Hydroxypropyl methylcelculose (hpmc) yindawo ye-ionic ye-ionic ye-ionic ye-ionic ye-prolymer efunyenwe ngokutshintsha kweekhemikhali kweselutali yendalo. Isetyenziswe ngokubanzi ekutyeni, amayeza, amayeza, amayeza kunye namashishini okwakha, ngakumbi njengomntu onamathela, i-thicker, i-eulssifier kunye ne-arhente yokumisa kumalungiselelo e-chimbeceutical. Kwinkqubo yokwenza isicelo, iimpawu zokubonisa i-HPMC Accous Coumoous ibalulekile kwintsebenzo yayo kwimimandla eyahlukeneyo.
1. Ulwakhiwo kunye neePropathi ze-Hydroxypropyl Methylcelcelce
Ubume be-phudm ye-HPMC inamaqela amabini aphantsi, i-hydroxypropyl (-Che₂Chohch₃) kunye ne-methyl (-och₃), eyenza ukuba ifumane amandla amnandi kunye nokukwazi ukulungiswa. I-HPMC molecular Choin inesakhiwo esithile esingqongqo, kodwa ikwazisa ubume benethiwekhi ezintathu kwisisombululo esinamandla, okukhokelela kukwanda kwe-viscofity. Ubunzima bayo bemolekyuli, uhlobo lokufaka endaweni kunye nenqanaba lokufakelwa (okt, inqanaba le-hydroxypropy kunye ne-methyl endaweni yeyunithi nganye) banefuthe elibalulekileyo kwi-viscosity yesisombululo.
2
Iimpawu ze-viscosity ye-HPMC Accough inxulumene ngokusondeleyo nezinto ezifana noxinzelelo, ubunzima bemolekyuli, ubushushu kunye nexabiso le-SLANT. Ngokubanzi, i-viscosity ye-HPMC AMAULO AMANQAKU AQHUBEKILEYO YONYANGO LWEZOBUCHULE. I-viscofity yayo ibonisa indlela yokuziphatha ye-non-Newtolian, oko kukuthi, njengoko inqanaba le-Shear lisonyuka, i-viscosity yesisombululo sihamba kancinci, sibonisa intlekele isheramen.
(1) Iziphumo zoxinzelelo
Kukho ubudlelwane obuthile phakathi kohlobo lwe-HPMC ACTEAUCH kunye noxinzelelo lwayo. Njengoko uxinzelelo lwe-HPMC, ukunxibelelana kwemolekyuli kwisisombululo se-AICT kuyaphuculwa, kwaye ukuntywila kunye nokudityaniswa komnqamlezo kunye nokudityaniswa kweemolekyuli kunyuke, kukhokelela kwi-viscosity yesisombululo. Kubuxakeka obuphantsi, uVekyusi we-HPMC AMAROOR AMANQAKU AQHELEKILE NGOKUGQIBELA, EMVA KOKUGQIBELA, UKUKHUSELEKA KOKUKHUSELEKILEYO kwesisombululo sithanda ukuba sifihlakele kwaye sifikelela kwixabiso elizinzileyo.
(2) Isiphumo sobunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC buchaphazela ngokuthe ngqo ukubonwa kwesisombululo sayo. I-HPMC ene-molecular yemolekyuli ineemolekyuli zemolekyuli kwaye inokwenza ubume benethiwekhi ezintathu zenethiwekhi kwisisombululo se-ACTEAGE, esikhokelela kwi-viscofity ephezulu. Ngokwahlukileyo, i-HPMC enemoyaratur esezantsi yemolekyuli inelungelo lokufumana inethiwekhi yenethiwekhi kunye no-Viscofity osezantsi ngenxa yeemolekyuli zayo ezimfutshane. Ke ngoko, xa usenza isicelo, kubaluleke kakhulu ukukhetha i-HPMC kunye nobunzima obuchanekileyo bemolekyuli ukufezekisa isiphumo se-viscofity efanelekileyo.
(3) Iziphumo zobushushu
Iqondo lokushisa yinto ebalulekileyo echaphazela i-viscofity yesisombululo se-HPMC. Njengoko iqondo lobushushu liyanda, intshukumo yeemolekyuli zamanzi iyaqina kwaye i-vickosity yesisombululo idla ngokuncipha. Kungenxa yokuba xa iqondo lobushushu liphuma, inkululeko ye-HPMC Molectur Chain inyuswe kwaye ukusebenzisana phakathi kweemolekyuli zibuthathaka, ngaloo ndlela kunciphisa i-viscosity yesisombululo. Nangona kunjalo, impendulo ye-HPMC evela kwiibatch ezahlukeneyo okanye ii-rands kwiqondo lokushisa linokwahluka, ke iimeko zobushushu kufuneka zilungiswe ngokweemfuno ezithile zesicelo.
(4) Isiphumo sexabiso le-pH
I-HPMC ngokwayo yindawo engeyiyo i-ionic, kwaye i-viscosity yesisombululo sayo esikhuthazayo inomdla kwi-PH. Nangona i-HPMC ibonakalisa iimpawu ezizinzileyo ze-acidic kwi-acidic okanye imeko engathathi hlangothi, ukuluka kunye nokubonisa i-HPMC kuya kuchaphazeleka kwiimeko ze-acidic okanye i-alkaline. Umzekelo, phantsi kwe-acid eqinileyo okanye imeko eyomeleleyo ye-alkaline, iimolekyuli ze-HPMC zinokuchithwa ngokuyinxalenye, ngaloo ndlela kuncitshiswa uVekyuli wesisombululo.
3. Uhlalutyo lwe-RTOOLOGOLORICICT IIMPAWU ZOKUGQIBELA ZE-HPMC ACTEAT
Ukuziphatha kakuhle kwesisombululo se-HPMC esihlala sibonisa iimpawu ezingengaseNew-Newtonid, ezithetha ukuba i-viscofity yayo ayihambelani kuphela nezinto ezifana noxinzelelo lwesisombululo kunye ne-molekyuli, kodwa kunye nenqanaba le-molek. Ngokubanzi, ngamaxabiso asezantsi asezantsi, isisombululo se-HPMC sibonisa i-viscofity ephezulu, ngelixa iqondo lechiza liyanda, i-viscosity ihla. Le ndlela yokuziphatha ibizwa ngokuba "shering clinting" okanye "ukucutha ichibi" kwaye kubaluleke kakhulu kwizicelo ezininzi ezisebenzayo. Umzekelo, kumasimi eengubo, amalungiselelo ngamayeza, ukulungiswa kokutya, njl njl.
4. Ezinye izinto ezichaphazela i-viscofity yesisombululo se-HPMC
(1) Isiphumo setyiwa
Ukongezwa kweecollorks zetyuwa (ezinje nge-sodium chloride) inokunyusa i-viscofity yesisombululo se-HPMC. Kungenxa yokuba ityiwa inokuphucula unxibelelwano phakathi kweemolekyuli ngokutshintsha amandla e-Ionic yesisombululo, ukuze iimolekyuli ze-HPMC zenza indawo yenethiwekhi ye-compact, ngaloo ndlela kunyusa i-viscofity. Nangona kunjalo, ifuthe lohlobo lwetyuwa kunye nokugxininisa kuhlobo lwe-viscofity kufuneka kulungiswe ngokweemeko ezithile.
(2) Isiphumo solunye izongezo
Ukongeza ezinye ii -opumetives (ezinje nge-surfacapes, iipolimers, njl njl) ukuya kwisisombululo se-HPMC ikwachaphazela i-vicmosity. Umzekelo, i-surfacapes inokunciphisa i-viscofity ye-HPMC, ngakumbi xa uxinzelelo lwe-surfacnt luphezulu. Ukongeza, iipolimes ezithile okanye amasuntswana anokunxibelelana ne-HPMC kwaye atshintshe iipropathi ze-suheological yesisombululo.
Iimpawu ze-viscosity zehydroxypropyl methylcelceluplose Isisombululo esinamandla sichaphazeleka zizinto ezininzi, kubandakanya ubunzima, ubunzima bemolekyuli, ixabiso le-PH, ixabisekile kwaye isetyenziswa ngokubanzi kwimimandla yamashishini ahlukeneyo kunye namayeza. Ukuqonda kunye nokusebenzisana ezi mpawu zokundwendwela kuya kunceda ekusebenziseni ukusetyenziswa kwe-HPMC kwizicelo ezahlukeneyo. Kwizicelo ezisebenzayo, uhlobo olufanelekileyo lwe-HPMC kunye neemeko zenkqubo kufuneka zikhethwe ngokweemfuno ezithile zokufumana i-viscofity efanelekileyo kunye neepropathi ze-ruduloc.
IXESHA LOKUQALA: UMar-01-2025