Itekhnoloji yobushushu be-hydroxypropyl methylcellulose (HPMC)

IHydroxypropyl Methyl Cellulose (HPMC) yi-ether ye-cellulose engeyo-ionic esetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, iingubo kunye namanye amashishini. Iimpawu zayo ezikhethekileyo zomzimba kunye neekhemikhali zinika ukuzinza okugqwesileyo kunye nokusebenza okusebenzayo kwiindawo eziphezulu zokushisa. Ngemfuno ekhulayo yezicelo zobushushu obuphezulu, ukumelana nobushushu obuphezulu kunye nokuguqulwa kwetekhnoloji ye-HPMC ngokuthe ngcembe ibe yindawo ephambili yophando.

1. Iimpawu ezisisiseko ze-HPMC

I-HPMC inokunyibilika kakuhle kwamanzi, ukutyeba, ukwenza ifilimu, ukumilisela, ukuzinza kunye nokuhambelana kwezinto eziphilayo. Ngaphantsi kweemeko eziphezulu zokushisa, ukunyibilika, ukuziphatha kwe-gelation kunye neempawu ze-rheological ze-HPMC ziya kuchaphazeleka, ngoko ke ukulungiswa kobuchwepheshe bokushisa okuphezulu kubaluleke kakhulu kwisicelo sayo.

2. Iimpawu eziphambili ze-HPMC phantsi kommandla wokushisa okuphezulu

I-gelation ye-thermal

I-HPMC ibonisa isiganeko esisodwa se-thermal gelation kwiindawo zobushushu obuphezulu. Xa iqondo lokushisa liphakama kuluhlu oluthile, i-viscosity yesisombululo se-HPMC iya kuncipha kwaye i-gelation iya kwenzeka kwiqondo lokushisa elithile. Olu phawu lubaluleke kakhulu kwizinto zokwakha (ezifana nodaka lwesamente, udaka lokuzilinganisa) kunye neshishini lokutya. Ngokomzekelo, kwiindawo eziphezulu zokushisa, i-HPMC inokubonelela ngokugcinwa kwamanzi okungcono kunye nokubuyisela umbane emva kokupholisa.

Uzinzo lobushushu obuphezulu

HPMC uzinzo elungileyo thermal kwaye akukho lula ukubola okanye denature kumaqondo obushushu aphezulu. Ngokuqhelekileyo, ukuzinza kwayo kwe-thermal kuhambelana neqondo lokuthatha indawo kunye neqondo le-polymerization. Ngokusebenzisa ukuguqulwa kweekhemikhali ezithile okanye ukulungiswa kokulungelelaniswa, ukuxhathisa ubushushu kunokuphuculwa ukuze kukwazi ukugcina iimpawu ezintle ze-rheological kunye nokusebenza kwiindawo eziphezulu zokushisa.

Ukuxhathisa ityuwa kunye nokuxhatshazwa kwe-alkali

Kwiindawo eziphezulu zokushisa, i-HPMC inokunyamezela okulungileyo kwi-acids, i-alkali kunye ne-electrolytes, ngokukodwa ukuxhathisa okunamandla kwe-alkali, eyenza ukuba ikwazi ukuphucula ngokufanelekileyo ukusebenza kokwakhiwa kwezinto ezisekelwe kwi-samente kwaye ihlale izinzile ngexesha lokusetyenziswa kwexesha elide.

Ukugcinwa kwamanzi

Ukugcinwa kwamanzi kubushushu obuphezulu be-HPMC luphawu olubalulekileyo kwisicelo salo esibanzi kushishino lokwakha. Kwiindawo zokushisa eziphezulu okanye ezomileyo, i-HPMC inokunciphisa ngokufanelekileyo ukukhuphuka kwamanzi, ukulibazisa ukusabela kwe-cement hydration, kunye nokuphucula ukusebenza kokwakhiwa, ngokunciphisa ukuveliswa kweentanda kunye nokuphucula umgangatho wemveliso yokugqibela.

Umsebenzi womphezulu kunye ne-dispersibility

Phantsi kobushushu obuphezulu, i-HPMC isenakho ukugcina i-emulsification elungileyo kunye ne-dispersibility, ukuzinzisa inkqubo, kwaye isetyenziswe ngokubanzi kwiingubo, iipeyinti, izinto zokwakha, ukutya kunye nezinye iindawo.

