I-Hydroxypropyl Methylcelcelsulose (HPMC) yi-Polymer eguquguqukayo esetyenziswa ngokubanzi kumashishini asusela kwi-surmmaceuticals ukuba abe nolwakhiwo ngenxa yepropathi eyakhayo. Kukupheliswa kweselselose, kunye namaqela e-hydroxyl kuthathelwe indawo yi-SAPEXY kunye namaqela e-hydroxypropy, ukuphucula amandla ayo emanzini kunye neenyibilikisi zezinto eziphilayo.
Iimpawu zokungasebenzi ze-HPMC
1. Ukuzalwa kwamanzi
I-HPMC inganyikithi kakhulu amanzi anyibilikayo. Ukuqina kwayo emanzini kuyachukunyiswa zizinto ezininzi:
Iqondo lokushisa: i-HPMC inyibilikisa kubanda okanye igumbi lamaqondo obushushu. Xa i-hell, i-HPMC inokwenza ijeli; Ukupholisa, ijeli iyaphumelela kwakhona, iyenza iphinde iphinde. Le gehula ye-thermal iluncedo kwizicelo ezinje ngokukhululwa iziyobisi ezilawulwa ngamachiza.
Uxinzelelo: Ukugxila okuphantsi (0.5-2%) ngokubanzi kuyanyibilikisa ngokulula. Ukugxininisa okuphezulu (ukuya kuthi ga kwi-10%) kunokufuna ukuvuselela kunye nexesha.
Ph: Izisombululo ze-HPMC ziyazinza kwi-pH yoluhlu lwe-PH (3-11), zisenza ukuba ziguqulwe ngendlela eyahlukileyo.
I-2. Izinyibilikisi zezinto eziphilayo
Ngelixa inyibiliki ye-i-HPMMC, i-HPMC inokuchitheka kwezinye izinyibilikisi, ngakumbi abo banenqanaba elithile leempawu zePolar. Oku kubandakanya:
I-alcohols: I-HPMC ibonisa ukugcwala okuhle kulutho olunjenge-methanol, ethanol, kunye ne-Iyopropanol. I-alcohols ephezulu isebenza kangako ngenxa yeekhonkco zawo ezinde.
I-Glycols: Propylene Glycol kunye nePolythylene Glycol (Peg) inokunyibilikisa i-HPMC. Ezi zinyibilikisi zihlala zisetyenziswa ngokudibeneyo namanzi okanye ii-alcohols zokuphucula ukubenzela amandla kunye nokuzinza kwesicombululo.
I-KETOSE: I-ketones ethile efana ne-acetone ne-methyl yeyyl ketone inokunyibilikisa i-HPMC, ngakumbi xa idityaniswa namanzi.
3. Imixube
I-HPMC inokuchithwa kwimixube yomxube weSolvent. Umzekelo, ukudibanisa amanzi nge-alcohols okanye i-Glycols inokuphucula isolula. I-synergy phakathi kwezinyibiliki zinokunciphisa uxinzelelo lwayo nayiphi na isoyile enye, ukulungisa ukutshitshiswa.
Indlela yokupheliswa
Ukuchithwa kwe-HPMC kwizinyithi kubandakanya ukwaphula imikhosi ye-intermolecular phakathi kweekhonkco ze-HPMC kunye nokwakha unxibelelwano olutsha kwiimolekyuli ezisisiseko. Izinto ezifutha le nkqubo zibandakanya:
I-Hydrogen Bonding: I-HPMC ye-Hydrogen Bonds ngamanzi nakwezinye izinto zepolar, ziququzelela ukuluka.
I-Polymer-Solmer-Solver-Solverve: amandla eemolekyuli zeSolvent ukungena nokunxibelelana nemixokelelwane ye-HPMC ichaphazela ukusebenza ngempumelelo.
Ukuphathwa koomatshini
Ukuqwalaselwa okusebenzayo ngokuphelisa i-HPMC
1. Indlela yokuphelisa
Ukuchithwa okusebenzayo, landela la manyathelo:
Ukudibanisa kancinci
Ulawulo lobushushu: Dibanisa i-HPMC kumanzi abandayo ukuphepha ukuhlaselwa kwangaphambili. Ezinye izinyibilikisi eziphilayo, ukufudumeza okuncinci kunokunceda.
Iindlela zokuxuba: Sebenzisa oomatshini oomatshini okanye i-homogenizers ukuxuba ngokufanelekileyo, ngakumbi ngamacala aphezulu.
2. Uxinzelelo kunye nokuFaniso
Uxinzelelo luka-HPMC lunefuthe kwi-viscosity yesisombululo:
Uxinzelelo oluphantsi: Iziphumo kwisisombululo se-viscofity ephantsi, zilungele izicelo ezinjengeengubo okanye iibhanti.
Uxinzelelo oluphezulu: Yenza isisombululo se-viscofity ephezulu okanye ijeli, iluncedo kwiifomu zamayeza zokukhululwa kwamayeza.
3. Ukuhambelana
Xa usebenzisa i-HPMC kwifomu, qinisekisa ukuhambelana nezinye izithako:
Uzinzo lwePH: Qinisekisa ukuba ezinye izinto zingatshintshi i-pH ngaphaya koluhlu oluzinzileyo lwe-HPMC.
Imvakalelo yobushushu: Cinga ngepropathi ye-thermal xa uyila iinkqubo ezibandakanya utshintsho lobushushu.
Ukusetyenziswa kwezisombululo ze-HPMC
Izisombululo ze-HPMC ziqashwe kumashishini ahlukeneyo ngenxa yepropathi yabo eyahlukileyo:
I-1. Amayeza
I-HPMC isebenza njenge-binder, ifilimu yangaphambili, kunye ne-arhente yokukhutshwa kwe-Intanethi:
Iitafile kunye neecapbules: Izisombululo ze-HPMC zinceda kwizithako ezibophelelayo kwaye zenze iifilimu zokuKhululwa kweziyobisi ezilawulwayo.
I-Gels: isetyenziswa kwimigaqo ephezulu yokuthambisa kunye nokuzinzisa iipropathi.
2. Ishishini lokutya
Njengesongezelelo sokutya, i-HPMC isetyenziselwa ukuzinzisa kwayo kunye nokulungisa iipropathi:
Abakhulu: iphucula ukwenziwa koluvo kunye nozinzo kwiisosi kunye nokunxiba.
Ukuqulunqwa kwefilimu: Yenza iifilimu ezidliwayo ngenxa yengubo kunye nemfuziselo.
I-3. Ulwakhiwo
Isisombululo se-HPMC Guqula iipropathi zezinto zokwakha:
Isamente kunye nodaka: Isetyenziselwa iarhente yokugcina amanzi kunye nokugcinwa kwamanzi kwiimveliso ezisekwe kwisamente.
Iipeyinti kunye neengubo
Iindlela eziphambili zokuchitheka
1. Unyango
Sebenzisa amaza e-Ultrasonic ukuchitha i-HPMC unokuphucula ireyithi yokuchitha kunye nokusebenza kakuhle ngokwaphula amasuntswana aphantsi kunye nokukhuthaza ukusasazeka kweyunifomu.
I-2. Ukudibana okungafaniyo
Abaxubeki-shistacari ophakamileyo babonelela ngokuxubusha kakhulu, ukunciphisa ixesha lokutshabalalisa kunye nokuphucula i-homogeneity, ngakumbi kwifomu-viscofity ephezulu.
Ukuqwalaselwa kokusiNgqongileyo nezokhuseleko
I-1 .Ukuibhadiogradise
I-HPMC yi-biodegradable, inobuhlobo obukhulu. Iyonakalisa izinto zendalo, ukunciphisa ifuthe kwendalo.
2. UKHUSELEKO
I-HPMC ayinatyhefu kwaye ikhuselekile ukuba isetyenziswe ekutyeni, amayeza, kunye ne-cosmetics. Nangona kunjalo, amaphepha edatha ezokhuseleko (i-SDS) kufuneka aphononongwe ukuphononongwa kunye nezikhokelo zokugcina.
Ukuphelisa i-HPMC ngokufanelekileyo kufuna ukuqonda iimpawu zalo zomelezelelo kunye nokudityaniswa ngeendlela ezahlukeneyo. Amanzi ahlala esona selufu kwesentloko, ngelixa oophono, i-Glycols, kunye nemixube yesinyithisileyo inika ezinye izisombululo kwizicelo ezithile. Iindlela ezifanelekileyo kunye nokuqwalaselwa nokuqwalaselwa qinisekisa ukutshitshiswa okusebenzayo, ukuqalisa ukusetyenziswa kwe-HPMP ngokuguquguqukayo kumashishini.
IXESHA LOKUQALA: Jun-14 ukuya ku-2424