Uphando malunga nokusetyenziswa kwe-hec kumalungiselelo e-chikeceutical

Hec (hydroxyythl seluplose)I-polymer eqhelekileyo yamanzi asetyenziswa kakhulu kumalungiselelo amayeza. Kukupheliswa kweselutase, kufunyenwe ngokusabela e-Ethanolamine (i-Ethoyne oxide) nge-sellyulose. Ngenxa yokuqina kwayo okuhle, uzinzo, ubuchule bokuhlengahlengiswa kobume be-viscosity kunye noluhlu olubanzi lweesethi kwintsimi yamachiza, ngakumbi uyilo lwe-Dosage kunye nolawulo lweziyobisi.

1. Iipropati ezisisiseko ze-hec
Hec, njengesellulose eguqulweyo, inezi propati zisisiseko zilandelayo:

I-Solidality yaManzi: I-Nunt.inccel®fuc inokwenza isisombululo se-vicous emanzini, kwaye ukuluka kwayo kunxulumene neqondo lobushushu kunye nePH. Le propati yenza ukuba isetyenziswe kwiifom ezahlukeneyo zethamo ezifana ne-oral kunye nezihloko.

I-biomicotible: hec ayinatyhefu kwaye ayicaphukisi emzimbeni womntu kwaye ihambelana neziyobisi ezininzi. Ke ngoko, isetyenziswe ngokubanzi kwiifom zokukhutshwa ezizinzileyo zokukhutshwa kunye neethamo zolawulo lwendawo yokuhlala.

I-viscosity eguqukayo: UVenkile yeHec unokuhlengahlengiswa ngokutshintsha ubunzima bayo okanye uxinzelelo, obaluleke kakhulu ekulawuleni inqanaba lokukhupha amachiza okanye ukuphucula uzinzo lwamachiza.

2. Ukusetyenziswa kwe-hec kumalungiselelo e-chimbeceutical
Njengombono obalulekileyo kumalungiselelo amayeza asechimeni, i-HEC inemisebenzi emininzi. Oku kulandelayo ziindawo zayo eziphambili zesicelo kumalungiselelo amachiza.

2.1 Isicelo kumalungiselelo omlomo
Kwiifom zedosi yomlomo, i-HEC ihlala isetyenziswa kwimveliso yeetafile, iicaphule kunye namacebo olwelo. Imisebenzi yayo ephambili ibandakanya:

I-Binder: kwiitafile kunye ne-granules, i-HEC inokusetyenziswa njenge-binder ukuze ibophe amasuntswana okanye i-powders kunye ukuqinisekisa ubunzima kunye nokuzinza kweetafile.
Ulawulo lokukhutshwa oluzinzileyo: Hec inokufikelela kwisiphumo sokukhululwa okuzinzileyo ngokulawula inqanaba lokukhutshwa kwechiza. Xa i-HCC isetyenziswa kunye nezinye izithako (ezinjenge-polyvinyl pylolidone, i-carboxeyymethyl sellyulose yeselula, njl njl), inokuphakamisa ixesha lokukhululwa kweyeza, kwaye liphucule ukuthotyelwa konyango.
I-thickener: Kumalungiselelo omlomo, i-Nqunulcel®fuc njenge-thi churener inokuphucula incasa yechiza kunye nokuzinza kwefom yedosi.

2.2 Ukusetyenziswa kwamalungiselelo aphezulu
I-HEC isetyenziswa ngokubanzi kwii-ointments eziphezulu, iikhrim, i-gels, i-lotions kunye namanye amalungiselelo, ukudlala iindima ezininzi:

I-Gel Matrix: Hec ihlala isetyenziswa njenge-matrix ye-Gels, ngakumbi kwiinkqubo zokuhambisa iziyobisi. Inokubonelela ngokungqinelana ngokufanelekileyo kwaye yonyusa ixesha lokuhlala lechiza eluswini, ngaloo ndlela iphucule ukusebenza kakuhle.
I-Viscofity kunye nokuzinza: Ukugcinwa kwe-HEC kunokuphucula amalungiselelo aphezulu kulusu kwaye kuthintele ichiza ukuba lingasebenzi kwangaphambili ngenxa ye-facring okanye ukuhlamba. Ukongeza, i-HEC inokuphucula uzinzo lweekhrim kunye ne-oyile kunye nokuthintela ukuhanjiswa okanye i-crystallization.
I-Lubrictant kunye ne-mostiurizer: I-HEC ineepropathi ezihle kwaye zinokunceda ukugcina ulusu lubethelele kwaye luthintele ukomisa, kunjalo nakwezinye iimveliso zesikhumba.

2.3 Isicelo se-Ophthalmic
Ukusetyenziswa kwe-hec kwilungiselelo le-Ophthalmic kubonakaliswa ikakhulu kwindima yayo njengokunamathela kunye neoyile:

I-Ophthalmimic Gels kunye ne-DAPS yeliso: I-HEC inokusetyenziswa njengokuthengiswa kwe-ophthalmimic ukuxhasa ixesha lokunxibelelana phakathi kwechiza kunye neliso kwaye kuqinisekiswe ukusebenza ngempumelelo kwechiza. Kwangelo xesha, uVecofity wayo unokuthintela kwakhona iliso liphuma ekuphulukaneni nawo ngokukhawuleza kwaye lande ixesha lokugcina ichiza.
I-Lubritetation: Hec inombala omhle kwaye inokubonelela ngokuqhubekayo kunyango lwezifo ze-Ophthalmic ezinje ngeliso elomileyo, ukunciphisa ukungalunganga.

2.4 Ukusetyenziswa kwamalungiselelo enaliti
I-hec inokusetyenziswa kulungiselelo lweefomu zentsholongwane, ngakumbi kwinaliti ende ixesha elide kunye namalungiselelo okukhutshwa enzondo. Imisebenzi ephambili ye-hec kula malungiselelo ibandakanya:

I-thi cokener kunye ne-stibilizer: Inaliti,Hecinokunyusa i-viscosity yesisombululo, icothe isantya se-inaliti yechiza, kwaye iphucule uzinzo lwechiza.
Ukulawula ukukhululwa kweziyobisi: Njengamnye wezinto zenkqubo yokukhutshwa kweziyobisi, i-HEC inokulawula inqanaba lokukhutshwa kwechiza ngokwenza i-gel fer emva kwenaliti emva kwenaliti, ukuze kufezekiswe injongo yonyango lwexesha elide.

3. Indima yeHec kwiinkqubo zokuhambisa iziyobisi
Ngokuphuhliswa kwetekhnoloji yamayeza, i-HEC isetyenziswe ngokubanzi kwiinkqubo ezahlukeneyo zokuhambisa iziyobisi, ngakumbi kumasimi e-Nano-Abriers, kunye nabathwali abazinzileyo. I-HEC inokudityaniswa kunye nezinto ezahlukeneyo zokuphatha iziyobisi zokwenza into ezinzileyo yokuqinisekisa ukukhululwa okuzinzileyo kunye nokuhanjiswa kweziyobisi ngokufanelekileyo.

I-Nano Carrier: I-HEC inokusetyenziswa njengesixhobo sokuziphatha kweziyobisi ukuba sithintele ukwahlula-hlula okanye ukwenziwa kwamasuntswana okutshaba kunye nokwandisa i-bioaaayints yeziyobisi.
I-microssores kunye namasuntswana anokusetyenziselwa ukulungiselela imicroscores kunye ne-virprecle carriers ukuqinisekisa ukukhululwa kweziyobisi kunye nokuphucula ukusebenza kweziyobisi.

Njengombono wexesha elininzi kunye neline. Ngokuphuhliswa okuqhubekayo kwetekhnoloji yamayeza, i-HEC idlala indima ebaluleke ngakumbi kulawulo lokukhutshwa kweziyobisi, ulawulo lwasekhaya, ukulungiselela ukukhululwa kunye neenkqubo ezintsha zokuhambisa iziyobisi. I-biocomini yayo elungileyo, i-viscosity eguquguqukayo kunye nozinzo zenza ukuba ihlawulwe kwintsimi yamayeza. Kwixa elizayo, ngophando olunzulu lwe-HeC, isicelo sayo kumalungiselelo asechiza siya kuba sande ngakumbi kwaye sahlukile.