Ukulawulwa kokukhohlisa kunye neendlela zokuziphatha kakuhle:
Iicwecwe zinokufuna ukutyeba okuthile kunye neempawu zokuqonda ukufezekisa iprofayili yokuphelisa enqwenelekayo. I-HPMC inokusetyenziselwa ukutshintsha inkathalo kunye nokungqinwa kweetafile, ukuchaphazela ukukhutshwa ngamachiza. Oku kubalulekile ukufezekisa iprofayili ye-pharmacokinetic yechiza.
I-6. Ithebhulethi ye-Loubricant:
I-HPMC isebenza njenge-thebhulet yetafile, ukunciphisa ukuxabana phakathi kweetafile kunye nezixhobo zokulungisa izinto ngexesha lokuvelisa. Oku kuququzelela inkqubo yemveliso efanelekileyo yetafile kwaye kuqinisekisa amacwecwe ayinamathisi izixhobo.
7. I-Mucoadshes:
Kwezinye iindlela, ngakumbi ukuhanjiswa kweziyobisi, okanye i-MUCE ye-mucosal yomlomo, i-HPMC inokusetyenziswa njengearhente ye-mucorhadhes. Inceda ukwandisa ixesha lokuhlala lefomu ye-dosage kumphezulu we-mucosal, ngaloo ndlela ukuphucula ukufunwa ngamachiza.
I-8. Ukuzinza kozinzo:
I-HPMC inceda ekuphuculeni uzinzo lwefomu yethebhulethi ngokuthintela ukufumanisa umswakama kunye nokukhusela ichiza kwizinto zokusingqongileyo. Oku kubaluleke kakhulu kumachiza anomdla wokufuma okanye othambekele ekufihleni.
9. Ukuhambelana nabanye abaqulunqi:
I-HPMC inonyamezelo olulungileyo kunye nabanemidlalo Oku kuhambelana nokusebenza kokuqulunqwa kweetafile kunye nezinto ezahlukeneyo zeziyobisi kunye nezinye izithako.
I-Hydroxypropyl Methylcelceltulose (HPMC) idlala indima ebalulekileyo kwifom yetafile, ibonelela ngemisebenzi emininzi enceda ukuphucula ukusebenza kunye nokusebenza kakuhle kwefom yedosi. Izicelo zisusela kwii-Binders kunye ne-Gransula yokuGqibela ukulawulwa kwe-Matrix Earners, izixhobo zokuhlalisa ifilimu, i-colibricants kunye nezixhobo zokuzinza. Ukusetyenziswa phaya kwe-HPMC kwenza isithako esixabisekileyo kwifomu yamayeza, kwaye ukuqhubeka kwayo nokusetyenziswa kwayo kubonisa ukubaluleka kwayo ekufezekiseni iziphumo ezinqwenelekayo zokunikezelwa kweziyobisi.
IXESHA LOKUQALA: