Intshayelelo kwiipropathi zeHydroxypropyl Methylcelce

I-Hydroxypropylmethylcelcelcelcelcebalose (i-HPMC) yi-polymer eguquguqukayo esetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yepropathi eyahlukileyo. Le phunga isuswe i-seluplose, i-polymer yendalo ifunyenwe kwiindonga zeseli zezityalo. I-Synthesis ye-HPMC ibandakanya ukunyanga ukunyanga i-selsulose nge-proplone oxide ukwazisa amaqela e-hydroxypropy kunye ne-methyl chloride ukwazisa amaqela e-methyl. I-polymer ebangela ibonakalisa uluhlu olubanzi lweepropathi zomzimba kunye nekhemikhali, zenza ilungele ukusetyenziswa kulwakhiwo, ukwakhiwa, ukutya kunye namanye amashishini.

1.Ukulwa ulwazi kunye nokubekwa:

I-Hydroxypropyl Methylcelcelcelose yi-polymer ye-semi-syntmer enesakhiwo esinekhemikhali. I-polybone ye-polymer iqulathe i-sellyu, intambo yomgca we-gucose molecus edityaniswe yi-β-1,4-Glycosidic Bonds. Iqela le-hydroxypropy laziswa ngokutshintsha iQela le-Hydroxyl (-) neQela lePropyl, kunye neqela le-METHyl laziswa ngendlela efanayo. Inqanaba lokufakwa endaweni (DS) libonisa inani le-hydroxypropy ye-hydropyl kunye ne-methyl icandelo ngalinye le-glucose kwaye lichaphazela ukuluka, ukubonwa, kunye neepropathi ze-polymer yepolymer.

I-2. Ukungasebenzi:

Enye yeempawu ezahlukileyo ze-HPMC yindlela yokuchitha inkunkuma. Inyibilika kumanzi obandayo ashushu, enikezela izibonelelo ezizodwa kwizicelo ezahlukeneyo. Ukunyibiliselwa kunokuhlengahlengiswa ngokuhlengahlengiswa kwenqanaba lokufaka endaweni kunye nemolekyuli yePolymer. Le ndawo yenza i-HPMC umgqatswa obalaseleyo wokuhambisa iziyobisi, apho amaxabiso okuchithwa adlala indima ebalulekileyo kwii-kinetics zokukhutshwa kweziyobisi.

I-3. UVIKILE:

I-HydroxyPOpyl Methylcelcelgalose ifumaneka kwinqanaba leentlobo zobufazi, kuxhomekeka kwizinto ezinje ngobunzima bemolekyuli, isidanga sokufaka kunye nesisombululo. Uhlobo lwe-vickosity yezisombululo ze-HPMC luvumela ukuba zisetyenziswe kwizicelo ezininzi zemizi-mveliso, kubandakanya amayeza, njengamanzi kwiifom ze-dosage ezingamanzi, kunye nezixhobo zokwenza iifilimu zengubo.

I-4. Ukusebenza kwefilimu:

Isakhono sokwenza ifilimu se-HPMC sibalulekile kwizicelo ezifana nokunxiba iziyobisi, apho isetyenziselwa ukubonelela ngomaleko okhuselayo kwi-Mask ye-Mask ye-Masking yeziyobisi, ukulawula iziyobisi, kunye nokuphucula uzinzo. Iifilimu ze-HPMC zicacile kwaye zibhetyebhetye, kwaye iipropathi zabo zinokulungelelaniswa ngokuhlengahlengisa uxinzelelo lwePolymer, ubunzima bomzimba kunye nomxholo weplastiki kunye nomxholo weplastiki.

5. Umsebenzi we-thermal:

I-Hydroxypropyl Methylcelcelgalose ibonisa uzinzo lobushushu obukhethekileyo. Iipropathi ze-thermal zichaphazeleka zizinto ezinje ngenqanaba lokufakwa endaweni, ubunzima bemolekyuli, kunye nobukho babaphangi. Ezi ndawo zenza i-HPMC ilungele izicelo apho uzinzo lozinza luphawuleka, njengokulungiselela ukwenziwa kwamayeza obushushu.

