IHydroxypropyl methylcellulose (HPMC) yi-ether ye-cellulose enganyibilikiyo yamanzi e-non-ionic esetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, izimonyo kunye namashishini amachiza. Iimpawu ze-viscosity zesisombululo sayo samanzi zizinto eziphambili ezichaphazela ukusebenza kwayo kwesicelo.
1. Iimpawu ezisisiseko ze-HPMC
I-AnxinCel®HPMC yi-cellulose ephuma kwi-cellulose eyenziwe ngokwazisa i-hydroxypropyl kunye namaqela e-methyl kwitsheyina le-molecular of cellulose. Inokunyibilika kakuhle kwamanzi kunye ne-viscosity ephezulu, kwaye isoloko isetyenziselwa ukulungisa izisombululo ezinamanzi kunye neempawu ezithile ze-rheological. Ezi mpawu zenza i-HPMC isetyenziswe ngokubanzi kwi-coatings, i-adhesives, ukukhululwa okuqhubekayo kweziyobisi, izongezo zokutya kunye namanye amashishini.
2. Iimpawu zeViscosity ze-HPMC isisombululo samanzi
Iimpawu ze-viscosity zesisombululo samanzi se-HPMC zichatshazelwa zizinto ezininzi, ngokukodwa kubandakanywa ukugxila, ubushushu, izinga lokucheba, ixabiso le-pH kunye nesakhiwo se-molecular.
Impembelelo yogxininiso kwi-viscosity
I-viscosity yesisombululo se-aqueous ye-HPMC inyuka ngokunyuka koxinzelelo. Xa i-concentration ye-HPMC iphantsi, isisombululo samanzi sincinci kwaye sine-viscosity ephantsi; njengoko uxinaniso lukhula, ukusebenzisana phakathi kwama-amolekyu kwanda, kwaye i-viscosity yesisombululo samanzi yanda kakhulu. Ngokuqhelekileyo, i-viscosity yesisombululo se-HPMC ihambelana ngokuthe ngqo nokugxininiswa kwayo, kodwa idla ngokuzinza kwindawo ethile, ibonisa iimpawu ze-viscosity zesisombululo.
Impembelelo yobushushu kwi-viscosity
Ubushushu yinto ebalulekileyo echaphazela i-viscosity ye-AnxinCel®HPMC isisombululo samanzi. Njengoko iqondo lokushisa liphakama, iibhondi ze-hydrogen kunye nokusebenzisana kwe-hydrophobic kwii-molecule ze-HPMC ziya kuba buthathaka, kubangele ukuhla kwamandla okubopha phakathi kwama-molecule, ngaloo ndlela kuncitshiswe i-viscosity yesisombululo samanzi. Ngokubanzi, i-viscosity yesisombululo samanzi se-HPMC sibonisa ukuhla okubalulekileyo ngokunyuka kwamaqondo obushushu, ngakumbi kuluhlu lobushushu obuphezulu. Olu phawu lwenza i-HPMC ibe namandla olawulo olungcono kwezinye izicelo zolawulo lobushushu.
Impembelelo yezinga lokucheba kwi-viscosity
Isisombululo samanzi se-HPMC sibonisa iimpawu ze-Newtonian fluid eziqhelekileyo kumazinga aphantsi okucheba, oko kukuthi, i-viscosity izinzile; nangona kunjalo, kumazinga aphezulu okucheba, i-viscosity yesisombululo se-HPMC iya kuncipha kakhulu, ebonisa ukuba ineempawu zokucheba. Iimolekyuli ze-HPMC zineempawu ezithile ze-rheological. Kwizinga eliphantsi lokucheba, iintambo ze-molecular zijijekile ngakumbi, zenza ukuchasana kwesakhiwo esiphezulu, esibonakaliswa njenge-viscosity ephezulu; kumazinga aphezulu e-shear, i-molecular chain chain iyancipha, i-fluidity iphuculwe, kwaye i-viscosity iyancipha.
Impembelelo yexabiso le-pH kwi-viscosity
Isisombululo samanzi se-HPMC ngokubanzi sigcina i-viscosity ezinzileyo phantsi kokungathathi hlangothi kwiimeko ezibuthathaka zealkaline. Kwindawo eqinileyo ye-asidi okanye isiseko esinamandla, iimolekyuli ze-HPMC zinokungena kwi-protonation okanye i-deprotonation reactions, okubangelwa utshintsho kwi-hydrophilicity, i-hydrophobicity kunye ne-intermolecular interactions phakathi kwama-molecule, ngaloo ndlela ichaphazela i-viscosity yesisombululo samanzi. Kwiimeko eziqhelekileyo, utshintsho kwi-pH lunempembelelo encinci kwi-viscosity yezisombululo ze-HPMC, kodwa phantsi kweemeko ezinzima ze-pH, utshintsho lwe-viscosity lunokubonakala ngakumbi.
