I-HydroxyPOpyTelmethylcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcel Enye yepropathi ephambili ye-HPMC kukukwazi ukugcina amanzi, echaphazela intsebenzo yayo njengokungafuneki kwamayeza. Kweli nqaku, siza kuphonononga izinto eziphambili ezichaphazela ukugcinwa kwamanzi kwe-HPMC, kubandakanya ubunzima bemolekyuli, uhlobo lokufaka endaweni, kunye ne-pH.
ubunzima bemolekyuli
Ubunzima be-MPMC budlala indima ebalulekileyo ekumiseleni umthamo wayo wokugcina amanzi. Ngokubanzi, ubunzima obuphezulu be-phummc yi-hydrophilic ngaphezulu kwe-molecrophilic ye-molecular ephantsi kwaye inokufumana amanzi amaninzi. Kungenxa yokuba i-HPMS yesilinganiselo esiphezulu se-roleculacs inamakhonkco amade anokuphawula kwaye enze inethiwekhi enkulu ngakumbi, ukwandisa inani lamanzi anokufunyanwa. Nangona kunjalo, kufuneka kuqatshelwe ukuba ubunzima bemolekyuli ephezulu kakhulu ye-HPMC iya kubangela iingxaki ezinje ngokubonisa i-viscofity kunye nobunzima bokulungisa.
enye
Enye into echaphazela umthamo wokugcinwa kwamanzi we-HPMC luhlobo lokufaka endaweni. I-HPMC ngokubanzi iza ngeendlela ezimbini: i-hydroxypropt-ye-Hydropyl-endaweni ye-APEXS. Uhlobo lwe-hydropvyl-endaweni ye-hydroplopy inomthamo ophezulu wokufumana amanzi kuneenkcukacha ezithethwayo. Kungenxa yokuba iqela le-hydroxypropy ekhoyo kwi-HPMC Molecule yi-hydrophilic kwaye yonyusa ubumbano lwe-HPMC yamanzi. Ngokwahlukileyo koko, uhlobo lwe-Mactionsxy-Pleations lungaphantsi kwaye ke inomthamo wokugcinwa kwamanzi asezantsi. Ke ngoko, ezinye iintlobo ze-HPMC kufuneka zikhethwe ngononophelo ngokusekwe kwiipropathi eziyimfuneko zemveliso yokugqibela.
gxila kwi
Uxinzelelo lwe-HPMC ikwachaphazela umthamo wayo wokugcina amanzi. Ngobuchule obuphantsi, i-HPMC ayibubumbanga kwesakhiwo esifana nejeli, ke amandla ayo ogcinayo amanzi aphantsi. Njengoko uxinzelelo lwe-HPMC lwalunyulu, iimolekyuli zepolymer zaqala ukubamba, zenza isakhiwo esifana nejeli. Eli jeli lejeli ifumana kwaye ligcine amanzi, kwaye umthamo wokugcinwa kwamanzi we-HPMC unyuswa ngoxinzelelo. Nangona kunjalo, kufuneka kuqatshelwe ukuba uxinzelelo oluphezulu kakhulu lwe-HPMC luya kukhokelela kwiingxaki zokuqulunqwa njengokubonakala kunye nobunzima bokulungisa. Ke ngoko, ukuxinana kwe-HPMC esetyenzisiweyo kufuneka kufezekiswe ukufezekisa umthamo wokugcina amanzi ofunekayo ngelixa uphephe iingxaki ezichazwe apha ngasentla.
Ixabiso
Ixabiso le-pH lendawo apho isetyenziselwe i-HPMC ikwachaphazela umthamo wokugcina amanzi. Isakhiwo se-HPMC siqukethe amaqela anaic (-Coo-) kunye ne-hydrophilic yestylcelcelsulose (----). I-ionis ye-e-Iyoo- amaqela yi-PH ixhomekeke, kwaye iqondo labo le-ions le-PH. Ke ngoko, i-HPMC inomsebenzi ophezulu wokugcina amanzi kwiPH. Kwi-PH ye-PH, i-i-lecoo- qela ikhutshiwe kwaye i-hydrophicicity ihla, ikhokelela kwinqanaba lokugcina amanzi eliphantsi. Ke ngoko, i-PH kufuneka ilungiselelwe ukufezekisa umthamo wokugcina amanzi onqwenelekayo ye-HPMC.
ukuququmbela
Ukuqukumbela, umthamo wokugcinwa kwamanzi we-HPMC yinto ephambili echaphazela intsebenzo yawo njengokungafuneki kwamayeza. Izinto eziphambili ezichaphazela umthamo wokugcinwa kwamanzi ze-HPMC zibandakanya ubunzima bemolekyuli, uhlobo lokufaka endaweni, uxinzelelo kunye nexabiso le-p. Ngokuhlengahlengiswa ngononophelo ezi zinto, umthamo wokugcinwa kwamanzi we-HPMC unokufaneleka ukufezekisa iipropathi eziyimfuneko zemveliso yokuphela. Abaphandi bamayeza kunye nabavelisi kufuneka banikele ingqalelo kule miba ukuqinisekisa owona mgangatho uphezulu kunye nokusebenza kwenkqubo ye-HPMC esekwe kwi-HPMC.
IXESHA LOKUQALA: AUG-05-2023