6. I-BioMPise:

Kumasimi echithwayo kunye ne-biomedical, i-biomial, i-biomatisicy luqwalaselo olubalulekileyo lwezixhobo ezisetyenziswa kwiinkqubo zokuhambisa iziyobisi. I-Hydroxypropyl Methylcelcelose ithathelwa ingqalelo kwaye ine-biomatini elungileyo. Isetyenziswe ngokubanzi ekuqulunweni kweefom zomnxeba zomlomo, iZisombululo ze-Ophthalmic Solutions kunye nokulawulwa kokuhanjiswa kweziyobisi.

7. Ukugcinwa kwamanzi kunye neepropathi ezinkulu:

I-HPMC's Abuks ukugcina izisombululo zamanzi kunye nezisombululo eziqinileyo ziyenza ixabiseke kwizixhobo zokwakha ezifana neemveliso ezisekwe kwisamente. Kwezi zicelo, i-HPMC isebenza njengearhente yokugcina amanzi, ukuphucula ukuqhutywa komoya kunye nokuthintela ukomisa ngaphambi kwexesha. Iipropathi ezinkulu zokuthambisa zikwasetyenziswa kwiimveliso zokutya ukuphucula ukuthunyelwa kunye nomlomo.

8. Ukuhanjiswa kweziyobisi:

Enye yezicelo ezibalulekileyo ze-hydroxypropyl methylcelcelose kukwenziwa kweenkqubo zokuhambisa iziyobisi. Ukunyibilisela kukaPolymer, i-viscosity, kunye neepropathi zokwenza ifilimu kuququzelela ukukhululwa kwamachiza amachiza, ukuvumela ukuhanjiswa kweziyobisi. Oku kuyingenelo ikakhulu ekuphuculeni ukuthotyelwa koguli kunye nokunciphisa iziphumo ebezingalindelekanga ezinxulumene nokukhutshwa kweziyobisi ngokukhawuleza.

9. Uzinzo phantsi kweemeko ezahlukeneyo zePP:

I-HPMC ibonakalisa uzinzo ngaphezulu kwe-PH ye-PH, esenza ilungele ukwenziwa okufuna uzinzo phantsi kwe-acidic okanye iimeko ze-alkaline. Le ndawo iluncedo kwiindawo zamachiza kuba iifomu ezinokuthi zikwazi ukudibana iimeko ezahlukeneyo ze-gestrointenal.

I-10. Iipropathi ze-ROOOLOCT:

Ukuziphatha kakuhle kwezisombululo ze-HPMC kubalulekile kwizicelo apho iipropathi zokuhamba zibalulekile, njengokulungiselela iingubo, imikhono kunye neegels. Ipropathi ye-ROOOLOTS inokulungelelaniswa ngokuhlengahlengiswa koxinzelelo kunye nobunzima bemoya ye-HPMC ukufezekisa iimpawu zokuhamba ezifunekayo ukuze zilawule i-e-Coll.

I-HydroxyPOpyl Methylcelcelsele iye yanguPolymer ebaluleke kakhulu kumashishini ahlukeneyo ngenxa yokudityaniswa kwayo, i-viscofity, ubuchule bokwenza ifilimu kunye nefilimu kunye nefilimu. Ukuhambahamba kwendlela yokuqhubela phambili kwenza ilungele iintlobo ngeentlobo zezicelo, ukusuka kwiindawo zamayeza kunye nezixhobo zokwakha nokutya kunye ne-cosmetics. Njengabaphandi bayaqhubeka nokuphonononga iindlela ezintsha kunye nezicelo, iipropathi ze-hydroxypropyl methylceltulose, ngokungathandabuzekiyo zinegalelo ekuqhubeni phambili kwiinkalo ezahlukeneyo, iqinisekisa ukubaluleka kwayo kwishishini lezenzululwazi kunye nemveliso.