Impembelelo yesakhiwo seemolekyuli kwi-viscosity
Iimpawu ze-viscosity ze-HPMC zihambelana ngokusondeleyo kwisakhiwo sayo se-molecular. Iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl kwi-molecule inempembelelo ebalulekileyo kwi-viscosity yesisombululo samanzi. Iqondo eliphezulu lokutshintshwa kweqela, linamandla ngakumbi i-hydrophilicity ye-HPMC kwaye iphezulu i-viscosity yesisombululo. Ukongeza, ubunzima bemolekyuli ye-HPMC ikwayinto ephambili echaphazela i-viscosity yayo. Ubukhulu be-molecular weight, ixesha elide i-molecular chain, kwaye intsebenziswano inamandla phakathi kweeathomu, okukhokelela kwi-viscosity ephezulu yesisombululo samanzi.
3. Ukubaluleka kweempawu ze-viscosity ze-HPMC isisombululo samanzi kwisicelo
Iimpawu ze-viscosity ze-HPMC isisombululo samanzi zibalulekile ekusebenziseni kwayo kwiinkalo ezahlukeneyo.
Intsimi yokwakha: I-HPMC isoloko isetyenziselwa udaka lwesamente kunye nezinto ezincamathelayo, kwaye inemisebenzi yokuqina, ukugcina ukufuma, kunye nokuphucula ukusebenza kolwakhiwo. Iimpawu zayo ze-viscosity zichaphazela ngokuthe ngqo ukusebenza kunye nokunamathela kodaka. Ngokulungelelanisa i-concentration kunye ne-molecular structure ye-HPMC, iimpawu ze-rheological zodaka zingalawulwa, ngaloo ndlela ziphucula ukukhululeka kokwakhiwa.
Umzi-mveliso wamachiza: I-AnxinCel®HPMC isisombululo samanzi sisoloko sisetyenziswa kumalungiselelo afana ne-agent-release-release agents, i-capsule shells, kunye ne-eye drops. Iimpawu zayo ze-viscosity zinokuchaphazela izinga lokukhululwa kweziyobisi kunye nokulawula inkqubo yokukhululwa kweziyobisi emzimbeni. Ngokukhetha i-HPMC enobunzima bemolekyuli obufanelekileyo kunye neqondo lokutshintshela, iimpawu zokukhululwa kwamachiza zinokuhlengahlengiswa ukufikelela iziphumo zonyango ezichanekileyo.
Ishishini lokutya: I-HPMC isetyenziswa njenge-thickener, stabilizer, kunye ne-emulsifier ekulungiseni ukutya. Iimpawu ze-viscosity zesisombululo sayo samanzi zichaphazela incasa kunye nokuzinza kokutya. Ngokulungelelanisa uhlobo kunye nesixa se-HPMC esisetyenzisiweyo, ukuthungwa kokutya kunokulawulwa ngokuchanekileyo.
Umzi-mveliso wokuthambisa: I-HPMC, njenge-thickener kunye ne-stabilizer kwi-cosmetics, inokuphucula ukuthungwa kwemveliso, inike ulwelo olufanelekileyo kunye nokuziva kakuhle. Iimpawu zayo ze-viscosity zinempembelelo ebalulekileyo kumava omsebenzisi kwiimveliso ezifana ne-creams, i-gels, kunye ne-shampoos.
Iimpawu ze-viscosity zeHPMC Izisombululo ezinamanzi zichatshazelwa zizinto ezininzi ezinje ngoxinaniso, ubushushu, izinga lokucheba, ixabiso le-pH, kunye nesakhiwo seemolekyuli. Ngokulungelelanisa le miba, ukusebenza kwesicelo se-HPMC kunokulungiswa ukuhlangabezana neemfuno zamashishini ahlukeneyo kwiipropati zayo ze-rheological. Uphando olunzulu kwiimpawu ze-viscosity ze-HPMC izisombululo zamanzi azincedi nje ukuqonda iimpawu zayo ezisisiseko, kodwa zibonelela ngesikhokelo sethiyori kwisicelo sayo kwimveliso yangempela.
Ixesha lokuposa: Jan-16-2025