3. HPMC iteknoloji yokuguqulwa kobushushu obuphezulu

Ukuphendula kwiimfuno zesicelo seqondo lokushisa eliphezulu, abaphandi kunye namashishini baye baphuhlisa iintlobo ezahlukeneyo zeteknoloji yokuguqulwa kwe-HPMC ukuphucula ukumelana nokushisa kunye nokuzinza komsebenzi. Iquka ikakhulu:

Ukwandisa iqondo lokuthatha indawo

Iqondo lokutshintshwa (DS) kunye nokutshintshwa kwe-molar (MS) ye-HPMC kunempembelelo ebalulekileyo ekuxhathiseni ubushushu. Ngokwandisa iqondo lokutshintshwa kwe-hydroxypropyl okanye i-methoxy, ukushisa kwayo kwe-thermal gelation kunokunciphisa ngokufanelekileyo kunye nokuzinza kwayo kokushisa okuphezulu kunokuphuculwa.

Ukuguqulwa kweCopolymerization

I-Copolymerization kunye nezinye iipolymers, ezifana nokudibanisa okanye ukudibanisa kunye ne-polyvinyl alcohol (PVA), i-polyacrylic acid (i-PAA), njl., inokuphucula ukuxhathisa ubushushu be-HPMC kwaye igcine iimpawu ezilungileyo zokusebenza phantsi kobushushu obuphezulu.

Ukuguqulwa kwe-cross-linking

Ukuzinza kwe-thermal ye-HPMC kunokuphuculwa nge-chemical cross-linking okanye ukudibanisa ngokomzimba, okwenza ukusebenza kwayo kuzinzile phantsi kweemeko eziphezulu zokushisa. Ngokomzekelo, ukusetyenziswa kwe-silicone okanye ukuguqulwa kwe-polyurethane kunokuphucula ukuxhathisa ubushushu kunye namandla omatshini we-HPMC.

Ukuguqulwa kweNanocomposite

Kwiminyaka yakutshanje, ukongezwa kwama-nanomaterials, njenge-nano-silicon dioxide (SiO₂) kunye ne-nano-cellulose, inokuphucula ngokufanelekileyo ukuxhathisa ubushushu kunye neempawu zemishini ye-HPMC, ukuze ikwazi ukugcina iimpawu ezintle ze-rheological phantsi kwemekobume yobushushu obuphezulu.

4. Intsimi yesicelo sobushushu obuphezulu be-HPMC

Izinto zokwakha

Kwizinto zokwakha ezifana nodaka olomileyo, i-tile adhesive, i-putty powder, kunye nenkqubo ye-insulation wall yangaphandle, i-HPMC inokuphucula ngokufanelekileyo umsebenzi wokwakha phantsi kwendawo yokushisa ephezulu, ukunciphisa ukuqhekeka, kunye nokuphucula ukugcinwa kwamanzi.

Ishishini lokutya

Njengesongezo sokutya, i-HPMC ingasetyenziswa ekutyeni okubhakiweyo okunobushushu obuphezulu ukuphucula ukugcinwa kwamanzi kunye nozinzo lokutya, ukunciphisa ilahleko yamanzi, kunye nokuphucula incasa.

Intsimi yezonyango

Kwishishini lamachiza, i-HPMC isetyenziswa njenge-tablet yokwambathisa kunye nezinto ezikhutshwa ngokuqhubekayo ukuphucula ukuzinza kwe-thermal yamachiza, ukulibazisa ukukhutshwa kweziyobisi, kunye nokuphucula i-bioavailability.

UKwemba iOyile

I-HPMC ingasetyenziswa njengesongezo solwelo lokomba ioyile ukuphucula uzinzo lobushushu obuphezulu bolwelo lokomba, ukuthintela ukudilika kodonga, kunye nokuphucula ukusebenza kakuhle kokomba.

HPMC ine-gelation ekhethekileyo ye-thermal, ukuzinza kobushushu obuphezulu, ukuxhathisa kwe-alkali kunye nokugcinwa kwamanzi phantsi kobushushu obuphezulu. Ukumelana nokushisa kwayo kunokuphuculwa ngakumbi ngokuguqulwa kweekhemikhali, ukuguqulwa kwe-copolymerization, ukuguqulwa kwe-cross-linking kunye nokuguqulwa kwe-nano-composite. Isetyenziswa ngokubanzi kumashishini amaninzi afana nokwakha, ukutya, amayeza, kunye nepetroleum, ebonisa amandla amakhulu emarike kunye namathemba okusebenza. Kwixesha elizayo, ngophando kunye nophuhliso lweemveliso eziphezulu ze-HPMC, izicelo ezininzi kwiindawo zokushisa eziphezulu ziya kwandiswa.